European AIDS Vaccine Initiative 2020

Livrables

EAVI2020 Public Events:

Two major events (M30 & M72) will be organised to disseminate project results and share its main findings across relevant stakeholders, i.e. clinical communities and patients

EAVI2020 Publications

Submission of up to 100 peerreviewed publications during the programme

Marketing and Dissemination Kit

Marketing and promotional materials developed for the EAVI2020 project, activities and outcomes.

EAVI2020 Website

EAVI2020 main platform for knowledge sharing and promotional activities

Up-selection of optimal T cell vaccine regimen

Up-selection of optimal T cell vaccine regimen according to breadth, potency and durability of cellular antiviral response

Up-selection of optimal humoral vaccine regimen

Upselection of optimal humoral vaccine regimen according to breadth potency and durability of induced antiviral Abs

Report on EAVI2020 training program

Report on outcomes of EAVI2020 training program

Publications

TL1A–DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1–Specific T Cell Responses

Auteurs: Bruna Oriol-Tordera, Alex Olvera, Clara Duran-Castells, Anuska Llano, Beatriz Mothe, Marta Massanella, Judith Dalmau, Carmela Ganoza, Jorge Sanchez, Maria Luz Calle, Bonaventura Clotet, Javier Martinez-Picado, Eugènia Negredo, Julià Blanco, Dennis Hartigan-O'Connor, Christian Brander, Marta Ruiz-Riol
Publié dans: The Journal of Immunology, Numéro 205/12, 2020, Page(s) 3348-3357, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.2000933

Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice

Auteurs: Alessandra Gallinaro, Martina Borghi, Maria Franca Pirillo, Serena Cecchetti, Roberta Bona, Andrea Canitano, Zuleika Michelini, Antonio Di Virgilio, Alex Olvera, Christian Brander, Donatella Negri, Andrea Cara
Publié dans: Molecular Therapy - Methods & Clinical Development, Numéro 17, 2020, Page(s) 418-428, ISSN 2329-0501
Éditeur: Elsevier
DOI: 10.1016/j.omtm.2020.01.013

Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

Auteurs: Morante V, Borghi M, Farina I, Michelini Z, Grasso F, Gallinaro A, Cecchetti S, Di Virgilio A, Canitano A, Pirillo MF, Bona R, Cara A, Negri D
Publié dans: Viruses, 2021, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13020355

Strategies for Immunomonitoring after Vaccination and during Infection

Auteurs: Adam L, Rosenbaum P, Bonduelle O, Combadière B
Publié dans: MDPI Vaccines, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9040365

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control

Auteurs: Bruna Oriol-Tordera, Maria Berdasco, Anuska Llano, Beatriz Mothe, Cristina Gálvez, Javier Martinez-Picado, Jorge Carrillo, Julià Blanco, Clara Duran-Castells, Carmela Ganoza, Jorge Sanchez, Bonaventura Clotet, Maria Luz Calle, Alex Sánchez-Pla, Manel Esteller, Christian Brander, Marta Ruiz-Riol
Publié dans: PLOS Pathogens, Numéro 16/8, 2020, Page(s) e1008678, ISSN 1553-7374
Éditeur: Public Library of Science San Francisco
DOI: 10.1371/journal.ppat.1008678

Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes

Auteurs: Dominik Damm, Ehsan Suleiman, Hannah Theobald, Jannik T. Wagner, Mirjam Batzoni, Bianca Ahlfeld, Bernd Walkenfort, Jens-Christian Albrecht, Jidnyasa Ingale, Lifei Yang, Mike Hasenberg, Richard T. Wyatt, Karola Vorauer-Uhl, Klaus Überla, Vladimir Temchura
Publié dans: Pharmaceutics, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071385

Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques.

Auteurs: Van Tilbeurgh M, Maisonnasse P, Palgen JL, Tolazzi M, Aldon Y, Dereuddre-Bosquet N, Cavarelli M, Beignon AS, Marcos-Lopez E, Gallouet AS, Gilson E, Ozorowski G, Ward AB, Bontjer I, McKay PF, Shattock RJ, Scarlatti G, Sanders RW, Le Grand R
Publié dans: Cell Reports Medicine, 2022, ISSN 2666-3791
Éditeur: Cell Press Elsevier
DOI: 10.1016/j.xcrm.2022.100751

Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques

Auteurs: Maria Blasi, Elizabeth C. Wescott, Erich J. Baker, Benjamin Mildenberg, Celia LaBranche, Wes Rountree, Barton F. Haynes, Kevin O. Saunders, M. Anthony Moody, Donatella Negri, Sampa Santra, Andrea Cara, Mary E. Klotman
Publié dans: npj Vaccines, Numéro 5/1, 2020, Page(s) 1--9, ISSN 2059-0105
Éditeur: Nature Publishing Group
DOI: 10.1038/s41541-020-0186-5

Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint.

