Towards Novel Inert (Photo-)toxic Ru(II) Polypyridyl Complexes

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Pubblicazioni

One‐ and Two‐Photon Phototherapeutic Effects of Ru II Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumor Spheroids and Tumor‐Bearing Mice**

Autori: Johannes Karges, Shi Kuang, Yih Ching Ong, Hui Chao, Gilles Gasser
Pubblicato in: Chemistry – A European Journal, Numero 27/1, 2021, Pagina/e 362-370, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003486

Synthesis, Characterization, and Biological Evaluation of the Polymeric Encapsulation of a Ruthenium(II) Polypyridine Complex with Pluronic F‐127/Poloxamer‐407 for Photodynamic Therapy Applications

Autori: Johannes Karges, Hui Chao, Gilles Gasser
Pubblicato in: European Journal of Inorganic Chemistry, Numero 2020/34, 2020, Pagina/e 3242-3248, ISSN 1434-1948
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.202000545

Synthesis, characterization, kinetic investigation and biological evaluation of Re( i ) di- and tricarbonyl complexes with tertiary phosphine ligands

Autori: Verity Lindy Gantsho, Mazzarine Dotou, Marta Jakubaszek, Bruno Goud, Gilles Gasser, Hendrik Gideon Visser, Marietjie Schutte-Smith
Pubblicato in: Dalton Transactions, Numero 49/1, 2020, Pagina/e 35-46, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/c9dt04025k

Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy

Autori: Valentin Buchter, Jeannine Hess, Gilles Gasser, Jennifer Keiser
Pubblicato in: Parasites & Vectors, Numero 11/1, 2018, ISSN 1756-3305
Editore: BioMed Central
DOI: 10.1186/s13071-018-3132-x

Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies

Autori: Anna Notaro, Angelo Frei, Riccardo Rubbiani, Marta Jakubaszek, Uttara Basu, Severin Koch, Cristina Mari, Mazzarine Dotou, Olivier Blacque, Jérémie Gouyon, Fethi Bedioui, Nils Rotthowe, Rainer F. Winter, Bruno Goud, Stefano Ferrari, Mickaël Tharaud, Martina Řezáčová, Jana Humajová, Pavel Tomšík, Gilles Gasser
Pubblicato in: Journal of Medicinal Chemistry, Numero 63/10, 2020, Pagina/e 5568-5584, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00431

Ruthenium polypyridyl complex-containing bioconjugates

Autori: Marta Martínez-Alonso; Gilles Gasser
Pubblicato in: Coordinations Chemistry Reviews, Numero 1, 2021, ISSN 0010-8545
Editore: Elsevier BV
DOI: 10.1016/j.ccr.2020.213736

A Luminescent NOTA-Based Terbium(III) “Turn-Off” Sensor for Copper

Autori: Michèle Clerc, Franz Heinemann, Bernhard Spingler, Gilles Gasser
Pubblicato in: Inorganic Chemistry, Numero 59/1, 2019, Pagina/e 669-677, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b02934

Note of Caution for the Aqueous Behaviour of Metal-Based Drug Candidates

Autori: Notaro, Anna; Gasser, Gilles; Castonguay, Annie
Pubblicato in: ChemMedChem, Numero 1, 2020, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201900677

Unveiling the Potential of Transition Metal Complexes for Medicine: Translational in Situ Activation of Metal‐Based Drugs from Bench to in Vivo Applications

Autori: Maria J. S. A. Silva, Pedro M. P. Gois, Gilles Gasser
Pubblicato in: ChemBioChem, 2021, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100015

Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1

Autori: Storm Hassell‐Hart, Sarah Picaud, Raphael Lengacher, Joshua Csucker, Regis Millet, Gilles Gasser, Roger Alberto, Hannah Maple, Robert Felix, Zbigniew J. Leśnikowski, Helen J. S. Stewart, Timothy J. Chevassut, Simon Morley, Panagis Filippakopoulos, John Spencer
Pubblicato in: Helvetica Chimica Acta, Numero 104/3, 2021, ISSN 0018-019X
Editore: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.202000214

Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy

Autori: Johannes Karges, Hui Chao, Gilles Gasser
Pubblicato in: JBIC Journal of Biological Inorganic Chemistry, Numero 25/8, 2020, Pagina/e 1035-1050, ISSN 0949-8257
Editore: Springer Verlag
DOI: 10.1007/s00775-020-01829-5

A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy

Autori: Luke K. McKenzie; Luke K. McKenzie; Marie Flamme; Marie Flamme; Marie Flamme; Patrick S. Felder; Johannes Karges; Frédéric J. Bonhomme; Albert Gandioso; Christian Malosse; Gilles Gasser; Marcel Hollenstein
Pubblicato in: RSC Chemical Biology, Numero 2, 2022, ISSN 2633-0679
Editore: RSC
DOI: 10.33774/chemrxiv-2021-5n9xv

Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?

Autori: Alain C. Jung; Fabien Moinard-Butot; Chloé Thibaudeau; Gilles Gasser; Christian Gaiddon
Pubblicato in: Pharmaceutics, Numero 1, 2020, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111788

Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro when Used as Photosensitizers for Photodynamic Therapy

Autori: Saonli Roy, Elisa Colombo, Robin Vinck, Cristina Mari, Riccardo Rubbiani, Malay Patra, Gilles Gasser
Pubblicato in: ChemBioChem, Numero 21/20, 2020, Pagina/e 2966-2973, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000289

A solid phase-assisted approach for the facile synthesis of a highly water-soluble zirconium-89 chelator for radiopharmaceutical development

Autori: Manon Briand, Margaret L. Aulsebrook, Thomas L. Mindt, Gilles Gasser
Pubblicato in: Dalton Transactions, Numero 46/47, 2017, Pagina/e 16387-16389, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/c7dt03639f

Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes as Potential Photosensitisers for Photodynamic Therapy

Autori: Karges, Johannes; Basu, Uttara; Blacque, Olivier; Chao, Hui; Gasser, Gilles
Pubblicato in: Angewandte Chemie, Numero 3, 2019, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.

Fe III –Salen‐Based Probes for the Selective and Sensitive Detection of E450 in Foodstuff

Autori: Prerna Yadav, Marta Jakubaszek, Bernhard Spingler, Bruno Goud, Gilles Gasser, Felix Zelder
Pubblicato in: Chemistry – A European Journal, Numero 26/25, 2020, Pagina/e 5717-5723, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905686

Efficient Amino‐Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS‐Activated Acrylamides

Autori: Maria J. S. A. Silva, Hélio Faustino, Jaime A. S. Coelho, Maria V. Pinto, Adelaide Fernandes, Ismael Compañón, Francisco Corzana, Gilles Gasser, Pedro M. P. Gois
Pubblicato in: Angewandte Chemie International Edition, Numero 60/19, 2021, Pagina/e 10850-10857, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202016936

Enzymatic construction of metal-mediated nucleic acid base pairs.

Autori: Marie Flamme; Chiara Figazzolo; Chiara Figazzolo; Gilles Gasser; Marcel Hollenstein
Pubblicato in: Metallomics, Numero 1, 2021, ISSN 1756-5901
Editore: Royal Society of Chemistry
DOI: 10.1093/mtomcs/mfab016

Synthesis and Biological Evaluation of Metallocene-Tethered Peptidyl Inhibitors of CDC25

Autori: Saonli Roy; Loganathan Rangasamy; Assia Nouar; Christiane Koenig; Vanessa Pierroz; Simon Kaeppeli; Stefano Ferrari; Malay Patra; Gilles Gasser
Pubblicato in: Organometallics, Numero 1, 2021, ISSN 0276-7333
Editore: American Chemical Society
DOI: 10.1021/acs.organomet.1c00345

Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes

Autori: Schoch, Silvia; Iacopini, Dalila; Dalla Pozza, Maria; Di Pietro, Sebastiano; Degano, Ilaria; Gasser, Gilles; Di Bussolo, Valeria; Marchetti, Fabio
Pubblicato in: Organometallics, Numero 1, 2022, ISSN 0276-7333
Editore: American Chemical Society
DOI: 10.1021/acs.organomet.1c00519

A Maltol‐Containing Ruthenium Polypyridyl Complex as a Potential Anticancer Agent

Autori: Anna Notaro, Marta Jakubaszek, Severin Koch, Riccardo Rubbiani, Orsolya Dömötör, Éva A. Enyedy, Mazzarine Dotou, Fethi Bedioui, Mickaël Tharaud, Bruno Goud, Stefano Ferrari, Enzo Alessio, Gilles Gasser
Pubblicato in: Chemistry – A European Journal, Numero 26/22, 2020, Pagina/e 4997-5009, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201904877

Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy

Autori: Nancy Soliman, Vincent Sol, Tan-Sothea Ouk, Christophe M. Thomas, Gilles Gasser
Pubblicato in: Pharmaceutics, Numero 12/10, 2020, Pagina/e 961, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12100961

Increasing the Cytotoxicity of Ru(II) Polypyridyl Complexes by Tuning the Electronic Structure of Dioxo Ligands

Autori: Anna Notaro, Marta Jakubaszek, Nils Rotthowe, Federica Maschietto, Robin Vinck, Patrick S. Felder, Bruno Goud, Mickaël Tharaud, Ilaria Ciofini, Fethi Bedioui, Rainer F. Winter, Gilles Gasser
Pubblicato in: Journal of the American Chemical Society, Numero 142/13, 2020, Pagina/e 6066-6084, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b12464

Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

Autori: Wenyu Wu; Gilles Gasser; Doris Hinger; Michele Larocca; Vipin Babu; Caroline Maake; Bernhard Spingler; Stefano Ferrari; Roxane Padrutt; Lukas Schneider; Christiane König; Anu Naik; Riccardo Rubbiani
Pubblicato in: Rubbiani, Riccardo; Wu, Wenyu; Naik, Anu; Larocca, Michele; Schneider, Lukas; Padrutt, Roxane; Babu, Vipin; König, Christiane; Hinger, Doris; Maake, Caroline; Ferrari, Stefano; Gasser, Gilles; Spingler, Bernhard (2020). Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling. Chemical Communications, 56(92):14373-14376., Numero 20, 2020, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.5167/uzh-192391

Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy

Autori: Johannes Karges, Olivier Blacque, Gilles Gasser
Pubblicato in: Inorganica Chimica Acta, Numero 505, 2020, Pagina/e 119482, ISSN 0020-1693
Editore: Elsevier BV
DOI: 10.1016/j.ica.2020.119482

Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

Autori: Sherri A. McFarland, Arkady Mandel, Roger Dumoulin-White, Gilles Gasser
Pubblicato in: Current Opinion in Chemical Biology, Numero 56, 2020, Pagina/e 23-27, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2019.10.004

Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands

Autori: Alexandra-Cristina Munteanu, Anna Notaro, Marta Jakubaszek, Joseph Cowell, Mickaël Tharaud, Bruno Goud, Valentina Uivarosi, Gilles Gasser
Pubblicato in: Inorganic Chemistry, Numero 59/7, 2020, Pagina/e 4424-4434, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b03562

Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole

Autori: Yan Lin, Yih Ching Ong, Sarah Keller, Johannes Karges, Rafika Bouchene, Eric Manoury, Olivier Blacque, Joachim Müller, Nicoleta Anghel, Andrew Hemphill, Cécile Häberli, Aya C. Taki, Robin B. Gasser, Kevin Cariou, Jennifer Keiser, Gilles Gasser
Pubblicato in: Dalton Transactions, Numero 49/20, 2020, Pagina/e 6616-6626, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/d0dt01107j

Recent developments of metal-based compounds against fungal pathogens

Autori: Lin, Yan; Betts, Harley; Keller, Sarah; Cariou, Kevin; Gasser, Gilles
Pubblicato in: Chemical Society Reviews, Numero 1, 2021, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cs00945h

Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the Spike/ACE2 interaction and the Papain-like Protease PLpro.

