European AIDS Vaccine Initiative 2020

Resultado final

EAVI2020 Public Events:

Two major events (M30 & M72) will be organised to disseminate project results and share its main findings across relevant stakeholders, i.e. clinical communities and patients

EAVI2020 Publications

Submission of up to 100 peerreviewed publications during the programme

Marketing and Dissemination Kit

Marketing and promotional materials developed for the EAVI2020 project, activities and outcomes.

EAVI2020 Website

EAVI2020 main platform for knowledge sharing and promotional activities

Up-selection of optimal T cell vaccine regimen

Up-selection of optimal T cell vaccine regimen according to breadth, potency and durability of cellular antiviral response

Up-selection of optimal humoral vaccine regimen

Upselection of optimal humoral vaccine regimen according to breadth potency and durability of induced antiviral Abs

Report on EAVI2020 training program

Report on outcomes of EAVI2020 training program

Publicaciones

TL1A–DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1–Specific T Cell Responses

Autores: Bruna Oriol-Tordera, Alex Olvera, Clara Duran-Castells, Anuska Llano, Beatriz Mothe, Marta Massanella, Judith Dalmau, Carmela Ganoza, Jorge Sanchez, Maria Luz Calle, Bonaventura Clotet, Javier Martinez-Picado, Eugènia Negredo, Julià Blanco, Dennis Hartigan-O'Connor, Christian Brander, Marta Ruiz-Riol
Publicado en: The Journal of Immunology, Edición 205/12, 2020, Página(s) 3348-3357, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.2000933

Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice

Autores: Alessandra Gallinaro, Martina Borghi, Maria Franca Pirillo, Serena Cecchetti, Roberta Bona, Andrea Canitano, Zuleika Michelini, Antonio Di Virgilio, Alex Olvera, Christian Brander, Donatella Negri, Andrea Cara
Publicado en: Molecular Therapy - Methods & Clinical Development, Edición 17, 2020, Página(s) 418-428, ISSN 2329-0501
Editor: Elsevier
DOI: 10.1016/j.omtm.2020.01.013

Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

Autores: Morante V, Borghi M, Farina I, Michelini Z, Grasso F, Gallinaro A, Cecchetti S, Di Virgilio A, Canitano A, Pirillo MF, Bona R, Cara A, Negri D
Publicado en: Viruses, 2021, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13020355

Strategies for Immunomonitoring after Vaccination and during Infection

Autores: Adam L, Rosenbaum P, Bonduelle O, Combadière B
Publicado en: MDPI Vaccines, 2021, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9040365

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control

Autores: Bruna Oriol-Tordera, Maria Berdasco, Anuska Llano, Beatriz Mothe, Cristina Gálvez, Javier Martinez-Picado, Jorge Carrillo, Julià Blanco, Clara Duran-Castells, Carmela Ganoza, Jorge Sanchez, Bonaventura Clotet, Maria Luz Calle, Alex Sánchez-Pla, Manel Esteller, Christian Brander, Marta Ruiz-Riol
Publicado en: PLOS Pathogens, Edición 16/8, 2020, Página(s) e1008678, ISSN 1553-7374
Editor: Public Library of Science San Francisco
DOI: 10.1371/journal.ppat.1008678

Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes

Autores: Dominik Damm, Ehsan Suleiman, Hannah Theobald, Jannik T. Wagner, Mirjam Batzoni, Bianca Ahlfeld, Bernd Walkenfort, Jens-Christian Albrecht, Jidnyasa Ingale, Lifei Yang, Mike Hasenberg, Richard T. Wyatt, Karola Vorauer-Uhl, Klaus Überla, Vladimir Temchura
Publicado en: Pharmaceutics, 2022, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071385

Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques.

Autores: Van Tilbeurgh M, Maisonnasse P, Palgen JL, Tolazzi M, Aldon Y, Dereuddre-Bosquet N, Cavarelli M, Beignon AS, Marcos-Lopez E, Gallouet AS, Gilson E, Ozorowski G, Ward AB, Bontjer I, McKay PF, Shattock RJ, Scarlatti G, Sanders RW, Le Grand R
Publicado en: Cell Reports Medicine, 2022, ISSN 2666-3791
Editor: Cell Press Elsevier
DOI: 10.1016/j.xcrm.2022.100751

Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques

Autores: Maria Blasi, Elizabeth C. Wescott, Erich J. Baker, Benjamin Mildenberg, Celia LaBranche, Wes Rountree, Barton F. Haynes, Kevin O. Saunders, M. Anthony Moody, Donatella Negri, Sampa Santra, Andrea Cara, Mary E. Klotman
Publicado en: npj Vaccines, Edición 5/1, 2020, Página(s) 1--9, ISSN 2059-0105
Editor: Nature Publishing Group
DOI: 10.1038/s41541-020-0186-5

Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint.

Autores: Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Van der Woude P, De Taeye SW, Van den Kerkhof TLGM, Klasse PJ, Ozorowski G, Van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Publicado en: Cell Reports, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109646

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms

Autores: Philip J.M. Brouwer, Rogier W. Sanders
Publicado en: Current Opinion in HIV and AIDS, Edición 14/4, 2019, Página(s) 302-308, ISSN 1746-630X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/coh.0000000000000549

Structure-guided envelope trimer design in HIV-1 vaccine development: a narrative review

Autores: Derking R, Sanders RW
Publicado en: Journal of the International AIDS Society, 2021, ISSN 1758-2652
Editor: International AIDS Society
DOI: 10.1002/jia2.25797

Specificity of CD8+ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya

Autores: Yehia S. Mohamed, Nicola J. Borthwick, Nathifa Moyo, Hayato Murakoshi, Tomohiro Akahoshi, Francesca Siliquini, Zara Hannoun, Alison Crook, Peter Hayes, Patricia E. Fast, Gaudensia Mutua, Walter Jaoko, Sandra Silva-Arrieta, Anuska Llano, Christian Brander, Masafumi Takiguchi, Tomáš Hanke
Publicado en: Vaccines, Edición 8/2, 2020, Página(s) 260, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8020260

Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

Autores: Jelle van Schooten, Elinaz Farokhi, Anna Schorcht, Tom L. G. M. van den Kerkhof, Hongmei Gao, Patricia van der Woude, Judith A. Burger, Tim G. Rijkhold Meesters, Tom Bijl, Riham Ghalaiyini, Hannah L. Turner, Jessica Dorning, Barbera D. C. van Schaik, Antoine H. C. van Kampen, Celia C. Labranche, Robyn L. Stanfield, Devin Sok, David C. Montefiori, Dennis R. Burton, Michael S. Seaman, Gabriel Ozorow
Publicado en: Nature communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32208-0

Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

Autores: Jelle van Schooten, Ilja C. Bontjer, J. A. Burger, Rogier W. Sanders, Marit J. van Gils
Publicado en: NPJ Vaccines, 2022, ISSN 2059-0105
Editor: Nature Research
DOI: 10.1038/s41541-022-00576-9

Novel Approaches Towards a Functional Cure of HIV/AIDS

Autores: Lucia Bailon, Beatriz Mothe, Lance Berman, Christian Brander
Publicado en: Drugs, Edición 80/9, 2020, Página(s) 859-868, ISSN 0012-6667
Editor: Adis International Ltd.
DOI: 10.1007/s40265-020-01322-y

Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity

Autores: Yi-Yu Lin, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, Donatella Negri
Publicado en: Molecular Therapy - Methods & Clinical Development, Edición 17, 2020, Página(s) 532-544, ISSN 2329-0501
Editor: Elsevier
DOI: 10.1016/j.omtm.2020.03.008

Glycans in HIV-1 vaccine design – engaging the shield

Autores: Deimel LP, Xue X, Sattentau QJ
Publicado en: Trends in Microbiology, 2022, ISSN 0966-842X
Editor: Elsevier BV
DOI: 10.1016/j.tim.2022.02.004

Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines

Autores: Nicola Borthwick, Sandra Silva-Arrieta, Anuska Llano, Masafumi Takiguchi, Christian Brander, Tomáš Hanke
Publicado en: Vaccines, Edición 8/1, 2020, Página(s) 28, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010028

Dichotomy in Neutralizing Antibody Induction to Peptide-Conjugated Vaccine in Squalene Emulsion Contrast With Aluminum Hydroxide Formulation

Autores: Bonduelle O, Chaudesaigues C, Tolazzi M, Suleiman E, De Bernard S, Alves K, Nourikyan J, Bohec M, Baudrin LG, Katinger D, Debré P, Scarlatti G, Vieillard V, Combadiere B
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2022.848571

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein

Autores: M. M. van Haaren, L. E. McCoy, J. L. Torres, W. Lee, C. A. Cottrell, J. L. Copps, P. van der Woude, A. Yasmeen, S. W. de Taeye, A. Torrents de la Peña, J. P. Moore, D. R. Burton, P. J. Klasse, A. B. Ward, R. W. Sanders, M. J. van Gils
Publicado en: Journal of Virology, 2021, ISSN 1098-5514
Editor: American Society for Microbiology
DOI: 10.1128/jvi.00094-21

Transcriptome Sequencing of Peripheral Blood Mononuclear Cells from Elite Controller-Long Term Non Progressors

Autores: Francisco Díez-Fuertes, Humberto Erick De La Torre-Tarazona, Esther Calonge, Maria Pernas, María del Mar Alonso-Socas, Laura Capa, Javier García-Pérez, Anavaj Sakuntabhai, José Alcamí
Publicado en: Scientific Reports, Edición 9/1, 2019, Página(s) 1--13, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-50642-x

Immunogenicity, safety, and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs

Autores: Maria Blasi, Donatella Negri, Kevin O. Saunders, Erich J. Baker, Hannah Stadtler, Celia LaBranche, Benjamin Mildenberg, Georgeanna Morton, Andrew Ciarla, Xiaoying Shen, Yunfei Wang, Wes Rountree, Bala Balakumaran, Sampa Santra, Barton F. Haynes, Anthony M. Moody, Andrea Cara, Mary E. Klotman
Publicado en: npj Vaccines, Edición 5/1, 2020, Página(s) 1--12, ISSN 2059-0105
Editor: Nature Publishing Group
DOI: 10.1038/s41541-020-00252-w

Comparison of blood and lymph node cells after intramuscular injection with HIV envelope immunogens

Autores: Suzanne Day, Charandeep Kaur, Hannah M. Cheeseman, Emily de Groot, Leon R. McFarlane, Maniola Tanaka, Sofia Coelho, Tom Cole, Nana-Marie Lemm, Adrian Lim, Rogier W. Sanders, Becca Asquith, Robin J. Shattock and Katrina M. Pollock
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2022.991509

In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial

Autores: Miriam Rosás-Umbert, Marta Ruiz-Riol, Marco A. Fernández, Marta Marszalek, Pep Coll, Christian Manzardo, Samandhy Cedeño, José M. Miró, Bonaventura Clotet, Tomáš Hanke, José Moltó, Beatriz Mothe, Christian Brander
Publicado en: Frontiers in Immunology, Edición 11, 2020, Página(s) 418, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2020.00418

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Autores: Sliepen KHEWJ, Bontjer IC, Burger JA, Brouwer PJM, Sanders RW
Publicado en: npj Vaccines, 2021, ISSN 2059-0105
Editor: Springer Nature
DOI: 10.1038/s41541-021-00364-x

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Autores: Aguado-Garcia D, Olvera A, Brander C, Sanchez-Merino V, and Yuste E
Publicado en: Vaccines, 2022, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10040484

Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

Autores: Gallinaro A, Pirillo MF, Aldon Y, Cecchetti S, Michelini Z, Tinari A, Borghi M, Canitano A, McKay PF, Bona R, Vescio MF, Grasso F, Blasi M, Baroncelli S, Scarlatti G, LaBranche C, Montefiori D, Klotman ME, Sanders RW, Shattock RJ, Negri D, Cara A
Publicado en: npj Vaccines, 2022, ISSN 2059-0105
Editor: Springer Nature
DOI: 10.1038/s41541-022-00465-1

HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)

Autores: Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C. Puertas, Sara Morón-López, Anuska Llano, Cristina Miranda, Samandhy Cedeño, Miriam López, Yovaninna Alarcón-Soto, Guadalupe Gómez Melis, Klaus Langohr, Ana M. Barriocanal, Jessica Toro, Irene Ruiz, Cristina Rovira, Antonio Carrillo, Michael Meulbroek, Alison Crook, Edmund G. Wee, Jose M. Miró, Bonaventura Clotet, Ma
Publicado en: Frontiers in Immunology, Edición 11, 2020, Página(s) 823, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2020.00823

