Livrables
iQSARs for KE for common respiratory toxicity pathways: a mathematical model to relate the calculated NM descriptors and the probability of the identified MIE/KE for specific respiratory TP/AOP.
Prediction of content of NP-BM corona in lung fluidsPrediction of content of NP-BM corona in lung fluids: calculation of binding affinities for lung surfactandt proteins and lipids, affinity ranking, and prediction of concentration of seleceted molecules in the NP corona for selected nanomaterials (up to 60).
Identification of potential AOPs for pulmonary exposure to NMsResutls of data mining in GEO database and other AOP resources for known NP-related adverse outcomes.
PMFs and binding free energies for interaction of NM with building blocks of biomoleculesResults of atomistic simulations: potnetials of mean force and binding free energies for interaction of selected NMs (up to 60) with building blocks of biomolecules - lipid fragments, headgroups, aminoacids.
List of NMsList of NM to be used within the project and characterization will be compiled based on assessment of the available and most suitable materials. NM Materials (the NM series) deposited in the EC, Joint Research Centre (selected by the OECD Nanomaterials Working Party) and a series of 64 materials (the NRCWE series) available at the NRCWE (Partner 4) will be assessed for suitability for in vivo inhalation and in vitro tracking studies.
Molecular mechanisms of interactions of key molecules of each TP with NMsResults of MD simulations of interaction between the specific molecules involved in the MIE/KE as identified in WP3 for selceted NMs. Report on binding rate, orientation, conformational change.
In vivo samples for transcriptomics studies (inhalation)In vivo samples for transcriptomics studies (inhalation - rats, mice): Lung tissues collected 3, 30, 90 and 180 days after the end of animal exposure to assess short and long term effects of NMs.
A CG model of epithelial lining fluid, surfactant and mucusA coarse-grained (DPD or LB/LD) molecular simulation model of epithelial lining fluid, surfactant and mucus including all the main components – lipids, proteins and sugars, validated against experimental data (surface tension, adsorption energy, viscosity).
Report of end-localization of NPs within relevant cellsReport of end-localization of NPs within relevant cells: results of cell lines (macrophages and lung epithelium cells) and lung tissue exposure to the functionalized and labeled NPs regarding trafficking, partitioning and accumulation of the NPs.
Identify and score the pathological outcome of the in vivo exposuresList and assessment of severity of pathological outcomes of the in vivo exposures: hystopathology, transcriptomics (and targeted proteomics) analyses of in vivo and in vitro exposures of mice and rats to the NMs.
Report on surface tension experimentsReport on surface tension experiments using the Constrained Drop Surfactometer: The effect of NMs adsorbed from aerosol on lung surfactant and on lung surface tension.
Report on statistical models that predict TPs for specific NMs.Description of developed statistical models for predicting toxicity for specific NMs.
In vivo samples for transcriptomics studies (instillation)In vivo samples for transcriptomics studies (instillation - mice): Lung tissues collected at different time points following animal exposure to assess short and long term effects of NMs.
Particle specific responses and their compliance between in vivo and in vitroReport on the particle specific responses and their compliance between in vivo and in vitro as obtained fro momics analysis. Discussion of possibility of in vitro-in vivo extrapolation.
Isolation and archiving of biological samples for subsequent analysisIsolation and archiving of biological in vivo samples (exposed mice / rats) for subsequent analysis (lung lavage analysis, hematology and histology, transcriptomics).
Labelled NPs for tracking within cells and tissuesNanoparticles fluorescently or isotopically labeled to enable tracking within the cells and evaluation of the interactions with the NP coats such as protein corona or lipid wraps.
Candidate genes and pathways relevant to the AOPs for validation experimentsResults of analysis of the toxicity pathways and AOPs to identify specific biomarkers, MIEs and KEs relevant to each AOPs for validation experiments. List of identified bimarkers, MIEs, KEs.
Database of NP-BM interactionsDatabase of NP-BM interactions: new descriptors, suitable for bionano interface, (protein bindign affinities, hydration energies, band gaps, dissolution rates, etc.) for selected NMs (ip to 60) as calcualted by ab initio MD, atomistic and CG MD simulations.
