Towards Novel Inert (Photo-)toxic Ru(II) Polypyridyl Complexes

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

One‐ and Two‐Photon Phototherapeutic Effects of Ru II Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumor Spheroids and Tumor‐Bearing Mice**

Autores: Johannes Karges, Shi Kuang, Yih Ching Ong, Hui Chao, Gilles Gasser
Publicado en: Chemistry – A European Journal, Edición 27/1, 2021, Página(s) 362-370, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003486

Synthesis, Characterization, and Biological Evaluation of the Polymeric Encapsulation of a Ruthenium(II) Polypyridine Complex with Pluronic F‐127/Poloxamer‐407 for Photodynamic Therapy Applications

Autores: Johannes Karges, Hui Chao, Gilles Gasser
Publicado en: European Journal of Inorganic Chemistry, Edición 2020/34, 2020, Página(s) 3242-3248, ISSN 1434-1948
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.202000545

Synthesis, characterization, kinetic investigation and biological evaluation of Re( i ) di- and tricarbonyl complexes with tertiary phosphine ligands

Autores: Verity Lindy Gantsho, Mazzarine Dotou, Marta Jakubaszek, Bruno Goud, Gilles Gasser, Hendrik Gideon Visser, Marietjie Schutte-Smith
Publicado en: Dalton Transactions, Edición 49/1, 2020, Página(s) 35-46, ISSN 1477-9226
Editor: Royal Society of Chemistry
DOI: 10.1039/c9dt04025k

Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy

Autores: Valentin Buchter, Jeannine Hess, Gilles Gasser, Jennifer Keiser
Publicado en: Parasites & Vectors, Edición 11/1, 2018, ISSN 1756-3305
Editor: BioMed Central
DOI: 10.1186/s13071-018-3132-x

Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies

Autores: Anna Notaro, Angelo Frei, Riccardo Rubbiani, Marta Jakubaszek, Uttara Basu, Severin Koch, Cristina Mari, Mazzarine Dotou, Olivier Blacque, Jérémie Gouyon, Fethi Bedioui, Nils Rotthowe, Rainer F. Winter, Bruno Goud, Stefano Ferrari, Mickaël Tharaud, Martina Řezáčová, Jana Humajová, Pavel Tomšík, Gilles Gasser
Publicado en: Journal of Medicinal Chemistry, Edición 63/10, 2020, Página(s) 5568-5584, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00431

Ruthenium polypyridyl complex-containing bioconjugates

Autores: Marta Martínez-Alonso; Gilles Gasser
Publicado en: Coordinations Chemistry Reviews, Edición 1, 2021, ISSN 0010-8545
Editor: Elsevier BV
DOI: 10.1016/j.ccr.2020.213736

A Luminescent NOTA-Based Terbium(III) “Turn-Off” Sensor for Copper

Autores: Michèle Clerc, Franz Heinemann, Bernhard Spingler, Gilles Gasser
Publicado en: Inorganic Chemistry, Edición 59/1, 2019, Página(s) 669-677, ISSN 0020-1669
Editor: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b02934

Note of Caution for the Aqueous Behaviour of Metal-Based Drug Candidates

Autores: Notaro, Anna; Gasser, Gilles; Castonguay, Annie
Publicado en: ChemMedChem, Edición 1, 2020, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201900677

Unveiling the Potential of Transition Metal Complexes for Medicine: Translational in Situ Activation of Metal‐Based Drugs from Bench to in Vivo Applications

Autores: Maria J. S. A. Silva, Pedro M. P. Gois, Gilles Gasser
Publicado en: ChemBioChem, 2021, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100015

Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1

Autores: Storm Hassell‐Hart, Sarah Picaud, Raphael Lengacher, Joshua Csucker, Regis Millet, Gilles Gasser, Roger Alberto, Hannah Maple, Robert Felix, Zbigniew J. Leśnikowski, Helen J. S. Stewart, Timothy J. Chevassut, Simon Morley, Panagis Filippakopoulos, John Spencer
Publicado en: Helvetica Chimica Acta, Edición 104/3, 2021, ISSN 0018-019X
Editor: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.202000214

Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy

Autores: Johannes Karges, Hui Chao, Gilles Gasser
Publicado en: JBIC Journal of Biological Inorganic Chemistry, Edición 25/8, 2020, Página(s) 1035-1050, ISSN 0949-8257
Editor: Springer Verlag
DOI: 10.1007/s00775-020-01829-5

A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy

Autores: Luke K. McKenzie; Luke K. McKenzie; Marie Flamme; Marie Flamme; Marie Flamme; Patrick S. Felder; Johannes Karges; Frédéric J. Bonhomme; Albert Gandioso; Christian Malosse; Gilles Gasser; Marcel Hollenstein
Publicado en: RSC Chemical Biology, Edición 2, 2022, ISSN 2633-0679
Editor: RSC
DOI: 10.33774/chemrxiv-2021-5n9xv

Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?

Autores: Alain C. Jung; Fabien Moinard-Butot; Chloé Thibaudeau; Gilles Gasser; Christian Gaiddon
Publicado en: Pharmaceutics, Edición 1, 2020, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111788

Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro when Used as Photosensitizers for Photodynamic Therapy

Autores: Saonli Roy, Elisa Colombo, Robin Vinck, Cristina Mari, Riccardo Rubbiani, Malay Patra, Gilles Gasser
Publicado en: ChemBioChem, Edición 21/20, 2020, Página(s) 2966-2973, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000289

A solid phase-assisted approach for the facile synthesis of a highly water-soluble zirconium-89 chelator for radiopharmaceutical development

Autores: Manon Briand, Margaret L. Aulsebrook, Thomas L. Mindt, Gilles Gasser
Publicado en: Dalton Transactions, Edición 46/47, 2017, Página(s) 16387-16389, ISSN 1477-9226
Editor: Royal Society of Chemistry
DOI: 10.1039/c7dt03639f

Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes as Potential Photosensitisers for Photodynamic Therapy

Autores: Karges, Johannes; Basu, Uttara; Blacque, Olivier; Chao, Hui; Gasser, Gilles
Publicado en: Angewandte Chemie, Edición 3, 2019, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.

Fe III –Salen‐Based Probes for the Selective and Sensitive Detection of E450 in Foodstuff

Autores: Prerna Yadav, Marta Jakubaszek, Bernhard Spingler, Bruno Goud, Gilles Gasser, Felix Zelder
Publicado en: Chemistry – A European Journal, Edición 26/25, 2020, Página(s) 5717-5723, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905686

Efficient Amino‐Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS‐Activated Acrylamides

Autores: Maria J. S. A. Silva, Hélio Faustino, Jaime A. S. Coelho, Maria V. Pinto, Adelaide Fernandes, Ismael Compañón, Francisco Corzana, Gilles Gasser, Pedro M. P. Gois
Publicado en: Angewandte Chemie International Edition, Edición 60/19, 2021, Página(s) 10850-10857, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202016936

Enzymatic construction of metal-mediated nucleic acid base pairs.

Autores: Marie Flamme; Chiara Figazzolo; Chiara Figazzolo; Gilles Gasser; Marcel Hollenstein
Publicado en: Metallomics, Edición 1, 2021, ISSN 1756-5901
Editor: Royal Society of Chemistry
DOI: 10.1093/mtomcs/mfab016

Synthesis and Biological Evaluation of Metallocene-Tethered Peptidyl Inhibitors of CDC25

Autores: Saonli Roy; Loganathan Rangasamy; Assia Nouar; Christiane Koenig; Vanessa Pierroz; Simon Kaeppeli; Stefano Ferrari; Malay Patra; Gilles Gasser
Publicado en: Organometallics, Edición 1, 2021, ISSN 0276-7333
Editor: American Chemical Society
DOI: 10.1021/acs.organomet.1c00345

Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes

Autores: Schoch, Silvia; Iacopini, Dalila; Dalla Pozza, Maria; Di Pietro, Sebastiano; Degano, Ilaria; Gasser, Gilles; Di Bussolo, Valeria; Marchetti, Fabio
Publicado en: Organometallics, Edición 1, 2022, ISSN 0276-7333
Editor: American Chemical Society
DOI: 10.1021/acs.organomet.1c00519

A Maltol‐Containing Ruthenium Polypyridyl Complex as a Potential Anticancer Agent

Autores: Anna Notaro, Marta Jakubaszek, Severin Koch, Riccardo Rubbiani, Orsolya Dömötör, Éva A. Enyedy, Mazzarine Dotou, Fethi Bedioui, Mickaël Tharaud, Bruno Goud, Stefano Ferrari, Enzo Alessio, Gilles Gasser
Publicado en: Chemistry – A European Journal, Edición 26/22, 2020, Página(s) 4997-5009, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201904877

Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy

Autores: Nancy Soliman, Vincent Sol, Tan-Sothea Ouk, Christophe M. Thomas, Gilles Gasser
Publicado en: Pharmaceutics, Edición 12/10, 2020, Página(s) 961, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12100961

Increasing the Cytotoxicity of Ru(II) Polypyridyl Complexes by Tuning the Electronic Structure of Dioxo Ligands

Autores: Anna Notaro, Marta Jakubaszek, Nils Rotthowe, Federica Maschietto, Robin Vinck, Patrick S. Felder, Bruno Goud, Mickaël Tharaud, Ilaria Ciofini, Fethi Bedioui, Rainer F. Winter, Gilles Gasser
Publicado en: Journal of the American Chemical Society, Edición 142/13, 2020, Página(s) 6066-6084, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.9b12464

Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

Autores: Wenyu Wu; Gilles Gasser; Doris Hinger; Michele Larocca; Vipin Babu; Caroline Maake; Bernhard Spingler; Stefano Ferrari; Roxane Padrutt; Lukas Schneider; Christiane König; Anu Naik; Riccardo Rubbiani
Publicado en: Rubbiani, Riccardo; Wu, Wenyu; Naik, Anu; Larocca, Michele; Schneider, Lukas; Padrutt, Roxane; Babu, Vipin; König, Christiane; Hinger, Doris; Maake, Caroline; Ferrari, Stefano; Gasser, Gilles; Spingler, Bernhard (2020). Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling. Chemical Communications, 56(92):14373-14376., Edición 20, 2020, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.5167/uzh-192391

Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy

Autores: Johannes Karges, Olivier Blacque, Gilles Gasser
Publicado en: Inorganica Chimica Acta, Edición 505, 2020, Página(s) 119482, ISSN 0020-1693
Editor: Elsevier BV
DOI: 10.1016/j.ica.2020.119482

Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

Autores: Sherri A. McFarland, Arkady Mandel, Roger Dumoulin-White, Gilles Gasser
Publicado en: Current Opinion in Chemical Biology, Edición 56, 2020, Página(s) 23-27, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/j.cbpa.2019.10.004

Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands

Autores: Alexandra-Cristina Munteanu, Anna Notaro, Marta Jakubaszek, Joseph Cowell, Mickaël Tharaud, Bruno Goud, Valentina Uivarosi, Gilles Gasser
Publicado en: Inorganic Chemistry, Edición 59/7, 2020, Página(s) 4424-4434, ISSN 0020-1669
Editor: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b03562

Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole

Autores: Yan Lin, Yih Ching Ong, Sarah Keller, Johannes Karges, Rafika Bouchene, Eric Manoury, Olivier Blacque, Joachim Müller, Nicoleta Anghel, Andrew Hemphill, Cécile Häberli, Aya C. Taki, Robin B. Gasser, Kevin Cariou, Jennifer Keiser, Gilles Gasser
Publicado en: Dalton Transactions, Edición 49/20, 2020, Página(s) 6616-6626, ISSN 1477-9226
Editor: Royal Society of Chemistry
DOI: 10.1039/d0dt01107j

Recent developments of metal-based compounds against fungal pathogens

Autores: Lin, Yan; Betts, Harley; Keller, Sarah; Cariou, Kevin; Gasser, Gilles
Publicado en: Chemical Society Reviews, Edición 1, 2021, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/d0cs00945h

Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the Spike/ACE2 interaction and the Papain-like Protease PLpro.