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates

Autores: Jelle van Schooten, Marlies M. van Haaren, Hui Li, Laura E. McCoy, Colin Havenar-Daughton, Christopher A. Cottrell, Judith A. Burger, Patricia van der Woude, Leanne C. Helgers, Ilhan Tomris, Celia C. Labranche, David C. Montefiori, Andrew B. Ward, Dennis R. Burton, John P. Moore, Rogier W. Sanders, Shane Crotty, George M. Shaw, Marit J. van Gils
Publicado en: PLOS Pathogens, 2021, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1009736

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival

Autores: Dispinseri S, Secchi M, Pirillo MF, Tolazzi M, Borghi M, Brigatti C, De Angelis ML, Baratella M, Bazzigaluppi E, Venturi G, Sironi F, Canitano A, Marzinotto I, Tresoldi C, Ciceri F, Piemonti L, Negri D, Cara A, Lampasona V, Scarlatti G
Publicado en: Nature communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-22958-8

Strategies for inducing effective neutralizing antibody responses against HIV-1

Autores: Iván del Moral-Sánchez, Kwinten Sliepen
Publicado en: Expert Review of Vaccines, Edición 18/11, 2019, Página(s) 1127-1143, ISSN 1476-0584
Editor: Future Drugs Ltd.
DOI: 10.1080/14760584.2019.1690458

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections

Autores: Luis Romero-Martin, Clara Duran-Castells, Mireia Olivella, Mı´riam Rosas-Umbert, Marta Ruiz-Riol, Jorge Sanchez, Dennis Hartigan-O´Connor, Beatriz Mothe, Àlex Olvera and Christian Brander
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2022.1027855

Safety and efficiency modifications of SIV-based integrase-defective lentiviral vectors for immunization

Autores: Bona R, Michelini Z, Mazzei C, Gallinaro A, Canitano A, Borghi M, Vescio MF, Di Virgilio A, Pirillo MF, Klotman ME, Negri D, Cara A
Publicado en: Molecular Therapy: Methods & Clinical Development, 2021, ISSN 2329-0501
Editor: Cell Press, Elsevier Inc
DOI: 10.1016/j.omtm.2021.09.011

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

Autores: Philip J. M. Brouwer, Aleksandar Antanasijevic, Marlon de Gast, Joel D. Allen, Tom P. L. Bijl, Anila Yasmeen, Rashmi Ravichandran, Judith A. Burger, Gabriel Ozorowski, Jonathan L. Torres, Celia LaBranche, David C. Montefiori, Rajesh P. Ringe, Marit J. van Gils, John P. Moore, Per Johan Klasse, Max Crispin, Neil P. King, Andrew B. Ward, Rogier W. Sanders
Publicado en: npj Vaccines, Edición 6/1, 2021, Página(s) 1-14, ISSN 2059-0105
Editor: Nature Publishing Group
DOI: 10.1038/s41541-021-00285-9

Genetic Co-Administration of Soluble PD-1 Ectodomains Modifies Immune Responses against Influenza A Virus Induced by DNA Vaccination

Autores: Pierre Tannig, Antonia Sophia Peter, Dennis Lapuente, Stephan Klessing, Anna Schmidt, Dominik Damm, Matthias Tenbusch, Klaus Überla, Vladimir Temchura
Publicado en: Vaccines, Edición 8/4, 2020, Página(s) 570, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040570

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans

Autores: Huettner I, Krumm SA, Serna S, Brzezicka K, Monaco S, Walpole S, van Diepen A, Allan F, Hicks T, Kimuda S, Emery AM, IAVI Protocol C Investigators & The IAVI African HIV Research Network, Landais E, Hokke CH, Angulo J, Reichardt N, Doores KJ
Publicado en: Cell Reports, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.110611

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Autores: Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker,
Publicado en: Nature communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25087-4

In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

Autores: Sandra Silva-Arrieta, Philip J. R. Goulder, Christian Brander
Publicado en: PLOS Pathogens, Edición 16/6, 2020, Página(s) e1008607, ISSN 1553-7374
Editor: Public Library of Science San Francisco
DOI: 10.1371/journal.ppat.1008607

CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help

Autores: Stephan Klessing, Vladimir Temchura, Pierre Tannig, Antonia Sophia Peter, Dennis Christensen, Roland Lang, Klaus Überla
Publicado en: Vaccines, Edición 8/4, 2020, Página(s) 604, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040604

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Autores: Anna K. Blakney, Paul F. McKay, Bárbara Ibarzo Yus, Yoann Aldon, Robin J. Shattock
Publicado en: Gene Therapy, Edición 26/9, 2019, Página(s) 363-372, ISSN 0969-7128
Editor: Nature Publishing Group
DOI: 10.1038/s41434-019-0095-2

Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8+ T cell antiviral responses

Autores: Yang H, Llano A, Cedeño S, von Delft A, Corcuera A, Gillespie GM, Knox A, Leneghan DB, Frater J, Stöhr W, Fidler S, Mothe B, Mak J, Brander C, Ternette N, Dorrell L
Publicado en: Cell Reports, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109103

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

Autores: Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn
Publicado en: eLife, Edición 10, 2021, Página(s) e65005, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.65005

T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

Autores: Luis Romero-Martin, Ferran Tarres-Freixas, Nuria Pedreño-Lopez, Maria L. Rodriguez de la Concepcio, Francesc Cunyat, Dennis Hartigan-O'Connor, Jorge Carrillo, Beatriz Mothe, Julià Blanco, Marta Ruiz-Riol, Christian Brander and Alex Olvera
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2022.928039

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers

Autores: Anna Schorcht, Tom L. G. M. van den Kerkhof, Christopher A. Cottrell, Joel D. Allen, Jonathan L. Torres, Anna-Janina Behrens, Edith E. Schermer, Judith A. Burger, Steven W. de Taeye, Alba Torrents de la Peña, Ilja Bontjer, Stephanie Gumbs, Gabriel Ozorowski, Celia C. LaBranche, Natalia de Val, Anila Yasmeen, Per Johan Klasse, David C. Montefiori, John P. Moore, Hanneke Schuitemaker, Max Crispin,
Publicado en: Journal of Virology, Edición 94/24, 2020, Página(s) volume={94}, number={24}, year={2020},, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/jvi.01214-20

Design Concepts of Virus-Like Particle-Based HIV-1 Vaccines

Autores: Chun-Wei Chen, Narcís Saubi, Joan Joseph-Munné
Publicado en: Frontiers in Immunology, Edición 11, 2020, Página(s) 573157, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2020.573157