Auteurs: Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Van der Woude P, De Taeye SW, Van den Kerkhof TLGM, Klasse PJ, Ozorowski G, Van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Publié dans: Cell Reports, 2021, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2021.109646

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms

Auteurs: Philip J.M. Brouwer, Rogier W. Sanders
Publié dans: Current Opinion in HIV and AIDS, Numéro 14/4, 2019, Page(s) 302-308, ISSN 1746-630X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/coh.0000000000000549

Structure-guided envelope trimer design in HIV-1 vaccine development: a narrative review

Auteurs: Derking R, Sanders RW
Publié dans: Journal of the International AIDS Society, 2021, ISSN 1758-2652
Éditeur: International AIDS Society
DOI: 10.1002/jia2.25797

Specificity of CD8+ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya

Auteurs: Yehia S. Mohamed, Nicola J. Borthwick, Nathifa Moyo, Hayato Murakoshi, Tomohiro Akahoshi, Francesca Siliquini, Zara Hannoun, Alison Crook, Peter Hayes, Patricia E. Fast, Gaudensia Mutua, Walter Jaoko, Sandra Silva-Arrieta, Anuska Llano, Christian Brander, Masafumi Takiguchi, Tomáš Hanke
Publié dans: Vaccines, Numéro 8/2, 2020, Page(s) 260, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8020260

Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

Auteurs: Jelle van Schooten, Elinaz Farokhi, Anna Schorcht, Tom L. G. M. van den Kerkhof, Hongmei Gao, Patricia van der Woude, Judith A. Burger, Tim G. Rijkhold Meesters, Tom Bijl, Riham Ghalaiyini, Hannah L. Turner, Jessica Dorning, Barbera D. C. van Schaik, Antoine H. C. van Kampen, Celia C. Labranche, Robyn L. Stanfield, Devin Sok, David C. Montefiori, Dennis R. Burton, Michael S. Seaman, Gabriel Ozorow
Publié dans: Nature communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32208-0

Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

Auteurs: Jelle van Schooten, Ilja C. Bontjer, J. A. Burger, Rogier W. Sanders, Marit J. van Gils
Publié dans: NPJ Vaccines, 2022, ISSN 2059-0105
Éditeur: Nature Research
DOI: 10.1038/s41541-022-00576-9

Novel Approaches Towards a Functional Cure of HIV/AIDS

Auteurs: Lucia Bailon, Beatriz Mothe, Lance Berman, Christian Brander
Publié dans: Drugs, Numéro 80/9, 2020, Page(s) 859-868, ISSN 0012-6667
Éditeur: Adis International Ltd.
DOI: 10.1007/s40265-020-01322-y

Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity

Auteurs: Yi-Yu Lin, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, Donatella Negri
Publié dans: Molecular Therapy - Methods & Clinical Development, Numéro 17, 2020, Page(s) 532-544, ISSN 2329-0501
Éditeur: Elsevier
DOI: 10.1016/j.omtm.2020.03.008

Glycans in HIV-1 vaccine design – engaging the shield

Auteurs: Deimel LP, Xue X, Sattentau QJ
Publié dans: Trends in Microbiology, 2022, ISSN 0966-842X
Éditeur: Elsevier BV
DOI: 10.1016/j.tim.2022.02.004

Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines

Auteurs: Nicola Borthwick, Sandra Silva-Arrieta, Anuska Llano, Masafumi Takiguchi, Christian Brander, Tomáš Hanke
Publié dans: Vaccines, Numéro 8/1, 2020, Page(s) 28, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010028

Dichotomy in Neutralizing Antibody Induction to Peptide-Conjugated Vaccine in Squalene Emulsion Contrast With Aluminum Hydroxide Formulation

Auteurs: Bonduelle O, Chaudesaigues C, Tolazzi M, Suleiman E, De Bernard S, Alves K, Nourikyan J, Bohec M, Baudrin LG, Katinger D, Debré P, Scarlatti G, Vieillard V, Combadiere B
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2022.848571

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein

Auteurs: M. M. van Haaren, L. E. McCoy, J. L. Torres, W. Lee, C. A. Cottrell, J. L. Copps, P. van der Woude, A. Yasmeen, S. W. de Taeye, A. Torrents de la Peña, J. P. Moore, D. R. Burton, P. J. Klasse, A. B. Ward, R. W. Sanders, M. J. van Gils
Publié dans: Journal of Virology, 2021, ISSN 1098-5514
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.00094-21

Transcriptome Sequencing of Peripheral Blood Mononuclear Cells from Elite Controller-Long Term Non Progressors

Auteurs: Francisco Díez-Fuertes, Humberto Erick De La Torre-Tarazona, Esther Calonge, Maria Pernas, María del Mar Alonso-Socas, Laura Capa, Javier García-Pérez, Anavaj Sakuntabhai, José Alcamí
Publié dans: Scientific Reports, Numéro 9/1, 2019, Page(s) 1--13, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-50642-x

Immunogenicity, safety, and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs

Auteurs: Maria Blasi, Donatella Negri, Kevin O. Saunders, Erich J. Baker, Hannah Stadtler, Celia LaBranche, Benjamin Mildenberg, Georgeanna Morton, Andrew Ciarla, Xiaoying Shen, Yunfei Wang, Wes Rountree, Bala Balakumaran, Sampa Santra, Barton F. Haynes, Anthony M. Moody, Andrea Cara, Mary E. Klotman
Publié dans: npj Vaccines, Numéro 5/1, 2020, Page(s) 1--12, ISSN 2059-0105
Éditeur: Nature Publishing Group
DOI: 10.1038/s41541-020-00252-w

Comparison of blood and lymph node cells after intramuscular injection with HIV envelope immunogens

Auteurs: Suzanne Day, Charandeep Kaur, Hannah M. Cheeseman, Emily de Groot, Leon R. McFarlane, Maniola Tanaka, Sofia Coelho, Tom Cole, Nana-Marie Lemm, Adrian Lim, Rogier W. Sanders, Becca Asquith, Robin J. Shattock and Katrina M. Pollock
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2022.991509

In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial

Auteurs: Miriam Rosás-Umbert, Marta Ruiz-Riol, Marco A. Fernández, Marta Marszalek, Pep Coll, Christian Manzardo, Samandhy Cedeño, José M. Miró, Bonaventura Clotet, Tomáš Hanke, José Moltó, Beatriz Mothe, Christian Brander
Publié dans: Frontiers in Immunology, Numéro 11, 2020, Page(s) 418, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2020.00418

