Objectif
A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other
computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.
Champ scientifique
- sciences naturellessciences biologiquesbiochimiebiomoléculeprotéinesprotéomique
- sciences naturellesinformatique et science de l'informationbases de données
- sciences naturellessciences physiquesphysique atomique
- sciences naturellesinformatique et science de l'informationscience informatique
- ingénierie et technologienanotechnologienanomatériaux
Programme(s)
Régime de financement
RIA - Research and Innovation action
Coordinateur
4 Dublin
Irlande
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Participants (12)
10691 Stockholm
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85764 Neuherberg
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2100 Kobenhavn
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75011 Paris
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1000 Ljubljana
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SW7 2AZ London
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54052 Nancy Cedex
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Participation terminée
CB4 0WN Cambridge
00250 Helsinki
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79183 Waldkirch
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L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.
0363 Oslo
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CV4 7HP Coventry
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