Report of in vitro and in vivo toxicological properties of NMReport of in vitro and in vivo toxicological properties of NM: Cytology and biochemistry of the bronchoalveolar fluid study to assess lung inflammation and toxicity, histological analyses on lung and liver, pulmonary inflammation in terms of broncho-alveolar lavage cell composition, DNA strand break levels in lung and liver tissues. Reverse Phase Protein Array study results to characterize classical signaling pathways activated by toxic NM.
In vitro samples for transcriptomics studiesCocultures of mouse macrophage and epithelial cells will be prepared and used to study the toxicity NM and investigate the cellular uptake of NM as well as cell-specific gene expression profile and production of cytokines (P3, P4). A murine dose controlled air-liquid interface cell exposure system, provided by P12 will be applied.
List of nanomaterials and respective doses to be tested as TP benchmarkList of nanomaterials and respective doses to be tested as TP benchmark: results of literature survey, data mining, initial tests regarding the materials with well established toxic action.
NP coat compositionNP corona composition as determined by lipidomics and protomics study of the particles exposed to in vitro cell cultures and model membranes.
Report on mechanisms of corona/lipid wrap evolutionReport on mechanisms of corona/lipid wrap evolution as obtained from label-free quantitative mass-spectrometry-based proteomics and from high resolution Q-Exctive mass spectrometer for lipids.
Report the deduced toxicity-pathway specific end-pointsToxicity mechanisms (pathways) as established in statistical modelling and Bayesian analysis performed on the in vivo and in vitro proteomics and transcriptomics data.
Position paper on predictive in vitro modelshe literature will be surveyed for providing a basis for the best selection of cultured cells and effects by different NMs. A position paper will be written on the poissibilities and limiations of in vitro toxicity assessment techniques.
Classification of NPs according to ability to penetrate membranesClassification of NPs according to ability to modify, penetrate, or destroy lipid membranes (lung and epithelial cell membranes) as obtained in atomistic and CG simulations and theory.
Report on validity of the extracted TPsReport on validation tests for the extracted TP/AOPs using blocking of pathways with pharmaceutical agents, gene silencing, or KO models (if available).
Exploitation plan for the materials modelling methods, in vitro toxicity assessment techniques, in silico toxicity assessment scheme.
Organisation of international conferencesAnnual symposia around a major theme (in vivo, in vitro, in silico) of the project each year, which will also serve as a progress review for the project (Year 1 – Dublin;Year 2 – Ljubljana; Year 3 – Nancy) with invitation of other significant EU players (related H2020 projects and major EU labs).
Submission of AOPs to OECD databaseSubmission of AOPs to OECD database: novel respiratory or NM-related AOPs (up to 5), established and validated within the project.
Final Nanotox SymposiumFinal Nanotox Symposium summarizing all the progress made and considering the next steps. All the partners represented, 5-6 invited speakers.
Development of the data portalPortal for data storage, exchange, annotation and evaluation between the partners as a part of the project website with restricted access.
Establishment of a stakeholder advisory boardEstablishment of a stakeholder advisory board: invitation of top experts in toxicology, nanomaterials, software engineering, environmental safety to participate in the project advisory board.
Development of a public database of NM descriptorsDevelopment of a public database of NM descriptors: a database format for the NM descriptors upon consultation with eNanoMapper, Nanoreg 2, NanoSafe, OpenTox.
Plan for dissemination, storage and maintenance of obtained data during and after project term. List of data to be stored, formats and technologies.
Publications
Auteurs:
Jérôme Devoy, Hervé Nunge, Elodie Bonfanti, Carole Seidel, Laurent Gaté, Frédéric Cosnier
Publié dans:
Nanotoxicology, 2020, Page(s) 1-14, ISSN 1743-5390
Éditeur:
Informa Healthcare
DOI:
10.1080/17435390.2020.1814439
Auteurs:
Hana Kokot, Boštjan Kokot, Aleksandar Sebastijanović, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester López, Pernille Høgh Danielsen, Claudia Contini, Mikhail Ivanov, Ana Krišelj, Petra Čotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Doumandji, Mojca Pušnik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Iztok Urban
Publié dans:
Advanced Materials, 2020, Page(s) 2003913, ISSN 0935-9648
Éditeur:
United Nations Industrial Developement Organization
DOI:
10.1002/adma.202003913
Auteurs:
Lin Yang, Regine Gradl, Martin Dierolf, Winfried Möller, David Kutschke, Annette Feuchtinger, Lorenz Hehn, Martin Donnelley, Benedikt Günther, Klaus Achterhold, Axel Walch, Tobias Stoeger, Daniel Razansky, Franz Pfeiffer, Kaye S. Morgan, Otmar Schmid
Publié dans:
Small, Numéro 15/49, 2019, Page(s) 1904112, ISSN 1613-6810
Éditeur:
Wiley - V C H Verlag GmbbH & Co.