Autori: Maria Gil-Moles; Sebastian Türck; Uttara Basu; Andrea Pettenuzzo; Saurav Bhattacharya; Ananthu Rajan; Xiang Ma; Rolf Büssing; Jessica Wölker; Hilke Burmeister; Henrik Hoffmeister; Pia Schneeberg; Andre Prause; Petra Lippmann; Josephine Kusi-Nimarko; Storm Hassell-Hart; Andrew McGown; Daniel Guest; Yan Lin; Anna Notaro; Robin Vinck; Johannes Karges; Kevin Cariou; Kun Peng; Xue Qin; Xing Wang; Jo
Pubblicato in: Chemistry - A European Journal, Numero 1, 2021, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103258

Monomeric and dimeric coordinatively saturated and substitutionally inert Ru( ii ) polypyridyl complexes as anticancer drug candidates

Autori: Anna Notaro, Gilles Gasser
Pubblicato in: Chemical Society Reviews, Numero 46/23, 2017, Pagina/e 7317-7337, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/C7CS00356K

Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy

Autori: Franz Heinemann, Johannes Karges, Gilles Gasser
Pubblicato in: Accounts of Chemical Research, Numero 50/11, 2017, Pagina/e 2727-2736, ISSN 0001-4842
Editore: American Chemical Society
DOI: 10.1021/acs.accounts.7b00180

ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Autori: Karun Mutreja, Jana Krietsch, Jeannine Hess, Sebastian Ursich, Matteo Berti, Fabienne K. Roessler, Ralph Zellweger, Malay Patra, Gilles Gasser, Massimo Lopes
Pubblicato in: Cell Reports, Numero 24/10, 2018, Pagina/e 2629-2642.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.08.019

Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes

Autori: Johannes Karges, Philippe Goldner, Gilles Gasser
Pubblicato in: Inorganics, Numero 7/1, 2019, Pagina/e 4, ISSN 2304-6740
Editore: MDPI AG
DOI: 10.3390/inorganics7010004

Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives

Autori: Marie Flamme, Emma Clarke, Gilles Gasser, Marcel Hollenstein
Pubblicato in: Molecules, Numero 23/7, 2018, Pagina/e 1515, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23071515

Mesoporous silica nanoparticles functionalised with a photoactive ruthenium( ii ) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser

Autori: Younes Ellahioui, Malay Patra, Cristina Mari, Rim Kaabi, Johannes Karges, Gilles Gasser, Santiago Gómez-Ruiz
Pubblicato in: Dalton Transactions, Numero 48/18, 2019, Pagina/e 5940-5951, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/c8dt02392a

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium( i ) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Autori: Sul Hwa Yu, Malay Patra, Stefano Ferrari, Paulina Ramirez Garcia, Nicholas A. Veldhuis, Lisa M. Kaminskas, Bim Graham, John F. Quinn, Michael R. Whittaker, Gilles Gasser, Thomas P. Davis
Pubblicato in: Journal of Materials Chemistry B, Numero 6/47, 2018, Pagina/e 7805-7810, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/C8TB02464B

Biological Evaluation of the NIR-Emissive Ruby Analogue [Cr(ddpd) 2 ][BF 4 ] 3 as a Photodynamic Therapy Photosensitizer

Autori: Uttara Basu, Sven Otto, Katja Heinze, Gilles Gasser
Pubblicato in: European Journal of Inorganic Chemistry, Numero 2019/1, 2019, Pagina/e 37-41, ISSN 1434-1948
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201801023

