Towards Novel Inert (Photo-)toxic Ru(II) Polypyridyl Complexes

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Publications

One‐ and Two‐Photon Phototherapeutic Effects of Ru II Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumor Spheroids and Tumor‐Bearing Mice**

Author(s): Johannes Karges, Shi Kuang, Yih Ching Ong, Hui Chao, Gilles Gasser
Published in: Chemistry – A European Journal, Issue 27/1, 2021, Page(s) 362-370, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003486

Synthesis, Characterization, and Biological Evaluation of the Polymeric Encapsulation of a Ruthenium(II) Polypyridine Complex with Pluronic F‐127/Poloxamer‐407 for Photodynamic Therapy Applications

Author(s): Johannes Karges, Hui Chao, Gilles Gasser
Published in: European Journal of Inorganic Chemistry, Issue 2020/34, 2020, Page(s) 3242-3248, ISSN 1434-1948
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.202000545

Synthesis, characterization, kinetic investigation and biological evaluation of Re( i ) di- and tricarbonyl complexes with tertiary phosphine ligands

Author(s): Verity Lindy Gantsho, Mazzarine Dotou, Marta Jakubaszek, Bruno Goud, Gilles Gasser, Hendrik Gideon Visser, Marietjie Schutte-Smith
Published in: Dalton Transactions, Issue 49/1, 2020, Page(s) 35-46, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9dt04025k

Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy

Author(s): Valentin Buchter, Jeannine Hess, Gilles Gasser, Jennifer Keiser
Published in: Parasites & Vectors, Issue 11/1, 2018, ISSN 1756-3305
Publisher: BioMed Central
DOI: 10.1186/s13071-018-3132-x

Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies

Author(s): Anna Notaro, Angelo Frei, Riccardo Rubbiani, Marta Jakubaszek, Uttara Basu, Severin Koch, Cristina Mari, Mazzarine Dotou, Olivier Blacque, Jérémie Gouyon, Fethi Bedioui, Nils Rotthowe, Rainer F. Winter, Bruno Goud, Stefano Ferrari, Mickaël Tharaud, Martina Řezáčová, Jana Humajová, Pavel Tomšík, Gilles Gasser
Published in: Journal of Medicinal Chemistry, Issue 63/10, 2020, Page(s) 5568-5584, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00431

Ruthenium polypyridyl complex-containing bioconjugates

Author(s): Marta Martínez-Alonso; Gilles Gasser
Published in: Coordinations Chemistry Reviews, Issue 1, 2021, ISSN 0010-8545
Publisher: Elsevier BV
DOI: 10.1016/j.ccr.2020.213736

A Luminescent NOTA-Based Terbium(III) “Turn-Off” Sensor for Copper

Author(s): Michèle Clerc, Franz Heinemann, Bernhard Spingler, Gilles Gasser
Published in: Inorganic Chemistry, Issue 59/1, 2019, Page(s) 669-677, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b02934

Note of Caution for the Aqueous Behaviour of Metal-Based Drug Candidates

Author(s): Notaro, Anna; Gasser, Gilles; Castonguay, Annie
Published in: ChemMedChem, Issue 1, 2020, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201900677

Unveiling the Potential of Transition Metal Complexes for Medicine: Translational in Situ Activation of Metal‐Based Drugs from Bench to in Vivo Applications

Author(s): Maria J. S. A. Silva, Pedro M. P. Gois, Gilles Gasser
Published in: ChemBioChem, 2021, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100015

Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1

Author(s): Storm Hassell‐Hart, Sarah Picaud, Raphael Lengacher, Joshua Csucker, Regis Millet, Gilles Gasser, Roger Alberto, Hannah Maple, Robert Felix, Zbigniew J. Leśnikowski, Helen J. S. Stewart, Timothy J. Chevassut, Simon Morley, Panagis Filippakopoulos, John Spencer
Published in: Helvetica Chimica Acta, Issue 104/3, 2021, ISSN 0018-019X
Publisher: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.202000214

Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy

Author(s): Johannes Karges, Hui Chao, Gilles Gasser
Published in: JBIC Journal of Biological Inorganic Chemistry, Issue 25/8, 2020, Page(s) 1035-1050, ISSN 0949-8257
Publisher: Springer Verlag
DOI: 10.1007/s00775-020-01829-5

A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy

Author(s): Luke K. McKenzie; Luke K. McKenzie; Marie Flamme; Marie Flamme; Marie Flamme; Patrick S. Felder; Johannes Karges; Frédéric J. Bonhomme; Albert Gandioso; Christian Malosse; Gilles Gasser; Marcel Hollenstein
Published in: RSC Chemical Biology, Issue 2, 2022, ISSN 2633-0679
Publisher: RSC
DOI: 10.33774/chemrxiv-2021-5n9xv

Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?

