European AIDS Vaccine Initiative 2020

Risultati finali

EAVI2020 Public Events:

Two major events (M30 & M72) will be organised to disseminate project results and share its main findings across relevant stakeholders, i.e. clinical communities and patients

EAVI2020 Publications

Submission of up to 100 peerreviewed publications during the programme

Marketing and Dissemination Kit

Marketing and promotional materials developed for the EAVI2020 project, activities and outcomes.

EAVI2020 Website

EAVI2020 main platform for knowledge sharing and promotional activities

Up-selection of optimal T cell vaccine regimen

Up-selection of optimal T cell vaccine regimen according to breadth, potency and durability of cellular antiviral response

Up-selection of optimal humoral vaccine regimen

Upselection of optimal humoral vaccine regimen according to breadth potency and durability of induced antiviral Abs

Report on EAVI2020 training program

Report on outcomes of EAVI2020 training program

Pubblicazioni

TL1A–DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1–Specific T Cell Responses

Autori: Bruna Oriol-Tordera, Alex Olvera, Clara Duran-Castells, Anuska Llano, Beatriz Mothe, Marta Massanella, Judith Dalmau, Carmela Ganoza, Jorge Sanchez, Maria Luz Calle, Bonaventura Clotet, Javier Martinez-Picado, Eugènia Negredo, Julià Blanco, Dennis Hartigan-O'Connor, Christian Brander, Marta Ruiz-Riol
Pubblicato in: The Journal of Immunology, Numero 205/12, 2020, Pagina/e 3348-3357, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.2000933

Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice

Autori: Alessandra Gallinaro, Martina Borghi, Maria Franca Pirillo, Serena Cecchetti, Roberta Bona, Andrea Canitano, Zuleika Michelini, Antonio Di Virgilio, Alex Olvera, Christian Brander, Donatella Negri, Andrea Cara
Pubblicato in: Molecular Therapy - Methods & Clinical Development, Numero 17, 2020, Pagina/e 418-428, ISSN 2329-0501
Editore: Elsevier
DOI: 10.1016/j.omtm.2020.01.013

Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

Autori: Morante V, Borghi M, Farina I, Michelini Z, Grasso F, Gallinaro A, Cecchetti S, Di Virgilio A, Canitano A, Pirillo MF, Bona R, Cara A, Negri D
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13020355

Strategies for Immunomonitoring after Vaccination and during Infection

Autori: Adam L, Rosenbaum P, Bonduelle O, Combadière B
Pubblicato in: MDPI Vaccines, 2021, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9040365

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control

Autori: Bruna Oriol-Tordera, Maria Berdasco, Anuska Llano, Beatriz Mothe, Cristina Gálvez, Javier Martinez-Picado, Jorge Carrillo, Julià Blanco, Clara Duran-Castells, Carmela Ganoza, Jorge Sanchez, Bonaventura Clotet, Maria Luz Calle, Alex Sánchez-Pla, Manel Esteller, Christian Brander, Marta Ruiz-Riol
Pubblicato in: PLOS Pathogens, Numero 16/8, 2020, Pagina/e e1008678, ISSN 1553-7374
Editore: Public Library of Science San Francisco
DOI: 10.1371/journal.ppat.1008678

Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes

Autori: Dominik Damm, Ehsan Suleiman, Hannah Theobald, Jannik T. Wagner, Mirjam Batzoni, Bianca Ahlfeld, Bernd Walkenfort, Jens-Christian Albrecht, Jidnyasa Ingale, Lifei Yang, Mike Hasenberg, Richard T. Wyatt, Karola Vorauer-Uhl, Klaus Überla, Vladimir Temchura
Pubblicato in: Pharmaceutics, 2022, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071385

Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques.