Mechanisms of action of Ru( ii ) polypyridyl complexes in living cells upon light irradiation

Autori: Marta Jakubaszek, Bruno Goud, Stefano Ferrari, Gilles Gasser
Pubblicato in: Chemical Communications, Numero 54/93, 2018, Pagina/e 13040-13059, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/C8CC05928D

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates

Autori: Faustine d'Orchymont, Jeannine Hess, Gordana Panic, Marta Jakubaszek, Lea Gemperle, Jennifer Keiser, Gilles Gasser
Pubblicato in: MedChemComm, Numero 9/11, 2018, Pagina/e 1905-1909, ISSN 2040-2503
Editore: Royal Society of Chemistry
DOI: 10.1039/c8md00396c

Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum

Autori: Afonso P. Basto, Nicoleta Anghel, Riccardo Rubbiani, Joachim Müller, David Stibal, Federico Giannini, Georg Süss-Fink, Vreni Balmer, Gilles Gasser, Julien Furrer, Andrew Hemphill
Pubblicato in: Metallomics, Numero 11/2, 2019, Pagina/e 462-474, ISSN 1756-5901
Editore: Royal Society of Chemistry
DOI: 10.1039/c8mt00307f

Polymer encapsulation of ruthenium complexes for biological and medicinal applications

Autori: Elise Villemin, Yih Ching Ong, Christophe M. Thomas, Gilles Gasser
Pubblicato in: Nature Reviews Chemistry, Numero 3/4, 2019, Pagina/e 261-282, ISSN 2397-3358
Editore: Springer
DOI: 10.1038/s41570-019-0088-0

Targeted photoredox catalysis in cancer cells

Autori: Huaiyi Huang, Samya Banerjee, Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser, Hui Chao, Peter J. Sadler
Pubblicato in: Nature Chemistry, Numero 11/11, 2019, Pagina/e 1041-1048, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-019-0328-4

Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy) 3 ] 2+ Core

Autori: Johannes Karges, Olivier Blacque, Philippe Goldner, Hui Chao, Gilles Gasser
Pubblicato in: European Journal of Inorganic Chemistry, Numero 2019/32, 2019, Pagina/e 3704-3712, ISSN 1434-1948
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201900569

Polymeric Bis(dipyrrinato) Zinc(II) Nanoparticles as Selective Imaging Probes for Lysosomes of Cancer Cells

Autori: Johannes Karges, Olivier Blacque, Hui Chao, Gilles Gasser
Pubblicato in: Inorganic Chemistry, Numero 58/18, 2019, Pagina/e 12422-12432, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b02019

Synthesis and Characterization of an Epidermal Growth Factor Receptor‐Selective Ru II Polypyridyl–Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy

Autori: Johannes Karges, Marta Jakubaszek, Cristina Mari, Kristof Zarschler, Bruno Goud, Holger Stephan, Gilles Gasser
Pubblicato in: ChemBioChem, 2019, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900419

Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers

Autori: Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao, Gilles Gasser
Pubblicato in: Angewandte Chemie International Edition, Numero 58/40, 2019, Pagina/e 14334-14340, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201907856

Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy

Autori: Johannes Karges, Gilles Gasser
Pubblicato in: Inorganica Chimica Acta, Numero 499, 2020, Pagina/e 119196, ISSN 0020-1693
Editore: Elsevier BV
DOI: 10.1016/j.ica.2019.119196

Towards Light‐Activated Ruthenium–Arene (RAPTA‐Type) Prodrug Candidates

Autori: Anna K. Renfrew, Johannes Karges, Rosario Scopelliti, Felix D. Bobbink, Patrycja Nowak‐Sliwinska, Gilles Gasser, Paul J. Dyson
Pubblicato in: ChemBioChem, Numero 20/22, 2019, Pagina/e 2876-2882, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900236

Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes

Autori: Johannes Karges, Olivier Blacque, Marta Jakubaszek, Bruno Goud, Philippe Goldner, Gilles Gasser
Pubblicato in: Journal of Inorganic Biochemistry, Numero 198, 2019, Pagina/e 110752, ISSN 0162-0134
Editore: Elsevier BV
DOI: 10.1016/j.jinorgbio.2019.110752

A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers

Autori: Johannes Karges, Franz Heinemann, Federica Maschietto, Malay Patra, Olivier Blacque, Ilaria Ciofini, Bernhard Spingler, Gilles Gasser
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero 27/12, 2019, Pagina/e 2666-2675, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2019.05.011

Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Autori: Marta Jakubaszek, Jeremie Rossier, Johannes Karges, Joachim Delasoie, Bruno Goud, Gilles Gasser, Fabio Zobi
Pubblicato in: Helvetica Chimica Acta, Numero 102/7, 2019, ISSN 0018-019X
Editore: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.201900104

Organometallic small molecule kinase inhibitors - direct incorporation of Re and 99mTc into Opaganib®.

Autori: Raphael Lengacher; Youchao Wang; Henrik Braband; Olivier Blacque; Gilles Gasser; Roger Alberto
Pubblicato in: Chemical communications, Numero 1, 2021, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cc03678e

A Multi‐action and Multi‐target Ru II –Pt IV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers

Autori: Johannes Karges, Thirumal Yempala, Mickaël Tharaud, Dan Gibson, Gilles Gasser
Pubblicato in: Angewandte Chemie International Edition, Numero 59/18, 2020, Pagina/e 7069-7075, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201916400

Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis

Autori: Nancy Soliman, Gilles Gasser, Christophe M. Thomas
Pubblicato in: Advanced Materials, Numero 32/47, 2020, Pagina/e 2003294, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202003294

Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers

Autori: Johannes Karges, Mickaël Tharaud, Gilles Gasser
Pubblicato in: Journal of Medicinal Chemistry, Numero 64/8, 2021, Pagina/e 4612-4622, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c02006

Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer

Autori: Nancy Soliman, Luke K. McKenzie, Johannes Karges, Emilie Bertrand, Mickaël Tharaud, Marta Jakubaszek, Vincent Guérineau, Bruno Goud, Marcel Hollenstein, Gilles Gasser, Christophe M. Thomas
Pubblicato in: Chemical Science, Numero 11/10, 2020, Pagina/e 2657-2663, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sc05976h

Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate

Autori: Marie Flamme, Pascal Röthlisberger, Fabienne Levi-Acobas, Mohit Chawla, Romina Oliva, Luigi Cavallo, Gilles Gasser, Philippe Marlière, Piet Herdewijn, Marcel Hollenstein
Pubblicato in: ACS Chemical Biology, Numero 15/11, 2020, Pagina/e 2872-2884, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.0c00396

cis-Locked Ru(II)-DMSO Precursors for the Microwave-Assisted Synthesis of Bis-Heteroleptic Polypyridyl Compounds

Autori: Alessio Vidal; Rudy Calligaro; Gilles Gasser; Roger Alberto; Gabriele Balducci; Enzo Alessio
Pubblicato in: Inorganic Chemistry, Numero 1, 2021, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.1c00240

Classification of Metal-Based Drugs according to Their Mechanisms of Action

Autori: Eszter Boros, Paul J. Dyson, Gilles Gasser
Pubblicato in: Chem, Numero 6/1, 2020, Pagina/e 41-60, ISSN 2451-9294
Editore: Cell Press
DOI: 10.1016/j.chempr.2019.10.013

Ru(II) Polypyridine Complex Functionalized Mesoporous Silica Nanoparticles as Photosensitizers for Cancer Targeted Photodynamic Therapy

Autori: Karges, Johannes; Díaz-García, Diana; Prashar, Sanjiv; Gómez-Ruiz, Santiago; Gasser, Gilles
Pubblicato in: ACS Applied Biomaterials, Numero 1, 2021, ISSN 2576-6422
Editore: American Chemical Society
DOI: 10.1021/acsabm.1c00151

Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy.

