Transforming the future of agriculture through synthetic photorespiration

Livrables

At least one synthetic pathway fully operational in E. coli

At least one synthetic pathway fully operating using purified enzymes

A computational model of plant photosynthesis and metabolism that demonstrates the expected effect of the synthetic pathways on the rate of photosynthesis and carbon fixation.

Synthetic pathways in cyanobacteria

At least one synthetic pathway that is fully active in cyanobacteria

Phenotypes of transgenic plant

Photosynthetic rate growth rate and other physiological characteristics of at least one modified plant that expresses a synthetic pathway

In vitro optimized pathways

Pathway optimization that includes catalytic efficiency stability andor localization of the different enzyme eg scaffolding

Project website

Publication of the website of the project (public pages).

Publications

Sulfur-Oxidizing Symbionts without Canonical Genes for Autotrophic CO 2 Fixation

Auteurs: Brandon K. B. Seah, Chakkiath Paul Antony, Bruno Huettel, Jan Zarzycki, Lennart Schada von Borzyskowski, Tobias J. Erb, Angela Kouris, Manuel Kleiner, Manuel Liebeke, Nicole Dubilier, Harald R. Gruber-Vodicka
Publié dans: mBio, Numéro 10/3, 2019, ISSN 2150-7511
Éditeur: American Society for Microbiology
DOI: 10.1128/mbio.01112-19

A short history of RubisCO: the rise and fall (?) of Nature's predominant CO 2 fixing enzyme

Auteurs: Tobias J Erb, Jan Zarzycki
Publié dans: Current Opinion in Biotechnology, Numéro 49, 2018, Page(s) 100-107, ISSN 0958-1669
Éditeur: Elsevier BV
DOI: 10.1016/j.copbio.2017.07.017

Synthetic metabolism: metabolic engineering meets enzyme design

Auteurs: Tobias J Erb, Patrik R Jones, Arren Bar-Even
Publié dans: Current Opinion in Chemical Biology, Numéro 37, 2017, Page(s) 56-62, ISSN 1367-5931
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpa.2016.12.023

Daring metabolic designs for enhanced plant carbon fixation

Auteurs: Arren Bar-Even
Publié dans: Plant Science, Numéro 273, 2018, Page(s) 71-83, ISSN 0168-9452
Éditeur: Elsevier BV
DOI: 10.1016/j.plantsci.2017.12.007

Enzyme engineering: reaching the maximal catalytic efficiency peak

Auteurs: Moshe Goldsmith, Dan S Tawfik
Publié dans: Current Opinion in Structural Biology, Numéro 47, 2017, Page(s) 140-150, ISSN 0959-440X
Éditeur: Elsevier BV
DOI: 10.1016/j.sbi.2017.09.002

Biochemical and synthetic biology approaches to improve photosynthetic CO2-fixation

Auteurs: Tobias J Erb, Jan Zarzycki
Publié dans: Current Opinion in Chemical Biology, Numéro 34, 2016, Page(s) 72-79, ISSN 1367-5931
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpa.2016.06.026

Design and in vitro realization of carbon-conserving photorespiration

Auteurs: Devin L. Trudeau, Christian Edlich-Muth, Jan Zarzycki, Marieke Scheffen, Moshe Goldsmith, Olga Khersonsky, Ziv Avizemer, Sarel J. Fleishman, Charles A. R. Cotton, Tobias J. Erb, Dan S. Tawfik, Arren Bar-Even
Publié dans: Proceedings of the National Academy of Sciences, Numéro 115/49, 2018, Page(s) E11455-E11464, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1812605115

Synthetic biology approaches for improving photosynthesis

Auteurs: Armin Kubis, Arren Bar-Even
Publié dans: Journal of Experimental Botany, Numéro 70/5, 2019, Page(s) 1425-1433, ISSN 0022-0957
Éditeur: Oxford University Press
DOI: 10.1093/jxb/erz029

A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation

Auteurs: Marieke Scheffen, Daniel G. Marchal, Thomas Beneyton, Sandra K. Schuller, Melanie Klose, Christoph Diehl, Jessica Lehmann, Pascal Pfister, Martina Carrillo, Hai He, Selçuk Aslan, Niña S. Cortina, Peter Claus, Daniel Bollschweiler, Jean-Christophe Baret, Jan M. Schuller, Jan Zarzycki, Arren Bar-Even, Tobias J. Erb
Publié dans: Nature Catalysis, 2021, ISSN 2520-1158
Éditeur: Springer Nature
DOI: 10.1038/s41929-020-00557-y

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