Autori: Van Tilbeurgh M, Maisonnasse P, Palgen JL, Tolazzi M, Aldon Y, Dereuddre-Bosquet N, Cavarelli M, Beignon AS, Marcos-Lopez E, Gallouet AS, Gilson E, Ozorowski G, Ward AB, Bontjer I, McKay PF, Shattock RJ, Scarlatti G, Sanders RW, Le Grand R
Pubblicato in: Cell Reports Medicine, 2022, ISSN 2666-3791
Editore: Cell Press Elsevier
DOI: 10.1016/j.xcrm.2022.100751

Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques

Autori: Maria Blasi, Elizabeth C. Wescott, Erich J. Baker, Benjamin Mildenberg, Celia LaBranche, Wes Rountree, Barton F. Haynes, Kevin O. Saunders, M. Anthony Moody, Donatella Negri, Sampa Santra, Andrea Cara, Mary E. Klotman
Pubblicato in: npj Vaccines, Numero 5/1, 2020, Pagina/e 1--9, ISSN 2059-0105
Editore: Nature Publishing Group
DOI: 10.1038/s41541-020-0186-5

Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint.

Autori: Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Van der Woude P, De Taeye SW, Van den Kerkhof TLGM, Klasse PJ, Ozorowski G, Van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Pubblicato in: Cell Reports, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109646

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms

Autori: Philip J.M. Brouwer, Rogier W. Sanders
Pubblicato in: Current Opinion in HIV and AIDS, Numero 14/4, 2019, Pagina/e 302-308, ISSN 1746-630X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/coh.0000000000000549

Structure-guided envelope trimer design in HIV-1 vaccine development: a narrative review

Autori: Derking R, Sanders RW
Pubblicato in: Journal of the International AIDS Society, 2021, ISSN 1758-2652
Editore: International AIDS Society
DOI: 10.1002/jia2.25797

Specificity of CD8+ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya

Autori: Yehia S. Mohamed, Nicola J. Borthwick, Nathifa Moyo, Hayato Murakoshi, Tomohiro Akahoshi, Francesca Siliquini, Zara Hannoun, Alison Crook, Peter Hayes, Patricia E. Fast, Gaudensia Mutua, Walter Jaoko, Sandra Silva-Arrieta, Anuska Llano, Christian Brander, Masafumi Takiguchi, Tomáš Hanke
Pubblicato in: Vaccines, Numero 8/2, 2020, Pagina/e 260, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8020260

Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

Autori: Jelle van Schooten, Elinaz Farokhi, Anna Schorcht, Tom L. G. M. van den Kerkhof, Hongmei Gao, Patricia van der Woude, Judith A. Burger, Tim G. Rijkhold Meesters, Tom Bijl, Riham Ghalaiyini, Hannah L. Turner, Jessica Dorning, Barbera D. C. van Schaik, Antoine H. C. van Kampen, Celia C. Labranche, Robyn L. Stanfield, Devin Sok, David C. Montefiori, Dennis R. Burton, Michael S. Seaman, Gabriel Ozorow
Pubblicato in: Nature communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32208-0

Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

Autori: Jelle van Schooten, Ilja C. Bontjer, J. A. Burger, Rogier W. Sanders, Marit J. van Gils
Pubblicato in: NPJ Vaccines, 2022, ISSN 2059-0105
Editore: Nature Research
DOI: 10.1038/s41541-022-00576-9

Novel Approaches Towards a Functional Cure of HIV/AIDS

Autori: Lucia Bailon, Beatriz Mothe, Lance Berman, Christian Brander
Pubblicato in: Drugs, Numero 80/9, 2020, Pagina/e 859-868, ISSN 0012-6667
Editore: Adis International Ltd.
DOI: 10.1007/s40265-020-01322-y

Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity

Autori: Yi-Yu Lin, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, Donatella Negri
Pubblicato in: Molecular Therapy - Methods & Clinical Development, Numero 17, 2020, Pagina/e 532-544, ISSN 2329-0501
Editore: Elsevier
DOI: 10.1016/j.omtm.2020.03.008

Glycans in HIV-1 vaccine design – engaging the shield

Autori: Deimel LP, Xue X, Sattentau QJ
Pubblicato in: Trends in Microbiology, 2022, ISSN 0966-842X
Editore: Elsevier BV
DOI: 10.1016/j.tim.2022.02.004

Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines

Autori: Nicola Borthwick, Sandra Silva-Arrieta, Anuska Llano, Masafumi Takiguchi, Christian Brander, Tomáš Hanke
Pubblicato in: Vaccines, Numero 8/1, 2020, Pagina/e 28, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010028

Dichotomy in Neutralizing Antibody Induction to Peptide-Conjugated Vaccine in Squalene Emulsion Contrast With Aluminum Hydroxide Formulation

Autori: Bonduelle O, Chaudesaigues C, Tolazzi M, Suleiman E, De Bernard S, Alves K, Nourikyan J, Bohec M, Baudrin LG, Katinger D, Debré P, Scarlatti G, Vieillard V, Combadiere B
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2022.848571

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein

Autori: M. M. van Haaren, L. E. McCoy, J. L. Torres, W. Lee, C. A. Cottrell, J. L. Copps, P. van der Woude, A. Yasmeen, S. W. de Taeye, A. Torrents de la Peña, J. P. Moore, D. R. Burton, P. J. Klasse, A. B. Ward, R. W. Sanders, M. J. van Gils
Pubblicato in: Journal of Virology, 2021, ISSN 1098-5514
Editore: American Society for Microbiology
DOI: 10.1128/jvi.00094-21

Transcriptome Sequencing of Peripheral Blood Mononuclear Cells from Elite Controller-Long Term Non Progressors

Autori: Francisco Díez-Fuertes, Humberto Erick De La Torre-Tarazona, Esther Calonge, Maria Pernas, María del Mar Alonso-Socas, Laura Capa, Javier García-Pérez, Anavaj Sakuntabhai, José Alcamí
Pubblicato in: Scientific Reports, Numero 9/1, 2019, Pagina/e 1--13, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-50642-x

Immunogenicity, safety, and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs

Autori: Maria Blasi, Donatella Negri, Kevin O. Saunders, Erich J. Baker, Hannah Stadtler, Celia LaBranche, Benjamin Mildenberg, Georgeanna Morton, Andrew Ciarla, Xiaoying Shen, Yunfei Wang, Wes Rountree, Bala Balakumaran, Sampa Santra, Barton F. Haynes, Anthony M. Moody, Andrea Cara, Mary E. Klotman
Pubblicato in: npj Vaccines, Numero 5/1, 2020, Pagina/e 1--12, ISSN 2059-0105
Editore: Nature Publishing Group
DOI: 10.1038/s41541-020-00252-w

Comparison of blood and lymph node cells after intramuscular injection with HIV envelope immunogens

Autori: Suzanne Day, Charandeep Kaur, Hannah M. Cheeseman, Emily de Groot, Leon R. McFarlane, Maniola Tanaka, Sofia Coelho, Tom Cole, Nana-Marie Lemm, Adrian Lim, Rogier W. Sanders, Becca Asquith, Robin J. Shattock and Katrina M. Pollock
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2022.991509

In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial

Autori: Miriam Rosás-Umbert, Marta Ruiz-Riol, Marco A. Fernández, Marta Marszalek, Pep Coll, Christian Manzardo, Samandhy Cedeño, José M. Miró, Bonaventura Clotet, Tomáš Hanke, José Moltó, Beatriz Mothe, Christian Brander
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, Pagina/e 418, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.00418

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Autori: Sliepen KHEWJ, Bontjer IC, Burger JA, Brouwer PJM, Sanders RW
Pubblicato in: npj Vaccines, 2021, ISSN 2059-0105
Editore: Springer Nature
DOI: 10.1038/s41541-021-00364-x

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Autori: Aguado-Garcia D, Olvera A, Brander C, Sanchez-Merino V, and Yuste E
Pubblicato in: Vaccines, 2022, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10040484

Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

Autori: Gallinaro A, Pirillo MF, Aldon Y, Cecchetti S, Michelini Z, Tinari A, Borghi M, Canitano A, McKay PF, Bona R, Vescio MF, Grasso F, Blasi M, Baroncelli S, Scarlatti G, LaBranche C, Montefiori D, Klotman ME, Sanders RW, Shattock RJ, Negri D, Cara A
Pubblicato in: npj Vaccines, 2022, ISSN 2059-0105
Editore: Springer Nature
DOI: 10.1038/s41541-022-00465-1

HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)

Autori: Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C. Puertas, Sara Morón-López, Anuska Llano, Cristina Miranda, Samandhy Cedeño, Miriam López, Yovaninna Alarcón-Soto, Guadalupe Gómez Melis, Klaus Langohr, Ana M. Barriocanal, Jessica Toro, Irene Ruiz, Cristina Rovira, Antonio Carrillo, Michael Meulbroek, Alison Crook, Edmund G. Wee, Jose M. Miró, Bonaventura Clotet, Ma
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, Pagina/e 823, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.00823

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates

Autori: Jelle van Schooten, Marlies M. van Haaren, Hui Li, Laura E. McCoy, Colin Havenar-Daughton, Christopher A. Cottrell, Judith A. Burger, Patricia van der Woude, Leanne C. Helgers, Ilhan Tomris, Celia C. Labranche, David C. Montefiori, Andrew B. Ward, Dennis R. Burton, John P. Moore, Rogier W. Sanders, Shane Crotty, George M. Shaw, Marit J. van Gils
Pubblicato in: PLOS Pathogens, 2021, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1009736

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival

Autori: Dispinseri S, Secchi M, Pirillo MF, Tolazzi M, Borghi M, Brigatti C, De Angelis ML, Baratella M, Bazzigaluppi E, Venturi G, Sironi F, Canitano A, Marzinotto I, Tresoldi C, Ciceri F, Piemonti L, Negri D, Cara A, Lampasona V, Scarlatti G
Pubblicato in: Nature communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-22958-8

Strategies for inducing effective neutralizing antibody responses against HIV-1

Autori: Iván del Moral-Sánchez, Kwinten Sliepen
Pubblicato in: Expert Review of Vaccines, Numero 18/11, 2019, Pagina/e 1127-1143, ISSN 1476-0584
Editore: Future Drugs Ltd.
DOI: 10.1080/14760584.2019.1690458

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections

Autori: Luis Romero-Martin, Clara Duran-Castells, Mireia Olivella, Mı´riam Rosas-Umbert, Marta Ruiz-Riol, Jorge Sanchez, Dennis Hartigan-O´Connor, Beatriz Mothe, Àlex Olvera and Christian Brander
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2022.1027855

Safety and efficiency modifications of SIV-based integrase-defective lentiviral vectors for immunization

Autori: Bona R, Michelini Z, Mazzei C, Gallinaro A, Canitano A, Borghi M, Vescio MF, Di Virgilio A, Pirillo MF, Klotman ME, Negri D, Cara A
Pubblicato in: Molecular Therapy: Methods & Clinical Development, 2021, ISSN 2329-0501
Editore: Cell Press, Elsevier Inc
DOI: 10.1016/j.omtm.2021.09.011

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

Autori: Philip J. M. Brouwer, Aleksandar Antanasijevic, Marlon de Gast, Joel D. Allen, Tom P. L. Bijl, Anila Yasmeen, Rashmi Ravichandran, Judith A. Burger, Gabriel Ozorowski, Jonathan L. Torres, Celia LaBranche, David C. Montefiori, Rajesh P. Ringe, Marit J. van Gils, John P. Moore, Per Johan Klasse, Max Crispin, Neil P. King, Andrew B. Ward, Rogier W. Sanders
Pubblicato in: npj Vaccines, Numero 6/1, 2021, Pagina/e 1-14, ISSN 2059-0105
Editore: Nature Publishing Group
DOI: 10.1038/s41541-021-00285-9

Genetic Co-Administration of Soluble PD-1 Ectodomains Modifies Immune Responses against Influenza A Virus Induced by DNA Vaccination

