Folate-Target Nanodevices To Activated Macrophages For Rheumatoid Arthritis

Project Information

FOLSMART

Grant agreement ID: 683356

DOI 10.3030/683356

Project closed

EC signature date 25 November 2015

Start date 1 January 2016

End date 31 December 2020

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Total cost € 4 993 833,75

EU contribution € 4 993 833,75

Coordinated by

ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (6)

Design of the logo, Launch of website, Twitter, Facebook, LinkedIn, Google Plus
Plan and formal distribution of essential internal procedures and tools
Exploitation activity - yearly report 1 in knowledge subjected of protection
Individualized press release for every partner
Exploitation activity - yearly report 3 in knowledge subjected of protection
Exploitation activity - yearly report 2 in knowledge subjected of protection

Websites, patent fillings, videos etc. (1)

Dissemination plan revised

Publications

Conference proceedings (5)

The role of phagocytic cells in acute respiratory distress syndrome

Author(s): Petre, A., A. Ohradanova-Repic, K. Krenn, R. Ullrich, K. Markstaller, and H. Stockinger
Published in: 5th European congress of immunology Amsterdam 2018 : September 2 - 5 : Abstract Book, 2018, Page(s) 151
Publisher: European Congress of Immunology

The purinergic pathway activated by the proinflammatory stimuli endows M-CSF-dependent folate receptor ß (FRß)+ macrophages with potent immunosuppressive capacity

Author(s): Ohradanova-Repic, A., C. Machacek, C. Charvet, F. Lager, D. Le Roux, R. Platzer, V. Leksa, G. Mitulovic, T. R. Burkard, G. J. Zlabinger, M. B. Fischer, G. Renault, S. Blüml, A. Cavaco-Paulo, J. B. Huppa, G. Bismuth, and H. Stockinger
Published in: Meeting Book of the Annual Meeting of the Austrian Society for Allergology and Immunology 2018, 2018, Page(s) 26
Publisher: Annual Meeting of the Austrian Society for Allergology and Immunology 2018

Folate-targeted liposomes for rheumatoid arthritis therapy

Author(s): Nogueira, Eugénia Sofia Costa; Cavaco-Paulo, Artur
Published in: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, 2018, Page(s) 43
Publisher: The Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)

Effect of sucrose in freeze-dried liposomes encapsulating drugs

Author(s): Diana Guimarães, Eugénia Nogueira, Artur Cavaco-Paulo
Published in: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, 2018, Page(s) 80
Publisher: The Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)

Folic acid-tagged protein nanoemulsions with controllable size for cancer therapy

Author(s): Loureiro, Ana Isabel Sá; Cavaco-Paulo, Artur
Published in: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, Issue 2, 2018, Page(s) 105
Publisher: The Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)

Monographic books (1)

Role of Metabolism in Regulating Immune Cell Fate Decisions

Author(s): Anna Ohradanova-Repic, Marianne Boes, Hannes Stockinger (Eds.)
Published in: Role of Metabolism in Regulating Immune Cell Fate Decisions, 2020, ISBN 9782889637218
Publisher: Frontiers Media
DOI: 10.3389/978-2-88963-721-8

Peer reviewed articles (17)

Quantification of drugs encapsulated in liposomes by 1H NMR

Author(s): Diana Guimarães, Jennifer Noro, Ana Loureiro, Artur Cavaco-Paulo, Eugénia Nogueira
Published in: Colloids and Surfaces B: Biointerfaces, Issue 179, 2019, Page(s) 414-420, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2019.03.039

PTS micelles for the delivery of hydrophobic methotrexate

Author(s): Patrícia Cerqueira, Jennifer Noro, Sofia Moura, Diana Guimarães, Carla Silva, Artur Cavaco-Paulo, Ana Loureiro
Published in: International Journal of Pharmaceutics, Issue 566, 2019, Page(s) 282-290, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2019.05.049

Editorial: Role of Metabolism in Regulating Immune Cell Fate Decisions

Author(s): Anna Ohradanova-Repic; Marianne Boes; Hannes Stockinger
Published in: Frontiers in Immunology, Issue 1, 2019, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.00527

Protective Effect of Saccharides on Freeze-Dried Liposomes Encapsulating Drugs

Author(s): Diana Guimarães, Jennifer Noro, Carla Silva, Artur Cavaco-Paulo, Eugénia Nogueira
Published in: Frontiers in Bioengineering and Biotechnology, Issue 7, 2019, ISSN 2296-4185
Publisher: Frontiers Media
DOI: 10.3389/fbioe.2019.00424

Glutathione from recovered glucose as ingredient in antioxidant nanocapsules for triggered flavor delivery

Author(s): Claudia Tallian, Vanessa Rumpler, Lukas Skopek, Hannes Russmayer, Matthias G. Steiger, Robert Vielnascher, Simone Weinberger, Alessandro Pellis, Sara Vecchiato, Georg M. Guebitz
Published in: Journal of Materials Chemistry B, Issue 7/25, 2019, Page(s) 3958-3969, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9tb00473d

Increased Encapsulation Efficiency of Methotrexate in Liposomes for Rheumatoid Arthritis Therapy

Author(s): Diana Guimarães, Jennifer Noro, Ana Loureiro, Franck Lager, Gilles Renault, Artur Cavaco-Paulo and Eugénia Nogueira
Published in: Biomedicines, 2020, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines8120630