Author(s): Alain C. Jung; Fabien Moinard-Butot; Chloé Thibaudeau; Gilles Gasser; Christian Gaiddon
Published in: Pharmaceutics, Issue 1, 2020, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111788

Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro when Used as Photosensitizers for Photodynamic Therapy

Author(s): Saonli Roy, Elisa Colombo, Robin Vinck, Cristina Mari, Riccardo Rubbiani, Malay Patra, Gilles Gasser
Published in: ChemBioChem, Issue 21/20, 2020, Page(s) 2966-2973, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000289

A solid phase-assisted approach for the facile synthesis of a highly water-soluble zirconium-89 chelator for radiopharmaceutical development

Author(s): Manon Briand, Margaret L. Aulsebrook, Thomas L. Mindt, Gilles Gasser
Published in: Dalton Transactions, Issue 46/47, 2017, Page(s) 16387-16389, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7dt03639f

Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes as Potential Photosensitisers for Photodynamic Therapy

Author(s): Karges, Johannes; Basu, Uttara; Blacque, Olivier; Chao, Hui; Gasser, Gilles
Published in: Angewandte Chemie, Issue 3, 2019, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.

Fe III –Salen‐Based Probes for the Selective and Sensitive Detection of E450 in Foodstuff

Author(s): Prerna Yadav, Marta Jakubaszek, Bernhard Spingler, Bruno Goud, Gilles Gasser, Felix Zelder
Published in: Chemistry – A European Journal, Issue 26/25, 2020, Page(s) 5717-5723, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905686

Efficient Amino‐Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS‐Activated Acrylamides

Author(s): Maria J. S. A. Silva, Hélio Faustino, Jaime A. S. Coelho, Maria V. Pinto, Adelaide Fernandes, Ismael Compañón, Francisco Corzana, Gilles Gasser, Pedro M. P. Gois
Published in: Angewandte Chemie International Edition, Issue 60/19, 2021, Page(s) 10850-10857, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202016936

Enzymatic construction of metal-mediated nucleic acid base pairs.

Author(s): Marie Flamme; Chiara Figazzolo; Chiara Figazzolo; Gilles Gasser; Marcel Hollenstein
Published in: Metallomics, Issue 1, 2021, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1093/mtomcs/mfab016

Synthesis and Biological Evaluation of Metallocene-Tethered Peptidyl Inhibitors of CDC25

Author(s): Saonli Roy; Loganathan Rangasamy; Assia Nouar; Christiane Koenig; Vanessa Pierroz; Simon Kaeppeli; Stefano Ferrari; Malay Patra; Gilles Gasser
Published in: Organometallics, Issue 1, 2021, ISSN 0276-7333
Publisher: American Chemical Society
DOI: 10.1021/acs.organomet.1c00345

Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes

Author(s): Schoch, Silvia; Iacopini, Dalila; Dalla Pozza, Maria; Di Pietro, Sebastiano; Degano, Ilaria; Gasser, Gilles; Di Bussolo, Valeria; Marchetti, Fabio
Published in: Organometallics, Issue 1, 2022, ISSN 0276-7333
Publisher: American Chemical Society
DOI: 10.1021/acs.organomet.1c00519

A Maltol‐Containing Ruthenium Polypyridyl Complex as a Potential Anticancer Agent

Author(s): Anna Notaro, Marta Jakubaszek, Severin Koch, Riccardo Rubbiani, Orsolya Dömötör, Éva A. Enyedy, Mazzarine Dotou, Fethi Bedioui, Mickaël Tharaud, Bruno Goud, Stefano Ferrari, Enzo Alessio, Gilles Gasser
Published in: Chemistry – A European Journal, Issue 26/22, 2020, Page(s) 4997-5009, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201904877

Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy

Author(s): Nancy Soliman, Vincent Sol, Tan-Sothea Ouk, Christophe M. Thomas, Gilles Gasser
Published in: Pharmaceutics, Issue 12/10, 2020, Page(s) 961, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12100961