DOI:
10.1002/smll.201904112
Auteurs:
Mélanie M. Leroux, Zahra Doumandji, Laetitia Chézeau, Laurent Gaté, Sara Nahle, Romain Hocquel, Vadim Zhernovkov, Sylvie Migot, Jafar Ghanbaja, Céline Bonnet, Raphaël Schneider, Bertrand H. Rihn, Luc Ferrari, Olivier Joubert
Publié dans:
International Journal of Molecular Sciences, Numéro 21/14, 2020, Page(s) 4855, ISSN 1422-0067
Éditeur:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21144855
Auteurs:
Marzieh Saeedimasine, Erik G. Brandt, Alexander P. Lyubartsev
Publié dans:
The Journal of Physical Chemistry B, 2020, ISSN 1520-6106
Éditeur:
American Chemical Society
DOI:
10.1021/acs.jpcb.0c08622
Auteurs:
Lorenzo Agosta, Erik G. Brandt, Alexander P. Lyubartsev
Publié dans:
The Journal of Chemical Physics, 2017, ISSN 0021-9606
Éditeur:
American Institute of Physics
DOI:
10.1063/1.4991381
Auteurs:
Claudia Contini, Matthew Schneemilch, Simon Gaisford, Nick Quirke
Publié dans:
Journal of Experimental Nanoscience, 2017, Page(s) 1-20, ISSN 1745-8080
Éditeur:
Taylor & Francis
DOI:
10.1080/17458080.2017.1413253
Auteurs:
Otmar Schmid, Flemming R. Cassee
Publié dans:
Particle and Fibre Toxicology, Numéro 14/1, 2017, ISSN 1743-8977
Éditeur:
BioMed Central
DOI:
10.1186/s12989-017-0233-1
Auteurs:
Ulla Vogel, Flemming R. Cassee
Publié dans:
Particle and Fibre Toxicology, Numéro 15/1, 2018, ISSN 1743-8977
Éditeur:
BioMed Central
DOI:
10.1186/s12989-018-0247-3
Auteurs:
M. Schneemilch, N. Quirke
Publié dans:
The Journal of Chemical Physics, Numéro 148/19, 2018, Page(s) 194704, ISSN 0021-9606
Éditeur:
American Institute of Physics
DOI:
10.1063/1.5028557
Auteurs:
Zahra M. Doumandji, Bertrand Rihn, Olivier Joubert
Publié dans:
Free Radical Biology and Medicine, Numéro 120, 2018, Page(s) S88, ISSN 0891-5849
Éditeur:
Elsevier BV
DOI:
10.1016/j.freeradbiomed.2018.04.290
Auteurs:
Iztok Urbančič, Maja Garvas, Boštjan Kokot, Hana Majaron, Polona Umek, Hilary Cassidy, Miha Škarabot, Falk Schneider, Silvia Galiani, Zoran Arsov, Tilen Koklic, David Matallanas, Miran Čeh, Igor Muševič, Christian Eggeling, Janez Štrancar
Publié dans:
Nano Letters, 2018, ISSN 1530-6984
Éditeur:
American Chemical Society
DOI:
10.1021/acs.nanolett.8b02291
Auteurs:
Kristina Bram Knudsen, Trine Berthing, Petra Jackson, Sarah Søs Poulsen, Alicja Mortensen, Nicklas Raun Jacobsen, Vidar Skaug, Józef Szarek, Karin Sørig Hougaard, Henrik Wolff, Håkan Wallin, Ulla Vogel
Publié dans:
Basic & Clinical Pharmacology & Toxicology, 2018, ISSN 1742-7835
Éditeur:
Nordic Pharmacological Society