Autores: Maria Gil-Moles; Sebastian Türck; Uttara Basu; Andrea Pettenuzzo; Saurav Bhattacharya; Ananthu Rajan; Xiang Ma; Rolf Büssing; Jessica Wölker; Hilke Burmeister; Henrik Hoffmeister; Pia Schneeberg; Andre Prause; Petra Lippmann; Josephine Kusi-Nimarko; Storm Hassell-Hart; Andrew McGown; Daniel Guest; Yan Lin; Anna Notaro; Robin Vinck; Johannes Karges; Kevin Cariou; Kun Peng; Xue Qin; Xing Wang; Jo
Publicado en: Chemistry - A European Journal, Edición 1, 2021, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103258

Monomeric and dimeric coordinatively saturated and substitutionally inert Ru( ii ) polypyridyl complexes as anticancer drug candidates

Autores: Anna Notaro, Gilles Gasser
Publicado en: Chemical Society Reviews, Edición 46/23, 2017, Página(s) 7317-7337, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/C7CS00356K

Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy

Autores: Franz Heinemann, Johannes Karges, Gilles Gasser
Publicado en: Accounts of Chemical Research, Edición 50/11, 2017, Página(s) 2727-2736, ISSN 0001-4842
Editor: American Chemical Society
DOI: 10.1021/acs.accounts.7b00180

ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Autores: Karun Mutreja, Jana Krietsch, Jeannine Hess, Sebastian Ursich, Matteo Berti, Fabienne K. Roessler, Ralph Zellweger, Malay Patra, Gilles Gasser, Massimo Lopes
Publicado en: Cell Reports, Edición 24/10, 2018, Página(s) 2629-2642.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.08.019

Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes

Autores: Johannes Karges, Philippe Goldner, Gilles Gasser
Publicado en: Inorganics, Edición 7/1, 2019, Página(s) 4, ISSN 2304-6740
Editor: MDPI AG
DOI: 10.3390/inorganics7010004

Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives

Autores: Marie Flamme, Emma Clarke, Gilles Gasser, Marcel Hollenstein
Publicado en: Molecules, Edición 23/7, 2018, Página(s) 1515, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23071515

Mesoporous silica nanoparticles functionalised with a photoactive ruthenium( ii ) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser

Autores: Younes Ellahioui, Malay Patra, Cristina Mari, Rim Kaabi, Johannes Karges, Gilles Gasser, Santiago Gómez-Ruiz
Publicado en: Dalton Transactions, Edición 48/18, 2019, Página(s) 5940-5951, ISSN 1477-9226
Editor: Royal Society of Chemistry
DOI: 10.1039/c8dt02392a

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium( i ) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Autores: Sul Hwa Yu, Malay Patra, Stefano Ferrari, Paulina Ramirez Garcia, Nicholas A. Veldhuis, Lisa M. Kaminskas, Bim Graham, John F. Quinn, Michael R. Whittaker, Gilles Gasser, Thomas P. Davis
Publicado en: Journal of Materials Chemistry B, Edición 6/47, 2018, Página(s) 7805-7810, ISSN 2050-7518
Editor: Royal Society of Chemistry
DOI: 10.1039/C8TB02464B

Biological Evaluation of the NIR-Emissive Ruby Analogue [Cr(ddpd) 2 ][BF 4 ] 3 as a Photodynamic Therapy Photosensitizer