Neutralizing Antibodies Targeting HIV-1 gp41

Autores: Christophe Caillat, Delphine Guilligay, Guidenn Sulbaran, Winfried Weissenhorn
Publicado en: Viruses, Edición 12/11, 2020, Página(s) 1210, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111210

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

Autores: Ronald Derking, Joel D. Allen, Christopher A. Cottrell, Kwinten Sliepen, Gemma E. Seabright, Wen-Hsin Lee, Yoann Aldon, Kimmo Rantalainen, Aleksandar Antanasijevic, Jeffrey Copps, Anila Yasmeen, Albert Cupo, Victor M. Cruz Portillo, Meliawati Poniman, Niki Bol, Patricia van der Woude, Steven W. de Taeye, Tom L.G.M. van den Kerkhof, P.J. Klasse, Gabriel Ozorowski, Marit J. van Gils, John P. Moore,
Publicado en: Cell Reports, Edición 35/1, 2021, Página(s) 108933, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.108933

Chimeric Human Papillomavirus-16 Virus-like Particles Presenting P18I10 and T20 Peptides from HIV-1 Envelope Induce HPV16 and HIV-1-Specific Humoral and T Cell-Mediated Immunity in BALB/c Mice

Autores: Jelle van Schooten, Ilja C. Bontjer, J. A. Burger, Rogier W. Sanders, Marit J. van Gils
Publicado en: Vaccines, 2022, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11010015

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

Autores: Goncalves E, Guillen Y, Lama JR, Sanchez J, Brander C, Paredes R and Combadière B
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2021.657162

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines

Autores: Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, Tomáš Hanke
Publicado en: PLOS ONE, Edición 12/4, 2017, Página(s) e0176418, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0176418

Neutralizing Antibodies Against a Specific Human Immunodeficiency Virus gp41 Epitope are Associated With Long-term Non-progressor Status

Autores: Olivier Lucar, Bin Su, Valérie Potard, Assia Samri, Brigitte Autran, Christiane Moog, Patrice Debré, Vincent Vieillard
Publicado en: EBioMedicine, Edición 22, 2017, Página(s) 122-132, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2017.07.007

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

Autores: Max Medina-Ramírez, Fernando Garces, Amelia Escolano, Patrick Skog, Steven W. de Taeye, Ivan Del Moral-Sanchez, Andrew T. McGuire, Anila Yasmeen, Anna-Janina Behrens, Gabriel Ozorowski, Tom L.G.M. van den Kerkhof, Natalia T. Freund, Pia Dosenovic, Yuanzi Hua, Alexander D. Gitlin, Albert Cupo, Patricia van der Woude, Michael Golabek, Kwinten Sliepen, Tanya Blane, Neeltje Kootstra, Mariëlle J. van
Publicado en: The Journal of Experimental Medicine, Edición 214/9, 2017, Página(s) 2573-2590, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20161160

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use

Autores: Max Medina-Ramírez, Rogier W. Sanders, Quentin J. Sattentau
Publicado en: Current Opinion in HIV and AIDS, Edición 12/3, 2017, Página(s) 241-249, ISSN 1746-630X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/COH.0000000000000363

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control

Autores: M. Ruiz-Riol, D. Berdnik, A. Llano, B. Mothe, C. Gálvez, S. Pérez-Álvarez, B. Oriol-Tordera, A. Olvera, S. Silva-Arrieta, M. Meulbroek, F. Pujol, J. Coll, J. Martinez-Picado, C. Ganoza, J. Sanchez, G. Gómez, T. Wyss-Coray, C. Brander
Publicado en: Journal of Virology, Edición 91/16, 2017, Página(s) e00441-17, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.00441-17

HIV-1 Conserved Mosaics Delivered by Regimens with Integration-Deficient DC-Targeting Lentiviral Vector Induce Robust T Cells

Autores: Edmund G. Wee, Beatrice Ondondo, Peter Berglund, Jacob Archer, Andrew J. McMichael, David Baltimore, Jan H. ter Meulen, Tomáš Hanke
Publicado en: Molecular Therapy, Edición 25/2, 2017, Página(s) 494-503, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2016.12.004

HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers

Autores: Silvia Capucci, Edmund G. Wee, Torben Schiffner, Celia C. LaBranche, Nicola Borthwick, Albert Cupo, Jonathan Dodd, Hansi Dean, Quentin Sattentau, David Montefiori, Per J. Klasse, Rogier W. Sanders, John P. Moore, Tomáš Hanke
Publicado en: PLOS ONE, Edición 12/8, 2017, Página(s) e0181886, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0181886

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

Autores: Marit J. van Gils, Tom L. G. M. van den Kerkhof, Gabriel Ozorowski, Christopher A. Cottrell, Devin Sok, Matthias Pauthner, Jesper Pallesen, Natalia de Val, Anila Yasmeen, Steven W. de Taeye, Anna Schorcht, Stephanie Gumbs, Inez Johanna, Karen Saye-Francisco, Chi-Hui Liang, Elise Landais, Xiaoyan Nie, Laura K. Pritchard, Max Crispin, Garnett Kelsoe, Ian A. Wilson, Hanneke Schuitemaker, Per Johan Kl
Publicado en: Nature Microbiology, Edición 2, 2016, Página(s) 16199, ISSN 2058-5276
Editor: Nature Microbiology
DOI: 10.1038/nmicrobiol.2016.199

Structural principles controlling HIV envelope glycosylation

Autores: Anna-Janina Behrens, Max Crispin
Publicado en: Current Opinion in Structural Biology, Edición 44, 2017, Página(s) 125-133, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2017.03.008

Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA

Autores: Nathifa Moyo, Annette B. Vogel, Søren Buus, Stephanie Erbar, Edmund G. Wee, Ugur Sahin, Tomáš Hanke
Publicado en: Molecular Therapy - Methods & Clinical Development, Edición 12, 2019, Página(s) 32-46, ISSN 2329-0501
Editor: Molecular Therapy
DOI: 10.1016/j.omtm.2018.10.010

Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination

Autores: Sven Kratochvil, Paul F. McKay, Amy W. Chung, Stephen J. Kent, Jill Gilmour, Robin J. Shattock
Publicado en: Frontiers in Immunology, Edición 8, 2017, ISSN 1664-3224
Editor: Front Immunol
DOI: 10.3389/fimmu.2017.01883

HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual

Autores: Karen P. Coss, Snezana Vasiljevic, Laura K. Pritchard, Stefanie A. Krumm, Molly Glaze, Sharon Madzorera, Penny L. Moore, Max Crispin, Katie J. Doores
Publicado en: Journal of Virology, Edición 90/24, 2016, Página(s) 11132-11144, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.01542-16

Intrastructural help

Autores: Vladimir Temchura, Klaus Überla
Publicado en: Current Opinion in HIV and AIDS, Edición 12/3, 2017, Página(s) 272-277, ISSN 1746-630X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/COH.0000000000000358

Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins

Autores: Torben Schiffner, Jesper Pallesen, Rebecca A. Russell, Jonathan Dodd, Natalia de Val, Celia C. LaBranche, David Montefiori, Georgia D. Tomaras, Xiaoying Shen, Scarlett L. Harris, Amin E. Moghaddam, Oleksandr Kalyuzhniy, Rogier W. Sanders, Laura E. McCoy, John P. Moore, Andrew B. Ward, Quentin J. Sattentau
Publicado en: PLOS Pathogens, Edición 14/5, 2018, Página(s) e1006986, ISSN 1553-7374
Editor: PLOS Pathogens
DOI: 10.1371/journal.ppat.1006986

Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors

Autores: Nuria González, Krisha McKee, Rebecca M. Lynch, Ivelin S. Georgiev, Laura Jimenez, Eulalia Grau, Eloísa Yuste, Peter D. Kwong, John R. Mascola, José Alcamí
Publicado en: PLOS ONE, Edición 13/3, 2018, Página(s) e0193773, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0193773

Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans

Autores: Jenna Anderson, Thorunn A. Olafsdottir, Sven Kratochvil, Paul F. McKay, Malin Östensson, Josefine Persson, Robin J. Shattock, Ali M. Harandi
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.00301

Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine

Autores: Hannah Mary Cheeseman, Suzanne Day, Leon Robert McFarlane, Sue Fleck, Aleisha Miller, Tom Cole, Nelson Sousa-Santos, Alethea Cope, Deniz Cizmeci, Monica Tolazzi, Edith Hwekwete, Drew Hannaman, Sven Kratochvil, Paul Francis McKay, Amy W. Chung, Stephen J. Kent, Adrian Cook, Gabriella Scarlatti, Sonya Abraham, Behazine Combadiere, Sheena McCormack, David John Lewis, Robin John Shattock
Publicado en: Human Gene Therapy, Edición 29/9, 2018, Página(s) 1011-1028, ISSN 1043-0342
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2018.075

Isolation and Characterization of Antigen-Specific Plasmablasts Using a Novel Flow Cytometry–Based Ig Capture Assay

Autores: Christopher L. Pinder, Sven Kratochvil, Deniz Cizmeci, Luke Muir, Yanping Guo, Robin J. Shattock, Paul F. McKay
Publicado en: The Journal of Immunology, Edición 199/12, 2017, Página(s) 4180-4188, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1701253

Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1

Autores: Anna-Janina Behrens, Weston B Struwe, Max Crispin
Publicado en: Expert Review of Proteomics, Edición 14/10, 2017, Página(s) 881-890, ISSN 1478-9450
Editor: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1376658

Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design

Autores: Edna O. Viegas, Arne Kroidl, Patricia J. Munseri, Marco Missanga, Charlotta Nilsson, Nelson Tembe, Asli Bauer, Agricola Joachim, Sarah Joseph, Philipp Mann, Christof Geldmacher, Sue Fleck, Wolfgang Stöhr, Gabriella Scarlatti, Said Aboud, Muhammad Bakari, Leonard Maboko, Michael Hoelscher, Britta Wahren, Merlin L. Robb, Jonathan Weber, Sheena McCormack, Gunnel Biberfeld, Ilesh V. Jani, Eric Sandst
Publicado en: PLOS ONE, Edición 13/11, 2018, Página(s) e0206838, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0206838

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

Autores: Yoann Aldon, Paul F. McKay, Joel Allen, Gabriel Ozorowski, Réka Felfödiné Lévai, Monica Tolazzi, Paul Rogers, Linling He, Natalia de Val, Katalin Fábián, Gabriella Scarlatti, Jiang Zhu, Andrew B. Ward, Max Crispin, Robin J. Shattock
Publicado en: Cell Reports, Edición 24/12, 2018, Página(s) 3324-3338.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.08.051

Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines

Autores: Hassan Elsayed, Ghulam Nabi, William J. McKinstry, Keith K. Khoo, Johnson Mak, Andres M. Salazar, Matthias Tenbusch, Vladimir Temchura, Klaus Überla
Publicado en: Journal of Virology, Edición 92/14, 2018, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.00141-18

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Autores: Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J. M. Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L. Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Peña, Mariëlle J. van Breemen, Juan Miguel Camacho-Sánchez, Judith A. Burger, Max Medina-Ramírez, Nuria G
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-10262-5

MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

Autores: Esther Broset, Narcís Saubi, Núria Guitart, Nacho Aguilo, Santiago Uranga, Athina Kilpeläinen, Yoshiki Eto, Tomáš Hanke, Jesús Gonzalo-Asensio, Carlos Martín, Joan Joseph-Munné
Publicado en: Molecular Therapy - Methods & Clinical Development, Edición 13, 2019, Página(s) 253-264, ISSN 2329-0501
Editor: Elsevier
DOI: 10.1016/j.omtm.2019.01.014

Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

Autores: Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Alex Olvera, Tomáš Hanke, Christian Brander, Joan Joseph
Publicado en: Vaccines, Edición 7/3, 2019, Página(s) 78, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines7030078

HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial

Autores: Vincent Vieillard, Béhazine Combadière, Roland Tubiana, Odile Launay, Gilles Pialoux, Laurent Cotte, Pierre-Marie Girard, Anne Simon, Yasmine Dudoit, Jacques Reynes, Jürgen Rockstroh, Felipe Garcia, Jose Gatell, Alain Devidas, Yazdan Yazdanpanah, Laurence Weiss, Gerd Fätkenheuer, Brigitte Autran, Delphine Joyeux, Shahin Gharakhanian, Patrice Debré, Christine Katlama
Publicado en: npj Vaccines, Edición 4/1, 2019, ISSN 2059-0105
Editor: Springer Nature
DOI: 10.1038/s41541-019-0117-5

High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis

Autores: Néstor Vázquez Bernat, Martin Corcoran, Uta Hardt, Mateusz Kaduk, Ganesh E. Phad, Marcel Martin, Gunilla B. Karlsson Hedestam
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2019.00660

Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination

Autores: Rebecca Heß, Michael Storcksdieck genannt Bonsmann, Dennis Lapuente, Andre Maaske, Carsten Kirschning, Jürgen Ruland, Bernd Lepenies, Drew Hannaman, Matthias Tenbusch, Klaus Überla
Publicado en: Viruses, Edición 11/2, 2019, Página(s) 153, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11020153

HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry

Autores: Dirk Eggink, Ilja Bontjer, Steven W. de Taeye, Johannes P. M. Langedijk, Ben Berkhout, Rogier W. Sanders
Publicado en: Journal of Biological Chemistry, Edición 294/15, 2019, Página(s) 5736-5746, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA119.007360

Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

Autores: Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Nathifa Moyo, Edmund G. Wee, Krupa Ravi, Tomáš Hanke, Joan Joseph
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2019.00923

Mechanisms of Abrupt Loss of Virus Control in a Cohort of Previous HIV Controllers

Autores: Miriam Rosás-Umbert, Anuska Llano, Rocío Bellido, Alex Olvera, Marta Ruiz-Riol, Muntsa Rocafort, Marco A. Fernández, Patricia Cobarsi, Manel Crespo, Lucy Dorrell, Jorge del Romero, José Alcami, Roger Paredes, Christian Brander, Beatriz Mothe
Publicado en: Journal of Virology, Edición 93/4, 2019, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/jvi.01436-18

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

Autores: Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-12080-1

Protein and Glycan Mimicry in HIV Vaccine Design

Autores: Gemma E. Seabright, Katie J. Doores, Dennis R. Burton, Max Crispin
Publicado en: Journal of Molecular Biology, Edición 431/12, 2019, Página(s) 2223-2247, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2019.04.016

Autores: Alba Torrents de la Peña, Kimmo Rantalainen, Christopher A. Cottrell, Joel D. Allen, Marit J. van Gils, Jonathan L. Torres, Max Crispin, Rogier W. Sanders, Andrew B. Ward
Publicado en: PLOS Pathogens, Edición 15/7, 2019, Página(s) e1007920, ISSN 1553-7374
Editor: PLOS
DOI: 10.1371/journal.ppat.1007920

Exploitation of glycosylation in enveloped virus pathobiology

Autores: Yasunori Watanabe, Thomas A. Bowden, Ian A. Wilson, Max Crispin
Publicado en: Biochimica et Biophysica Acta (BBA) - General Subjects, Edición 1863/10, 2019, Página(s) 1480-1497, ISSN 0304-4165
Editor: Elsevier BV
DOI: 10.1016/j.bbagen.2019.05.012

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

Autores: Meng Yuan, Christopher A. Cottrell, Gabriel Ozorowski, Marit J. van Gils, Sonu Kumar, Nicholas C. Wu, Anita Sarkar, Jonathan L. Torres, Natalia de Val, Jeffrey Copps, John P. Moore, Rogier W. Sanders, Andrew B. Ward, Ian A. Wilson
Publicado en: Cell Host & Microbe, Edición 25/6, 2019, Página(s) 873-883.e5, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2019.04.011

Can we just kick-and-kill HIV: possible challenges posed by the epigenetically controlled interplay between HIV and host immunity

Autores: Marta Ruiz-Riol, Christian Brander
Publicado en: Immunotherapy, Edición 11/11, 2019, Página(s) 931-935, ISSN 1750-743X
Editor: Future Medicine Ltd.
DOI: 10.2217/imt-2019-0092

Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies

Autores: Mitch Brinkkemper, Kwinten Sliepen
Publicado en: Vaccines, Edición 7/3, 2019, Página(s) 76, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines7030076

Peptide-Based Vaccination for Antibody Responses Against HIV

Autores: Combadière, Beaujean, Chaudesaigues, Vieillard
Publicado en: Vaccines, Edición 7/3, 2019, Página(s) 105, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines7030105

Preclinical Development of BCG.HIVA 2auxo.int , Harboring an Integrative Expression Vector, for a HIV-TB Pediatric vaccine. Enhancement of Stability and Specific HIV-1 T-cell Immunity

Autores: Aakash Mahant, Narcís Saubi, Yoshiki Eto, Núria Guitart, Josep M ª Gatell, Tomáš Hanke, Joan Joseph
Publicado en: Human Vaccines & Immunotherapeutics, 2017, Página(s) 00-00, ISSN 2164-5515
Editor: Landes Bioscience
DOI: 10.1080/21645515.2017.1316911

Native-like Env trimers as a platform for HIV-1 vaccine design

Autores: Rogier W. Sanders, John P. Moore
Publicado en: Immunological Reviews, Edición 275/1, 2017, Página(s) 161-182, ISSN 0105-2896
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imr.12481

TOX is expressed by exhausted and polyfunctional human effector memory CD8 + T cells

Autores: Takuya Sekine, André Perez-Potti, Son Nguyen, Jean-Baptiste Gorin, Vincent H. Wu, Emma Gostick, Sian Llewellyn-Lacey, Quirin Hammer, Sara Falck-Jones, Sindhu Vangeti, Meng Yu, Anna Smed-Sörensen, Ahmed Gaballa, Michael Uhlin, Johan K. Sandberg, Christian Brander, Piotr Nowak, Paul A. Goepfert, David A. Price, Michael R. Betts, Marcus Buggert
Publicado en: Science Immunology, Edición 5/49, 2020, Página(s) eaba7918, ISSN 2470-9468
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciimmunol.aba7918

Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

Autores: Aldon Y, McKay P, Moreno Herrero J, Vogel A, Lévai R, Maisonnasse P, Dereuddre-Bosquet N; Haas H, Fábián K, Le Grand R, Sahin U, Shattock R
Publicado en: Molecular Therapy: Nucleic Acids, 2021, ISSN 2162-2531
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2021.06.008

High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers

Autores: Del Moral Sanchez I, Schermer EE, Torrents de la Pena A, Sliepen KHEWJ, Sanders RW
Publicado en: npj Vaccines, 2022, ISSN 2059-0105
Editor: Springer Nature
DOI: 10.1038/s41541-022-00446-4

Conjugation of Native-Like HIV-1 Envelope Trimers onto Liposomes Using EDC/Sulfo-NHS Chemistry: Requirements and Limitations