Internalization of Methotrexate Conjugates by Folate Receptor-α

Author(s): Eugénia Nogueira, Marisa P. Sárria, Nuno G. Azoia, Egipto Antunes, Ana Loureiro, Diana Guimarães, Jennifer Noro, Alexandra Rollett, Georg Guebitz, Artur Cavaco-Paulo
Published in: Biochemistry, Issue 57/49, 2018, Page(s) 6780-6786, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.8b00607

Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances

Author(s): Anna Ohradanova-Repic, Christian Machacek, Celine Charvet, Franck Lager, Delphine Le Roux, René Platzer, Vladimir Leksa, Goran Mitulovic, Thomas R. Burkard, Gerhard J. Zlabinger, Michael B. Fischer, Vincent Feuillet, Gilles Renault, Stephan Blüml, Miroslav Benko, Miloslav Suchanek, Johannes B. Huppa, Takami Matsuyama, Artur Cavaco-Paulo, Georges Bismuth, Hannes Stockinger
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.00852

Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis

Author(s): Johannes J. Kovarik, Elisabeth Kernbauer, Markus A. Hölzl, Johannes Hofer, Guido A. Gualdoni, Klaus G. Schmetterer, Fitore Miftari, Yury Sobanov, Anastasia Meshcheryakova, Diana Mechtcheriakova, Nadine Witzeneder, Georg Greiner, Anna Ohradanova-Repic, Petra Waidhofer-Söllner, Marcus D. Säemann, Thomas Decker, Gerhard J. Zlabinger
Published in: PLOS ONE, Issue 12/7, 2017, Page(s) e0180900, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0180900

Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells

Author(s): Anna Ohradanova-Repic, Eugénia Nogueira, Ingrid Hartl, Andreia C. Gomes, Ana Preto, Eva Steinhuber, Vanessa Mühlgrabner, Marko Repic, Mario Kuttke, Alexander Zwirzitz, Marek Prouza, Miloslav Suchanek, Gordana Wozniak-Knopp, Vaclav Horejsi, Gernot Schabbauer, Artur Cavaco-Paulo, Hannes Stockinger
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 14/1, 2018, Page(s) 123-130, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2017.09.003

Starved viable but non-culturable (VBNC) Legionella strains can infect and replicate in amoebae and human macrophages

Author(s): Elisabeth Dietersdorfer, Alexander Kirschner, Barbara Schrammel, Anna Ohradanova-Repic, Hannes Stockinger, Regina Sommer, Julia Walochnik, Sílvia Cervero-Aragó
Published in: Water Research, Issue 141, 2018, Page(s) 428-438, ISSN 0043-1354
Publisher: Elsevier BV
DOI: 10.1016/j.watres.2018.01.058

Lactoferrin is a natural inhibitor of plasminogen activation

Author(s): Alexander Zwirzitz, Michael Reiter, Rostislav Skrabana, Anna Ohradanova-Repic, Otto Majdic, Marianna Gutekova, Ondrej Cehlar, Eva Petrovčíková, Eva Kutejova, Gerold Stanek, Hannes Stockinger, Vladimir Leksa
Published in: Journal of Biological Chemistry, Issue 293/22, 2018, Page(s) 8600-8613, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.003145

Absence of Albumin Improves in Vitro Cellular Uptake and Disruption of Poloxamer 407-Based Nanoparticles inside Cancer Cells

Author(s): Ana Loureiro, Jennifer Noro, Ana S. Abreu, Eugénia Nogueira, Diana Soares da Costa, Carla Silva, Artur Cavaco-Paulo
Published in: Molecular Pharmaceutics, Issue 15/2, 2018, Page(s) 527-535, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.7b00893

Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules

Author(s): Claudia Tallian, Alexandra Herrero-Rollett, Karina Stadler, Robert Vielnascher, Karin Wieland, Anna M. Weihs, Alessandro Pellis, Andreas H. Teuschl, Bernhard Lendl, Heinz Amenitsch, Georg M. Guebitz
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 133, 2018, Page(s) 176-187, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2018.10.002

Dynamic Interaction- and Phospho-Proteomics Reveal Lck as a Major Signaling Hub of CD147 in T Cells

Author(s): Verena Supper, Ingrid Hartl, Cyril Boulègue, Anna Ohradanova-Repic, Hannes Stockinger
Published in: The Journal of Immunology, Issue 198/6, 2017, Page(s) 2468-2478, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1600355

The mannose 6‐phosphate/insulin‐like growth factor 2 receptor mediates plasminogen‐induced efferocytosis

Author(s): Ohradanova‐Repic, Anna; Machacek, Christian; Donner, Clemens; Mühlgrabner, Vanessa; Petrovčíková, Eva; Zahradníková, Alexandra; Vičíková, Kristína; Hořejší, Václav; Stockinger, Hannes; Leksa, Vladimir
Published in: Journal of Leukocyte Biology, Issue 1, 2019, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1002/jlb.1ab0417-160rr

Poloxamer 407 based-nanoparticles for controlled release of methotrexate

Author(s): Sofia Moura, Jennifer Noro, Patrícia Cerqueira, Carla Silva, Artur Cavaco-Paulo, Ana Loureiro
Published in: International Journal of Pharmaceutics, Issue 575, 2020, Page(s) 118924, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2019.118924

Intellectual Property Rights

Patent (1)

METHOD FOR PRODUCTION OF LIPOSOMES

Application/Publication number: 20 20054346
Date: 2020-05-07
Applicant(s): SOLFARCOS - SOLUÇÕES FARMACÊUTICAS E COSMÉTICAS LDA