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Auteurs: Sliepen KHEWJ, Bontjer IC, Burger JA, Brouwer PJM, Sanders RW
Publié dans: npj Vaccines, 2021, ISSN 2059-0105
Éditeur: Springer Nature
DOI: 10.1038/s41541-021-00364-x

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Auteurs: Aguado-Garcia D, Olvera A, Brander C, Sanchez-Merino V, and Yuste E
Publié dans: Vaccines, 2022, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10040484

Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

Auteurs: Gallinaro A, Pirillo MF, Aldon Y, Cecchetti S, Michelini Z, Tinari A, Borghi M, Canitano A, McKay PF, Bona R, Vescio MF, Grasso F, Blasi M, Baroncelli S, Scarlatti G, LaBranche C, Montefiori D, Klotman ME, Sanders RW, Shattock RJ, Negri D, Cara A
Publié dans: npj Vaccines, 2022, ISSN 2059-0105
Éditeur: Springer Nature
DOI: 10.1038/s41541-022-00465-1

HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)

Auteurs: Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C. Puertas, Sara Morón-López, Anuska Llano, Cristina Miranda, Samandhy Cedeño, Miriam López, Yovaninna Alarcón-Soto, Guadalupe Gómez Melis, Klaus Langohr, Ana M. Barriocanal, Jessica Toro, Irene Ruiz, Cristina Rovira, Antonio Carrillo, Michael Meulbroek, Alison Crook, Edmund G. Wee, Jose M. Miró, Bonaventura Clotet, Ma
Publié dans: Frontiers in Immunology, Numéro 11, 2020, Page(s) 823, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2020.00823

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates

Auteurs: Jelle van Schooten, Marlies M. van Haaren, Hui Li, Laura E. McCoy, Colin Havenar-Daughton, Christopher A. Cottrell, Judith A. Burger, Patricia van der Woude, Leanne C. Helgers, Ilhan Tomris, Celia C. Labranche, David C. Montefiori, Andrew B. Ward, Dennis R. Burton, John P. Moore, Rogier W. Sanders, Shane Crotty, George M. Shaw, Marit J. van Gils
Publié dans: PLOS Pathogens, 2021, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1009736

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival

Auteurs: Dispinseri S, Secchi M, Pirillo MF, Tolazzi M, Borghi M, Brigatti C, De Angelis ML, Baratella M, Bazzigaluppi E, Venturi G, Sironi F, Canitano A, Marzinotto I, Tresoldi C, Ciceri F, Piemonti L, Negri D, Cara A, Lampasona V, Scarlatti G
Publié dans: Nature communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-22958-8

Strategies for inducing effective neutralizing antibody responses against HIV-1

Auteurs: Iván del Moral-Sánchez, Kwinten Sliepen
Publié dans: Expert Review of Vaccines, Numéro 18/11, 2019, Page(s) 1127-1143, ISSN 1476-0584
Éditeur: Future Drugs Ltd.
DOI: 10.1080/14760584.2019.1690458

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections

Auteurs: Luis Romero-Martin, Clara Duran-Castells, Mireia Olivella, Mı´riam Rosas-Umbert, Marta Ruiz-Riol, Jorge Sanchez, Dennis Hartigan-O´Connor, Beatriz Mothe, Àlex Olvera and Christian Brander
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2022.1027855

Safety and efficiency modifications of SIV-based integrase-defective lentiviral vectors for immunization

Auteurs: Bona R, Michelini Z, Mazzei C, Gallinaro A, Canitano A, Borghi M, Vescio MF, Di Virgilio A, Pirillo MF, Klotman ME, Negri D, Cara A
Publié dans: Molecular Therapy: Methods & Clinical Development, 2021, ISSN 2329-0501
Éditeur: Cell Press, Elsevier Inc
DOI: 10.1016/j.omtm.2021.09.011

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

Auteurs: Philip J. M. Brouwer, Aleksandar Antanasijevic, Marlon de Gast, Joel D. Allen, Tom P. L. Bijl, Anila Yasmeen, Rashmi Ravichandran, Judith A. Burger, Gabriel Ozorowski, Jonathan L. Torres, Celia LaBranche, David C. Montefiori, Rajesh P. Ringe, Marit J. van Gils, John P. Moore, Per Johan Klasse, Max Crispin, Neil P. King, Andrew B. Ward, Rogier W. Sanders
Publié dans: npj Vaccines, Numéro 6/1, 2021, Page(s) 1-14, ISSN 2059-0105
Éditeur: Nature Publishing Group
DOI: 10.1038/s41541-021-00285-9

Genetic Co-Administration of Soluble PD-1 Ectodomains Modifies Immune Responses against Influenza A Virus Induced by DNA Vaccination

Auteurs: Pierre Tannig, Antonia Sophia Peter, Dennis Lapuente, Stephan Klessing, Anna Schmidt, Dominik Damm, Matthias Tenbusch, Klaus Überla, Vladimir Temchura
Publié dans: Vaccines, Numéro 8/4, 2020, Page(s) 570, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040570

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans

Auteurs: Huettner I, Krumm SA, Serna S, Brzezicka K, Monaco S, Walpole S, van Diepen A, Allan F, Hicks T, Kimuda S, Emery AM, IAVI Protocol C Investigators & The IAVI African HIV Research Network, Landais E, Hokke CH, Angulo J, Reichardt N, Doores KJ
Publié dans: Cell Reports, 2022, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.110611

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Auteurs: Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker,
Publié dans: Nature communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-25087-4

