Next-Generation Personalized Diagnostic Nanotechnologies for Predicting Response to Cancer Medicine

Project Information

BARCODE DIAGNOSTICS

Grant agreement ID: 680242

DOI

10.3030/680242

Project closed

EC signature date 29 March 2016

Start date 1 April 2016

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 250,00

EU contribution

€ 1 499 250,00

Coordinated by

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Author(s): Assaf Zinger, Lilach Koren, Omer Adir, Maria Poley, Mohammed Alyan, Zvi Yaari, Nadav Noor, Nitzan Krinsky, Assaf Simon, Hadas Gibori, Majd Krayem, Yelena Mumblat, Shira Kasten, Sivan Ofir, Eran Fridman, Neta Milman, Michael M Lübtow, Lior Liba, Jeny Shklover, Janna Shainsky-Roitman, Yoav Binenbaum, Dov Hershkovitz, Ziv Gil, Tal Dvir, Robert Luxenhofer, Ronit Satchi-Fainaro, Avi Schroeder
Published in: Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors, Issue 22;13(10), 2019, Page(s) 11008-11021, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b02395

Synthetic Cells with Self-Activating Optogenetic Proteins Communicate with Natural Cells

Author(s): Omer Adir, Mia R. Albalak, Ravit Abel, Lucien E. Weiss, Gal Chen, Amit Gruber, Oskar Staufer, Yaniv Kurman, Ido Kaminer, Jeny Shklover, Janna Shainsky-Roitman, Ilia Platzman, Lior Gepstein, Yoav Shechtman, Benjamin Horwitz, Avi Schroeder
Published in: Nature Communications, Issue 28;13(1), 2022, Page(s) 2328, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29871-8

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Author(s): Omer Adir, Noga Sharf-Pauker, Gal Chen, Maya Kaduri, Nitzan Krinsky, Janna Shainsky-Roitman, Jeny Shklover, Avi Schroeder
Published in: JoVE (Journal of Visualized Experiments), 2020, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/60829

Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Cancer Treatment and Fertility

Author(s): Maria Poley, Patricia Mora-Raimundo, Yael Shammai, Maya Kaduri, Lilach Koren, Omer Adir, Jeny Shklover, Janna Shainsky-Roitman, Srinivas Ramishetti, Francis Man, Rafael T. M. de Rosales, Assaf Zinger, Dan Peer, Irit Ben-Aharon, Avi Schroeder
Published in: ACS Nano, Issue 16/4, 2022, Page(s) 5246-5257, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c07237

Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases

Author(s): Maya Kaduri, Mor Sela, Shaked Kagan, Maria Poley, Hanan Abumanhal-Masarweh, Patricia Mora-Raimundo, Alberto Ouro, Nitsan Dahan, Dov Hershkovitz, Jeny Shklover, Janna Shainsky-Roitman, Yosef Buganim, Avi Schroeder
Published in: Science Advances, Issue 7/41, 2021, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abj5435

Lung targeted liposomes for treating ARDS

Author(s): Sivan Arber Raviv, Mohammed Alyan, Egor Egorov, Agam Zano, Moshit Yaskin Harush, Calvin Pieters, Hila Korach-Rechtman, Adi Saadya, Galoz Kaneti, Igor Nudelman, Shai Farkash, Ofri Doppelt Flikshtain, Lucy N Mekies, Lilach Koren, Yoav Gal, Ella Dor, Janna Shainsky, Jeny Shklover, Yochai Adir, Avi Schroeder
Published in: Journal of Controlled Release, Issue 346, 2022, Page(s) 421-433, ISSN 2352-3409
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.03.028

Three-dimensional localization microscopy in live flowing cells

Author(s): Lucien E. Weiss; Yael Shalev Ezra; Sarah Goldberg; Boris Ferdman; Boris Ferdman; Omer Adir; Avi Schroeder; Onit Alalouf; Yoav Shechtman
Published in: Three-dimensional localization microscopy in live flowing cells, Issue 15(6), 2020, Page(s) 500–506, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-020-0662-0

Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems

Author(s): Egor Egorov, Calvin Pieters, Hila Korach-Rechtman, Jeny Shklover, Avi Schroeder
Published in: Drug Delivery and Translational Research, Issue 11/2, 2021, Page(s) 345-352, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-021-00929-2

A Simple and Rapid Method for Preparing a Cell-Free Bacterial Lysate for Protein Synthesis

Author(s): Nitzan Krinsky, Maya Kaduri, Janna Shainsky-Roitman, Mor Goldfeder, Eran Ivanir, Itai Benhar, Yuval Shoham, Avi Schroeder
Published in: PLOS ONE, Issue 11/10, 2016, Page(s) e0165137, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0165137

