Targeting common oncogenes with intracellular monobodies

Informazioni relative al progetto

ONCOINTRABODY

ID dell’accordo di sovvenzione: 682311

DOI 10.3030/682311

Progetto chiuso

Data della firma CE 18 Aprile 2016

Data di avvio 1 Agosto 2016

Data di completamento 31 Dicembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 996 055,00

Contributo UE € 1 996 055,00

Coordinato da

PHILIPPS UNIVERSITAET MARBURG
Germany

Pubblicazioni

Peer reviewed articles (9)

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Autori: Georgios N. Hatzopoulos, Tim Kükenshöner, Niccolò Banterle, Tatiana Favez, Isabelle Flückiger, Virginie Hamel, Santiago Andany, Georg E. Fantner, Oliver Hantschel, Pierre Gönczy
Pubblicato in: Nature Communications, Numero 12/1, 2021, Pagina/e 3805, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23897-0

Synthesis of the <scp>l</scp>- and <scp>d</scp>-SH2 domain of the leukaemia oncogene Bcr-Abl

Autori: Nina Schmidt; Frank Abendroth; Olalla Vázquez; Oliver Hantschel
Pubblicato in: RSC Chemical Biology, Numero 3(8), 2022, Pagina/e 1008-1012, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d2cb00108j

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Autori: Grégory La Sala, Camille Michiels, Tim Kükenshöner, Tania Brandstoetter, Barbara Maurer, Akiko Koide, Kelvin Lau, Florence Pojer, Shohei Koide, Veronika Sexl, Laure Dumoutier, Oliver Hantschel
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17920-z

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Autori: Tim Kükenshöner, Nadine Eliane Schmit, Emilie Bouda, Fern Sha, Florence Pojer, Akiko Koide, Markus Seeliger, Shohei Koide, Oliver Hantschel
Pubblicato in: Journal of Molecular Biology, Numero 429/9, 2017, Pagina/e 1364-1380, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2017.03.023

Monobodies as possible next-generation protein therapeutics – a perspective

Autori: Hantschel, Oliver
Pubblicato in: Swiss Medical Weekly, Numero 147/4748, 2017, ISSN 1424-7860
Editore: EMH Swiss Medical Publishers Ltd
DOI: 10.4414/smw.2017.14545

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

Autori: Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02313-6

Monobodies as enabling tools for structural and mechanistic biology

Autori: Oliver Hantschel, Matthew Biancalana, Shohei Koide
Pubblicato in: Current Opinion in Structural Biology, Numero 60, 2020, Pagina/e 167-174, ISSN 0959-440X
Editore: Elsevier BV
DOI: 10.1016/j.sbi.2020.01.015

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

Autori: Nadine Eliane Schmit, Katyayanee Neopane, Oliver Hantschel
Pubblicato in: ACS Chemical Biology, Numero 14/5, 2019, Pagina/e 916-924, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.9b00113

Improving the pharmacokinetics, biodistribution and plasma stability of monobodies

Autori: Adrian Valentin Dinh-Fricke, Oliver Hantschel
Pubblicato in: Frontiers in Pharmacology, Numero 15, 2024, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1393112