DOI:
10.1111/bcpt.13119
Auteurs:
Shigeyuki Magi, Kazunari Iwamoto, Noriko Yumoto, Michio Hiroshima, Takeshi Nagashima, Rieko Ohki, Amaya Garcia-Munoz, Natalia Volinsky, Alexander Von Kriegsheim, Yasushi Sako, Koichi Takahashi, Shuhei Kimura, Boris N. Kholodenko, Mariko Okada-Hatakeyama
Publié dans:
Journal of Biological Chemistry, Numéro 293/6, 2018, Page(s) 2206-2218, ISSN 0021-9258
Éditeur:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/jbc.M117.778399
Auteurs:
Tapesh Santra, Oleksii Rukhlenko, Vadim Zhernovkov, Boris N. Kholodenko
Publié dans:
Current Opinion in Systems Biology, Numéro 9, 2018, Page(s) 11-21, ISSN 2452-3100
Éditeur:
Elsevier BV
DOI:
10.1016/j.coisb.2018.02.003
Auteurs:
Keesha E. Erickson, Oleksii S. Rukhlenko, Richard G. Posner, William S. Hlavacek, Boris N. Kholodenko
Publié dans:
Seminars in Cancer Biology, 2018, ISSN 1044-579X
Éditeur:
Academic Press
DOI:
10.1016/j.semcancer.2018.02.008
Auteurs:
Oleksii S. Rukhlenko, Fahimeh Khorsand, Aleksandar Krstic, Jan Rozanc, Leonidas G. Alexopoulos, Nora Rauch, Keesha E. Erickson, William S. Hlavacek, Richard G. Posner, Silvia Gómez-Coca, Edina Rosta, Cheree Fitzgibbon, David Matallanas, Jens Rauch, Walter Kolch, Boris N. Kholodenko
Publié dans:
Cell Systems, Numéro 7/2, 2018, Page(s) 161-179.e14, ISSN 2405-4712
Éditeur:
Elsevier BV
DOI:
10.1016/j.cels.2018.06.002
Auteurs:
Susanne Fritsch-Decker, Clarissa Marquardt, Tobias Stoeger, Silvia Diabaté, Carsten Weiss
Publié dans:
Archives of Toxicology, Numéro 92/7, 2018, Page(s) 2163-2174, ISSN 0340-5761
Éditeur:
Springer Verlag
DOI:
10.1007/s00204-018-2223-y
Auteurs:
Rauch N., Rukhlenko O., Kolch W., Kholodenko B.
Publié dans:
Current Opinion in Structural Biology, Numéro 41, 2016, Page(s) 151–158, ISSN 0959-440X
Éditeur:
Elsevier BV
DOI:
10.1016/j.sbi.2016.07.019
Auteurs:
Schneemilch M., Quirke N.
Publié dans:
Free energy of adsorption of supported lipid bilayers from molecular dynamics simulation, Numéro 664, 2016, Page(s) 199–204, ISSN 0009-2614
Éditeur:
Elsevier BV
DOI:
10.1016/j.cplett.2016.10.010
Auteurs:
Agosta L., Brandt e., Lyubartsev A.P.
Publié dans:
Nanoscale, Numéro 8, 2016, Page(s) 13385-13398, ISSN 2040-3364
Éditeur:
Royal Society of Chemistry
DOI:
10.1039/c6nr02791a
Auteurs:
Lan K. Nguyen, Boris N. Kholodenko, Alex von Kriegsheim
Publié dans:
Small GTPases, Numéro 17, 2016, Page(s) 1-6, ISSN 2154-1248
Éditeur:
Landes Bioscience
DOI:
10.1080/21541248.2016.1224399
Auteurs:
Fallahi E, O'Driscoll NA, Matallanas D.
