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Folate-Target Nanodevices To Activated Macrophages For Rheumatoid Arthritis

Deliverables

Design of the logo, Launch of website, Twitter, Facebook, LinkedIn, Google Plus

Design of the logo, Launch of website, Twitter, Facebook, LinkedIn, Google Plus

Plan and formal distribution of essential internal procedures and tools

Plan and formal distribution of essential internal procedures and tools

Exploitation activity - yearly report 1 in knowledge subjected of protection

Exploitation activity - yearly report 1 in knowledge subjected of protection

Individualized press release for every partner

Individualized press release for every partner

Exploitation activity - yearly report 3 in knowledge subjected of protection

Exploitation activity - yearly report 3 in knowledge subjected of protection

Exploitation activity - yearly report 2 in knowledge subjected of protection

Exploitation activity - yearly report 2 in knowledge subjected of protection

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Publications

Ultrasound-assisted biosynthesis of novel methotrexate-conjugates

Author(s): Jennifer Noro, Rui L. Reis, Artur Cavaco-Paulo, Carla Silva
Published in: Ultrasonics Sonochemistry, Issue 48, 2018, Page(s) 51-56, ISSN 1350-4177
DOI: 10.1016/j.ultsonch.2018.05.017

Internalization of Methotrexate Conjugates by Folate Receptor-α

Author(s): Eugénia Nogueira, Marisa P. Sárria, Nuno G. Azoia, Egipto Antunes, Ana Loureiro, Diana Guimarães, Jennifer Noro, Alexandra Rollett, Georg Guebitz, Artur Cavaco-Paulo
Published in: Biochemistry, Issue 57/49, 2018, Page(s) 6780-6786, ISSN 0006-2960
DOI: 10.1021/acs.biochem.8b00607

Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances

Author(s): Anna Ohradanova-Repic, Christian Machacek, Celine Charvet, Franck Lager, Delphine Le Roux, René Platzer, Vladimir Leksa, Goran Mitulovic, Thomas R. Burkard, Gerhard J. Zlabinger, Michael B. Fischer, Vincent Feuillet, Gilles Renault, Stephan Blüml, Miroslav Benko, Miloslav Suchanek, Johannes B. Huppa, Takami Matsuyama, Artur Cavaco-Paulo, Georges Bismuth, Hannes Stockinger
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.00852

Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis

Author(s): Johannes J. Kovarik, Elisabeth Kernbauer, Markus A. Hölzl, Johannes Hofer, Guido A. Gualdoni, Klaus G. Schmetterer, Fitore Miftari, Yury Sobanov, Anastasia Meshcheryakova, Diana Mechtcheriakova, Nadine Witzeneder, Georg Greiner, Anna Ohradanova-Repic, Petra Waidhofer-Söllner, Marcus D. Säemann, Thomas Decker, Gerhard J. Zlabinger
Published in: PLOS ONE, Issue 12/7, 2017, Page(s) e0180900, ISSN 1932-6203
DOI: 10.1371/journal.pone.0180900

Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells

Author(s): Anna Ohradanova-Repic, Eugénia Nogueira, Ingrid Hartl, Andreia C. Gomes, Ana Preto, Eva Steinhuber, Vanessa Mühlgrabner, Marko Repic, Mario Kuttke, Alexander Zwirzitz, Marek Prouza, Miloslav Suchanek, Gordana Wozniak-Knopp, Vaclav Horejsi, Gernot Schabbauer, Artur Cavaco-Paulo, Hannes Stockinger
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 14/1, 2018, Page(s) 123-130, ISSN 1549-9634
DOI: 10.1016/j.nano.2017.09.003

Starved viable but non-culturable (VBNC) Legionella strains can infect and replicate in amoebae and human macrophages

Author(s): Elisabeth Dietersdorfer, Alexander Kirschner, Barbara Schrammel, Anna Ohradanova-Repic, Hannes Stockinger, Regina Sommer, Julia Walochnik, Sílvia Cervero-Aragó
Published in: Water Research, Issue 141, 2018, Page(s) 428-438, ISSN 0043-1354
DOI: 10.1016/j.watres.2018.01.058

Lactoferrin is a natural inhibitor of plasminogen activation

Author(s): Alexander Zwirzitz, Michael Reiter, Rostislav Skrabana, Anna Ohradanova-Repic, Otto Majdic, Marianna Gutekova, Ondrej Cehlar, Eva Petrovčíková, Eva Kutejova, Gerold Stanek, Hannes Stockinger, Vladimir Leksa
Published in: Journal of Biological Chemistry, Issue 293/22, 2018, Page(s) 8600-8613, ISSN 0021-9258
DOI: 10.1074/jbc.ra118.003145

Absence of Albumin Improves in Vitro Cellular Uptake and Disruption of Poloxamer 407-Based Nanoparticles inside Cancer Cells

Author(s): Ana Loureiro, Jennifer Noro, Ana S. Abreu, Eugénia Nogueira, Diana Soares da Costa, Carla Silva, Artur Cavaco-Paulo
Published in: Molecular Pharmaceutics, Issue 15/2, 2018, Page(s) 527-535, ISSN 1543-8384
DOI: 10.1021/acs.molpharmaceut.7b00893

Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules

Author(s): Claudia Tallian, Alexandra Herrero-Rollett, Karina Stadler, Robert Vielnascher, Karin Wieland, Anna M. Weihs, Alessandro Pellis, Andreas H. Teuschl, Bernhard Lendl, Heinz Amenitsch, Georg M. Guebitz
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 133, 2018, Page(s) 176-187, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2018.10.002

Dynamic Interaction- and Phospho-Proteomics Reveal Lck as a Major Signaling Hub of CD147 in T Cells

Author(s): Verena Supper, Ingrid Hartl, Cyril Boulègue, Anna Ohradanova-Repic, Hannes Stockinger
Published in: The Journal of Immunology, Issue 198/6, 2017, Page(s) 2468-2478, ISSN 0022-1767
DOI: 10.4049/jimmunol.1600355

Folate-targeted liposomes for rheumatoid arthritis therapy

Author(s): Nogueira, Eugénia Sofia Costa; Cavaco-Paulo, Artur
Published in: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, 2018, Page(s) 43

Effect of sucrose in freeze-dried liposomes encapsulating drugs

Author(s): Diana Guimarães, Eugénia Nogueira, Artur Cavaco-Paulo
Published in: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, 2018, Page(s) 80

Folic acid-tagged protein nanoemulsions with controllable size for cancer therapy

Author(s): Loureiro, Ana Isabel Sá; Cavaco-Paulo, Artur
Published in: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, Issue 2, 2018, Page(s) 105

Structural insights in modified HSA-SF nanocapsules for targeted drug delivery in rheumatoid arthritis therapy

Author(s): Tallian, C., Herrero-Rollett, A., Stadler, K., Vielnascher, R., Wieland, K., Weihs, A. M., Teuschl, A. H., Lendl, B., Amenitsch, H, Guebitz, G. M.
Published in: Book of Abstracts of the 6th DocDay 2018, 2018, Page(s) 14

Release studies of stimuli-responsive modified HSA microcapsules for targeted drug delivery

Author(s): C. Tallian, A. Herrero-Rollett, G. Tegl, D. Huber, L. Gutmann, R. Vielnascher and G.M. Guebitz
Published in: BioNanoMed, 2017

Development of protein-based targeted drug delivery systems

Author(s): Claudia Tallian, Karina Stadler, Lisa Gutmann, Alexandra Herrero-Rollett and Georg M. Guebitz
Published in: Designer Biology, 2017

Development of protein-based stimuli responsive drug delivery systems