Autori: Pierre Tannig, Antonia Sophia Peter, Dennis Lapuente, Stephan Klessing, Anna Schmidt, Dominik Damm, Matthias Tenbusch, Klaus Überla, Vladimir Temchura
Pubblicato in: Vaccines, Numero 8/4, 2020, Pagina/e 570, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040570

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans

Autori: Huettner I, Krumm SA, Serna S, Brzezicka K, Monaco S, Walpole S, van Diepen A, Allan F, Hicks T, Kimuda S, Emery AM, IAVI Protocol C Investigators & The IAVI African HIV Research Network, Landais E, Hokke CH, Angulo J, Reichardt N, Doores KJ
Pubblicato in: Cell Reports, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.110611

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Autori: Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker,
Pubblicato in: Nature communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25087-4

In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

Autori: Sandra Silva-Arrieta, Philip J. R. Goulder, Christian Brander
Pubblicato in: PLOS Pathogens, Numero 16/6, 2020, Pagina/e e1008607, ISSN 1553-7374
Editore: Public Library of Science San Francisco
DOI: 10.1371/journal.ppat.1008607

CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help

Autori: Stephan Klessing, Vladimir Temchura, Pierre Tannig, Antonia Sophia Peter, Dennis Christensen, Roland Lang, Klaus Überla
Pubblicato in: Vaccines, Numero 8/4, 2020, Pagina/e 604, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040604

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Autori: Anna K. Blakney, Paul F. McKay, Bárbara Ibarzo Yus, Yoann Aldon, Robin J. Shattock
Pubblicato in: Gene Therapy, Numero 26/9, 2019, Pagina/e 363-372, ISSN 0969-7128
Editore: Nature Publishing Group
DOI: 10.1038/s41434-019-0095-2

Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8+ T cell antiviral responses

Autori: Yang H, Llano A, Cedeño S, von Delft A, Corcuera A, Gillespie GM, Knox A, Leneghan DB, Frater J, Stöhr W, Fidler S, Mothe B, Mak J, Brander C, Ternette N, Dorrell L
Pubblicato in: Cell Reports, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109103

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

Autori: Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn
Pubblicato in: eLife, Numero 10, 2021, Pagina/e e65005, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.65005

T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

Autori: Luis Romero-Martin, Ferran Tarres-Freixas, Nuria Pedreño-Lopez, Maria L. Rodriguez de la Concepcio, Francesc Cunyat, Dennis Hartigan-O'Connor, Jorge Carrillo, Beatriz Mothe, Julià Blanco, Marta Ruiz-Riol, Christian Brander and Alex Olvera
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2022.928039

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers

Autori: Anna Schorcht, Tom L. G. M. van den Kerkhof, Christopher A. Cottrell, Joel D. Allen, Jonathan L. Torres, Anna-Janina Behrens, Edith E. Schermer, Judith A. Burger, Steven W. de Taeye, Alba Torrents de la Peña, Ilja Bontjer, Stephanie Gumbs, Gabriel Ozorowski, Celia C. LaBranche, Natalia de Val, Anila Yasmeen, Per Johan Klasse, David C. Montefiori, John P. Moore, Hanneke Schuitemaker, Max Crispin,
Pubblicato in: Journal of Virology, Numero 94/24, 2020, Pagina/e volume={94}, number={24}, year={2020},, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.01214-20

Design Concepts of Virus-Like Particle-Based HIV-1 Vaccines

Autori: Chun-Wei Chen, Narcís Saubi, Joan Joseph-Munné
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, Pagina/e 573157, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2020.573157

Neutralizing Antibodies Targeting HIV-1 gp41

Autori: Christophe Caillat, Delphine Guilligay, Guidenn Sulbaran, Winfried Weissenhorn
Pubblicato in: Viruses, Numero 12/11, 2020, Pagina/e 1210, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111210