Nanoparticles target early-stage breast cancer metastasis in vivo

Author(s): Evgeniya Goldman, Assaf Zinger, Dana da Silva, Zvi Yaari, Ashima Kajal, Dikla Vardi-Oknin, Mor Goldfeder, Josh E. Schroeder, Janna Shainsky-Roitman, Dov Hershkovitz, Avi Schroeder
Published in: Nanotechnology, Issue 28/43, 2017, Page(s) 43LT01, ISSN 0957-4484
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6528/aa8a3d

Theranostic barcoded nanoparticles for personalized cancer medicine

Author(s): Zvi Yaari, Dana da Silva, Assaf Zinger, Evgeniya Goldman, Ashima Kajal, Rafi Tshuva, Efrat Barak, Nitsan Dahan, Dov Hershkovitz, Mor Goldfeder, Janna Shainsky Roitman, Avi Schroeder
Published in: Nature Communications, Issue 7, 2016, Page(s) 13325, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13325

Synthetic Cells Synthesize Therapeutic Proteins inside Tumors

Author(s): Nitzan Krinsky, Maya Kaduri, Assaf Zinger, Janna Shainsky-Roitman, Mor Goldfeder, Itai Benhar, Dov Hershkovitz, Avi Schroeder
Published in: Advanced Healthcare Materials, Issue 7/9, 2018, Page(s) 1701163, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201701163

Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems

Author(s): Dana da Silva, Maya Kaduri, Maria Poley, Omer Adir, Nitzan Krinsky, Janna Shainsky-Roitman, Avi Schroeder
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 9-14, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2018.01.010

Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin

Author(s): Hanan Abumanhal-Masarweh, Lilach Koren, Assaf Zinger, Zvi Yaari, Nitzan Krinsky, Galoz Kaneti, Nitsan Dahan, Yael Lupu-Haber, Edith Suss-Toby, Esther Weiss-Messer, Michal Schlesinger-Laufer, Janna Shainsky-Roitman, Avi Schroeder
Published in: Journal of Controlled Release, Issue 296, 2019, Page(s) 1-13, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.01.004

Proteolytic Nanoparticles Replace a Surgical Blade by Controllably Remodeling the Oral Connective Tissue

Author(s): Assaf Zinger, Omer Adir, Matan Alper, Assaf Simon, Maria Poley, Chen Tzror, Zvi Yaari, Majd Krayem, Shira Kasten, Guy Nawy, Avishai Herman, Yael Nir, Sharon Akrish, Tidhar Klein, Janna Shainsky-Roitman, Dov Hershkovitz, Avi Schroeder
Published in: ACS Nano, Issue 12/2, 2018, Page(s) 1482-1490, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.7b07983

Autonomous bacterial nanoswimmers target cancer

Author(s): Nour Zoaby, Janna Shainsky-Roitman, Samah Badarneh, Hanan Abumanhal, Alex Leshansky, Sima Yaron, Avi Schroeder
Published in: Journal of Controlled Release, Issue 257, 2017, Page(s) 68-75, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2016.10.006

Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells

Author(s): Hanan Abumanhal-Masarweh, Dana da Silva, Maria Poley, Assaf Zinger, Evgenya Goldman, Nitzan Krinsky, Ron Kleiner, Gal Shenbach, Josh E. Schroeder, Jeny Shklover, Janna Shainsky-Roitman, Avi Schroeder
Published in: Journal of Controlled Release, Issue 307, 2019, Page(s) 331-341, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.06.025

Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine

Author(s): Omer Adir, Maria Poley, Gal Chen, Sahar Froim, Nitzan Krinsky, Jeny Shklover, Janna Shainsky‐Roitman, Twan Lammers, Avi Schroeder
Published in: Advanced Materials, Issue 32/13, 2019, Page(s) 1901989, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201901989

Intellectual Property Rights

Patent (5)

COLLAGENASE LOADED LIPOSOMES FOR ENHANCING DRUG DELIVERY

Application/Publication number: 19 743889
Date: 2019-01-23
Applicant(s): TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Delivery system comprising a proteolytic enzyme or effector thereof for use in a method for oral treatment and uses thereof AD Schroeder, AY ZINGER, A HERMAN

Application/Publication number: US 10183064B2
Date: 2015-03-19
Applicant(s): TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Methods and kits for cell-free transcription and translation. AV Schroeder, J Shainsky-roitman, M Goldfeder, N Krinsky, Y Shoham

Application/Publication number: US 20170198326A1
Date: 2015-07-08
Applicant(s): TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

HYBRID MUCO-ADHESIVE DELIVERY SYSTEMS AND USE THEREOF

Application/Publication number: 17 814897
Date: 2017-06-21
Applicant(s): TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Compositions and methods for therapeutics prescreening. A Schroeder, Z Yaari

Application/Publication number: US 20170233823A1
Date: 2015-08-13
Applicant(s): TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY