Role of Tumour Suppressor Gene Products of Common Fragile Sites in Human Diseases

Project Information

TSGPs-of-CFSs

Grant agreement ID: 682118

DOI 10.3030/682118

Project closed

EC signature date 23 April 2016

Start date 1 May 2016

End date 31 October 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

THE HEBREW UNIVERSITY OF JERUSALEM
Israel

Publications

Peer reviewed articles (22)

Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects

Author(s): Srinivasarao Repudi, Daniel J Steinberg, Nimrod Elazar 2, Vanessa L Breton 3, Mark S Aquilino 3, Afifa Saleem 3, Sara Abu-Swai 1, Anna Vainshtein 2, Yael Eshed-Eisenbach 2, Bharath Vijayaragavan 2, Oded Behar 4, Jacob J Hanna 5, Elior Peles 2, Peter L Carlen 3, Rami I Aqeilan 1
Published in: Brain, Issue 12, 2021, Page(s) 3061-3077, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awab174

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis

Author(s): Saleh Khawaled, Giovanni Nigita, Rosario Distefano, Sara Oster, Sung-Suk Suh, Yoav Smith, Abed Khalaileh, Yong Peng, Carlo M. Croce, Tamar Geiger, Victoria L. Seewaldt, Rami I. Aqeilan
Published in: Signal Transduction and Targeted Therapy, Issue 5/1, 2020, ISSN 2059-3635
Publisher: Springer Nature
DOI: 10.1038/s41392-020-0136-8

Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids-A New Method to Characterize the Metabolism of Brain Organoids?

Author(s): Gal Sapir, Daniel J Steinberg, Rami I Aqeilan, Rachel Katz-Brull
Published in: Pharmaceuticals (Basel), Issue 12, 2021, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14090878

Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes

Author(s): Srinivasarao Repudi, Irina Kustanovich, Sara Abu-Swai, Shani Stern, Rami I Aqeilan
Published in: EMBO Molecular Medicine, Issue 12, 2020, ISSN 1757-4684
Publisher: EMBO press
DOI: 10.15252/emmm.202114599

Modeling genetic epileptic encephalopathies using brain organoids

Author(s): Daniel J Steinberg, Srinivasarao Repudi, Afifa Saleem, Irina Kustanovich, Sergey Viukov, Baraa Abudiab, Ehud Banne, Muhammad Mahajnah, Jacob H Hanna, Shani Stern, Peter L Carlen, Rami I Aqeilan
Published in: EMBO Molecular Medicine, Issue 12, 2021, ISSN 1757-4684
Publisher: EMBO press
DOI: 10.15252/emmm.202013610

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Author(s): Vanessa L Breton, Mark S Aquilino, Srinivasarao Repudi, Afifa Saleem, Shanthini Mylvaganam, Sara Abu-Swai, Berj L Bardakjian, Rami I Aqeilan, Peter L Carlen
Published in: Neurobiol of Disease, Issue 12, 2021, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2021.105529

Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States

Author(s): Sara Oster, Rami I. Aqeilan
Published in: Cells, Issue 9/8, 2020, Page(s) 1870, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9081870

RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs

Author(s): Feras E Machour, Enas R Abu-Zhayia, Samah W Awwad, Tirza Bidany-Mizrahi, Stefan Meinke, Laila A Bishara, Florian Heyd, Rami I Aqeilan, Nabieh Ayoub
Published in: Nucleic Acid Research, Issue 12, 2021, ISSN 1362-4962
Publisher: Oxford
DOI: 10.1093/nar/gkab976

Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response

Author(s): Idit Hazan, Thomas G. Hofmann, Rami I. Aqeilan
Published in: PLOS Genetics, Issue 12/12, 2016, Page(s) e1006436, ISSN 1553-7404
Publisher: Plos Genetics
DOI: 10.1371/journal.pgen.1006436

Modeling WWOX Loss of Function in vivo: What Have We Learned?

Author(s): Mayur Tanna, Rami I. Aqeilan
Published in: Frontiers in Oncology, Issue 8, 2018, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00420

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer

Author(s): Suhaib K. Abdeen, Uri Ben-David, Aya Shweiki, Bella Maly, Rami I. Aqeilan
Published in: Cell Death & Disease, Issue 9/8, 2018, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-018-0896-z

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia

Author(s): Muhannad Abu-Remaileh, Abed Khalaileh, Eli Pikarsky, Rami I. Aqeilan
Published in: Cell Death & Disease, Issue 9/5, 2018, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-018-0510-4

WWOX Inhibits Metastasis of Triple-Negative Breast Cancer Cells via Modulation of miRNAs

Author(s): Saleh Khawaled, Sung Suk Suh, Suhaib K. Abdeen, Jonathan Monin, Rosario Distefano, Giovanni Nigita, Carlo M. Croce, Rami I. Aqeilan
Published in: Cancer Research, Issue 79/8, 2019, Page(s) 1784-1798, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-18-0614

Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells

Author(s): Teresa Druck, Douglas G. Cheung, Dongju Park, Francesco Trapasso, Flavia Pichiorri, Marco Gaspari, Tiziana Palumbo, Rami I. Aqeilan, Eugenio Gaudio, Hiroshi Okumura, Rodolfo Iuliano, Cinzia Raso, Kari Green, Kay Huebner, Carlo M. Croce
Published in: Cell Death & Disease, Issue 10/3, 2019, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-019-1414-7

WWOX somatic ablation in skeletal muscles alters glucose metabolism

Author(s): Muhannad Abu-Remaileh, Monther Abu-Remaileh, Rania Akkawi, Ibrahim Knani, Shiran Udi, Micheal E. Pacold, Joseph Tam, Rami I. Aqeilan
Published in: Molecular Metabolism, Issue 22, 2019, Page(s) 132-140, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.01.010

Decoding the link between WWOX and p53 in aggressive breast cancer

Author(s): Suhaib K. Abdeen, Rami I. Aqeilan
Published in: Cell Cycle, Issue 18/11, 2019, Page(s) 1177-1186, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2019.1616998

WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives

Author(s): Daniel J Steinberg, Rami I Aqeilan
Published in: Cells, Issue 12, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10113082

Neurological Disorders Associated with WWOX Germline Mutations-A Comprehensive Overview

Author(s): Ehud Banne, Baraa Abudiab, Sara Abu-Swai, Srinivasa Rao Repudi, Daniel J Steinberg, Diala Shatleh, Sarah Alshammery, Leszek Lisowski, Wendy Gold, Peter L Carlen, Rami I Aqeilan
Published in: Cells, Issue 12, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10040824

Mapping the breakome reveals tight regulation on oncogenic super-enhancers

Author(s): Sara Oster, Rami I. Aqeilan
Published in: Molecular & Cellular Oncology, Issue 7/3, 2020, Page(s) 1698933, ISSN 2372-3556
Publisher: Taylor & Francis Online
DOI: 10.1080/23723556.2019.1698933

Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51

Author(s): Idit Hazan, Jonathan Monin, Britta A.M. Bouwman, Nicola Crosetto, Rami I. Aqeilan
Published in: Cell Reports, Issue 29/3, 2019, Page(s) 560-572.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.09.001

Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders

Author(s): Nan-Shan Chang, Rongtuan Lin, Chun-I Sze, Rami I. Aqeilan
Published in: Frontiers in Oncology, Issue 9, 2019, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00719

Engineering organoids: a promising platform to understand biology and treat diseases

Author(s): Rami I. Aqeilan
Published in: Cell Death & Differentiation, 2021, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-020-00680-0