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

Autori: Ronald Derking, Joel D. Allen, Christopher A. Cottrell, Kwinten Sliepen, Gemma E. Seabright, Wen-Hsin Lee, Yoann Aldon, Kimmo Rantalainen, Aleksandar Antanasijevic, Jeffrey Copps, Anila Yasmeen, Albert Cupo, Victor M. Cruz Portillo, Meliawati Poniman, Niki Bol, Patricia van der Woude, Steven W. de Taeye, Tom L.G.M. van den Kerkhof, P.J. Klasse, Gabriel Ozorowski, Marit J. van Gils, John P. Moore,
Pubblicato in: Cell Reports, Numero 35/1, 2021, Pagina/e 108933, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.108933

Chimeric Human Papillomavirus-16 Virus-like Particles Presenting P18I10 and T20 Peptides from HIV-1 Envelope Induce HPV16 and HIV-1-Specific Humoral and T Cell-Mediated Immunity in BALB/c Mice

Autori: Jelle van Schooten, Ilja C. Bontjer, J. A. Burger, Rogier W. Sanders, Marit J. van Gils
Pubblicato in: Vaccines, 2022, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11010015

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

Autori: Goncalves E, Guillen Y, Lama JR, Sanchez J, Brander C, Paredes R and Combadière B
Pubblicato in: Frontiers in Immunology, 2021, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2021.657162

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines

Autori: Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, Tomáš Hanke
Pubblicato in: PLOS ONE, Numero 12/4, 2017, Pagina/e e0176418, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0176418

Neutralizing Antibodies Against a Specific Human Immunodeficiency Virus gp41 Epitope are Associated With Long-term Non-progressor Status

Autori: Olivier Lucar, Bin Su, Valérie Potard, Assia Samri, Brigitte Autran, Christiane Moog, Patrice Debré, Vincent Vieillard
Pubblicato in: EBioMedicine, Numero 22, 2017, Pagina/e 122-132, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2017.07.007

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

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Stabilized HIV-1 envelope glycoprotein trimers for vaccine use

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HIV-1 Conserved Mosaics Delivered by Regimens with Integration-Deficient DC-Targeting Lentiviral Vector Induce Robust T Cells

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HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers

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Structural principles controlling HIV envelope glycosylation

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Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA

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Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination

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HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual

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Intrastructural help

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Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins

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Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans

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Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine

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Isolation and Characterization of Antigen-Specific Plasmablasts Using a Novel Flow Cytometry–Based Ig Capture Assay

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Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1

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Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design

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Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

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Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines

Autori: Hassan Elsayed, Ghulam Nabi, William J. McKinstry, Keith K. Khoo, Johnson Mak, Andres M. Salazar, Matthias Tenbusch, Vladimir Temchura, Klaus Überla
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Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

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MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

Autori: Esther Broset, Narcís Saubi, Núria Guitart, Nacho Aguilo, Santiago Uranga, Athina Kilpeläinen, Yoshiki Eto, Tomáš Hanke, Jesús Gonzalo-Asensio, Carlos Martín, Joan Joseph-Munné
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Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

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HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial

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High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis

Autori: Néstor Vázquez Bernat, Martin Corcoran, Uta Hardt, Mateusz Kaduk, Ganesh E. Phad, Marcel Martin, Gunilla B. Karlsson Hedestam
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Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination

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HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry

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Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

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Mechanisms of Abrupt Loss of Virus Control in a Cohort of Previous HIV Controllers

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Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

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Protein and Glycan Mimicry in HIV Vaccine Design

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Can we just kick-and-kill HIV: possible challenges posed by the epigenetically controlled interplay between HIV and host immunity

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Peptide-Based Vaccination for Antibody Responses Against HIV

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Preclinical Development of BCG.HIVA 2auxo.int , Harboring an Integrative Expression Vector, for a HIV-TB Pediatric vaccine. Enhancement of Stability and Specific HIV-1 T-cell Immunity

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High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers

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The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With Disease Progression

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Conjugation of a Toll-Like Receptor Agonist to Glycans of an HIV Native-Like Envelope Trimer Preserves Neutralization Epitopes

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Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Autori: Borgognone E, Noguera-Julian M, Oriol B, Noël-Romas L, Ruiz-Riol M, Guillén Y, Parera M, Casadellà M, Duran C, Puertas MC, Català-Moll F, De Leon M, Knodel S, Birse K, Manzardo C, Miró JM, Clotet B, Martinez-Picado J, Moltó J, Mothe B, Burgener A, Brander C, Paredes R, and the BCN02 Study Group
Pubblicato in: Microbiome, 2022, ISSN 2049-2618
Editore: BioMed Central
DOI: 10.1186/s40168-022-01247-6

Does Antigen Glycosylation Impact the HIV-Specific T Cell Immunity?

