Targeting common oncogenes with intracellular monobodies

Project Information

ONCOINTRABODY

Grant agreement ID: 682311

DOI 10.3030/682311

Project closed

EC signature date 18 April 2016

Start date 1 August 2016

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 996 055,00

EU contribution € 1 996 055,00

Coordinated by

PHILIPPS UNIVERSITAET MARBURG
Germany

Publications

Peer reviewed articles (9)

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Author(s): Georgios N. Hatzopoulos, Tim Kükenshöner, Niccolò Banterle, Tatiana Favez, Isabelle Flückiger, Virginie Hamel, Santiago Andany, Georg E. Fantner, Oliver Hantschel, Pierre Gönczy
Published in: Nature Communications, Issue 12/1, 2021, Page(s) 3805, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23897-0

Synthesis of the <scp>l</scp>- and <scp>d</scp>-SH2 domain of the leukaemia oncogene Bcr-Abl

Author(s): Nina Schmidt; Frank Abendroth; Olalla Vázquez; Oliver Hantschel
Published in: RSC Chemical Biology, Issue 3(8), 2022, Page(s) 1008-1012, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cb00108j

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Author(s): Grégory La Sala, Camille Michiels, Tim Kükenshöner, Tania Brandstoetter, Barbara Maurer, Akiko Koide, Kelvin Lau, Florence Pojer, Shohei Koide, Veronika Sexl, Laure Dumoutier, Oliver Hantschel
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17920-z

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Author(s): Tim Kükenshöner, Nadine Eliane Schmit, Emilie Bouda, Fern Sha, Florence Pojer, Akiko Koide, Markus Seeliger, Shohei Koide, Oliver Hantschel
Published in: Journal of Molecular Biology, Issue 429/9, 2017, Page(s) 1364-1380, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2017.03.023

Monobodies as possible next-generation protein therapeutics – a perspective

Author(s): Hantschel, Oliver
Published in: Swiss Medical Weekly, Issue 147/4748, 2017, ISSN 1424-7860
Publisher: EMH Swiss Medical Publishers Ltd
DOI: 10.4414/smw.2017.14545

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

Author(s): Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02313-6

Monobodies as enabling tools for structural and mechanistic biology

Author(s): Oliver Hantschel, Matthew Biancalana, Shohei Koide
Published in: Current Opinion in Structural Biology, Issue 60, 2020, Page(s) 167-174, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.01.015

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

Author(s): Nadine Eliane Schmit, Katyayanee Neopane, Oliver Hantschel
Published in: ACS Chemical Biology, Issue 14/5, 2019, Page(s) 916-924, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.9b00113

Improving the pharmacokinetics, biodistribution and plasma stability of monobodies

Author(s): Adrian Valentin Dinh-Fricke, Oliver Hantschel
Published in: Frontiers in Pharmacology, Issue 15, 2024, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1393112