Role of Tumour Suppressor Gene Products of Common Fragile Sites in Human Diseases

Información del proyecto

TSGPs-of-CFSs

Identificador del acuerdo de subvención: 682118

DOI 10.3030/682118

Proyecto cerrado

Fecha de la firma de la CE 23 Abril 2016

Fecha de inicio 1 Mayo 2016

Fecha de finalización 31 Octubre 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 2 000 000,00

Aportación de la UE € 2 000 000,00

Coordinado por

THE HEBREW UNIVERSITY OF JERUSALEM
Israel

Publicaciones

Peer reviewed articles (22)

Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects

Autores: Srinivasarao Repudi, Daniel J Steinberg, Nimrod Elazar 2, Vanessa L Breton 3, Mark S Aquilino 3, Afifa Saleem 3, Sara Abu-Swai 1, Anna Vainshtein 2, Yael Eshed-Eisenbach 2, Bharath Vijayaragavan 2, Oded Behar 4, Jacob J Hanna 5, Elior Peles 2, Peter L Carlen 3, Rami I Aqeilan 1
Publicado en: Brain, Edición 12, 2021, Página(s) 3061-3077, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awab174

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis

Autores: Saleh Khawaled, Giovanni Nigita, Rosario Distefano, Sara Oster, Sung-Suk Suh, Yoav Smith, Abed Khalaileh, Yong Peng, Carlo M. Croce, Tamar Geiger, Victoria L. Seewaldt, Rami I. Aqeilan
Publicado en: Signal Transduction and Targeted Therapy, Edición 5/1, 2020, ISSN 2059-3635
Editor: Springer Nature
DOI: 10.1038/s41392-020-0136-8

Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids-A New Method to Characterize the Metabolism of Brain Organoids?

Autores: Gal Sapir, Daniel J Steinberg, Rami I Aqeilan, Rachel Katz-Brull
Publicado en: Pharmaceuticals (Basel), Edición 12, 2021, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14090878

Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes

Autores: Srinivasarao Repudi, Irina Kustanovich, Sara Abu-Swai, Shani Stern, Rami I Aqeilan
Publicado en: EMBO Molecular Medicine, Edición 12, 2020, ISSN 1757-4684
Editor: EMBO press
DOI: 10.15252/emmm.202114599

Modeling genetic epileptic encephalopathies using brain organoids

Autores: Daniel J Steinberg, Srinivasarao Repudi, Afifa Saleem, Irina Kustanovich, Sergey Viukov, Baraa Abudiab, Ehud Banne, Muhammad Mahajnah, Jacob H Hanna, Shani Stern, Peter L Carlen, Rami I Aqeilan
Publicado en: EMBO Molecular Medicine, Edición 12, 2021, ISSN 1757-4684
Editor: EMBO press
DOI: 10.15252/emmm.202013610

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Autores: Vanessa L Breton, Mark S Aquilino, Srinivasarao Repudi, Afifa Saleem, Shanthini Mylvaganam, Sara Abu-Swai, Berj L Bardakjian, Rami I Aqeilan, Peter L Carlen
Publicado en: Neurobiol of Disease, Edición 12, 2021, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2021.105529

Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States

Autores: Sara Oster, Rami I. Aqeilan
Publicado en: Cells, Edición 9/8, 2020, Página(s) 1870, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9081870

RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs

Autores: Feras E Machour, Enas R Abu-Zhayia, Samah W Awwad, Tirza Bidany-Mizrahi, Stefan Meinke, Laila A Bishara, Florian Heyd, Rami I Aqeilan, Nabieh Ayoub
Publicado en: Nucleic Acid Research, Edición 12, 2021, ISSN 1362-4962
Editor: Oxford
DOI: 10.1093/nar/gkab976

Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response

Autores: Idit Hazan, Thomas G. Hofmann, Rami I. Aqeilan
Publicado en: PLOS Genetics, Edición 12/12, 2016, Página(s) e1006436, ISSN 1553-7404
Editor: Plos Genetics
DOI: 10.1371/journal.pgen.1006436

Modeling WWOX Loss of Function in vivo: What Have We Learned?