Autori: Alex Olvera, Samandhy Cedeño, Anuska Llano, Beatriz Mothe, Jorge Sanchez, Gemma Arsequell, Christian Brander
Pubblicato in: Frontiers in Immunology, Numero 11, 2021, Pagina/e N/A, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2020.573928

Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01

Autori: Dora Pinto, Craig Fenwick, Christophe Caillat, Chiara Silacci, Serafima Guseva, François Dehez, Christophe Chipot, Sonia Barbieri, Andrea Minola, David Jarrossay, Georgia D. Tomaras, Xiaoying Shen, Agostino Riva, Maciej Tarkowski, Olivier Schwartz, Timothée Bruel, Jérémy Dufloo, Michael S. Seaman, David C. Montefiori, Antonio Lanzavecchia, Davide Corti, Giuseppe Pantaleo, Winfried Weissenhorn
Pubblicato in: Cell Host & Microbe, Numero 26/5, 2019, Pagina/e 623-637.e8, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2019.09.016

Continuous HIV-1 Escape from Autologous Neutralization and Development of Cross-Reactive Antibody Responses Characterizes Slow Disease Progression of Children

Autori: Stefania Dispinseri, Mariangela Cavarelli, Monica Tolazzi, Anna Maria Plebani, Marianne Jansson, Gabriella Scarlatti
Pubblicato in: Vaccines, Numero 9/3, 2021, Pagina/e 260, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9030260

VDJ Gene Usage in IgM Repertoires of Rhesus and Cynomolgus Macaques

Autori: Chernyshev M, Kaduk M, Corcoran M, Karlsson Hedestam GB
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2021.815680

Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome

Autori: Oriol-Tordera B , Esteve-Codina A, Berdasco M, Rosás-Umbert M, Gonçalves E, Duran-Castells C, Català-Moll F, Llano A, Cedeño S, Puertas MC, Tolstrup M, Søgaard OS, Clotet B, Martínez-Picado J, Hanke T, Combadiere B, Paredes R, Hartigan-O'Connor D, Esteller M, Meulbroek M, Luz Calle M, Sanchez-Pla A, Moltó J, Mothe B, Brander C, Ruiz-Riol M
Pubblicato in: eBioMedicine, 2022, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103956

Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

Autori: Jorge Sanchez, Elena Gonçalves, Anuska Llano, Pedro Gonzáles, María Fernández-Maldonado, Annika Vogt, Angele Soria, Susana Perez, Samandhy Cedeño, Marco Antonio Fernández, Julien Nourikyan, Simon de Bernard, Carmela Ganoza, Eric Pedruzzi, Olivia Bonduelle, Beatriz Mothe, Carmen E. Gòmez, Mariano Esteban, Felipe Garcia, Javier R. Lama, Christian Brander, Behazine Combadiere
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, Pagina/e 2866, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.586124

Expression of Chimeric HPV-HIV Protein L1P18 in Pichia pastoris; Purification and Characterization of the Virus-like Particles

Autori: Eto Y, Saubi N, Ferrer P, Joseph-Munné J
Pubblicato in: Pharmaceutics, 2021, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111967

Isolation and Characterization of Mouse Monoclonal Antibodies That Neutralize SARS-CoV-2 and Its Variants of Concern Alpha, Beta, Gamma and Delta by Binding Conformational Epitopes of Glycosylated RBD With High Potency