Autores: Uttara Basu, Sven Otto, Katja Heinze, Gilles Gasser
Publicado en: European Journal of Inorganic Chemistry, Edición 2019/1, 2019, Página(s) 37-41, ISSN 1434-1948
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201801023

Mechanisms of action of Ru( ii ) polypyridyl complexes in living cells upon light irradiation

Autores: Marta Jakubaszek, Bruno Goud, Stefano Ferrari, Gilles Gasser
Publicado en: Chemical Communications, Edición 54/93, 2018, Página(s) 13040-13059, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/C8CC05928D

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates

Autores: Faustine d'Orchymont, Jeannine Hess, Gordana Panic, Marta Jakubaszek, Lea Gemperle, Jennifer Keiser, Gilles Gasser
Publicado en: MedChemComm, Edición 9/11, 2018, Página(s) 1905-1909, ISSN 2040-2503
Editor: Royal Society of Chemistry
DOI: 10.1039/c8md00396c

Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum

Autores: Afonso P. Basto, Nicoleta Anghel, Riccardo Rubbiani, Joachim Müller, David Stibal, Federico Giannini, Georg Süss-Fink, Vreni Balmer, Gilles Gasser, Julien Furrer, Andrew Hemphill
Publicado en: Metallomics, Edición 11/2, 2019, Página(s) 462-474, ISSN 1756-5901
Editor: Royal Society of Chemistry
DOI: 10.1039/c8mt00307f

Polymer encapsulation of ruthenium complexes for biological and medicinal applications

Autores: Elise Villemin, Yih Ching Ong, Christophe M. Thomas, Gilles Gasser
Publicado en: Nature Reviews Chemistry, Edición 3/4, 2019, Página(s) 261-282, ISSN 2397-3358
Editor: Springer
DOI: 10.1038/s41570-019-0088-0

Targeted photoredox catalysis in cancer cells

Autores: Huaiyi Huang, Samya Banerjee, Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser, Hui Chao, Peter J. Sadler
Publicado en: Nature Chemistry, Edición 11/11, 2019, Página(s) 1041-1048, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-019-0328-4

Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy) 3 ] 2+ Core

Autores: Johannes Karges, Olivier Blacque, Philippe Goldner, Hui Chao, Gilles Gasser
Publicado en: European Journal of Inorganic Chemistry, Edición 2019/32, 2019, Página(s) 3704-3712, ISSN 1434-1948
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201900569

Polymeric Bis(dipyrrinato) Zinc(II) Nanoparticles as Selective Imaging Probes for Lysosomes of Cancer Cells

Autores: Johannes Karges, Olivier Blacque, Hui Chao, Gilles Gasser
Publicado en: Inorganic Chemistry, Edición 58/18, 2019, Página(s) 12422-12432, ISSN 0020-1669
Editor: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b02019

Synthesis and Characterization of an Epidermal Growth Factor Receptor‐Selective Ru II Polypyridyl–Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy

Autores: Johannes Karges, Marta Jakubaszek, Cristina Mari, Kristof Zarschler, Bruno Goud, Holger Stephan, Gilles Gasser
Publicado en: ChemBioChem, 2019, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900419

Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers

Autores: Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao, Gilles Gasser
Publicado en: Angewandte Chemie International Edition, Edición 58/40, 2019, Página(s) 14334-14340, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201907856

Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy

Autores: Johannes Karges, Gilles Gasser
Publicado en: Inorganica Chimica Acta, Edición 499, 2020, Página(s) 119196, ISSN 0020-1693
Editor: Elsevier BV
DOI: 10.1016/j.ica.2019.119196

Towards Light‐Activated Ruthenium–Arene (RAPTA‐Type) Prodrug Candidates

Autores: Anna K. Renfrew, Johannes Karges, Rosario Scopelliti, Felix D. Bobbink, Patrycja Nowak‐Sliwinska, Gilles Gasser, Paul J. Dyson
Publicado en: ChemBioChem, Edición 20/22, 2019, Página(s) 2876-2882, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900236

Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes

Autores: Johannes Karges, Olivier Blacque, Marta Jakubaszek, Bruno Goud, Philippe Goldner, Gilles Gasser
Publicado en: Journal of Inorganic Biochemistry, Edición 198, 2019, Página(s) 110752, ISSN 0162-0134
Editor: Elsevier BV
DOI: 10.1016/j.jinorgbio.2019.110752

A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers

Autores: Johannes Karges, Franz Heinemann, Federica Maschietto, Malay Patra, Olivier Blacque, Ilaria Ciofini, Bernhard Spingler, Gilles Gasser
Publicado en: Bioorganic & Medicinal Chemistry, Edición 27/12, 2019, Página(s) 2666-2675, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2019.05.011

Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Autores: Marta Jakubaszek, Jeremie Rossier, Johannes Karges, Joachim Delasoie, Bruno Goud, Gilles Gasser, Fabio Zobi
Publicado en: Helvetica Chimica Acta, Edición 102/7, 2019, ISSN 0018-019X
Editor: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.201900104

Organometallic small molecule kinase inhibitors - direct incorporation of Re and 99mTc into Opaganib®.

Autores: Raphael Lengacher; Youchao Wang; Henrik Braband; Olivier Blacque; Gilles Gasser; Roger Alberto
Publicado en: Chemical communications, Edición 1, 2021, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cc03678e

A Multi‐action and Multi‐target Ru II –Pt IV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers

Autores: Johannes Karges, Thirumal Yempala, Mickaël Tharaud, Dan Gibson, Gilles Gasser
Publicado en: Angewandte Chemie International Edition, Edición 59/18, 2020, Página(s) 7069-7075, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201916400

Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis

Autores: Nancy Soliman, Gilles Gasser, Christophe M. Thomas
Publicado en: Advanced Materials, Edición 32/47, 2020, Página(s) 2003294, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202003294

Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers

Autores: Johannes Karges, Mickaël Tharaud, Gilles Gasser
Publicado en: Journal of Medicinal Chemistry, Edición 64/8, 2021, Página(s) 4612-4622, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c02006

Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer

Autores: Nancy Soliman, Luke K. McKenzie, Johannes Karges, Emilie Bertrand, Mickaël Tharaud, Marta Jakubaszek, Vincent Guérineau, Bruno Goud, Marcel Hollenstein, Gilles Gasser, Christophe M. Thomas
Publicado en: Chemical Science, Edición 11/10, 2020, Página(s) 2657-2663, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c9sc05976h

Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate

Autores: Marie Flamme, Pascal Röthlisberger, Fabienne Levi-Acobas, Mohit Chawla, Romina Oliva, Luigi Cavallo, Gilles Gasser, Philippe Marlière, Piet Herdewijn, Marcel Hollenstein
Publicado en: ACS Chemical Biology, Edición 15/11, 2020, Página(s) 2872-2884, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.0c00396

cis-Locked Ru(II)-DMSO Precursors for the Microwave-Assisted Synthesis of Bis-Heteroleptic Polypyridyl Compounds

Autores: Alessio Vidal; Rudy Calligaro; Gilles Gasser; Roger Alberto; Gabriele Balducci; Enzo Alessio
Publicado en: Inorganic Chemistry, Edición 1, 2021, ISSN 0020-1669
Editor: American Chemical Society
DOI: 10.1021/acs.inorgchem.1c00240

Classification of Metal-Based Drugs according to Their Mechanisms of Action

Autores: Eszter Boros, Paul J. Dyson, Gilles Gasser
Publicado en: Chem, Edición 6/1, 2020, Página(s) 41-60, ISSN 2451-9294
Editor: Cell Press
DOI: 10.1016/j.chempr.2019.10.013

Ru(II) Polypyridine Complex Functionalized Mesoporous Silica Nanoparticles as Photosensitizers for Cancer Targeted Photodynamic Therapy

Autores: Karges, Johannes; Díaz-García, Diana; Prashar, Sanjiv; Gómez-Ruiz, Santiago; Gasser, Gilles
Publicado en: ACS Applied Biomaterials, Edición 1, 2021, ISSN 2576-6422
Editor: American Chemical Society
DOI: 10.1021/acsabm.1c00151

Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy.