Autori: Karges, Johannes; Kuang, Shi; Maschietto, Federica; Blacque, Olivier; Ciofini, Ilaria; Chao, Hui; Gasser, Gilles
Pubblicato in: https://hal.archives-ouvertes.fr/hal-02890539, Numero 22, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.5167/uzh-191123

A tutorial for the assessment of the stability of organometallic complexes in biological media

Autori: Sarah Keller, Yih Ching Ong, Yan Lin, Kevin Cariou, Gilles Gasser
Pubblicato in: Journal of Organometallic Chemistry, Numero 906, 2020, Pagina/e 121059, ISSN 0022-328X
Editore: Elsevier BV
DOI: 10.1016/j.jorganchem.2019.121059

Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy

Autori: Johannes Karges, Jia Li, Leli Zeng, Hui Chao, Gilles Gasser
Pubblicato in: ACS Applied Materials & Interfaces, Numero 12/49, 2020, Pagina/e 54433-54444, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.0c16119

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

Autori: Gourdon, Lisa; Cariou, Kevin; Gasser, Gilles
Pubblicato in: Chemical Society Reviews, Numero 1, 2022, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cs00609f

Recent Approaches towards the Development of Ru(II) Polypyridyl Complexes for Anticancer Photodynamic Therapy.

Autori: Albert Gandioso; Kallol Purkait; Gilles Gasser
Pubblicato in: Chimia, Numero 1, 2021, ISSN 0009-4293
Editore: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2021.845

Radiolabelling of the octadentate chelators DFO* and oxoDFO* with zirconium-89 and gallium-68

Autori: Marie Brandt, Joseph Cowell, Margaret L. Aulsebrook, Gilles Gasser, Thomas L. Mindt
Pubblicato in: JBIC Journal of Biological Inorganic Chemistry, Numero 25/5, 2020, Pagina/e 789-796, ISSN 0949-8257
Editore: Springer Verlag
DOI: 10.1007/s00775-020-01800-4

Polymetallic Complexes for Applications as Photosensitisers in Anticancer Photodynamic Therapy

Autori: Patrick S. Felder, Sarah Keller, Gilles Gasser
Pubblicato in: Advanced Therapeutics, Numero 3/1, 2020, Pagina/e 1900139, ISSN 2366-3987
Editore: Wiley
DOI: 10.1002/adtp.201900139

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Autori: Johannes Karges, Franz Heinemann, Marta Jakubaszek, Federica Maschietto, Chloé Subecz, Mazzarine Dotou, Robin Vinck, Olivier Blacque, Mickaël Tharaud, Bruno Goud, Emilio Viñuelas Zahı́nos, Bernhard Spingler, Ilaria Ciofini, Gilles Gasser
Pubblicato in: Journal of the American Chemical Society, Numero 142/14, 2020, Pagina/e 6578-6587, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b13620

Physical, spectroscopic, and biological properties of ruthenium and osmium photosensitizers bearing diversely substituted 4,4'-di(styryl)-2,2'-bipyridine ligands.

Autori: Robin Vinck; Johannes Karges; Mickaël Tharaud; Kevin Cariou; Gilles Gasser
Pubblicato in: Dalton Transaction, Numero 1, 2021, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/d1dt02083h

Highly cytotoxic copper(II) terpyridine complexes as anticancer drug candidates

Autori: Johannes Karges, Kai Xiong, Olivier Blacque, Hui Chao, Gilles Gasser
Pubblicato in: Inorganica Chimica Acta, Numero 516, 2021, Pagina/e 120137, ISSN 0020-1693
Editore: Elsevier BV
DOI: 10.1016/j.ica.2020.120137

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