Risultati finali
iQSARs for KE for common respiratory toxicity pathways: a mathematical model to relate the calculated NM descriptors and the probability of the identified MIE/KE for specific respiratory TP/AOP.
Prediction of content of NP-BM corona in lung fluidsPrediction of content of NP-BM corona in lung fluids: calculation of binding affinities for lung surfactandt proteins and lipids, affinity ranking, and prediction of concentration of seleceted molecules in the NP corona for selected nanomaterials (up to 60).
Identification of potential AOPs for pulmonary exposure to NMsResutls of data mining in GEO database and other AOP resources for known NP-related adverse outcomes.
PMFs and binding free energies for interaction of NM with building blocks of biomoleculesResults of atomistic simulations: potnetials of mean force and binding free energies for interaction of selected NMs (up to 60) with building blocks of biomolecules - lipid fragments, headgroups, aminoacids.
List of NMsList of NM to be used within the project and characterization will be compiled based on assessment of the available and most suitable materials. NM Materials (the NM series) deposited in the EC, Joint Research Centre (selected by the OECD Nanomaterials Working Party) and a series of 64 materials (the NRCWE series) available at the NRCWE (Partner 4) will be assessed for suitability for in vivo inhalation and in vitro tracking studies.
Molecular mechanisms of interactions of key molecules of each TP with NMsResults of MD simulations of interaction between the specific molecules involved in the MIE/KE as identified in WP3 for selceted NMs. Report on binding rate, orientation, conformational change.
In vivo samples for transcriptomics studies (inhalation)In vivo samples for transcriptomics studies (inhalation - rats, mice): Lung tissues collected 3, 30, 90 and 180 days after the end of animal exposure to assess short and long term effects of NMs.
A CG model of epithelial lining fluid, surfactant and mucusA coarse-grained (DPD or LB/LD) molecular simulation model of epithelial lining fluid, surfactant and mucus including all the main components – lipids, proteins and sugars, validated against experimental data (surface tension, adsorption energy, viscosity).
Report of end-localization of NPs within relevant cellsReport of end-localization of NPs within relevant cells: results of cell lines (macrophages and lung epithelium cells) and lung tissue exposure to the functionalized and labeled NPs regarding trafficking, partitioning and accumulation of the NPs.
Identify and score the pathological outcome of the in vivo exposuresList and assessment of severity of pathological outcomes of the in vivo exposures: hystopathology, transcriptomics (and targeted proteomics) analyses of in vivo and in vitro exposures of mice and rats to the NMs.
Report on surface tension experimentsReport on surface tension experiments using the Constrained Drop Surfactometer: The effect of NMs adsorbed from aerosol on lung surfactant and on lung surface tension.
Report on statistical models that predict TPs for specific NMs.Description of developed statistical models for predicting toxicity for specific NMs.
In vivo samples for transcriptomics studies (instillation)In vivo samples for transcriptomics studies (instillation - mice): Lung tissues collected at different time points following animal exposure to assess short and long term effects of NMs.
Particle specific responses and their compliance between in vivo and in vitroReport on the particle specific responses and their compliance between in vivo and in vitro as obtained fro momics analysis. Discussion of possibility of in vitro-in vivo extrapolation.
Isolation and archiving of biological samples for subsequent analysisIsolation and archiving of biological in vivo samples (exposed mice / rats) for subsequent analysis (lung lavage analysis, hematology and histology, transcriptomics).
Labelled NPs for tracking within cells and tissuesNanoparticles fluorescently or isotopically labeled to enable tracking within the cells and evaluation of the interactions with the NP coats such as protein corona or lipid wraps.
Candidate genes and pathways relevant to the AOPs for validation experimentsResults of analysis of the toxicity pathways and AOPs to identify specific biomarkers, MIEs and KEs relevant to each AOPs for validation experiments. List of identified bimarkers, MIEs, KEs.
Database of NP-BM interactionsDatabase of NP-BM interactions: new descriptors, suitable for bionano interface, (protein bindign affinities, hydration energies, band gaps, dissolution rates, etc.) for selected NMs (ip to 60) as calcualted by ab initio MD, atomistic and CG MD simulations.