Increasing the Cytotoxicity of Ru(II) Polypyridyl Complexes by Tuning the Electronic Structure of Dioxo Ligands

Author(s): Anna Notaro, Marta Jakubaszek, Nils Rotthowe, Federica Maschietto, Robin Vinck, Patrick S. Felder, Bruno Goud, Mickaël Tharaud, Ilaria Ciofini, Fethi Bedioui, Rainer F. Winter, Gilles Gasser
Published in: Journal of the American Chemical Society, Issue 142/13, 2020, Page(s) 6066-6084, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b12464

Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

Author(s): Wenyu Wu; Gilles Gasser; Doris Hinger; Michele Larocca; Vipin Babu; Caroline Maake; Bernhard Spingler; Stefano Ferrari; Roxane Padrutt; Lukas Schneider; Christiane König; Anu Naik; Riccardo Rubbiani
Published in: Rubbiani, Riccardo; Wu, Wenyu; Naik, Anu; Larocca, Michele; Schneider, Lukas; Padrutt, Roxane; Babu, Vipin; König, Christiane; Hinger, Doris; Maake, Caroline; Ferrari, Stefano; Gasser, Gilles; Spingler, Bernhard (2020). Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling. Chemical Communications, 56(92):14373-14376., Issue 20, 2020, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.5167/uzh-192391

Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy

Author(s): Johannes Karges, Olivier Blacque, Gilles Gasser
Published in: Inorganica Chimica Acta, Issue 505, 2020, Page(s) 119482, ISSN 0020-1693
Publisher: Elsevier BV
DOI: 10.1016/j.ica.2020.119482

Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

Author(s): Sherri A. McFarland, Arkady Mandel, Roger Dumoulin-White, Gilles Gasser
Published in: Current Opinion in Chemical Biology, Issue 56, 2020, Page(s) 23-27, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2019.10.004

Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands

Author(s): Alexandra-Cristina Munteanu, Anna Notaro, Marta Jakubaszek, Joseph Cowell, Mickaël Tharaud, Bruno Goud, Valentina Uivarosi, Gilles Gasser
Published in: Inorganic Chemistry, Issue 59/7, 2020, Page(s) 4424-4434, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b03562

Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole

Author(s): Yan Lin, Yih Ching Ong, Sarah Keller, Johannes Karges, Rafika Bouchene, Eric Manoury, Olivier Blacque, Joachim Müller, Nicoleta Anghel, Andrew Hemphill, Cécile Häberli, Aya C. Taki, Robin B. Gasser, Kevin Cariou, Jennifer Keiser, Gilles Gasser
Published in: Dalton Transactions, Issue 49/20, 2020, Page(s) 6616-6626, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0dt01107j

Recent developments of metal-based compounds against fungal pathogens

Author(s): Lin, Yan; Betts, Harley; Keller, Sarah; Cariou, Kevin; Gasser, Gilles
Published in: Chemical Society Reviews, Issue 1, 2021, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00945h

Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the Spike/ACE2 interaction and the Papain-like Protease PLpro.

Author(s): Maria Gil-Moles; Sebastian Türck; Uttara Basu; Andrea Pettenuzzo; Saurav Bhattacharya; Ananthu Rajan; Xiang Ma; Rolf Büssing; Jessica Wölker; Hilke Burmeister; Henrik Hoffmeister; Pia Schneeberg; Andre Prause; Petra Lippmann; Josephine Kusi-Nimarko; Storm Hassell-Hart; Andrew McGown; Daniel Guest; Yan Lin; Anna Notaro; Robin Vinck; Johannes Karges; Kevin Cariou; Kun Peng; Xue Qin; Xing Wang; Jo
Published in: Chemistry - A European Journal, Issue 1, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103258

Monomeric and dimeric coordinatively saturated and substitutionally inert Ru( ii ) polypyridyl complexes as anticancer drug candidates

Author(s): Anna Notaro, Gilles Gasser
Published in: Chemical Society Reviews, Issue 46/23, 2017, Page(s) 7317-7337, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7CS00356K

Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy

Author(s): Franz Heinemann, Johannes Karges, Gilles Gasser
Published in: Accounts of Chemical Research, Issue 50/11, 2017, Page(s) 2727-2736, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.7b00180

ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Author(s): Karun Mutreja, Jana Krietsch, Jeannine Hess, Sebastian Ursich, Matteo Berti, Fabienne K. Roessler, Ralph Zellweger, Malay Patra, Gilles Gasser, Massimo Lopes
Published in: Cell Reports, Issue 24/10, 2018, Page(s) 2629-2642.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.08.019

Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes

Author(s): Johannes Karges, Philippe Goldner, Gilles Gasser
Published in: Inorganics, Issue 7/1, 2019, Page(s) 4, ISSN 2304-6740
Publisher: MDPI AG
DOI: 10.3390/inorganics7010004

Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives

Author(s): Marie Flamme, Emma Clarke, Gilles Gasser, Marcel Hollenstein
Published in: Molecules, Issue 23/7, 2018, Page(s) 1515, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23071515

Mesoporous silica nanoparticles functionalised with a photoactive ruthenium( ii ) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser

Author(s): Younes Ellahioui, Malay Patra, Cristina Mari, Rim Kaabi, Johannes Karges, Gilles Gasser, Santiago Gómez-Ruiz
Published in: Dalton Transactions, Issue 48/18, 2019, Page(s) 5940-5951, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8dt02392a

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium( i ) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Author(s): Sul Hwa Yu, Malay Patra, Stefano Ferrari, Paulina Ramirez Garcia, Nicholas A. Veldhuis, Lisa M. Kaminskas, Bim Graham, John F. Quinn, Michael R. Whittaker, Gilles Gasser, Thomas P. Davis
Published in: Journal of Materials Chemistry B, Issue 6/47, 2018, Page(s) 7805-7810, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8TB02464B

Biological Evaluation of the NIR-Emissive Ruby Analogue [Cr(ddpd) 2 ][BF 4 ] 3 as a Photodynamic Therapy Photosensitizer

Author(s): Uttara Basu, Sven Otto, Katja Heinze, Gilles Gasser
Published in: European Journal of Inorganic Chemistry, Issue 2019/1, 2019, Page(s) 37-41, ISSN 1434-1948
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201801023

Mechanisms of action of Ru( ii ) polypyridyl complexes in living cells upon light irradiation

Author(s): Marta Jakubaszek, Bruno Goud, Stefano Ferrari, Gilles Gasser
Published in: Chemical Communications, Issue 54/93, 2018, Page(s) 13040-13059, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8CC05928D

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates

Author(s): Faustine d'Orchymont, Jeannine Hess, Gordana Panic, Marta Jakubaszek, Lea Gemperle, Jennifer Keiser, Gilles Gasser
Published in: MedChemComm, Issue 9/11, 2018, Page(s) 1905-1909, ISSN 2040-2503
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8md00396c

Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum

Author(s): Afonso P. Basto, Nicoleta Anghel, Riccardo Rubbiani, Joachim Müller, David Stibal, Federico Giannini, Georg Süss-Fink, Vreni Balmer, Gilles Gasser, Julien Furrer, Andrew Hemphill
Published in: Metallomics, Issue 11/2, 2019, Page(s) 462-474, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8mt00307f

Polymer encapsulation of ruthenium complexes for biological and medicinal applications

Author(s): Elise Villemin, Yih Ching Ong, Christophe M. Thomas, Gilles Gasser
Published in: Nature Reviews Chemistry, Issue 3/4, 2019, Page(s) 261-282, ISSN 2397-3358
Publisher: Springer
DOI: 10.1038/s41570-019-0088-0

Targeted photoredox catalysis in cancer cells

Author(s): Huaiyi Huang, Samya Banerjee, Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser, Hui Chao, Peter J. Sadler
Published in: Nature Chemistry, Issue 11/11, 2019, Page(s) 1041-1048, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-019-0328-4

Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy) 3 ] 2+ Core

Author(s): Johannes Karges, Olivier Blacque, Philippe Goldner, Hui Chao, Gilles Gasser
Published in: European Journal of Inorganic Chemistry, Issue 2019/32, 2019, Page(s) 3704-3712, ISSN 1434-1948
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201900569

Polymeric Bis(dipyrrinato) Zinc(II) Nanoparticles as Selective Imaging Probes for Lysosomes of Cancer Cells

Author(s): Johannes Karges, Olivier Blacque, Hui Chao, Gilles Gasser
Published in: Inorganic Chemistry, Issue 58/18, 2019, Page(s) 12422-12432, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b02019