In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

Auteurs: Sandra Silva-Arrieta, Philip J. R. Goulder, Christian Brander
Publié dans: PLOS Pathogens, Numéro 16/6, 2020, Page(s) e1008607, ISSN 1553-7374
Éditeur: Public Library of Science San Francisco
DOI: 10.1371/journal.ppat.1008607

CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help

Auteurs: Stephan Klessing, Vladimir Temchura, Pierre Tannig, Antonia Sophia Peter, Dennis Christensen, Roland Lang, Klaus Überla
Publié dans: Vaccines, Numéro 8/4, 2020, Page(s) 604, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040604

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Auteurs: Anna K. Blakney, Paul F. McKay, Bárbara Ibarzo Yus, Yoann Aldon, Robin J. Shattock
Publié dans: Gene Therapy, Numéro 26/9, 2019, Page(s) 363-372, ISSN 0969-7128
Éditeur: Nature Publishing Group
DOI: 10.1038/s41434-019-0095-2

Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8+ T cell antiviral responses

Auteurs: Yang H, Llano A, Cedeño S, von Delft A, Corcuera A, Gillespie GM, Knox A, Leneghan DB, Frater J, Stöhr W, Fidler S, Mothe B, Mak J, Brander C, Ternette N, Dorrell L
Publié dans: Cell Reports, 2021, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2021.109103

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

Auteurs: Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn
Publié dans: eLife, Numéro 10, 2021, Page(s) e65005, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.65005

T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

Auteurs: Luis Romero-Martin, Ferran Tarres-Freixas, Nuria Pedreño-Lopez, Maria L. Rodriguez de la Concepcio, Francesc Cunyat, Dennis Hartigan-O'Connor, Jorge Carrillo, Beatriz Mothe, Julià Blanco, Marta Ruiz-Riol, Christian Brander and Alex Olvera
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2022.928039

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers

Auteurs: Anna Schorcht, Tom L. G. M. van den Kerkhof, Christopher A. Cottrell, Joel D. Allen, Jonathan L. Torres, Anna-Janina Behrens, Edith E. Schermer, Judith A. Burger, Steven W. de Taeye, Alba Torrents de la Peña, Ilja Bontjer, Stephanie Gumbs, Gabriel Ozorowski, Celia C. LaBranche, Natalia de Val, Anila Yasmeen, Per Johan Klasse, David C. Montefiori, John P. Moore, Hanneke Schuitemaker, Max Crispin,
Publié dans: Journal of Virology, Numéro 94/24, 2020, Page(s) volume={94}, number={24}, year={2020},, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.01214-20

Design Concepts of Virus-Like Particle-Based HIV-1 Vaccines

Auteurs: Chun-Wei Chen, Narcís Saubi, Joan Joseph-Munné
Publié dans: Frontiers in Immunology, Numéro 11, 2020, Page(s) 573157, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2020.573157

Neutralizing Antibodies Targeting HIV-1 gp41

Auteurs: Christophe Caillat, Delphine Guilligay, Guidenn Sulbaran, Winfried Weissenhorn
Publié dans: Viruses, Numéro 12/11, 2020, Page(s) 1210, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111210

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

Auteurs: Ronald Derking, Joel D. Allen, Christopher A. Cottrell, Kwinten Sliepen, Gemma E. Seabright, Wen-Hsin Lee, Yoann Aldon, Kimmo Rantalainen, Aleksandar Antanasijevic, Jeffrey Copps, Anila Yasmeen, Albert Cupo, Victor M. Cruz Portillo, Meliawati Poniman, Niki Bol, Patricia van der Woude, Steven W. de Taeye, Tom L.G.M. van den Kerkhof, P.J. Klasse, Gabriel Ozorowski, Marit J. van Gils, John P. Moore,
Publié dans: Cell Reports, Numéro 35/1, 2021, Page(s) 108933, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2021.108933

Chimeric Human Papillomavirus-16 Virus-like Particles Presenting P18I10 and T20 Peptides from HIV-1 Envelope Induce HPV16 and HIV-1-Specific Humoral and T Cell-Mediated Immunity in BALB/c Mice

Auteurs: Jelle van Schooten, Ilja C. Bontjer, J. A. Burger, Rogier W. Sanders, Marit J. van Gils
Publié dans: Vaccines, 2022, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11010015

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

Auteurs: Goncalves E, Guillen Y, Lama JR, Sanchez J, Brander C, Paredes R and Combadière B
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2021.657162

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines

Auteurs: Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, Tomáš Hanke
Publié dans: PLOS ONE, Numéro 12/4, 2017, Page(s) e0176418, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0176418

Neutralizing Antibodies Against a Specific Human Immunodeficiency Virus gp41 Epitope are Associated With Long-term Non-progressor Status

Auteurs: Olivier Lucar, Bin Su, Valérie Potard, Assia Samri, Brigitte Autran, Christiane Moog, Patrice Debré, Vincent Vieillard
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Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

Auteurs: Max Medina-Ramírez, Fernando Garces, Amelia Escolano, Patrick Skog, Steven W. de Taeye, Ivan Del Moral-Sanchez, Andrew T. McGuire, Anila Yasmeen, Anna-Janina Behrens, Gabriel Ozorowski, Tom L.G.M. van den Kerkhof, Natalia T. Freund, Pia Dosenovic, Yuanzi Hua, Alexander D. Gitlin, Albert Cupo, Patricia van der Woude, Michael Golabek, Kwinten Sliepen, Tanya Blane, Neeltje Kootstra, Mariëlle J. van
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Stabilized HIV-1 envelope glycoprotein trimers for vaccine use

Auteurs: Max Medina-Ramírez, Rogier W. Sanders, Quentin J. Sattentau
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Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control