Autores: Mayur Tanna, Rami I. Aqeilan
Publicado en: Frontiers in Oncology, Edición 8, 2018, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00420

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer

Autores: Suhaib K. Abdeen, Uri Ben-David, Aya Shweiki, Bella Maly, Rami I. Aqeilan
Publicado en: Cell Death & Disease, Edición 9/8, 2018, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-018-0896-z

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia

Autores: Muhannad Abu-Remaileh, Abed Khalaileh, Eli Pikarsky, Rami I. Aqeilan
Publicado en: Cell Death & Disease, Edición 9/5, 2018, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-018-0510-4

WWOX Inhibits Metastasis of Triple-Negative Breast Cancer Cells via Modulation of miRNAs

Autores: Saleh Khawaled, Sung Suk Suh, Suhaib K. Abdeen, Jonathan Monin, Rosario Distefano, Giovanni Nigita, Carlo M. Croce, Rami I. Aqeilan
Publicado en: Cancer Research, Edición 79/8, 2019, Página(s) 1784-1798, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-18-0614

Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells

Autores: Teresa Druck, Douglas G. Cheung, Dongju Park, Francesco Trapasso, Flavia Pichiorri, Marco Gaspari, Tiziana Palumbo, Rami I. Aqeilan, Eugenio Gaudio, Hiroshi Okumura, Rodolfo Iuliano, Cinzia Raso, Kari Green, Kay Huebner, Carlo M. Croce
Publicado en: Cell Death & Disease, Edición 10/3, 2019, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-019-1414-7

WWOX somatic ablation in skeletal muscles alters glucose metabolism

Autores: Muhannad Abu-Remaileh, Monther Abu-Remaileh, Rania Akkawi, Ibrahim Knani, Shiran Udi, Micheal E. Pacold, Joseph Tam, Rami I. Aqeilan
Publicado en: Molecular Metabolism, Edición 22, 2019, Página(s) 132-140, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.01.010

Decoding the link between WWOX and p53 in aggressive breast cancer

Autores: Suhaib K. Abdeen, Rami I. Aqeilan
Publicado en: Cell Cycle, Edición 18/11, 2019, Página(s) 1177-1186, ISSN 1538-4101
Editor: Landes Bioscience
DOI: 10.1080/15384101.2019.1616998

WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives

Autores: Daniel J Steinberg, Rami I Aqeilan
Publicado en: Cells, Edición 12, 2021, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10113082

Neurological Disorders Associated with WWOX Germline Mutations-A Comprehensive Overview

Autores: Ehud Banne, Baraa Abudiab, Sara Abu-Swai, Srinivasa Rao Repudi, Daniel J Steinberg, Diala Shatleh, Sarah Alshammery, Leszek Lisowski, Wendy Gold, Peter L Carlen, Rami I Aqeilan
Publicado en: Cells, Edición 12, 2021, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10040824

Mapping the breakome reveals tight regulation on oncogenic super-enhancers

Autores: Sara Oster, Rami I. Aqeilan
Publicado en: Molecular & Cellular Oncology, Edición 7/3, 2020, Página(s) 1698933, ISSN 2372-3556
Editor: Taylor & Francis Online
DOI: 10.1080/23723556.2019.1698933

Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51

Autores: Idit Hazan, Jonathan Monin, Britta A.M. Bouwman, Nicola Crosetto, Rami I. Aqeilan
Publicado en: Cell Reports, Edición 29/3, 2019, Página(s) 560-572.e4, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.09.001

Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders

Autores: Nan-Shan Chang, Rongtuan Lin, Chun-I Sze, Rami I. Aqeilan
Publicado en: Frontiers in Oncology, Edición 9, 2019, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00719

Engineering organoids: a promising platform to understand biology and treat diseases

Autores: Rami I. Aqeilan
Publicado en: Cell Death & Differentiation, 2021, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-020-00680-0