Role of Tumour Suppressor Gene Products of Common Fragile Sites in Human Diseases

Informazioni relative al progetto

TSGPs-of-CFSs

ID dell’accordo di sovvenzione: 682118

DOI 10.3030/682118

Progetto chiuso

Data della firma CE 23 Aprile 2016

Data di avvio 1 Maggio 2016

Data di completamento 31 Ottobre 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 000 000,00

Contributo UE € 2 000 000,00

Coordinato da

THE HEBREW UNIVERSITY OF JERUSALEM
Israel

Pubblicazioni

Peer reviewed articles (22)

Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects

Autori: Srinivasarao Repudi, Daniel J Steinberg, Nimrod Elazar 2, Vanessa L Breton 3, Mark S Aquilino 3, Afifa Saleem 3, Sara Abu-Swai 1, Anna Vainshtein 2, Yael Eshed-Eisenbach 2, Bharath Vijayaragavan 2, Oded Behar 4, Jacob J Hanna 5, Elior Peles 2, Peter L Carlen 3, Rami I Aqeilan 1
Pubblicato in: Brain, Numero 12, 2021, Pagina/e 3061-3077, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awab174

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis

Autori: Saleh Khawaled, Giovanni Nigita, Rosario Distefano, Sara Oster, Sung-Suk Suh, Yoav Smith, Abed Khalaileh, Yong Peng, Carlo M. Croce, Tamar Geiger, Victoria L. Seewaldt, Rami I. Aqeilan
Pubblicato in: Signal Transduction and Targeted Therapy, Numero 5/1, 2020, ISSN 2059-3635
Editore: Springer Nature
DOI: 10.1038/s41392-020-0136-8

Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids-A New Method to Characterize the Metabolism of Brain Organoids?

Autori: Gal Sapir, Daniel J Steinberg, Rami I Aqeilan, Rachel Katz-Brull
Pubblicato in: Pharmaceuticals (Basel), Numero 12, 2021, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14090878

Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes

Autori: Srinivasarao Repudi, Irina Kustanovich, Sara Abu-Swai, Shani Stern, Rami I Aqeilan
Pubblicato in: EMBO Molecular Medicine, Numero 12, 2020, ISSN 1757-4684
Editore: EMBO press
DOI: 10.15252/emmm.202114599

Modeling genetic epileptic encephalopathies using brain organoids

Autori: Daniel J Steinberg, Srinivasarao Repudi, Afifa Saleem, Irina Kustanovich, Sergey Viukov, Baraa Abudiab, Ehud Banne, Muhammad Mahajnah, Jacob H Hanna, Shani Stern, Peter L Carlen, Rami I Aqeilan
Pubblicato in: EMBO Molecular Medicine, Numero 12, 2021, ISSN 1757-4684
Editore: EMBO press
DOI: 10.15252/emmm.202013610

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Autori: Vanessa L Breton, Mark S Aquilino, Srinivasarao Repudi, Afifa Saleem, Shanthini Mylvaganam, Sara Abu-Swai, Berj L Bardakjian, Rami I Aqeilan, Peter L Carlen
Pubblicato in: Neurobiol of Disease, Numero 12, 2021, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2021.105529

Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States

Autori: Sara Oster, Rami I. Aqeilan
Pubblicato in: Cells, Numero 9/8, 2020, Pagina/e 1870, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9081870

RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs

Autori: Feras E Machour, Enas R Abu-Zhayia, Samah W Awwad, Tirza Bidany-Mizrahi, Stefan Meinke, Laila A Bishara, Florian Heyd, Rami I Aqeilan, Nabieh Ayoub
Pubblicato in: Nucleic Acid Research, Numero 12, 2021, ISSN 1362-4962
Editore: Oxford
DOI: 10.1093/nar/gkab976

Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response

Autori: Idit Hazan, Thomas G. Hofmann, Rami I. Aqeilan
Pubblicato in: PLOS Genetics, Numero 12/12, 2016, Pagina/e e1006436, ISSN 1553-7404
Editore: Plos Genetics
DOI: 10.1371/journal.pgen.1006436

Modeling WWOX Loss of Function in vivo: What Have We Learned?