Auteurs: M. Ruiz-Riol, D. Berdnik, A. Llano, B. Mothe, C. Gálvez, S. Pérez-Álvarez, B. Oriol-Tordera, A. Olvera, S. Silva-Arrieta, M. Meulbroek, F. Pujol, J. Coll, J. Martinez-Picado, C. Ganoza, J. Sanchez, G. Gómez, T. Wyss-Coray, C. Brander
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HIV-1 Conserved Mosaics Delivered by Regimens with Integration-Deficient DC-Targeting Lentiviral Vector Induce Robust T Cells

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HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers

Auteurs: Silvia Capucci, Edmund G. Wee, Torben Schiffner, Celia C. LaBranche, Nicola Borthwick, Albert Cupo, Jonathan Dodd, Hansi Dean, Quentin Sattentau, David Montefiori, Per J. Klasse, Rogier W. Sanders, John P. Moore, Tomáš Hanke
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An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

Auteurs: Marit J. van Gils, Tom L. G. M. van den Kerkhof, Gabriel Ozorowski, Christopher A. Cottrell, Devin Sok, Matthias Pauthner, Jesper Pallesen, Natalia de Val, Anila Yasmeen, Steven W. de Taeye, Anna Schorcht, Stephanie Gumbs, Inez Johanna, Karen Saye-Francisco, Chi-Hui Liang, Elise Landais, Xiaoyan Nie, Laura K. Pritchard, Max Crispin, Garnett Kelsoe, Ian A. Wilson, Hanneke Schuitemaker, Per Johan Kl
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Structural principles controlling HIV envelope glycosylation

Auteurs: Anna-Janina Behrens, Max Crispin
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Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA

Auteurs: Nathifa Moyo, Annette B. Vogel, Søren Buus, Stephanie Erbar, Edmund G. Wee, Ugur Sahin, Tomáš Hanke
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Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination

Auteurs: Sven Kratochvil, Paul F. McKay, Amy W. Chung, Stephen J. Kent, Jill Gilmour, Robin J. Shattock
Publié dans: Frontiers in Immunology, Numéro 8, 2017, ISSN 1664-3224
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HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual

Auteurs: Karen P. Coss, Snezana Vasiljevic, Laura K. Pritchard, Stefanie A. Krumm, Molly Glaze, Sharon Madzorera, Penny L. Moore, Max Crispin, Katie J. Doores
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Intrastructural help

Auteurs: Vladimir Temchura, Klaus Überla
Publié dans: Current Opinion in HIV and AIDS, Numéro 12/3, 2017, Page(s) 272-277, ISSN 1746-630X
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Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins

Auteurs: Torben Schiffner, Jesper Pallesen, Rebecca A. Russell, Jonathan Dodd, Natalia de Val, Celia C. LaBranche, David Montefiori, Georgia D. Tomaras, Xiaoying Shen, Scarlett L. Harris, Amin E. Moghaddam, Oleksandr Kalyuzhniy, Rogier W. Sanders, Laura E. McCoy, John P. Moore, Andrew B. Ward, Quentin J. Sattentau
Publié dans: PLOS Pathogens, Numéro 14/5, 2018, Page(s) e1006986, ISSN 1553-7374
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Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors

Auteurs: Nuria González, Krisha McKee, Rebecca M. Lynch, Ivelin S. Georgiev, Laura Jimenez, Eulalia Grau, Eloísa Yuste, Peter D. Kwong, John R. Mascola, José Alcamí
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Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans

Auteurs: Jenna Anderson, Thorunn A. Olafsdottir, Sven Kratochvil, Paul F. McKay, Malin Östensson, Josefine Persson, Robin J. Shattock, Ali M. Harandi
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
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Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine

Auteurs: Hannah Mary Cheeseman, Suzanne Day, Leon Robert McFarlane, Sue Fleck, Aleisha Miller, Tom Cole, Nelson Sousa-Santos, Alethea Cope, Deniz Cizmeci, Monica Tolazzi, Edith Hwekwete, Drew Hannaman, Sven Kratochvil, Paul Francis McKay, Amy W. Chung, Stephen J. Kent, Adrian Cook, Gabriella Scarlatti, Sonya Abraham, Behazine Combadiere, Sheena McCormack, David John Lewis, Robin John Shattock
Publié dans: Human Gene Therapy, Numéro 29/9, 2018, Page(s) 1011-1028, ISSN 1043-0342
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Isolation and Characterization of Antigen-Specific Plasmablasts Using a Novel Flow Cytometry–Based Ig Capture Assay

Auteurs: Christopher L. Pinder, Sven Kratochvil, Deniz Cizmeci, Luke Muir, Yanping Guo, Robin J. Shattock, Paul F. McKay
Publié dans: The Journal of Immunology, Numéro 199/12, 2017, Page(s) 4180-4188, ISSN 0022-1767
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Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1

Auteurs: Anna-Janina Behrens, Weston B Struwe, Max Crispin
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Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design

Auteurs: Edna O. Viegas, Arne Kroidl, Patricia J. Munseri, Marco Missanga, Charlotta Nilsson, Nelson Tembe, Asli Bauer, Agricola Joachim, Sarah Joseph, Philipp Mann, Christof Geldmacher, Sue Fleck, Wolfgang Stöhr, Gabriella Scarlatti, Said Aboud, Muhammad Bakari, Leonard Maboko, Michael Hoelscher, Britta Wahren, Merlin L. Robb, Jonathan Weber, Sheena McCormack, Gunnel Biberfeld, Ilesh V. Jani, Eric Sandst
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Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

