Beta Cell Generation by Stem Cell-Derived Implants in Diabetes

Risultati finali

Assay using hu-iPS-PE-device generated beta cells identifies compounds with positive effect on functional human beta cell mass

Milestone at month 18 sets proofofprinciple Equivalency with pancreatic human beta cells will be first examined Utility for screening libraries for compounds with this effect and thus for identifying agents for associated treatment to stem cell therapy

Production of biodegradable microparticles for local release of VEGF, NGF and exenatide

In vitro kinetics and in vivo compatibility should be determined in mice

Human beta cell preparations with QC data for comparative assessment of human iPS-derived implants in preclinical model and their use in screening assay

To be delivered to WP6-9 for interpretation outcome human iPS-derived implants, and to WP6 for screening assay

Human beta cell grafts with QC data for start transplants in subgroup of type 1 diabetes recipients of VCTM implant

To be delivered to WP4 for treatment of patient cohort that ended VCTM-01 trial under immune therapy

Communication network operational

See 3.2 and 3.3 Part B

Time-table for public information on program

See milestone

BetaCellTherapy website revised and updated

Milestones on annual updates website on passwordprotected member section and on general guidelines for consortium publications

Transfer of stem cells and technology for further use in BetaCellTherapy program

Transfer stem cell lines by WP2 and WP3 during last year project Assistance now fordifferentiation protocol Persepctive in continuation BCT program

Effect of micro-environmental modulators on human pancreatic islet cell implants in preclinical model

Assessment of higher and longer plasma human Cpeptide in graft recipients

Effect of micro-environmental modulator(s) on human stem cell-generated beta cell implant in preclinical model

Involves collaboration with WP6 and its model Data might lead to implementation in clinical VCTM01protocol

Pubblicazioni

Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I-/- iPSCs for β cell replacement.

Autori: Chimienti R, Baccega T, Torchio S, Manenti F, Pellegrini S, Cospito A, Amabile A, Lombardo MT, Monti P, Sordi V, Lombardo A, Malnati M, Piemonti L.
Pubblicato in: Cell Reports, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.111423

Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution

Autori: Diedert L. De Paep, Freya Van Hulle, Zhidong Ling, Marian Vanhoeij, Jacques Pirenne, Bart Keymeulen, Daniel Pipeleers, Daniel Jacobs-Tulleneers-Thevissen
Pubblicato in: PLOS ONE, Numero 16/5, 2021, Pagina/e e0251055, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0251055

Defining outcomes for beta cell replacement therapy: a work in progress

Autori: Lorenzo Piemonti, Eelco J. P. de Koning, Thierry Berney, Jon S. Odorico, James F. Markmann, Peter G. Stock, Michael R. Rickels
Pubblicato in: Diabetologia, Numero 61/6, 2018, Pagina/e 1273-1276, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4588-0

Warm ischemia time influences human islet cell isolation yield when assessed as beta cell number but not as islet equivalent number

Autori: Diedert L. De Paep, Daniel Jacobs‐Tulleneers‐Thevissen
Pubblicato in: American Journal of Transplantation, 2021, ISSN 1600-6135
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ajt.16691

Treating iPSC-Derived β Cells with an Anti-CD30 Antibody-Drug Conjugate Eliminates the Risk of Teratoma Development upon Transplantation.

Autori: Pellegrini S, Zamarian V, Landi E, Cospito A, Lombardo MT, Manenti F, Citro A, Schiavo Lena M, Piemonti L, Sordi V.
Pubblicato in: Int J Mol Sci., 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23179699

Biofabrication of a vascularized islet organ for type 1 diabetes

Autori: Antonio Citro, Philipp T. Moser, Erica Dugnani, Taufiek K. Rajab, Xi Ren, Daniele Evangelista-Leite, Jonathan M. Charest, Andrea Peloso, Bruno K. Podesser, Fabio Manenti, Silvia Pellegrini, Lorenzo Piemonti, Harald C. Ott
Pubblicato in: Biomaterials, Numero 199, 2019, Pagina/e 40-51, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.01.035