Autores: Ehsan Suleiman, Julia Mayer, Elisabeth Lehner, Bianca Kohlhauser, Alexandra Katholnig, Mirjam Batzoni, Dominik Damm, Vladimir Temchura, Andreas Wagner, Klaus Überla, Karola Vorauer-Uhl
Publicado en: Pharmaceutics, Edición 12/10, 2020, Página(s) 979, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12100979

The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With Disease Progression

Autores: Sara Moron-Lopez, Victor Urrea, Judith Dalmau, Miguel Lopez, Maria C Puertas, Dan Ouchi, Antonio Gómez, Caroline Passaes, Beatriz Mothe, Christian Brander, Asier Saez-Cirion, Bonaventura Clotet, Manel Esteller, Maria Berdasco, Javier Martinez-Picado
Publicado en: Clinical Infectious Diseases, Edición 72/9, 2020, Página(s) e256-e264, ISSN 1058-4838
Editor: University of Chicago Press
DOI: 10.1093/cid/ciaa1047

LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic Complications

Autores: Combadière B, Adam L, Guillou N, Quentric P, Rosenbaum P, Dorgham K, Bonduelle O, Parizot C, Sauce D, Mayaux J, Luyt C-E, Boissonnas A, Amoura Z, Pourcher V, Miyara M, Gorochov G, Guihot A, Combadière C
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2021.752612

Electrostatically Driven Encapsulation of Hydrophilic, Non-Conformational Peptide Epitopes into Liposomes

Autores: Ehsan Suleiman, Dominik Damm, Mirjam Batzoni, Vladimir Temchura, Andreas Wagner, Klaus Überla, Karola Vorauer-Uhl
Publicado en: Pharmaceutics, Edición 11/11, 2019, Página(s) 619, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11110619

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

Autores: Christopher A. Cottrell, Jelle van Schooten, Charles A. Bowman, Meng Yuan, David Oyen, Mia Shin, Robert Morpurgo, Patricia van der Woude, Mariëlle van Breemen, Jonathan L. Torres, Raj Patel, Justin Gross, Leigh M. Sewall, Jeffrey Copps, Gabriel Ozorowski, Bartek Nogal, Devin Sok, Eva G. Rakasz, Celia Labranche, Vladimir Vigdorovich, Scott Christley, Diane G. Carnathan, D. Noah Sather, David Monte
Publicado en: PLOS Pathogens, Edición 16/8, 2020, Página(s) e1008753, ISSN 1553-7374
Editor: Public Library of Science San Francisco, CA USA
DOI: 10.1371/journal.ppat.1008753

Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses

Autores: Beltran-Pavez C, Bontjer I, Gonzalez N, Pernas M, Merino-Mansilla A, Olvera A, Miro JM, Brander C, Alcami J, Sanders RW, Sanchez-Merino V, Yuste E
Publicado en: Journal of Virology, 2022, ISSN 1098-5514
Editor: American Society of Microbiology
DOI: 10.1128/jvi.01343-21

Effect of epitope variant co-delivery on the depth of CD8 T cell responses induced by HIV-1 conserved mosaic vaccines

Autores: Wee EG, Moyo N, Hannoun Z, Giorgi E, Korber B, Hanke T
Publicado en: Molecular Therapy Methods & Clinical Development, 2021, ISSN 2329-0501
Editor: Elsevier Inc
DOI: 10.1016/j.omtm.2021.04.018

CD8+PD-L1+CXCR3+ polyfunctional T cell abundances are associated with survival in critical SARS-CoV-2–infected patients

Autores: Adam L, Rosenbaum P, Quentric P, Parizot C, Bonduelle O, Guillou N, Corneau A, Dorgham K, Miyara M, Luyt C-E, Guihot A, Gorochov G, Combadière C, Combadière B
Publicado en: JCI Insight, 2021, ISSN 2379-3708
Editor: ASCI
DOI: 10.1172/jci.insight.151571

Association of a single nucleotide polymorphism in the ubxn6 gene with long-term non-progression phenotype in HIV-positive individuals

Autores: F. Díez-Fuertes, H.E. De La Torre-Tarazona, E. Calonge, M. Pernas, M. Bermejo, J. García-Pérez, A. Álvarez, L. Capa, F. García-García, M. Saumoy, M. Riera, A. Boland-Auge, C. López-Galíndez, M. Lathrop, J. Dopazo, A. Sakuntabhai, J. Alcamí
Publicado en: Clinical Microbiology and Infection, Edición 26/1, 2020, Página(s) 107-114, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2019.05.015

Conjugation of a Toll-Like Receptor Agonist to Glycans of an HIV Native-Like Envelope Trimer Preserves Neutralization Epitopes

Autores: Zeshi Li, Ronald Derking, Wen-Hsin Lee, Gerlof P Bosman, Andrew B Ward, Rogier W Sanders, Geert-Jan Boons
Publicado en: Chembiochem, 2022, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200236

Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Autores: Borgognone E, Noguera-Julian M, Oriol B, Noël-Romas L, Ruiz-Riol M, Guillén Y, Parera M, Casadellà M, Duran C, Puertas MC, Català-Moll F, De Leon M, Knodel S, Birse K, Manzardo C, Miró JM, Clotet B, Martinez-Picado J, Moltó J, Mothe B, Burgener A, Brander C, Paredes R, and the BCN02 Study Group
Publicado en: Microbiome, 2022, ISSN 2049-2618
Editor: BioMed Central
DOI: 10.1186/s40168-022-01247-6

Does Antigen Glycosylation Impact the HIV-Specific T Cell Immunity?