Autori: Mariotti S, Capocefalo A, Chiantore MV, Iacobino A, Teloni R, De Angelis ML, Gallinaro A, Pirillo MF, Borghi M, Canitano A, Michelini Z, Baggieri M, Marchi A, Bucci P, McKay PF, Acchioni C, Sandini S, Sgarbanti M, Tosini F, Di Virgilio A, Venturi G, Marino F, Esposito V, Di Bonito P, Magurano F, Cara A, Negri D, Nisini R
Pubblicato in: Frontiers in Immunology, 2021, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2021.750386

Priming with Recombinant BCG Expressing HTI Enhances the Magnitude and Breadth of the T-Cell Immune Responses Elicited by MVA.HTI in BALB/c Mice

Autori: Narcís Saubi, Athina Kilpeläinen, Yoshiki Eto, Chun-Wei Chen, Àlex Olvera, Tomáš Hanke, Christian Brander, Joan Joseph-Munné
Pubblicato in: Vaccines, Numero 8/4, 2020, Pagina/e 678, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040678

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

Autori: Alessio D'addabbo; Max Crispin; Christopher A. Cottrell; Anna-Janina Beherns; Joel D. Allen; Gemma E. Seabright; Marit J. van Gils; Yasunori Watanabe; Rogier W. Sanders; Natalia de Val; Allison Maker; D.J. Harvey; Snezana Vasiljevic; Andrew B. Ward
Pubblicato in: Structure, Numero 23, 2020, Pagina/e 897--909, ISSN 0969-2126
Editore: Elsevier
DOI: 10.1101/2020.02.21.959981

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

Autori: Aleksandar Antanasijevic, George Ueda, Philip J. M. Brouwer, Jeffrey Copps, Deli Huang, Joel D. Allen, Christopher A. Cottrell, Anila Yasmeen, Leigh M. Sewall, Ilja Bontjer, Thomas J. Ketas, Hannah L. Turner, Zachary T. Berndsen, David C. Montefiori, Per Johan Klasse, Max Crispin, David Nemazee, John P. Moore, Rogier W. Sanders, Neil P. King, David Baker, Andrew B. Ward
Pubblicato in: PLOS Pathogens, Numero 16/8, 2020, Pagina/e e1008665, ISSN 1553-7374
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1008665

Seasonal Betacoronavirus Antibodies' Expansion Post-BNT161b2 Vaccination Associates with Reduced SARS-CoV-2 VoC Neutralization

Autori: Dispinseri S, Marzinotto I, Brigatti C, Pirillo M, Tolazzi M, Bazzigaluppi E, Canitano A, Borghi M, Gallinaro A, Caccia R, Vercesi R, McKay P, Ciceri F, Piemonti L, Negri D, Cinque P, Cara A, Scarlatti G, Lampasona V
Pubblicato in: Journal of Clinical Immunology, 2022, ISSN 0271-9142
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-021-01190-5

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens

Autori: Martin G, Russell RA, Mundsperger P, Harris S, Jovanoska L, Trajano LF, Schiffner T, Fabian K, Tolazzi M, Scarlatti G, McFarlane L, Cheeseman H, Aldon Y, Breemen M, Sliepen K, Katinger D, Kunert R, Sanders RW, Shattock R, Ward AB, Sattentau QJ
Pubblicato in: BioRxiv, 2021, ISSN 2692-8205
Editore: Cold Spring Harbour Laboratory
DOI: 10.1101/2021.07.26.453798

HIV T-cell immunogen design and delivery

Autori: Christian Brander and Dennis Hartigan-O'Connord
Pubblicato in: Current Opinion in HIV and AIDS, 2022, ISSN 1746-6318
Editore: Wolters Kluwer
DOI: 10.1097/coh.0000000000000765

Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro

Autori: Alex Olvera, Javier P. Martinez, Maria Casadellà, Anuska Llano, Míriam Rosás, Beatriz Mothe, Marta Ruiz-Riol, Gemma Arsequell, Gregorio Valencia, Marc Noguera-Julian, Roger Paredes, Andreas Meyerhans, Christian Brander
Pubblicato in: Frontiers in Immunology, Numero 8, 2018, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.02010

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