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy

Autori: Cornelis R. van der Torren, Arnaud Zaldumbide, Dave L. Roelen, Gaby Duinkerken, Simone H. Brand-Schaaf, Mark Peakman, Paul Czernichow, Philippe Ravassard, Raphael Scharfmann, and Bart O. Roep
Pubblicato in: Diabetologia, 2016, ISSN 0012-186x
Editore: Springer Verlag
DOI: 10.1007/s00125-015-3779-1

Utility of Islet Cell Preparations From Donor Pancreases After Euthanasia

Autori: Diedert L. De Paep; Freya Van Hulle; Zhidong Ling; Marian Vanhoeij; Robert Hilbrands; Wim Distelmans; Pieter Gillard; Bart Keymeulen; Daniel Pipeleers; Daniel Jacobs-Tulleneers-Thevissen
Pubblicato in: Cell Transplantation, Numero 1, 2022, ISSN 1555-3892
Editore: Elmsford, NY Cognizant Communication Corp.
DOI: 10.1177/09636897221096160

Cell therapy for type 1 diabetes: from islet transplantation to stem cells.

Autori: Sordi V, Monaco L, Piemonti L.
Pubblicato in: Horm Res Paediatr, 2022, ISSN 1663-2826
Editore: Karger
DOI: 10.1159/000526618

Comparison of Omentum and Subcutis as Implant Sites for Device-Encapsulated Human iPSC-Derived Pancreatic Endoderm in Nude Rats

Autori: Jolien R. Nijns; Ines De Mesmaeker; Krista G. Suenens; Geert M. Stangé; Kaat De Groot; Maria Marques de Lima; Marine R. C. Kraus; Bart Keymeulen; Wim Waelput; Daniel Jacobs-Tulleneers Thevissen; Daniel G. Pipeleers
Pubblicato in: Crossref, Numero 1, 2023, ISSN 2158-2440
Editore: SAGE Publications Inc.
DOI: 10.1177/09636897231167323

Cell Mass Increase Associated with Formation of Glucose‐Controlling β‐Cell Mass in Device‐Encapsulated Implants of hiPS‐Derived Pancreatic Endoderm

Autori: Thomas Robert, Ines De Mesmaeker, Freya O. Van Hulle, Krista G. Suenens, Geert M. Stangé, Zhidong Ling, Corinne Haller, Nicolas Bouche, Bart Keymeulen, Marine R.C. Kraus, Daniel G. Pipeleers
Pubblicato in: STEM CELLS Translational Medicine, Numero 8/12, 2019, Pagina/e 1296-1305, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.1002/sctm.19-0043

Encapsulated stem cell-derived β cells exert glucose control in patients with type 1 diabetes

Autori: Bart Keymeulen, Kaat De Groot, Daniel Jacobs-Tulleneers-Thevissen, David M Thompson, Melena D Bellin, Evert J Kroon, Mark Daniels, Richard Wang, Manasi Jaiman, Timothy J Kieffer, Howard L Foyt, Daniel Pipeleers
Pubblicato in: Nature Biotechnology, 2023, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-023-02055-5

Transcriptional dynamics of induced pluripotent stem cell differentiation into β cells reveals full endodermal commitment and homology with human islets.

Autori: Pellegrini S, Chimienti R, Scotti GM, Giannese F, Lazarevic D, Manenti F, Poggi G, Lombardo MT, Cospito A, Nano R, Piemonti L, Sordi V.
Pubblicato in: Cytotherapy, 2021, ISSN 1477-2566
Editore: Elsevier
DOI: 10.1016/j.jcyt.2020.10.004

Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control

Autori: Thomas Robert, Ines De Mesmaeker, Geert M. Stangé, Krista G. Suenens, Zhidong Ling, Evert J. Kroon, Daniel G. Pipeleers
Pubblicato in: Stem Cell Reports, Numero 10/3, 2018, Pagina/e 739-750, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2018.01.040

The potential and challenges of alternative sources of β cells for the cure of type 1 diabetes

Autori: Monia Cito, Silvia Pellegrini, Lorenzo Piemonti, Valeria Sordi
Pubblicato in: Endocrine Connections, Numero 7/3, 2018, Pagina/e R114-R125, ISSN 2049-3614
Editore: BioScientifica Ltd.
DOI: 10.1530/EC-18-0012

