Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy

Información del proyecto

INNODERM

Identificador del acuerdo de subvención: 687866

DOI

10.3030/687866

Proyecto cerrado

Fecha de la firma de la CE 11 Noviembre 2015

Fecha de inicio 1 Marzo 2016

Fecha de finalización 31 Agosto 2021

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Coste total

€ 4 595 125,00

Aportación de la UE

€ 3 869 879,13

Coordinado por

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (10)

Report on LiNBO3 vs PZT element transducers

Report on LiNBO3 vs PZT element transducers (TUM) and measured progress achieved on performance, cost and manufacturing / reliability characteristics.

Report on a validated Portfolio of Imaging Features (PIF)

Report on a validated Portfolio of Imaging Features (PIF) (HUNIMED, M60) to outline the most promising imaging/imaging features from TABLE 1, 2 confirmed in patients.

Report or publication on read-electronics speeds and efficiency

Report or publication on read-electronics speeds and efficiency (iThera) detailing the inversion speed gains of GPU implementation.

Report on safety findings of RSOM2 on skin in-vivo

Report on safety findings of RSOM2 on skin in-vivo (HUNIMED) as a function of illuminating energy delivered to tissue.

Final dissemination report

Final dissemination report (iThera, M60)

Second report on microscopy imaging features in skin diseases

Second report on microscopy imaging features in skin diseases (TUM) for the final microscopy implementation, performed in co-operation with HUNIMED and TUM.

Second report on mesoscopy imaging features in skin diseases

Second eport on mesoscopy imaging features in skin diseases (HUNIMED, M60) for the final scanner implementation, performed in co-operation with HUNIMED and the other partners.

Report on performance of RSOM2

Report on performance of RSOM2 (TUM) on phantoms and animals for detailing functional, operational and manufacturing/cost characteristics of the technology.

Report on first single element transducer implementation

Report on first single element transducer implementation (TUM) for the scanner based on single element transducer technology at 450nm-650nm and 700nm-950nm detailing technical details and performance of the system.

Report or publication on algorithmic acceleration

Report or publication on algorithmic acceleration (RAYFOS) detailing the inversion speed gains of GPU implementation.

Websites, patent fillings, videos etc. (7)

Program, presentation slides and summarized findings of dissemination workshop

Program, presentation slides and summarized findings of dissemination workshop (RAYFOS) Talks (slides) and major findings and workshop achievements and feedback will be reported

Project web site

Project web site containing INNODERM manual, logo, internal and public areas, data and document repository and description of INNODERM goals; updated regularly.

Update, communication kit

mid-term update on communication kit

First communication kit

First communication kit, beginning of project

Press release, public promotion leaflet and RSOM2 postcard

Public promotion leaflet and RSOM2 postcard (HUNIMED) Public awareness documents containing EU, Horizon 2020, INNODERM and partner logos and impressive images generated by RSOM2 and explanation of INNODERM goals, achievements and impact.

Final communication kit

final update of communication kit at the end of the project

Press release, project launch

press release when project launches in compliance with EU communication requirements

Other (2)

Final single element transducers for RSOM with low noise amplification

Final single element transducers for RSOM with low noise amplification (SONAXIS) and manufacturing and performance specification for mesoscopy implementation.

Functioning RSOM2 prototype

Functioning RSOM2 prototype (iThera) operating in mesoscopy and microscopy mode.

Publicaciones

Peer reviewed articles (21)

Homogentisic acid-derived pigment as a biocompatible label for optoacoustic imaging of macrophages

Autores: Ina Weidenfeld, Christian Zakian, Peter Duewell, Andriy Chmyrov, Uwe Klemm, Juan Aguirre, Vasilis Ntziachristos, Andre C. Stiel
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-13041-4

Quantification of skin sensitivity to ultraviolet radiation using ultrawideband optoacoustic mesoscopy

Autores: B. Hindelang, J. Aguirre, A. Berezhnoi, T. Biedermann, U. Darsow, B. Eberlein, V. Ntziachristos
Publicado en: British Journal of Dermatology, Edición 184/2, 2021, Página(s) 352-354, ISSN 0007-0963
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjd.19463