Autores: Karges, Johannes; Kuang, Shi; Maschietto, Federica; Blacque, Olivier; Ciofini, Ilaria; Chao, Hui; Gasser, Gilles
Publicado en: https://hal.archives-ouvertes.fr/hal-02890539, Edición 22, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.5167/uzh-191123

A tutorial for the assessment of the stability of organometallic complexes in biological media

Autores: Sarah Keller, Yih Ching Ong, Yan Lin, Kevin Cariou, Gilles Gasser
Publicado en: Journal of Organometallic Chemistry, Edición 906, 2020, Página(s) 121059, ISSN 0022-328X
Editor: Elsevier BV
DOI: 10.1016/j.jorganchem.2019.121059

Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy

Autores: Johannes Karges, Jia Li, Leli Zeng, Hui Chao, Gilles Gasser
Publicado en: ACS Applied Materials & Interfaces, Edición 12/49, 2020, Página(s) 54433-54444, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.0c16119

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

Autores: Gourdon, Lisa; Cariou, Kevin; Gasser, Gilles
Publicado en: Chemical Society Reviews, Edición 1, 2022, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cs00609f

Recent Approaches towards the Development of Ru(II) Polypyridyl Complexes for Anticancer Photodynamic Therapy.

Autores: Albert Gandioso; Kallol Purkait; Gilles Gasser
Publicado en: Chimia, Edición 1, 2021, ISSN 0009-4293
Editor: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2021.845

Radiolabelling of the octadentate chelators DFO* and oxoDFO* with zirconium-89 and gallium-68

Autores: Marie Brandt, Joseph Cowell, Margaret L. Aulsebrook, Gilles Gasser, Thomas L. Mindt
Publicado en: JBIC Journal of Biological Inorganic Chemistry, Edición 25/5, 2020, Página(s) 789-796, ISSN 0949-8257
Editor: Springer Verlag
DOI: 10.1007/s00775-020-01800-4

Polymetallic Complexes for Applications as Photosensitisers in Anticancer Photodynamic Therapy

Autores: Patrick S. Felder, Sarah Keller, Gilles Gasser
Publicado en: Advanced Therapeutics, Edición 3/1, 2020, Página(s) 1900139, ISSN 2366-3987
Editor: Wiley
DOI: 10.1002/adtp.201900139

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Autores: Johannes Karges, Franz Heinemann, Marta Jakubaszek, Federica Maschietto, Chloé Subecz, Mazzarine Dotou, Robin Vinck, Olivier Blacque, Mickaël Tharaud, Bruno Goud, Emilio Viñuelas Zahı́nos, Bernhard Spingler, Ilaria Ciofini, Gilles Gasser
Publicado en: Journal of the American Chemical Society, Edición 142/14, 2020, Página(s) 6578-6587, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.9b13620

Physical, spectroscopic, and biological properties of ruthenium and osmium photosensitizers bearing diversely substituted 4,4'-di(styryl)-2,2'-bipyridine ligands.

Autores: Robin Vinck; Johannes Karges; Mickaël Tharaud; Kevin Cariou; Gilles Gasser
Publicado en: Dalton Transaction, Edición 1, 2021, ISSN 1477-9226
Editor: Royal Society of Chemistry
DOI: 10.1039/d1dt02083h

Highly cytotoxic copper(II) terpyridine complexes as anticancer drug candidates

Autores: Johannes Karges, Kai Xiong, Olivier Blacque, Hui Chao, Gilles Gasser
Publicado en: Inorganica Chimica Acta, Edición 516, 2021, Página(s) 120137, ISSN 0020-1693
Editor: Elsevier BV
DOI: 10.1016/j.ica.2020.120137

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