Auteurs: Yoann Aldon, Paul F. McKay, Joel Allen, Gabriel Ozorowski, Réka Felfödiné Lévai, Monica Tolazzi, Paul Rogers, Linling He, Natalia de Val, Katalin Fábián, Gabriella Scarlatti, Jiang Zhu, Andrew B. Ward, Max Crispin, Robin J. Shattock
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Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines

Auteurs: Hassan Elsayed, Ghulam Nabi, William J. McKinstry, Keith K. Khoo, Johnson Mak, Andres M. Salazar, Matthias Tenbusch, Vladimir Temchura, Klaus Überla
Publié dans: Journal of Virology, Numéro 92/14, 2018, ISSN 0022-538X
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Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Auteurs: Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J. M. Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L. Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Peña, Mariëlle J. van Breemen, Juan Miguel Camacho-Sánchez, Judith A. Burger, Max Medina-Ramírez, Nuria G
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
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MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

Auteurs: Esther Broset, Narcís Saubi, Núria Guitart, Nacho Aguilo, Santiago Uranga, Athina Kilpeläinen, Yoshiki Eto, Tomáš Hanke, Jesús Gonzalo-Asensio, Carlos Martín, Joan Joseph-Munné
Publié dans: Molecular Therapy - Methods & Clinical Development, Numéro 13, 2019, Page(s) 253-264, ISSN 2329-0501
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Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

Auteurs: Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Alex Olvera, Tomáš Hanke, Christian Brander, Joan Joseph
Publié dans: Vaccines, Numéro 7/3, 2019, Page(s) 78, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
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HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial

Auteurs: Vincent Vieillard, Béhazine Combadière, Roland Tubiana, Odile Launay, Gilles Pialoux, Laurent Cotte, Pierre-Marie Girard, Anne Simon, Yasmine Dudoit, Jacques Reynes, Jürgen Rockstroh, Felipe Garcia, Jose Gatell, Alain Devidas, Yazdan Yazdanpanah, Laurence Weiss, Gerd Fätkenheuer, Brigitte Autran, Delphine Joyeux, Shahin Gharakhanian, Patrice Debré, Christine Katlama
Publié dans: npj Vaccines, Numéro 4/1, 2019, ISSN 2059-0105
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High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis

Auteurs: Néstor Vázquez Bernat, Martin Corcoran, Uta Hardt, Mateusz Kaduk, Ganesh E. Phad, Marcel Martin, Gunilla B. Karlsson Hedestam
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
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Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination

Auteurs: Rebecca Heß, Michael Storcksdieck genannt Bonsmann, Dennis Lapuente, Andre Maaske, Carsten Kirschning, Jürgen Ruland, Bernd Lepenies, Drew Hannaman, Matthias Tenbusch, Klaus Überla
Publié dans: Viruses, Numéro 11/2, 2019, Page(s) 153, ISSN 1999-4915
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HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry

Auteurs: Dirk Eggink, Ilja Bontjer, Steven W. de Taeye, Johannes P. M. Langedijk, Ben Berkhout, Rogier W. Sanders
Publié dans: Journal of Biological Chemistry, Numéro 294/15, 2019, Page(s) 5736-5746, ISSN 0021-9258
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Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

Auteurs: Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Nathifa Moyo, Edmund G. Wee, Krupa Ravi, Tomáš Hanke, Joan Joseph
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
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Mechanisms of Abrupt Loss of Virus Control in a Cohort of Previous HIV Controllers

Auteurs: Miriam Rosás-Umbert, Anuska Llano, Rocío Bellido, Alex Olvera, Marta Ruiz-Riol, Muntsa Rocafort, Marco A. Fernández, Patricia Cobarsi, Manel Crespo, Lucy Dorrell, Jorge del Romero, José Alcami, Roger Paredes, Christian Brander, Beatriz Mothe
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Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

Auteurs: Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance
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Protein and Glycan Mimicry in HIV Vaccine Design

Auteurs: Gemma E. Seabright, Katie J. Doores, Dennis R. Burton, Max Crispin
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Auteurs: Alba Torrents de la Peña, Kimmo Rantalainen, Christopher A. Cottrell, Joel D. Allen, Marit J. van Gils, Jonathan L. Torres, Max Crispin, Rogier W. Sanders, Andrew B. Ward
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Exploitation of glycosylation in enveloped virus pathobiology

Auteurs: Yasunori Watanabe, Thomas A. Bowden, Ian A. Wilson, Max Crispin
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Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

Auteurs: Meng Yuan, Christopher A. Cottrell, Gabriel Ozorowski, Marit J. van Gils, Sonu Kumar, Nicholas C. Wu, Anita Sarkar, Jonathan L. Torres, Natalia de Val, Jeffrey Copps, John P. Moore, Rogier W. Sanders, Andrew B. Ward, Ian A. Wilson
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Can we just kick-and-kill HIV: possible challenges posed by the epigenetically controlled interplay between HIV and host immunity

Auteurs: Marta Ruiz-Riol, Christian Brander
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Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies

Auteurs: Mitch Brinkkemper, Kwinten Sliepen
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Peptide-Based Vaccination for Antibody Responses Against HIV

Auteurs: Combadière, Beaujean, Chaudesaigues, Vieillard
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Preclinical Development of BCG.HIVA 2auxo.int , Harboring an Integrative Expression Vector, for a HIV-TB Pediatric vaccine. Enhancement of Stability and Specific HIV-1 T-cell Immunity

Auteurs: Aakash Mahant, Narcís Saubi, Yoshiki Eto, Núria Guitart, Josep M ª Gatell, Tomáš Hanke, Joan Joseph
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Native-like Env trimers as a platform for HIV-1 vaccine design

Auteurs: Rogier W. Sanders, John P. Moore
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TOX is expressed by exhausted and polyfunctional human effector memory CD8 + T cells