Synthesis and Characterization of an Epidermal Growth Factor Receptor‐Selective Ru II Polypyridyl–Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy

Author(s): Johannes Karges, Marta Jakubaszek, Cristina Mari, Kristof Zarschler, Bruno Goud, Holger Stephan, Gilles Gasser
Published in: ChemBioChem, 2019, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900419

Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers

Author(s): Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao, Gilles Gasser
Published in: Angewandte Chemie International Edition, Issue 58/40, 2019, Page(s) 14334-14340, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201907856

Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy

Author(s): Johannes Karges, Gilles Gasser
Published in: Inorganica Chimica Acta, Issue 499, 2020, Page(s) 119196, ISSN 0020-1693
Publisher: Elsevier BV
DOI: 10.1016/j.ica.2019.119196

Towards Light‐Activated Ruthenium–Arene (RAPTA‐Type) Prodrug Candidates

Author(s): Anna K. Renfrew, Johannes Karges, Rosario Scopelliti, Felix D. Bobbink, Patrycja Nowak‐Sliwinska, Gilles Gasser, Paul J. Dyson
Published in: ChemBioChem, Issue 20/22, 2019, Page(s) 2876-2882, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900236

Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes

Author(s): Johannes Karges, Olivier Blacque, Marta Jakubaszek, Bruno Goud, Philippe Goldner, Gilles Gasser
Published in: Journal of Inorganic Biochemistry, Issue 198, 2019, Page(s) 110752, ISSN 0162-0134
Publisher: Elsevier BV
DOI: 10.1016/j.jinorgbio.2019.110752

A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers

Author(s): Johannes Karges, Franz Heinemann, Federica Maschietto, Malay Patra, Olivier Blacque, Ilaria Ciofini, Bernhard Spingler, Gilles Gasser
Published in: Bioorganic & Medicinal Chemistry, Issue 27/12, 2019, Page(s) 2666-2675, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2019.05.011

Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Author(s): Marta Jakubaszek, Jeremie Rossier, Johannes Karges, Joachim Delasoie, Bruno Goud, Gilles Gasser, Fabio Zobi
Published in: Helvetica Chimica Acta, Issue 102/7, 2019, ISSN 0018-019X
Publisher: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.201900104

Organometallic small molecule kinase inhibitors - direct incorporation of Re and 99mTc into Opaganib®.

Author(s): Raphael Lengacher; Youchao Wang; Henrik Braband; Olivier Blacque; Gilles Gasser; Roger Alberto
Published in: Chemical communications, Issue 1, 2021, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc03678e

A Multi‐action and Multi‐target Ru II –Pt IV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers

Author(s): Johannes Karges, Thirumal Yempala, Mickaël Tharaud, Dan Gibson, Gilles Gasser
Published in: Angewandte Chemie International Edition, Issue 59/18, 2020, Page(s) 7069-7075, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201916400

Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis

Author(s): Nancy Soliman, Gilles Gasser, Christophe M. Thomas
Published in: Advanced Materials, Issue 32/47, 2020, Page(s) 2003294, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202003294

Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers

Author(s): Johannes Karges, Mickaël Tharaud, Gilles Gasser
Published in: Journal of Medicinal Chemistry, Issue 64/8, 2021, Page(s) 4612-4622, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c02006

Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer

Author(s): Nancy Soliman, Luke K. McKenzie, Johannes Karges, Emilie Bertrand, Mickaël Tharaud, Marta Jakubaszek, Vincent Guérineau, Bruno Goud, Marcel Hollenstein, Gilles Gasser, Christophe M. Thomas
Published in: Chemical Science, Issue 11/10, 2020, Page(s) 2657-2663, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc05976h

Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate

Author(s): Marie Flamme, Pascal Röthlisberger, Fabienne Levi-Acobas, Mohit Chawla, Romina Oliva, Luigi Cavallo, Gilles Gasser, Philippe Marlière, Piet Herdewijn, Marcel Hollenstein
Published in: ACS Chemical Biology, Issue 15/11, 2020, Page(s) 2872-2884, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.0c00396

cis-Locked Ru(II)-DMSO Precursors for the Microwave-Assisted Synthesis of Bis-Heteroleptic Polypyridyl Compounds

Author(s): Alessio Vidal; Rudy Calligaro; Gilles Gasser; Roger Alberto; Gabriele Balducci; Enzo Alessio
Published in: Inorganic Chemistry, Issue 1, 2021, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.1c00240