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients

Autori: Zhidong Ling, Pieter De Pauw, Daniel Jacobs-Tulleneers-Thevissen, Rui Mao, Pieter Gillard, Christiane S. Hampe, Geert A. Martens, Peter In't Veld, Åke Lernmark, Bart Keymeulen, Frans Gorus, Daniel Pipeleers
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, Numero 100/6, 2015, Pagina/e 2314-2321, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/jc.2015-1216

Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D

Autori: Sarah Roels, Olivier R Costa, Sarah A Tersey, Geert Stangé, Dieter De Smet, Eric V Balti, Pieter Gillard, Bart Keymeulen, Zhidong Ling, Daniel G Pipeleers, Frans K Gorus, Raghavendra G Mirmira, Geert A Martens
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, Numero 104/2, 2018, Pagina/e 451-460, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/jc.2017-02520

Concise Review: Markers for Assessing Human Stem Cell-Derived Implants as β-Cell Replacement in Type 1 Diabetes

Autori: Daniel Pipeleers, Thomas Robert, Ines De Mesmaeker, Zhidong Ling
Pubblicato in: STEM CELLS Translational Medicine, Numero 5/10, 2016, Pagina/e 1338-1344, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.5966/sctm.2015-0187

SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients

Autori: Else M. Balke, Simke Demeester, DaHae Lee, Pieter Gillard, Robert Hilbrands, Ursule Van de Velde, Bart J. Van der Auwera, Zhidong Ling, Bart O. Roep, Daniël G. Pipeleers, Bart Keymeulen, Frans K. Gorus
Pubblicato in: Diabetologia, Numero 61/7, 2018, Pagina/e 1623-1632, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4609-z

Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line

Autori: Silvia Pellegrini, Fabio Manenti, Raniero Chimienti, Rita Nano, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Philippe Ravassard, Lorenzo Piemonti, Valeria Sordi
Pubblicato in: Cell Transplantation, Numero 27/10, 2018, Pagina/e 1548-1560, ISSN 0963-6897
Editore: Cognizant Communication Corp.
DOI: 10.1177/0963689718798564

Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody–Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles

Autori: Else M. Balke, Eric V. Balti, Bart Van der Auwera, Ilse Weets, Olivier Costa, Simke Demeester, Pascale Abrams, Kristina Casteels, Marina Coeckelberghs, Sylvie Tenoutasse, Bart Keymeulen, Daniel G. Pipeleers, Frans K. Gorus
Pubblicato in: Diabetes Care, Numero 41/5, 2018, Pagina/e 1076-1083, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc17-2462

Increase Functional β-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells

Autori: Ines De Mesmaeker, Thomas Robert, Krista G. Suenens, Geert M. Stangé, Freya Van Hulle, Zhidong Ling, Peter Tomme, Daniel Jacobs-Tulleneers-Thevissen, Bart Keymeulen, Daniel G. Pipeleers
Pubblicato in: Diabetes, Numero 67/12, 2018, Pagina/e 2640-2649, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db18-0709

Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo

Autori: Silvia Pellegrini, Federica Ungaro, Alessia Mercalli, Raffaella Melzi, Guido Sebastiani, Francesco Dotta, Vania Broccoli, Lorenzo Piemonti, Valeria Sordi
Pubblicato in: Acta Diabetologica, Numero 52/6, 2015, Pagina/e 1025-1035, ISSN 0940-5429
Editore: Springer Verlag
DOI: 10.1007/s00592-015-0726-z

Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentially

Autori: Sarah Akbib, Jordy Stichelmans, Geert Stangé, Zhidong Ling, Zerihun Assefa, Karine H. Hellemans
Pubblicato in: PLOS ONE, Numero 14/2, 2019, Pagina/e e0212210, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0212210

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65

Autori: Olivier R. Costa, Katrijn Verhaeghen, Sarah Roels, Geert Stangé, Zhidong Ling, Daniel Pipeleers, Frans K. Gorus, Geert A. Martens
Pubblicato in: PLOS ONE, Numero 13/3, 2018, Pagina/e e0193670, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0193670

Pluripotent stem cell replacement approaches to treat type 1 diabetes

Autori: Silvia Pellegrini, Lorenzo Piemonti, Valeria Sordi
Pubblicato in: Current Opinion in Pharmacology, Numero 43, 2018, Pagina/e 20-26, ISSN 1471-4892
Editore: Elsevier BV
DOI: 10.1016/j.coph.2018.07.007