Publié dans:
Genes (Basel), Numéro 17, 2016, ISSN 2073-4425
Éditeur:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/genes7060028
Auteurs:
Laurent Gaté, Kristina Bram Knudsen, Carole Seidel, Trine Berthing, Laëtitia Chézeau, Nicklas Raun Jacobsen, Sarah Valentino, Håkan Wallin, Sébastien Bau, Henrik Wolff, Sylvie Sébillaud, Mylène Lorcin, Stéphane Grossmann, Stéphane Viton, Hervé Nunge, Christian Darne, Ulla Vogel, Frédéric Cosnier
Publié dans:
Toxicology and Applied Pharmacology, Numéro 375, 2019, Page(s) 17-31, ISSN 0041-008X
Éditeur:
Academic Press
DOI:
10.1016/j.taap.2019.05.001
Auteurs:
M. Schneemilch, N. Quirke
Publié dans:
The Journal of Chemical Physics, Numéro 150/22, 2019, Page(s) 229901, ISSN 0021-9606
Éditeur:
American Institute of Physics
DOI:
10.1063/1.5111197
Auteurs:
Vadim Zhernovkov, Tapesh Santra, Hilary Cassidy, Oleksii Rukhlenko, David Matallanas, Aleksandar Krstic, Walter Kolch, Vladimir Lobaskin, Boris N Kholodenko
Publié dans:
Toxicological Sciences, 2019, ISSN 1096-6080
Éditeur:
Oxford University Press
DOI:
10.1093/toxsci/kfz151
Auteurs:
Niels Hadrup, Feriel Rahmani, Nicklas R. Jacobsen, Anne T. Saber, Petra Jackson, Stefan Bengtson, Andrew Williams, Håkan Wallin, Sabina Halappanavar, Ulla Vogel
Publié dans:
Nanotoxicology, 2019, Page(s) 1-18, ISSN 1743-5390
Éditeur:
Informa Healthcare
DOI:
10.1080/17435390.2019.1654004
Auteurs:
David Power, Ian Rouse, Stefano Poggio, Erik Brandt, Hender Lopez, Alexander Lyubartsev, Vladimir Lobaskin
Publié dans:
Modelling and Simulation in Materials Science and Engineering, Numéro 27/8, 2019, Page(s) 084003, ISSN 0965-0393
Éditeur:
Institute of Physics Publishing
DOI:
10.1088/1361-651x/ab3b6e
Auteurs:
M. Schneemilch, N. Quirke
Publié dans:
The Journal of Chemical Physics, Numéro 151/13, 2019, Page(s) 134707, ISSN 0021-9606
Éditeur:
American Institute of Physics
DOI:
10.1063/1.5120810
Auteurs:
Pernille Høgh Danielsen, Kristina Bram Knudsen, Janez Štrancar, Polona Umek, Tilen Koklič, Maja Garvas, Esa Vanhala, Sauli Savukoski, Yaobo Ding, Anne Mette Madsen, Nicklas Raun Jacobsen, Ingrid Konow Weydahl, Trine Berthing, Sarah Søs Poulsen, Otmar Schmid, Henrik Wolff, Ulla Vogel
Publié dans:
Toxicology and Applied Pharmacology, 2019, Page(s) 114830, ISSN 0041-008X
Éditeur:
Academic Press
DOI:
10.1016/j.taap.2019.114830
Auteurs:
Sabina Halappanavar, Luna Rahman, Jake Nikota, Sarah S. Poulsen, Yaobo Ding, Petra Jackson, Hakan Wallin, Otmar Schmid, Ulla Vogel, Andrew Williams
Publié dans:
NanoImpact, Numéro 14, 2019, Page(s) 100158, ISSN 2452-0748
Éditeur:
Elsevier BV
DOI:
10.1016/j.impact.2019.100158
Auteurs:
Niels Hadrup, Anne T. Saber, Zdenka O. Kyjovska, Nicklas R. Jacobsen, Minnamari Vippola, Essi Sarlin, Yaobo Ding, Otmar Schmid, Håkan Wallin, Keld A. Jensen, Ulla Vogel
Publié dans:
Environmental Toxicology and Pharmacology, 2019, Page(s) 103303, ISSN 1382-6689
Éditeur:
Elsevier BV
DOI:
10.1016/j.etap.2019.103303
Auteurs:
Doumandji Zahra, Safar Ramia, Lovera-Leroux Mélanie, Nahle Sara, Cassidy Hilary, Matallanas David, Rihn Bertrand, Ferrari Luc, Joubert Olivier
Publié dans:
Cell Biology and Toxicology, 2019, ISSN 0742-2091
Éditeur:
Kluwer Academic Publishers
DOI:
10.1007/s10565-019-09484-6
Auteurs:
Fernando Luís Barroso da Silva, Paolo Carloni, David Cheung, Grazia Cottone, Serena Donnini, E. Allen Foegeding, Muhammad Gulzar, Jean Christophe Jacquier, Vladimir Lobaskin, Donal MacKernan, Zeynab Mohammad Hosseini Naveh, Ravi Radhakrishnan, Erik E. Santiso
Publié dans:
Annual Review of Food Science and Technology, Numéro 11/1, 2020, Page(s) 365-387, ISSN 1941-1413
Éditeur:
Annual Reviews Inc.