Auteurs: Takuya Sekine, André Perez-Potti, Son Nguyen, Jean-Baptiste Gorin, Vincent H. Wu, Emma Gostick, Sian Llewellyn-Lacey, Quirin Hammer, Sara Falck-Jones, Sindhu Vangeti, Meng Yu, Anna Smed-Sörensen, Ahmed Gaballa, Michael Uhlin, Johan K. Sandberg, Christian Brander, Piotr Nowak, Paul A. Goepfert, David A. Price, Michael R. Betts, Marcus Buggert
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Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

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High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers

Auteurs: Del Moral Sanchez I, Schermer EE, Torrents de la Pena A, Sliepen KHEWJ, Sanders RW
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Conjugation of Native-Like HIV-1 Envelope Trimers onto Liposomes Using EDC/Sulfo-NHS Chemistry: Requirements and Limitations

Auteurs: Ehsan Suleiman, Julia Mayer, Elisabeth Lehner, Bianca Kohlhauser, Alexandra Katholnig, Mirjam Batzoni, Dominik Damm, Vladimir Temchura, Andreas Wagner, Klaus Überla, Karola Vorauer-Uhl
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The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With Disease Progression

Auteurs: Sara Moron-Lopez, Victor Urrea, Judith Dalmau, Miguel Lopez, Maria C Puertas, Dan Ouchi, Antonio Gómez, Caroline Passaes, Beatriz Mothe, Christian Brander, Asier Saez-Cirion, Bonaventura Clotet, Manel Esteller, Maria Berdasco, Javier Martinez-Picado
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LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic Complications

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Electrostatically Driven Encapsulation of Hydrophilic, Non-Conformational Peptide Epitopes into Liposomes

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Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

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Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses

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Effect of epitope variant co-delivery on the depth of CD8 T cell responses induced by HIV-1 conserved mosaic vaccines

Auteurs: Wee EG, Moyo N, Hannoun Z, Giorgi E, Korber B, Hanke T
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CD8+PD-L1+CXCR3+ polyfunctional T cell abundances are associated with survival in critical SARS-CoV-2–infected patients

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Association of a single nucleotide polymorphism in the ubxn6 gene with long-term non-progression phenotype in HIV-positive individuals

Auteurs: F. Díez-Fuertes, H.E. De La Torre-Tarazona, E. Calonge, M. Pernas, M. Bermejo, J. García-Pérez, A. Álvarez, L. Capa, F. García-García, M. Saumoy, M. Riera, A. Boland-Auge, C. López-Galíndez, M. Lathrop, J. Dopazo, A. Sakuntabhai, J. Alcamí
Publié dans: Clinical Microbiology and Infection, Numéro 26/1, 2020, Page(s) 107-114, ISSN 1198-743X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2019.05.015

Conjugation of a Toll-Like Receptor Agonist to Glycans of an HIV Native-Like Envelope Trimer Preserves Neutralization Epitopes

Auteurs: Zeshi Li, Ronald Derking, Wen-Hsin Lee, Gerlof P Bosman, Andrew B Ward, Rogier W Sanders, Geert-Jan Boons
Publié dans: Chembiochem, 2022, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200236

Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Auteurs: Borgognone E, Noguera-Julian M, Oriol B, Noël-Romas L, Ruiz-Riol M, Guillén Y, Parera M, Casadellà M, Duran C, Puertas MC, Català-Moll F, De Leon M, Knodel S, Birse K, Manzardo C, Miró JM, Clotet B, Martinez-Picado J, Moltó J, Mothe B, Burgener A, Brander C, Paredes R, and the BCN02 Study Group
Publié dans: Microbiome, 2022, ISSN 2049-2618
Éditeur: BioMed Central
DOI: 10.1186/s40168-022-01247-6

Does Antigen Glycosylation Impact the HIV-Specific T Cell Immunity?

Auteurs: Alex Olvera, Samandhy Cedeño, Anuska Llano, Beatriz Mothe, Jorge Sanchez, Gemma Arsequell, Christian Brander
Publié dans: Frontiers in Immunology, Numéro 11, 2021, Page(s) N/A, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2020.573928

Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01

Auteurs: Dora Pinto, Craig Fenwick, Christophe Caillat, Chiara Silacci, Serafima Guseva, François Dehez, Christophe Chipot, Sonia Barbieri, Andrea Minola, David Jarrossay, Georgia D. Tomaras, Xiaoying Shen, Agostino Riva, Maciej Tarkowski, Olivier Schwartz, Timothée Bruel, Jérémy Dufloo, Michael S. Seaman, David C. Montefiori, Antonio Lanzavecchia, Davide Corti, Giuseppe Pantaleo, Winfried Weissenhorn
Publié dans: Cell Host & Microbe, Numéro 26/5, 2019, Page(s) 623-637.e8, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2019.09.016

Continuous HIV-1 Escape from Autologous Neutralization and Development of Cross-Reactive Antibody Responses Characterizes Slow Disease Progression of Children

Auteurs: Stefania Dispinseri, Mariangela Cavarelli, Monica Tolazzi, Anna Maria Plebani, Marianne Jansson, Gabriella Scarlatti
Publié dans: Vaccines, Numéro 9/3, 2021, Page(s) 260, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9030260

VDJ Gene Usage in IgM Repertoires of Rhesus and Cynomolgus Macaques

Auteurs: Chernyshev M, Kaduk M, Corcoran M, Karlsson Hedestam GB
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2021.815680

Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome

Auteurs: Oriol-Tordera B , Esteve-Codina A, Berdasco M, Rosás-Umbert M, Gonçalves E, Duran-Castells C, Català-Moll F, Llano A, Cedeño S, Puertas MC, Tolstrup M, Søgaard OS, Clotet B, Martínez-Picado J, Hanke T, Combadiere B, Paredes R, Hartigan-O'Connor D, Esteller M, Meulbroek M, Luz Calle M, Sanchez-Pla A, Moltó J, Mothe B, Brander C, Ruiz-Riol M
Publié dans: eBioMedicine, 2022, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103956

Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

Auteurs: Jorge Sanchez, Elena Gonçalves, Anuska Llano, Pedro Gonzáles, María Fernández-Maldonado, Annika Vogt, Angele Soria, Susana Perez, Samandhy Cedeño, Marco Antonio Fernández, Julien Nourikyan, Simon de Bernard, Carmela Ganoza, Eric Pedruzzi, Olivia Bonduelle, Beatriz Mothe, Carmen E. Gòmez, Mariano Esteban, Felipe Garcia, Javier R. Lama, Christian Brander, Behazine Combadiere
Publié dans: Frontiers in Immunology, Numéro 11, 2020, Page(s) 2866, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2020.586124

Expression of Chimeric HPV-HIV Protein L1P18 in Pichia pastoris; Purification and Characterization of the Virus-like Particles

Auteurs: Eto Y, Saubi N, Ferrer P, Joseph-Munné J
Publié dans: Pharmaceutics, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111967

Isolation and Characterization of Mouse Monoclonal Antibodies That Neutralize SARS-CoV-2 and Its Variants of Concern Alpha, Beta, Gamma and Delta by Binding Conformational Epitopes of Glycosylated RBD With High Potency

Auteurs: Mariotti S, Capocefalo A, Chiantore MV, Iacobino A, Teloni R, De Angelis ML, Gallinaro A, Pirillo MF, Borghi M, Canitano A, Michelini Z, Baggieri M, Marchi A, Bucci P, McKay PF, Acchioni C, Sandini S, Sgarbanti M, Tosini F, Di Virgilio A, Venturi G, Marino F, Esposito V, Di Bonito P, Magurano F, Cara A, Negri D, Nisini R
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2021.750386

Priming with Recombinant BCG Expressing HTI Enhances the Magnitude and Breadth of the T-Cell Immune Responses Elicited by MVA.HTI in BALB/c Mice

Auteurs: Narcís Saubi, Athina Kilpeläinen, Yoshiki Eto, Chun-Wei Chen, Àlex Olvera, Tomáš Hanke, Christian Brander, Joan Joseph-Munné
Publié dans: Vaccines, Numéro 8/4, 2020, Page(s) 678, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040678

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

Auteurs: Alessio D'addabbo; Max Crispin; Christopher A. Cottrell; Anna-Janina Beherns; Joel D. Allen; Gemma E. Seabright; Marit J. van Gils; Yasunori Watanabe; Rogier W. Sanders; Natalia de Val; Allison Maker; D.J. Harvey; Snezana Vasiljevic; Andrew B. Ward
Publié dans: Structure, Numéro 23, 2020, Page(s) 897--909, ISSN 0969-2126
Éditeur: Elsevier
DOI: 10.1101/2020.02.21.959981

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

Auteurs: Aleksandar Antanasijevic, George Ueda, Philip J. M. Brouwer, Jeffrey Copps, Deli Huang, Joel D. Allen, Christopher A. Cottrell, Anila Yasmeen, Leigh M. Sewall, Ilja Bontjer, Thomas J. Ketas, Hannah L. Turner, Zachary T. Berndsen, David C. Montefiori, Per Johan Klasse, Max Crispin, David Nemazee, John P. Moore, Rogier W. Sanders, Neil P. King, David Baker, Andrew B. Ward
Publié dans: PLOS Pathogens, Numéro 16/8, 2020, Page(s) e1008665, ISSN 1553-7374
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1008665

Seasonal Betacoronavirus Antibodies' Expansion Post-BNT161b2 Vaccination Associates with Reduced SARS-CoV-2 VoC Neutralization

Auteurs: Dispinseri S, Marzinotto I, Brigatti C, Pirillo M, Tolazzi M, Bazzigaluppi E, Canitano A, Borghi M, Gallinaro A, Caccia R, Vercesi R, McKay P, Ciceri F, Piemonti L, Negri D, Cinque P, Cara A, Scarlatti G, Lampasona V
Publié dans: Journal of Clinical Immunology, 2022, ISSN 0271-9142
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-021-01190-5

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens

Auteurs: Martin G, Russell RA, Mundsperger P, Harris S, Jovanoska L, Trajano LF, Schiffner T, Fabian K, Tolazzi M, Scarlatti G, McFarlane L, Cheeseman H, Aldon Y, Breemen M, Sliepen K, Katinger D, Kunert R, Sanders RW, Shattock R, Ward AB, Sattentau QJ
Publié dans: BioRxiv, 2021, ISSN 2692-8205
Éditeur: Cold Spring Harbour Laboratory
DOI: 10.1101/2021.07.26.453798

HIV T-cell immunogen design and delivery

Auteurs: Christian Brander and Dennis Hartigan-O'Connord
Publié dans: Current Opinion in HIV and AIDS, 2022, ISSN 1746-6318
Éditeur: Wolters Kluwer
DOI: 10.1097/coh.0000000000000765

Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro

Auteurs: Alex Olvera, Javier P. Martinez, Maria Casadellà, Anuska Llano, Míriam Rosás, Beatriz Mothe, Marta Ruiz-Riol, Gemma Arsequell, Gregorio Valencia, Marc Noguera-Julian, Roger Paredes, Andreas Meyerhans, Christian Brander
Publié dans: Frontiers in Immunology, Numéro 8, 2018, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.02010

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