Targeting common oncogenes with intracellular monobodies

Publikacje

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Autorzy: Georgios N. Hatzopoulos, Tim Kükenshöner, Niccolò Banterle, Tatiana Favez, Isabelle Flückiger, Virginie Hamel, Santiago Andany, Georg E. Fantner, Oliver Hantschel, Pierre Gönczy
Opublikowane w: Nature Communications, Numer 12/1, 2021, Strona(/y) 3805, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23897-0

Synthesis of the <scp>l</scp>- and <scp>d</scp>-SH2 domain of the leukaemia oncogene Bcr-Abl

Autorzy: Nina Schmidt; Frank Abendroth; Olalla Vázquez; Oliver Hantschel
Opublikowane w: RSC Chemical Biology, Numer 3(8), 2022, Strona(/y) 1008-1012, ISSN 2633-0679
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2cb00108j

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Autorzy: Grégory La Sala, Camille Michiels, Tim Kükenshöner, Tania Brandstoetter, Barbara Maurer, Akiko Koide, Kelvin Lau, Florence Pojer, Shohei Koide, Veronika Sexl, Laure Dumoutier, Oliver Hantschel
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-17920-z

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Autorzy: Tim Kükenshöner, Nadine Eliane Schmit, Emilie Bouda, Fern Sha, Florence Pojer, Akiko Koide, Markus Seeliger, Shohei Koide, Oliver Hantschel
Opublikowane w: Journal of Molecular Biology, Numer 429/9, 2017, Strona(/y) 1364-1380, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/j.jmb.2017.03.023

Monobodies as possible next-generation protein therapeutics – a perspective

Autorzy: Hantschel, Oliver
Opublikowane w: Swiss Medical Weekly, Numer 147/4748, 2017, ISSN 1424-7860
Wydawca: EMH Swiss Medical Publishers Ltd
DOI: 10.4414/smw.2017.14545

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

Autorzy: Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Opublikowane w: Nature Communications, Numer 8/1, 2017, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-02313-6

Monobodies as enabling tools for structural and mechanistic biology

Autorzy: Oliver Hantschel, Matthew Biancalana, Shohei Koide
Opublikowane w: Current Opinion in Structural Biology, Numer 60, 2020, Strona(/y) 167-174, ISSN 0959-440X
Wydawca: Elsevier BV
DOI: 10.1016/j.sbi.2020.01.015

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

Autorzy: Nadine Eliane Schmit, Katyayanee Neopane, Oliver Hantschel
Opublikowane w: ACS Chemical Biology, Numer 14/5, 2019, Strona(/y) 916-924, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.9b00113

Improving the pharmacokinetics, biodistribution and plasma stability of monobodies

Autorzy: Adrian Valentin Dinh-Fricke, Oliver Hantschel
Opublikowane w: Frontiers in Pharmacology, Numer 15, 2024, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1393112

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