In Vitro Characterization of Hypoxia Preconditioned Serum (HPS)—Fibrin Hydrogels: Basis for an Injectable Biomimetic Tissue Regeneration Therapy

Autores: Ektoras Hadjipanayi, Philipp Moog, Sanjar Bekeran, Katharina Kirchhoff, Andrei Berezhnoi, Juan Aguirre, Anna-Theresa Bauer, Haydar Kükrek, Daniel Schmauss, Ursula Hopfner, Sarah Isenburg, Vasilis Ntziachristos, Milomir Ninkovic, Hans-Günther Machens, Arndt F. Schilling, Ulf Dornseifer
Publicado en: Journal of Functional Biomaterials, Edición 10/2, 2019, Página(s) 22, ISSN 2079-4983
Editor: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jfb10020022

High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

Autores: Katja Haedicke, Lilach Agemy, Murad Omar, Andrei Berezhnoi, Sheryl Roberts, Camila Longo-Machado, Magdalena Skubal, Karan Nagar, Hsiao-Ting Hsu, Kwanghee Kim, Thomas Reiner, Jonathan Coleman, Vasilis Ntziachristos, Avigdor Scherz, Jan Grimm
Publicado en: Nature Biomedical Engineering, Edición 4/3, 2020, Página(s) 286-297, ISSN 2157-846X
Editor: Springer Nature
DOI: 10.1038/s41551-020-0527-8

Fully automated identification of skin morphology in raster‐scan optoacoustic mesoscopy using artificial intelligence

Autores: Serafeim Moustakidis, Murad Omar, Juan Aguirre, Pouyan Mohajerani, Vasilis Ntziachristos
Publicado en: Medical Physics, Edición 46/9, 2019, Página(s) 4046-4056, ISSN 0094-2405
Editor: American Association of Physicists in Medicine
DOI: 10.1002/mp.13725

Skin Surface Detection in 3D Optoacoustic Mesoscopy Based on Dynamic Programming

Autores: Suhanyaa Nitkunanantharajah, Guillaume Zahnd, Malini Olivo, Nassir Navab, Pouyan Mohajerani, Vasilis Ntziachristos
Publicado en: IEEE Transactions on Medical Imaging, Edición 39/2, 2020, Página(s) 458-467, ISSN 0278-0062
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2928393

Optoakustische Bildgebung – Licht rein, Schall raus?

Autores: B. Hindelang, C. Schönmann, J. Aguirre, V. Ntziachristos, T. Biedermann, U. Darsow
Publicado en: Aktuelle Dermatologie, Edición 46/04, 2020, Página(s) 171-178, ISSN 0340-2541
Editor: Georg Thieme Verlag
DOI: 10.1055/a-1072-7195

Optical features of human skin revealed by optoacoustic mesoscopy in the visible and short-wave infrared regions

Autores: Andrei Berezhnoi, Juan Aguirre, Benedikt Hindelang, Natalie Garzorz-Stark, Murad Omar, Ulf Darsow, Kilian Eyerich, Vasilis Ntziachristos
Publicado en: Optics Letters, Edición 44/17, 2019, Página(s) 4119, ISSN 0146-9592
Editor: Optical Society of America
DOI: 10.1364/ol.44.004119

Motion correction in optoacoustic mesoscopy

Autores: Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-11277-y

Role of the HLA-C*06 allele in clinical response to ustekinumab: evidence from real life in a large cohort of European patients

Autores: M. Talamonti, M. Galluzzo, J.M. van den Reek, E.M. de Jong, J.L.W. Lambert, P. Malagoli, L. Bianchi, A. Costanzo
Publicado en: British Journal of Dermatology, Edición 177/2, 2017, Página(s) 489-496, ISSN 0007-0963
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjd.15387

Diagnostic imaging: Listening in to skin disease

Autores: Alessandra Narcisi, Rebecca Favaro, Antonio Costanzo
Publicado en: Nature Biomedical Engineering, Edición 1/5, 2017, Página(s) 0076, ISSN 2157-846X
Editor: Nature Biomedical Engineering
DOI: 10.1038/s41551-017-0076

Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy

Autores: Andrei Berezhnoi, Mathias Schwarz, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Publicado en: Journal of Biophotonics, Edición 11/11, 2018, Página(s) e201700359, ISSN 1864-063X
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201700359

Non-invasive imaging in dermatology and the unique potential of Raster-Scan Optoacoustic Mesoscopy (RSOM)

Autores: B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Publicado en: Journal of the European Academy of Dermatology and Venereology, 2018, ISSN 0926-9959
Editor: Elsevier BV
DOI: 10.1111/jdv.15342

Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy

Autores: J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Publicado en: Photoacoustics, Edición 10, 2018, Página(s) 31-37, ISSN 2213-5979
Editor: Elsevier GmbH
DOI: 10.1016/j.pacs.2018.02.002

Continuous wave laser diodes enable fast optoacoustic imaging

Autores: Antonios Stylogiannis, Ludwig Prade, Andreas Buehler, Juan Aguirre, George Sergiadis, Vasilis Ntziachristos
Publicado en: Photoacoustics, Edición 9, 2018, Página(s) 31-38, ISSN 2213-5979
Editor: Elsevier GmbH
DOI: 10.1016/j.pacs.2017.12.002

Optoacoustic mesoscopy for biomedicine

Autores: Murad Omar, Juan Aguirre, Vasilis Ntziachristos
Publicado en: Nature Biomedical Engineering, 2019, ISSN 2157-846X
Editor: Springer Nature
DOI: 10.1038/s41551-019-0377-4

Motion quantification and automated correction in clinical RSOM

Autores: Juan Aguirre, Andrei Berezhnoi, Hailong He, Mathias Schwarz, Benedikt Hindelang, Murad Omar, Vasilis Ntziachristos
Publicado en: IEEE Transactions on Medical Imaging, 2019, Página(s) 1-1, ISSN 0278-0062
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2018.2883154

Optoacoustic Dermoscopy of the Human Skin: Tuning Excitation Energy for Optimal Detection Bandwidth with Fast and Deep Imaging in vivo

Autores: Mathias Schwarz, Dominik Soliman, Murad Omar, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Publicado en: IEEE Transactions on Medical Imaging, 2017, Página(s) 1-1, ISSN 0278-0062
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TMI.2017.2664142

Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy

Autores: Juan Aguirre, Mathias Schwarz, Natalie Garzorz, Murad Omar, Andreas Buehler, Kilian Eyerich, Vasilis Ntziachristos
Publicado en: Nature Biomedical Engineering, Edición 1/5, 2017, Página(s) 0068, ISSN 2157-846X
Editor: nature publishing group
DOI: 10.1038/s41551-017-0068

Optoacoustic mesoscopy shows potential to increase accuracy of allergy patch testing

Autores: Benedikt Hindelang, Juan Aguirre, Andrei Berezhnoi, Hailong He, Kilian Eyerich, Vasilis Ntziachristos, Tilo Biedermann, Ulf Darsow
Publicado en: Contact Dermatitis, Edición 83/3, 2020, Página(s) 206-214, ISSN 0105-1873
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cod.13563

Concomitant Pyoderma Gangrenosum-like and Amicrobial Pustulosis of the Folds: a Case Report

Autores: Paola Facheris, Maria De Santis, Luigi Gargiulo, Giulia Pavia, Mario Valenti, Sofia Manara, Riccardo G. Borroni, Antonio Costanzo, Alessandra Narcisi
Publicado en: Journal of Clinical Immunology, Edición 40/7, 2020, Página(s) 1038-1040, ISSN 0271-9142
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-020-00819-1

Book chapters (1)

Optical and Optoacoustic Imaging

Autores: Daniel Razansky, Vasilis Ntziachristos
Publicado en: Molecular Imaging in Oncology, Edición 216, 2020, Página(s) 155-187, ISBN 978-3-030-42617-0
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-42618-7_5