Targeting common oncogenes with intracellular monobodies

Publicaciones

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Autores: Georgios N. Hatzopoulos, Tim Kükenshöner, Niccolò Banterle, Tatiana Favez, Isabelle Flückiger, Virginie Hamel, Santiago Andany, Georg E. Fantner, Oliver Hantschel, Pierre Gönczy
Publicado en: Nature Communications, Edición 12/1, 2021, Página(s) 3805, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-23897-0

Synthesis of the <scp>l</scp>- and <scp>d</scp>-SH2 domain of the leukaemia oncogene Bcr-Abl

Autores: Nina Schmidt; Frank Abendroth; Olalla Vázquez; Oliver Hantschel
Publicado en: RSC Chemical Biology, Edición 3(8), 2022, Página(s) 1008-1012, ISSN 2633-0679
Editor: Royal Society of Chemistry
DOI: 10.1039/d2cb00108j

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Autores: Grégory La Sala, Camille Michiels, Tim Kükenshöner, Tania Brandstoetter, Barbara Maurer, Akiko Koide, Kelvin Lau, Florence Pojer, Shohei Koide, Veronika Sexl, Laure Dumoutier, Oliver Hantschel
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17920-z

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Autores: Tim Kükenshöner, Nadine Eliane Schmit, Emilie Bouda, Fern Sha, Florence Pojer, Akiko Koide, Markus Seeliger, Shohei Koide, Oliver Hantschel
Publicado en: Journal of Molecular Biology, Edición 429/9, 2017, Página(s) 1364-1380, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2017.03.023

Monobodies as possible next-generation protein therapeutics – a perspective

Autores: Hantschel, Oliver
Publicado en: Swiss Medical Weekly, Edición 147/4748, 2017, ISSN 1424-7860
Editor: EMH Swiss Medical Publishers Ltd
DOI: 10.4414/smw.2017.14545

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

Autores: Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02313-6

Monobodies as enabling tools for structural and mechanistic biology

Autores: Oliver Hantschel, Matthew Biancalana, Shohei Koide
Publicado en: Current Opinion in Structural Biology, Edición 60, 2020, Página(s) 167-174, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2020.01.015

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

Autores: Nadine Eliane Schmit, Katyayanee Neopane, Oliver Hantschel
Publicado en: ACS Chemical Biology, Edición 14/5, 2019, Página(s) 916-924, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.9b00113

Improving the pharmacokinetics, biodistribution and plasma stability of monobodies

Autores: Adrian Valentin Dinh-Fricke, Oliver Hantschel
Publicado en: Frontiers in Pharmacology, Edición 15, 2024, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1393112

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