CCL 2/ MCP ‐1 and CXCL 12/ SDF ‐1 blockade by L‐aptamers improve pancreatic islet engraftment and survival in mouse

Autori: Antonio Citro, Silvia Pellegrini, Erica Dugnani, Dirk Eulberg, Sven Klussmann, Lorenzo Piemonti
Pubblicato in: American Journal of Transplantation, Numero 19/11, 2019, Pagina/e 3131-3138, ISSN 1600-6135
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ajt.15518

Islets for Research: Nothing Is Perfect, but We Can Do Better

Autori: Rita Nano, Julie A. Kerr-Conte, Domenico Bosco, Marie Karlsson, Vanessa Lavallard, Raffaella Melzi, Valery Gmyr, Alessia Mercalli, Thierry Berney, François Pattou, Olle Korsgren, Lorenzo Piemonti
Pubblicato in: Diabetes, Numero 68/8, 2019, Pagina/e 1541-1543, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db19-0367

Transplant Site Influences the Immune Response After Islet Transplantation

Autori: Elisa Cantarelli, Antonio Citro, Silvia Pellegrini, Alessia Mercalli, Raffaella Melzi, Erica Dugnani, Tatiana Jofra, Georgia Fousteri, Anna Mondino, Lorenzo Piemonti
Pubblicato in: Transplantation, Numero 101/5, 2017, Pagina/e 1046-1055, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/TP.0000000000001462

Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio

Autori: Annelien Van Dalem, Simke Demeester, Eric V. Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K. Gorus
Pubblicato in: PLOS ONE, Numero 11/12, 2016, Pagina/e e0166702, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0166702

Immunological Issues After Stem Cell-Based β Cell Replacement

Autori: Valeria Sordi, Silvia Pellegrini, Lorenzo Piemonti
Pubblicato in: Current Diabetes Reports, Numero 17/9, 2017, ISSN 1534-4827
Editore: Current Science Inc.
DOI: 10.1007/s11892-017-0901-4

Antiinflammatory strategies in intrahepatic islet transplantation

Autori: A. Citro, E. Cantarelli, S. Pellegrini, E. Dugnani, L. Piemonti
Pubblicato in: Transplantation, 2017, Pagina/e 1, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/TP.0000000000001925

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

Autori: Maria J L Kracht, Menno van Lummel, Tatjana Nikolic, Antoinette M Joosten, Sandra Laban, Arno R van der Slik, Peter A van Veelen, Françoise Carlotti, Eelco J P de Koning, Rob C Hoeben, Arnaud Zaldumbide, Bart O Roep
Pubblicato in: Nature Medicine, Numero 23/4, 2017, Pagina/e 501-507, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/nm.4289

HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft

Autori: Simke Demeester, Else M. Balke, Bart J. Van der Auwera, Pieter Gillard, Robert Hilbrands, DaHae Lee, Ursule Van de Velde, Zhidong Ling, Bart O. Roep, Daniel G. Pipeleers, Frans K. Gorus, Bart Keymeulen
Pubblicato in: Diabetes Care, Numero 39/6, 2016, Pagina/e 1060-1064, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc15-2768

Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes

Autori: Cornelis R. van der Torren, Annemarie A. Verrijn Stuart, DaHae Lee, Jenny Meerding, Ursule van de Velde, Daniel Pipeleers, Pieter Gillard, Bart Keymeulen, Wilco de Jager, Bart O. Roep
Pubblicato in: PLOS ONE, Numero 11/1, 2016, Pagina/e e0146649, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0146649

Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants

Autori: Daniel Pipeleers, Ines De Mesmaeker, Thomas Robert, Freya Van Hulle
Pubblicato in: Current Diabetes Reports, Numero 17/10, 2017, ISSN 1534-4827
Editore: Current Science Inc.
DOI: 10.1007/s11892-017-0925-9

Correction: Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio

Autori: Annelien Van Dalem, Simke Demeester, Eric V. Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K. Gorus
Pubblicato in: PLOS ONE, Numero 12/6, 2017, Pagina/e e0179108, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0179108

Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes

Autori: Frans K. Gorus, Eric V. Balti, Anissa Messaaoui, Simke Demeester, Annelien Van Dalem, Olivier Costa, Harry Dorchy, Chantal Mathieu, Luc Van Gaal, Bart Keymeulen, Daniël G. Pipeleers, Ilse Weets
Pubblicato in: Diabetes Care, Numero 40/8, 2017, Pagina/e 1065-1072, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc16-2228

Immunogenicity of human embryonic stem cell-derived beta cells

Autori: Cornelis R. van der Torren, Arnaud Zaldumbide, Gaby Duinkerken, Simone H. Brand-Schaaf, Mark Peakman, Geert Stangé, Laura Martinson, Evert Kroon, Eugene P. Brandon, Daniel Pipeleers, Bart O. Roep
Pubblicato in: Diabetologia, Numero 60/1, 2017, Pagina/e 126-133, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-016-4125-y

Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death

Autori: Olivier R. Costa, Geert Stangé, Katrijn Verhaeghen, Benedicte Brackeva, Ellen Nonneman, Christiane S. Hampe, Zhidong Ling, Daniel Pipeleers, Frans K. Gorus, Geert A. Martens
Pubblicato in: Endocrinology, Numero 156/12, 2015, Pagina/e 4755-4760, ISSN 0013-7227
Editore: The Endocrine Society
DOI: 10.1210/en.2015-1636

Selective local irradiation improves islet engraftment and survival in intra–bone marrow islet transplantation

Autori: Silvia Pellegrini, Elisa Cantarelli, Antonio Citro, Elena Incerti, Lorenzo Piemonti, Valeria Sordi
Pubblicato in: Cytotherapy, Numero 21/10, 2019, Pagina/e 1025-1032, ISSN 1465-3249
Editore: Taylor & Francis
DOI: 10.1016/j.jcyt.2019.07.005

Identification of Donor Origin and Condition of Transplanted Islets in Situ in the Liver of a Type 1 Diabetic Recipient

Autori: Cornelis R. Van Der Torren, Jessica S. Suwandi, Dahae Lee, Ernst-Jan T. Van't Wout, Gaby Duinkerken, Godelieve Swings, Arend Mulder, Frans H. J. Claas, Zhidong Ling, Pieter Gillard, Bart Keymeulen, Peter In't Veld, and Bart O. Roep
Pubblicato in: Cell Transplantation, 2017, ISSN 0963-6897
Editore: Cognizant Communication Corp.
DOI: 10.3727/096368916x693437

Function and composition of pancreatic islet cell implants in omentum of type 1 diabetes patients

Autori: Freya Van Hulle; Kaat De Groot; Robert Hilbrands; Ursule Van de Velde; Krista Suenens; Geert Stangé; Ines De Mesmaeker; Ines De Mesmaeker; Diedert Luc De Paep; Diedert Luc De Paep; Zhidong Ling; Zhidong Ling; Bart O. Roep; Pieter Gillard; Daniel Pipeleers; Bart Keymeulen; Daniel Jacobs-Tulleneers-Thevissen
Pubblicato in: American journal of Transplantation, Numero 1, 2022, ISSN 1600-6135
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ajt.16884

Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens

Autori: Silke Smeets, Diedert Luc De Paep, Geert Stangé, Katrijn Verhaeghen, Bart Van der Auwera, Bart Keymeulen, Ilse Weets, Zhidong Ling, Peter in’t Veld, Frans Gorus
Pubblicato in: Virchows Archiv, 2020, ISSN 0945-6317
Editore: Springer Verlag
DOI: 10.1007/s00428-021-03055-z

Formation of amyloid in encapsulated human pancreatic and human stem cell‐generated beta cell implants

Autori: Freya Van Hulle, Kaat De Groot, Geert Stangé, Krista Suenens, Ines De Mesmaeker, Diedert L. De Paep, Zhidong Ling, Robert Hilbrands, Pieter Gillard, Bart Keymeulen, Evert Kroon, Gunilla T. Westermark, Daniel Jacobs‐Tulleneers‐Thevissen, Daniel Pipeleers
Pubblicato in: American Journal of Transplantation, Numero 21/6, 2021, Pagina/e 2090-2099, ISSN 1600-6135
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ajt.16398

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