Autores: Alex Olvera, Samandhy Cedeño, Anuska Llano, Beatriz Mothe, Jorge Sanchez, Gemma Arsequell, Christian Brander
Publicado en: Frontiers in Immunology, Edición 11, 2021, Página(s) N/A, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2020.573928

Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01

Autores: Dora Pinto, Craig Fenwick, Christophe Caillat, Chiara Silacci, Serafima Guseva, François Dehez, Christophe Chipot, Sonia Barbieri, Andrea Minola, David Jarrossay, Georgia D. Tomaras, Xiaoying Shen, Agostino Riva, Maciej Tarkowski, Olivier Schwartz, Timothée Bruel, Jérémy Dufloo, Michael S. Seaman, David C. Montefiori, Antonio Lanzavecchia, Davide Corti, Giuseppe Pantaleo, Winfried Weissenhorn
Publicado en: Cell Host & Microbe, Edición 26/5, 2019, Página(s) 623-637.e8, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2019.09.016

Continuous HIV-1 Escape from Autologous Neutralization and Development of Cross-Reactive Antibody Responses Characterizes Slow Disease Progression of Children

Autores: Stefania Dispinseri, Mariangela Cavarelli, Monica Tolazzi, Anna Maria Plebani, Marianne Jansson, Gabriella Scarlatti
Publicado en: Vaccines, Edición 9/3, 2021, Página(s) 260, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9030260

VDJ Gene Usage in IgM Repertoires of Rhesus and Cynomolgus Macaques

Autores: Chernyshev M, Kaduk M, Corcoran M, Karlsson Hedestam GB
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2021.815680

Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome

Autores: Oriol-Tordera B , Esteve-Codina A, Berdasco M, Rosás-Umbert M, Gonçalves E, Duran-Castells C, Català-Moll F, Llano A, Cedeño S, Puertas MC, Tolstrup M, Søgaard OS, Clotet B, Martínez-Picado J, Hanke T, Combadiere B, Paredes R, Hartigan-O'Connor D, Esteller M, Meulbroek M, Luz Calle M, Sanchez-Pla A, Moltó J, Mothe B, Brander C, Ruiz-Riol M
Publicado en: eBioMedicine, 2022, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103956

Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

Autores: Jorge Sanchez, Elena Gonçalves, Anuska Llano, Pedro Gonzáles, María Fernández-Maldonado, Annika Vogt, Angele Soria, Susana Perez, Samandhy Cedeño, Marco Antonio Fernández, Julien Nourikyan, Simon de Bernard, Carmela Ganoza, Eric Pedruzzi, Olivia Bonduelle, Beatriz Mothe, Carmen E. Gòmez, Mariano Esteban, Felipe Garcia, Javier R. Lama, Christian Brander, Behazine Combadiere
Publicado en: Frontiers in Immunology, Edición 11, 2020, Página(s) 2866, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2020.586124

Expression of Chimeric HPV-HIV Protein L1P18 in Pichia pastoris; Purification and Characterization of the Virus-like Particles

Autores: Eto Y, Saubi N, Ferrer P, Joseph-Munné J
Publicado en: Pharmaceutics, 2021, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111967

Isolation and Characterization of Mouse Monoclonal Antibodies That Neutralize SARS-CoV-2 and Its Variants of Concern Alpha, Beta, Gamma and Delta by Binding Conformational Epitopes of Glycosylated RBD With High Potency

Autores: Mariotti S, Capocefalo A, Chiantore MV, Iacobino A, Teloni R, De Angelis ML, Gallinaro A, Pirillo MF, Borghi M, Canitano A, Michelini Z, Baggieri M, Marchi A, Bucci P, McKay PF, Acchioni C, Sandini S, Sgarbanti M, Tosini F, Di Virgilio A, Venturi G, Marino F, Esposito V, Di Bonito P, Magurano F, Cara A, Negri D, Nisini R
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2021.750386

Priming with Recombinant BCG Expressing HTI Enhances the Magnitude and Breadth of the T-Cell Immune Responses Elicited by MVA.HTI in BALB/c Mice

Autores: Narcís Saubi, Athina Kilpeläinen, Yoshiki Eto, Chun-Wei Chen, Àlex Olvera, Tomáš Hanke, Christian Brander, Joan Joseph-Munné
Publicado en: Vaccines, Edición 8/4, 2020, Página(s) 678, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040678

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

Autores: Alessio D'addabbo; Max Crispin; Christopher A. Cottrell; Anna-Janina Beherns; Joel D. Allen; Gemma E. Seabright; Marit J. van Gils; Yasunori Watanabe; Rogier W. Sanders; Natalia de Val; Allison Maker; D.J. Harvey; Snezana Vasiljevic; Andrew B. Ward
Publicado en: Structure, Edición 23, 2020, Página(s) 897--909, ISSN 0969-2126
Editor: Elsevier
DOI: 10.1101/2020.02.21.959981

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

Autores: Aleksandar Antanasijevic, George Ueda, Philip J. M. Brouwer, Jeffrey Copps, Deli Huang, Joel D. Allen, Christopher A. Cottrell, Anila Yasmeen, Leigh M. Sewall, Ilja Bontjer, Thomas J. Ketas, Hannah L. Turner, Zachary T. Berndsen, David C. Montefiori, Per Johan Klasse, Max Crispin, David Nemazee, John P. Moore, Rogier W. Sanders, Neil P. King, David Baker, Andrew B. Ward
Publicado en: PLOS Pathogens, Edición 16/8, 2020, Página(s) e1008665, ISSN 1553-7374
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1008665

Seasonal Betacoronavirus Antibodies' Expansion Post-BNT161b2 Vaccination Associates with Reduced SARS-CoV-2 VoC Neutralization

Autores: Dispinseri S, Marzinotto I, Brigatti C, Pirillo M, Tolazzi M, Bazzigaluppi E, Canitano A, Borghi M, Gallinaro A, Caccia R, Vercesi R, McKay P, Ciceri F, Piemonti L, Negri D, Cinque P, Cara A, Scarlatti G, Lampasona V
Publicado en: Journal of Clinical Immunology, 2022, ISSN 0271-9142
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-021-01190-5

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens

Autores: Martin G, Russell RA, Mundsperger P, Harris S, Jovanoska L, Trajano LF, Schiffner T, Fabian K, Tolazzi M, Scarlatti G, McFarlane L, Cheeseman H, Aldon Y, Breemen M, Sliepen K, Katinger D, Kunert R, Sanders RW, Shattock R, Ward AB, Sattentau QJ
Publicado en: BioRxiv, 2021, ISSN 2692-8205
Editor: Cold Spring Harbour Laboratory
DOI: 10.1101/2021.07.26.453798

HIV T-cell immunogen design and delivery

Autores: Christian Brander and Dennis Hartigan-O'Connord
Publicado en: Current Opinion in HIV and AIDS, 2022, ISSN 1746-6318
Editor: Wolters Kluwer
DOI: 10.1097/coh.0000000000000765

Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro

Autores: Alex Olvera, Javier P. Martinez, Maria Casadellà, Anuska Llano, Míriam Rosás, Beatriz Mothe, Marta Ruiz-Riol, Gemma Arsequell, Gregorio Valencia, Marc Noguera-Julian, Roger Paredes, Andreas Meyerhans, Christian Brander
Publicado en: Frontiers in Immunology, Edición 8, 2018, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.02010

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