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Transforming the future of agriculture through synthetic photorespiration

Deliverables

Synthetic pathways in E. coli

At least one synthetic pathway fully operational in E. coli

In vitro reconstructed pathways

At least one synthetic pathway fully operating using purified enzymes

Model of plant photosynthesis

A computational model of plant photosynthesis and metabolism that demonstrates the expected effect of the synthetic pathways on the rate of photosynthesis and carbon fixation.

Synthetic pathways in cyanobacteria

At least one synthetic pathway that is fully active in cyanobacteria

Phenotypes of transgenic plant

Photosynthetic rate growth rate and other physiological characteristics of at least one modified plant that expresses a synthetic pathway

In vitro optimized pathways

Pathway optimization that includes catalytic efficiency stability andor localization of the different enzyme eg scaffolding

Project website

Publication of the website of the project (public pages).

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Publications

Sulfur-Oxidizing Symbionts without Canonical Genes for Autotrophic CO 2 Fixation

Author(s): Brandon K. B. Seah, Chakkiath Paul Antony, Bruno Huettel, Jan Zarzycki, Lennart Schada von Borzyskowski, Tobias J. Erb, Angela Kouris, Manuel Kleiner, Manuel Liebeke, Nicole Dubilier, Harald R. Gruber-Vodicka
Published in: mBio, 10/3, 2019, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.01112-19

A short history of RubisCO: the rise and fall (?) of Nature's predominant CO 2 fixing enzyme

Author(s): Tobias J Erb, Jan Zarzycki
Published in: Current Opinion in Biotechnology, 49, 2018, Page(s) 100-107, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2017.07.017

Synthetic metabolism: metabolic engineering meets enzyme design

Author(s): Tobias J Erb, Patrik R Jones, Arren Bar-Even
Published in: Current Opinion in Chemical Biology, 37, 2017, Page(s) 56-62, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2016.12.023

Daring metabolic designs for enhanced plant carbon fixation

Author(s): Arren Bar-Even
Published in: Plant Science, 273, 2018, Page(s) 71-83, ISSN 0168-9452
Publisher: Elsevier BV
DOI: 10.1016/j.plantsci.2017.12.007

Enzyme engineering: reaching the maximal catalytic efficiency peak

Author(s): Moshe Goldsmith, Dan S Tawfik
Published in: Current Opinion in Structural Biology, 47, 2017, Page(s) 140-150, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2017.09.002

Biochemical and synthetic biology approaches to improve photosynthetic CO2-fixation

Author(s): Tobias J Erb, Jan Zarzycki
Published in: Current Opinion in Chemical Biology, 34, 2016, Page(s) 72-79, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2016.06.026

Design and in vitro realization of carbon-conserving photorespiration

Author(s): Devin L. Trudeau, Christian Edlich-Muth, Jan Zarzycki, Marieke Scheffen, Moshe Goldsmith, Olga Khersonsky, Ziv Avizemer, Sarel J. Fleishman, Charles A. R. Cotton, Tobias J. Erb, Dan S. Tawfik, Arren Bar-Even
Published in: Proceedings of the National Academy of Sciences, 115/49, 2018, Page(s) E11455-E11464, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1812605115

Synthetic biology approaches for improving photosynthesis

Author(s): Armin Kubis, Arren Bar-Even
Published in: Journal of Experimental Botany, 70/5, 2019, Page(s) 1425-1433, ISSN 0022-0957
Publisher: Oxford University Press
DOI: 10.1093/jxb/erz029

A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation

Author(s): Marieke Scheffen, Daniel G. Marchal, Thomas Beneyton, Sandra K. Schuller, Melanie Klose, Christoph Diehl, Jessica Lehmann, Pascal Pfister, Martina Carrillo, Hai He, Selçuk Aslan, Niña S. Cortina, Peter Claus, Daniel Bollschweiler, Jean-Christophe Baret, Jan M. Schuller, Jan Zarzycki, Arren Bar-Even, Tobias J. Erb
Published in: Nature Catalysis, 2021, ISSN 2520-1158
Publisher: Springer Nature
DOI: 10.1038/s41929-020-00557-y