Autori: Mayur Tanna, Rami I. Aqeilan
Pubblicato in: Frontiers in Oncology, Numero 8, 2018, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00420

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer

Autori: Suhaib K. Abdeen, Uri Ben-David, Aya Shweiki, Bella Maly, Rami I. Aqeilan
Pubblicato in: Cell Death & Disease, Numero 9/8, 2018, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-0896-z

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia

Autori: Muhannad Abu-Remaileh, Abed Khalaileh, Eli Pikarsky, Rami I. Aqeilan
Pubblicato in: Cell Death & Disease, Numero 9/5, 2018, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-0510-4

WWOX Inhibits Metastasis of Triple-Negative Breast Cancer Cells via Modulation of miRNAs

Autori: Saleh Khawaled, Sung Suk Suh, Suhaib K. Abdeen, Jonathan Monin, Rosario Distefano, Giovanni Nigita, Carlo M. Croce, Rami I. Aqeilan
Pubblicato in: Cancer Research, Numero 79/8, 2019, Pagina/e 1784-1798, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-18-0614

Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells

Autori: Teresa Druck, Douglas G. Cheung, Dongju Park, Francesco Trapasso, Flavia Pichiorri, Marco Gaspari, Tiziana Palumbo, Rami I. Aqeilan, Eugenio Gaudio, Hiroshi Okumura, Rodolfo Iuliano, Cinzia Raso, Kari Green, Kay Huebner, Carlo M. Croce
Pubblicato in: Cell Death & Disease, Numero 10/3, 2019, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-019-1414-7

WWOX somatic ablation in skeletal muscles alters glucose metabolism

Autori: Muhannad Abu-Remaileh, Monther Abu-Remaileh, Rania Akkawi, Ibrahim Knani, Shiran Udi, Micheal E. Pacold, Joseph Tam, Rami I. Aqeilan
Pubblicato in: Molecular Metabolism, Numero 22, 2019, Pagina/e 132-140, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.01.010

Decoding the link between WWOX and p53 in aggressive breast cancer

Autori: Suhaib K. Abdeen, Rami I. Aqeilan
Pubblicato in: Cell Cycle, Numero 18/11, 2019, Pagina/e 1177-1186, ISSN 1538-4101
Editore: Landes Bioscience
DOI: 10.1080/15384101.2019.1616998

WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives

Autori: Daniel J Steinberg, Rami I Aqeilan
Pubblicato in: Cells, Numero 12, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10113082

Neurological Disorders Associated with WWOX Germline Mutations-A Comprehensive Overview

Autori: Ehud Banne, Baraa Abudiab, Sara Abu-Swai, Srinivasa Rao Repudi, Daniel J Steinberg, Diala Shatleh, Sarah Alshammery, Leszek Lisowski, Wendy Gold, Peter L Carlen, Rami I Aqeilan
Pubblicato in: Cells, Numero 12, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10040824

Mapping the breakome reveals tight regulation on oncogenic super-enhancers

Autori: Sara Oster, Rami I. Aqeilan
Pubblicato in: Molecular & Cellular Oncology, Numero 7/3, 2020, Pagina/e 1698933, ISSN 2372-3556
Editore: Taylor & Francis Online
DOI: 10.1080/23723556.2019.1698933

Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51

Autori: Idit Hazan, Jonathan Monin, Britta A.M. Bouwman, Nicola Crosetto, Rami I. Aqeilan
Pubblicato in: Cell Reports, Numero 29/3, 2019, Pagina/e 560-572.e4, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.09.001

Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders

Autori: Nan-Shan Chang, Rongtuan Lin, Chun-I Sze, Rami I. Aqeilan
Pubblicato in: Frontiers in Oncology, Numero 9, 2019, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00719

Engineering organoids: a promising platform to understand biology and treat diseases

Autori: Rami I. Aqeilan
Pubblicato in: Cell Death & Differentiation, 2021, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-020-00680-0