Objective FOLSMART will bring to phase I clinical trials novel folate-based nanodevices (FBN) for the treatment of rheumatoid arthritis (RA). These nanodevices for folic acid (FA)-mediated targeting of activated macrophages showed improved clinical scores in a mouse model of RA when compared to methotrexate (MTX), first-line drug therapy for the treatment of RA. In this way, FBN will be benchmarked against this drug. MTX has significant associated toxicity and second-line biological therapies pose a great economic burden to hospital/public health systems. In parallel, nanodevices encapsulating Sulfasalazine (SSZ), will be tested. SSZ is a second line indication for the treatment of RA, unresponsive to MTX or MTX–intolerant patients. Furthermore, FOLSMART proposes the optimization of mechanisms for the release of the drugs, through pH and temperature-sensitive nanodevices. Exploitation and business plans will be elaborated. In parallel, the initial economic evaluation of all proposed treatments will be performed to validate these claims.Specific technological objectives of FOLSMART will be:Good Manufacturing Practice (GMP) production of the FBN based therapies which have been positively bench-marked in the previous FP7 European project NANOFOL in comparison with the use of MTX in a RA mouse model: -Liposomal MTX and SSZ with FA-“neck domain” peptide as targeting agent-Nanoparticles from HSA-FA/MTX conjugates and SSZ-Optimization of mechanisms of drug release and application to other fieldsPre-clinical development on RA models:-Toxicology and pharmacokinetics, to determine tolerability and efficacy benefit in two animal models rat and dog, under Good Laboratory Practice (GLP) standards-Genotoxicity and CarcinogenicityPreparation for Phase I clinical trial of the best therapies bench marketed against MTX:-Nanodevices with MTX and SSZ will offer improved tolerance and greater efficacy meaning that patients who do not do well on MTX will have cost-effective alternatives Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicinerheumatologymedical and health sciencesbasic medicinepharmacology and pharmacypharmacokineticsmedical and health sciencesbasic medicineimmunologyimmunotherapymedical and health sciencesbasic medicinetoxicology Programme(s) H2020-EU.2.1.2. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies Main Programme H2020-EU.2.1.2.2. - Ensuring the safe and sustainable development and application of nanotechnologies H2020-EU.2.1.2.5. - Developing and standardisation of capacity-enhancing techniques, measuring methods and equipment H2020-EU.2.1.2.3. - Developing the societal dimension of nanotechnology Topic(s) NMP-06-2015 - Novel nanomatrices and nanocapsules Call for proposal H2020-NMP-2014-2015 See other projects for this call Sub call H2020-NMP-PILOTS-2015 Funding Scheme RIA - Research and Innovation action Coordinator ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO Net EU contribution € 1 130 037,70 Address Campus de azurem universidade do minho 4800 058 Guimaraes Portugal See on map Region Continente Norte Ave Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all SYNOVO GMBH Germany Net EU contribution € 296 087,50 Address Paul ehrlich str 15 72076 Tuebingen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAET FUER BODENKULTUR WIEN Austria Net EU contribution € 395 643,75 Address Gregor mendel strasse 33 1180 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BLUECLINICAL - INVESTIGACAO E DESENVOLVIMENTO EM SAUDE LDA Portugal Net EU contribution € 442 853,30 Address Avenida villagarcia de arosa 1919 1 4460 439 Motosinhos See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MEDIZINISCHE UNIVERSITAET WIEN Austria Net EU contribution € 400 597,50 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 484 487,50 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Portugal Net EU contribution € 432 911,25 Address Rua alfredo allen 208 4200 135 Porto See on map Region Continente Norte Área Metropolitana do Porto Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Participation ended Germany Net EU contribution € 8 875,00 Address Oskar von miller ring 29 80333 Muenchen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 APTUIT (VERONA) SRL Italy Net EU contribution € 653 240,00 Address Via alessandro fleming 4 37135 Verona See on map Region Nord-Est Veneto Verona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BLUEPHARMA - INDUSTRIA FARMACEUTICASA Portugal Net EU contribution € 343 758,55 Address Sao martinho do bispo 3045 016 Coimbra See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Centro (PT) Região de Coimbra Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SOLFARCOS - SOLUÇÕES FARMACÊUTICAS E COSMÉTICAS LDA Portugal Net EU contribution € 405 341,70 Address Rua quinta dos orfaos bloco a loja 6 4710-453 Braga See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Norte Cávado Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