Report of in vitro and in vivo toxicological properties of NMReport of in vitro and in vivo toxicological properties of NM: Cytology and biochemistry of the bronchoalveolar fluid study to assess lung inflammation and toxicity, histological analyses on lung and liver, pulmonary inflammation in terms of broncho-alveolar lavage cell composition, DNA strand break levels in lung and liver tissues. Reverse Phase Protein Array study results to characterize classical signaling pathways activated by toxic NM.
In vitro samples for transcriptomics studiesCocultures of mouse macrophage and epithelial cells will be prepared and used to study the toxicity NM and investigate the cellular uptake of NM as well as cell-specific gene expression profile and production of cytokines (P3, P4). A murine dose controlled air-liquid interface cell exposure system, provided by P12 will be applied.
List of nanomaterials and respective doses to be tested as TP benchmarkList of nanomaterials and respective doses to be tested as TP benchmark: results of literature survey, data mining, initial tests regarding the materials with well established toxic action.
NP coat compositionNP corona composition as determined by lipidomics and protomics study of the particles exposed to in vitro cell cultures and model membranes.
Report on mechanisms of corona/lipid wrap evolutionReport on mechanisms of corona/lipid wrap evolution as obtained from label-free quantitative mass-spectrometry-based proteomics and from high resolution Q-Exctive mass spectrometer for lipids.
Report the deduced toxicity-pathway specific end-pointsToxicity mechanisms (pathways) as established in statistical modelling and Bayesian analysis performed on the in vivo and in vitro proteomics and transcriptomics data.
Position paper on predictive in vitro modelshe literature will be surveyed for providing a basis for the best selection of cultured cells and effects by different NMs. A position paper will be written on the poissibilities and limiations of in vitro toxicity assessment techniques.
Classification of NPs according to ability to penetrate membranesClassification of NPs according to ability to modify, penetrate, or destroy lipid membranes (lung and epithelial cell membranes) as obtained in atomistic and CG simulations and theory.
Report on validity of the extracted TPsReport on validation tests for the extracted TP/AOPs using blocking of pathways with pharmaceutical agents, gene silencing, or KO models (if available).
Exploitation plan for the materials modelling methods, in vitro toxicity assessment techniques, in silico toxicity assessment scheme.
Organisation of international conferencesAnnual symposia around a major theme (in vivo, in vitro, in silico) of the project each year, which will also serve as a progress review for the project (Year 1 – Dublin;Year 2 – Ljubljana; Year 3 – Nancy) with invitation of other significant EU players (related H2020 projects and major EU labs).
Submission of AOPs to OECD databaseSubmission of AOPs to OECD database: novel respiratory or NM-related AOPs (up to 5), established and validated within the project.
Final Nanotox SymposiumFinal Nanotox Symposium summarizing all the progress made and considering the next steps. All the partners represented, 5-6 invited speakers.
Development of the data portalPortal for data storage, exchange, annotation and evaluation between the partners as a part of the project website with restricted access.
Establishment of a stakeholder advisory boardEstablishment of a stakeholder advisory board: invitation of top experts in toxicology, nanomaterials, software engineering, environmental safety to participate in the project advisory board.
Development of a public database of NM descriptorsDevelopment of a public database of NM descriptors: a database format for the NM descriptors upon consultation with eNanoMapper, Nanoreg 2, NanoSafe, OpenTox.
Plan for dissemination, storage and maintenance of obtained data during and after project term. List of data to be stored, formats and technologies.
Pubblicazioni
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Power D, Poggio S, Lopez H, Lobaskin V.
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2019, ISBN 978-9814-800648
Editore:
Jenny Stanford Publishing
Autori:
Joubert O., Rihn,P., Rihn B.H.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Krebs T., Mülhopt S., Diabaté S., Schlager C., Paur H.R., Dilger M.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
André J.C, Simon J, Rihn B.H.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Ferrari L., Diab R., Nemos C., Safar R., Puisney C.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Eidi H., Doumandji Z., Tomljenovic L., Rihn B.H.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Abdel-Wahhab M.A., Joubert O., El-Nekeety A.A., Abdel-Wahhab K.G., Ronzani C., Safar R., El-Kady A.A., Hassan N.S, Mannaa F.A, Rihn B.H.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
Autori:
Gaté L., Cosnier F.,Cassee F.R.
Pubblicato in:
Biomedical Application of Nanoparticles, 2017, ISBN 9781-498750011
Editore:
CRC Press
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