DOI:
10.1146/annurev-food-032519-051640
Auteurs:
Martin Thomas Horsch, Christoph Niethammer, Gianluca Boccardo, Paola Carbone, Silvia Chiacchiera, Mara Chiricotto, Joshua D. Elliott, Vladimir Lobaskin, Philipp Neumann, Peter Schiffels, Michael A. Seaton, Ilian T. Todorov, Jadran Vrabec, Welchy Leite Cavalcanti
Publié dans:
Journal of Chemical & Engineering Data, Numéro 65/3, 2020, Page(s) 1313-1329, ISSN 0021-9568
Éditeur:
American Chemical Society
DOI:
10.1021/acs.jced.9b00739
Auteurs:
Hana Majaron, Boštjan Kokot, Aleksandar Sebastijanović, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester López, Pernille Høgh Danielsen, Claudia Contini, Mikhail Ivanov, Ana Krišelj, Petra Čotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Manel Doumandji, Mojca Pušnik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Izto
Publié dans:
BioRxiv, 2020, ISSN 1943-0264
Éditeur:
Cold Spring Harbor Laboratory Press
DOI:
10.1101/2020.02.27.966036
Auteurs:
Niels Hadrup, Vadim Zhernovkov, Nicklas Raun Jacobsen, Carola Voss, Maximilian Strunz, Meshal Ansari, Herbert B. Schiller, Sabina Halappanavar, Sarah S. Poulsen, Boris Kholodenko, Tobias Stoeger, Anne Thoustrup Saber, Ulla Vogel
Publié dans:
Small, 2020, Page(s) 1907476, ISSN 1613-6810
Éditeur:
Wiley - V C H Verlag GmbbH & Co.
DOI:
10.1002/smll.201907476
Auteurs:
Sabina Halappanavar, Sybille van den Brule, Penny Nymark, Laurent Gaté, Carole Seidel, Sarah Valentino, Vadim Zhernovkov, Pernille Høgh Danielsen, Andrea De Vizcaya, Henrik Wolff, Tobias Stöger, Andrey Boyadziev, Sarah Søs Poulsen, Jorid Birkelund Sørli, Ulla Vogel
Publié dans:
Particle and Fibre Toxicology, Numéro 17/1, 2020, ISSN 1743-8977
Éditeur:
BioMed Central
DOI:
10.1186/s12989-020-00344-4
Auteurs:
James D. Ede, Vladimir Lobaskin, Ulla Vogel, Iseult Lynch, Sabina Halappanavar, Shareen H. Doak, Megan G. Roberts, Jo Anne Shatkin
Publié dans:
Nanomaterials, Numéro 10/6, 2020, Page(s) 1229, ISSN 2079-4991
Éditeur:
MDPI AG
DOI:
10.3390/nano10061229
Auteurs:
Jorid Sørli
Publié dans:
ALTEX, 2017, ISSN 1868-596X
Éditeur:
ALTEX
DOI:
10.14573/altex.1705181
Auteurs:
Lorenzo Agosta, Erik G. Brandt, Alexander P. Lyubartsev
Publié dans:
The Journal of Chemical Physics, Numéro 147/2, 2017, Page(s) 024704, ISSN 0021-9606
Éditeur:
American Institute of Physics
DOI:
10.1063/1.4991381
Auteurs:
Dirk Fey, Edita Aksamitiene, Anatoly Kiyatkin, Boris N. Kholodenko
Publié dans:
Methods Mol Biol, Numéro 1636, 2017, Page(s) 417-453, ISSN 1064-3745
Éditeur:
Humana Press, Inc.