Classification of Metal-Based Drugs according to Their Mechanisms of Action

Author(s): Eszter Boros, Paul J. Dyson, Gilles Gasser
Published in: Chem, Issue 6/1, 2020, Page(s) 41-60, ISSN 2451-9294
Publisher: Cell Press
DOI: 10.1016/j.chempr.2019.10.013

Ru(II) Polypyridine Complex Functionalized Mesoporous Silica Nanoparticles as Photosensitizers for Cancer Targeted Photodynamic Therapy

Author(s): Karges, Johannes; Díaz-García, Diana; Prashar, Sanjiv; Gómez-Ruiz, Santiago; Gasser, Gilles
Published in: ACS Applied Biomaterials, Issue 1, 2021, ISSN 2576-6422
Publisher: American Chemical Society
DOI: 10.1021/acsabm.1c00151

Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy.

Author(s): Karges, Johannes; Kuang, Shi; Maschietto, Federica; Blacque, Olivier; Ciofini, Ilaria; Chao, Hui; Gasser, Gilles
Published in: https://hal.archives-ouvertes.fr/hal-02890539, Issue 22, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.5167/uzh-191123

A tutorial for the assessment of the stability of organometallic complexes in biological media

Author(s): Sarah Keller, Yih Ching Ong, Yan Lin, Kevin Cariou, Gilles Gasser
Published in: Journal of Organometallic Chemistry, Issue 906, 2020, Page(s) 121059, ISSN 0022-328X
Publisher: Elsevier BV
DOI: 10.1016/j.jorganchem.2019.121059

Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy

Author(s): Johannes Karges, Jia Li, Leli Zeng, Hui Chao, Gilles Gasser
Published in: ACS Applied Materials & Interfaces, Issue 12/49, 2020, Page(s) 54433-54444, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c16119

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

Author(s): Gourdon, Lisa; Cariou, Kevin; Gasser, Gilles
Published in: Chemical Society Reviews, Issue 1, 2022, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cs00609f

Recent Approaches towards the Development of Ru(II) Polypyridyl Complexes for Anticancer Photodynamic Therapy.

Author(s): Albert Gandioso; Kallol Purkait; Gilles Gasser
Published in: Chimia, Issue 1, 2021, ISSN 0009-4293
Publisher: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2021.845

Radiolabelling of the octadentate chelators DFO* and oxoDFO* with zirconium-89 and gallium-68

Author(s): Marie Brandt, Joseph Cowell, Margaret L. Aulsebrook, Gilles Gasser, Thomas L. Mindt
Published in: JBIC Journal of Biological Inorganic Chemistry, Issue 25/5, 2020, Page(s) 789-796, ISSN 0949-8257
Publisher: Springer Verlag
DOI: 10.1007/s00775-020-01800-4

Polymetallic Complexes for Applications as Photosensitisers in Anticancer Photodynamic Therapy

Author(s): Patrick S. Felder, Sarah Keller, Gilles Gasser
Published in: Advanced Therapeutics, Issue 3/1, 2020, Page(s) 1900139, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.201900139

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Author(s): Johannes Karges, Franz Heinemann, Marta Jakubaszek, Federica Maschietto, Chloé Subecz, Mazzarine Dotou, Robin Vinck, Olivier Blacque, Mickaël Tharaud, Bruno Goud, Emilio Viñuelas Zahı́nos, Bernhard Spingler, Ilaria Ciofini, Gilles Gasser
Published in: Journal of the American Chemical Society, Issue 142/14, 2020, Page(s) 6578-6587, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b13620

Physical, spectroscopic, and biological properties of ruthenium and osmium photosensitizers bearing diversely substituted 4,4'-di(styryl)-2,2'-bipyridine ligands.

Author(s): Robin Vinck; Johannes Karges; Mickaël Tharaud; Kevin Cariou; Gilles Gasser
Published in: Dalton Transaction, Issue 1, 2021, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1dt02083h

Highly cytotoxic copper(II) terpyridine complexes as anticancer drug candidates

Author(s): Johannes Karges, Kai Xiong, Olivier Blacque, Hui Chao, Gilles Gasser
Published in: Inorganica Chimica Acta, Issue 516, 2021, Page(s) 120137, ISSN 0020-1693
Publisher: Elsevier BV
DOI: 10.1016/j.ica.2020.120137

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