DOI:
10.1007/978-1-4939-7154-1_27
Auteurs:
Andrea Degasperi, Dirk Fey, Boris N. Kholodenko
Publié dans:
npj Systems Biology and Applications, Numéro 3/1, 2017, ISSN 2056-7189
Éditeur:
Springer Nature
DOI:
10.1038/s41540-017-0023-2
Auteurs:
Koustav Ganguly, Dariusch Ettehadieh, Swapna Upadhyay, Shinji Takenaka, Thure Adler, Erwin Karg, Fritz Krombach, Wolfgang G. Kreyling, Holger Schulz, Otmar Schmid, Tobias Stoeger
Publié dans:
Particle and Fibre Toxicology, Numéro 14/1, 2017, ISSN 1743-8977
Éditeur:
BioMed Central
DOI:
10.1186/s12989-017-0200-x
Auteurs:
Christine Sattler, Franco Moritz, Shanze Chen, Beatrix Steer, David Kutschke, Martin Irmler, Johannes Beckers, Oliver Eickelberg, Philippe Schmitt-Kopplin, Heiko Adler, Tobias Stoeger
Publié dans:
Particle and Fibre Toxicology, Numéro 14/1, 2017, ISSN 1743-8977
Éditeur:
BioMed Central
DOI:
10.1186/s12989-016-0181-1
Auteurs:
Jake Nikota, Allyson Banville, Laura Rose Goodwin, Dongmei Wu, Andrew Williams, Carole Lynn Yauk, Håkan Wallin, Ulla Vogel, Sabina Halappanavar
Publié dans:
Particle and Fibre Toxicology, Numéro 14/1, 2017, ISSN 1743-8977
Éditeur:
BioMed Central
DOI:
10.1186/s12989-017-0218-0
Auteurs:
M. Meunier, A. Goupil, P. Lienard
Publié dans:
International Journal of Pharmaceutics, Numéro 526/1-2, 2017, Page(s) 157-166, ISSN 0378-5173
Éditeur:
Elsevier BV
DOI:
10.1016/j.ijpharm.2017.04.043
Auteurs:
Sara Nahle, Hilary Cassidy, Mélanie M. Leroux, Reuben Mercier, Jaafar Ghanbaja, Zahra Doumandji, David Matallanas, Bertrand H. Rihn, Olivier Joubert, Luc Ferrari
Publié dans:
Journal of Nanobiotechnology, Numéro 18/1, 2020, ISSN 1477-3155
Éditeur:
BioMed Central
DOI:
10.1186/s12951-020-0587-7
Auteurs:
Yaobo Ding, Patrick Weindl, Anke-Gabriele Lenz, Paula Mayer, Tobias Krebs, Otmar Schmid
Publié dans:
Particle and Fibre Toxicology, Numéro 17/1, 2020, ISSN 1743-8977
Éditeur:
BioMed Central
DOI:
10.1186/s12989-020-00376-w
Auteurs:
Carole Seidel, Vadim Zhernovkov, Hilary Cassidy, Boris Kholodenko, David Matallanas, Frédéric Cosnier, Laurent Gaté
Publié dans:
Nanotoxicology, 2020, Page(s) 1-19, ISSN 1743-5390
Éditeur:
Informa Healthcare
DOI:
10.1080/17435390.2020.1851418
Auteurs:
Shada A. Alsharif, David Power, Ian Rouse, Vladimir Lobaskin
Publié dans:
Nanomaterials, Numéro 10/10, 2020, Page(s) 1967, ISSN 2079-4991
Éditeur:
MDPI AG
DOI:
10.3390/nano10101967
Auteurs:
Claudia Contini, James W. Hindley, Tom Macdonald, Joseph Barritt, Oscar Ces, Nick Quirke
Publié dans:
ChemRxiv, 2019, ISSN 2573-2293
Éditeur:
American Chemical Society (ACS)
DOI:
10.26434/chemrxiv.10246928
Auteurs:
Power D, Poggio S, Lopez H, Lobaskin V.
Publié dans:
2019, ISBN 978-9814-800648
Éditeur:
Jenny Stanford Publishing
Auteurs:
Joubert O., Rihn,P., Rihn B.H.
Publié dans:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Éditeur:
CRC Press
Auteurs:
Krebs T., Mülhopt S., Diabaté S., Schlager C., Paur H.R., Dilger M.
Publié dans:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Éditeur:
CRC Press
Auteurs:
André J.C, Simon J, Rihn B.H.
Publié dans:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Éditeur:
CRC Press
Auteurs:
Ferrari L., Diab R., Nemos C., Safar R., Puisney C.
Publié dans:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Éditeur:
CRC Press
Auteurs:
Eidi H., Doumandji Z., Tomljenovic L., Rihn B.H.
Publié dans:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Éditeur:
CRC Press
Auteurs:
Abdel-Wahhab M.A., Joubert O., El-Nekeety A.A., Abdel-Wahhab K.G., Ronzani C., Safar R., El-Kady A.A., Hassan N.S, Mannaa F.A, Rihn B.H.
Publié dans:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Éditeur:
CRC Press
Auteurs:
Gaté L., Cosnier F.,Cassee F.R.
Publié dans:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Éditeur:
CRC Press
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