Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy

Informations projet

INNODERM

N° de convention de subvention: 687866

DOI

10.3030/687866

Projet clôturé

Date de signature de la CE 11 Novembre 2015

Date de début 1 Mars 2016

Date de fin 31 Août 2021

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Coût total

€ 4 595 125,00

Contribution de l’UE

€ 3 869 879,13

Coordonné par

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (10)

Report on LiNBO3 vs PZT element transducers

Report on LiNBO3 vs PZT element transducers (TUM) and measured progress achieved on performance, cost and manufacturing / reliability characteristics.

Report on a validated Portfolio of Imaging Features (PIF)

Report on a validated Portfolio of Imaging Features (PIF) (HUNIMED, M60) to outline the most promising imaging/imaging features from TABLE 1, 2 confirmed in patients.

Report or publication on read-electronics speeds and efficiency

Report or publication on read-electronics speeds and efficiency (iThera) detailing the inversion speed gains of GPU implementation.

Report on safety findings of RSOM2 on skin in-vivo

Report on safety findings of RSOM2 on skin in-vivo (HUNIMED) as a function of illuminating energy delivered to tissue.

Final dissemination report

Final dissemination report (iThera, M60)

Second report on microscopy imaging features in skin diseases

Second report on microscopy imaging features in skin diseases (TUM) for the final microscopy implementation, performed in co-operation with HUNIMED and TUM.

Second report on mesoscopy imaging features in skin diseases

Second eport on mesoscopy imaging features in skin diseases (HUNIMED, M60) for the final scanner implementation, performed in co-operation with HUNIMED and the other partners.

Report on performance of RSOM2

Report on performance of RSOM2 (TUM) on phantoms and animals for detailing functional, operational and manufacturing/cost characteristics of the technology.

Report on first single element transducer implementation

Report on first single element transducer implementation (TUM) for the scanner based on single element transducer technology at 450nm-650nm and 700nm-950nm detailing technical details and performance of the system.

Report or publication on algorithmic acceleration

Report or publication on algorithmic acceleration (RAYFOS) detailing the inversion speed gains of GPU implementation.

Websites, patent fillings, videos etc. (7)

Program, presentation slides and summarized findings of dissemination workshop

Program, presentation slides and summarized findings of dissemination workshop (RAYFOS) Talks (slides) and major findings and workshop achievements and feedback will be reported

Project web site

Project web site containing INNODERM manual, logo, internal and public areas, data and document repository and description of INNODERM goals; updated regularly.

Update, communication kit

mid-term update on communication kit

First communication kit

First communication kit, beginning of project

Press release, public promotion leaflet and RSOM2 postcard

Public promotion leaflet and RSOM2 postcard (HUNIMED) Public awareness documents containing EU, Horizon 2020, INNODERM and partner logos and impressive images generated by RSOM2 and explanation of INNODERM goals, achievements and impact.

Final communication kit

final update of communication kit at the end of the project

Press release, project launch

press release when project launches in compliance with EU communication requirements

Other (2)

Final single element transducers for RSOM with low noise amplification

Final single element transducers for RSOM with low noise amplification (SONAXIS) and manufacturing and performance specification for mesoscopy implementation.

Functioning RSOM2 prototype

Functioning RSOM2 prototype (iThera) operating in mesoscopy and microscopy mode.

Publications

Peer reviewed articles (21)

Homogentisic acid-derived pigment as a biocompatible label for optoacoustic imaging of macrophages

Auteurs: Ina Weidenfeld, Christian Zakian, Peter Duewell, Andriy Chmyrov, Uwe Klemm, Juan Aguirre, Vasilis Ntziachristos, Andre C. Stiel
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-13041-4

Quantification of skin sensitivity to ultraviolet radiation using ultrawideband optoacoustic mesoscopy

Auteurs: B. Hindelang, J. Aguirre, A. Berezhnoi, T. Biedermann, U. Darsow, B. Eberlein, V. Ntziachristos
Publié dans: British Journal of Dermatology, Numéro 184/2, 2021, Page(s) 352-354, ISSN 0007-0963
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bjd.19463

In Vitro Characterization of Hypoxia Preconditioned Serum (HPS)—Fibrin Hydrogels: Basis for an Injectable Biomimetic Tissue Regeneration Therapy

Auteurs: Ektoras Hadjipanayi, Philipp Moog, Sanjar Bekeran, Katharina Kirchhoff, Andrei Berezhnoi, Juan Aguirre, Anna-Theresa Bauer, Haydar Kükrek, Daniel Schmauss, Ursula Hopfner, Sarah Isenburg, Vasilis Ntziachristos, Milomir Ninkovic, Hans-Günther Machens, Arndt F. Schilling, Ulf Dornseifer
Publié dans: Journal of Functional Biomaterials, Numéro 10/2, 2019, Page(s) 22, ISSN 2079-4983
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jfb10020022

High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

Auteurs: Katja Haedicke, Lilach Agemy, Murad Omar, Andrei Berezhnoi, Sheryl Roberts, Camila Longo-Machado, Magdalena Skubal, Karan Nagar, Hsiao-Ting Hsu, Kwanghee Kim, Thomas Reiner, Jonathan Coleman, Vasilis Ntziachristos, Avigdor Scherz, Jan Grimm
Publié dans: Nature Biomedical Engineering, Numéro 4/3, 2020, Page(s) 286-297, ISSN 2157-846X
Éditeur: Springer Nature
DOI: 10.1038/s41551-020-0527-8

Fully automated identification of skin morphology in raster‐scan optoacoustic mesoscopy using artificial intelligence

Auteurs: Serafeim Moustakidis, Murad Omar, Juan Aguirre, Pouyan Mohajerani, Vasilis Ntziachristos
Publié dans: Medical Physics, Numéro 46/9, 2019, Page(s) 4046-4056, ISSN 0094-2405
Éditeur: American Association of Physicists in Medicine
DOI: 10.1002/mp.13725

Skin Surface Detection in 3D Optoacoustic Mesoscopy Based on Dynamic Programming

Auteurs: Suhanyaa Nitkunanantharajah, Guillaume Zahnd, Malini Olivo, Nassir Navab, Pouyan Mohajerani, Vasilis Ntziachristos
Publié dans: IEEE Transactions on Medical Imaging, Numéro 39/2, 2020, Page(s) 458-467, ISSN 0278-0062
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2928393

Optoakustische Bildgebung – Licht rein, Schall raus?

Auteurs: B. Hindelang, C. Schönmann, J. Aguirre, V. Ntziachristos, T. Biedermann, U. Darsow
Publié dans: Aktuelle Dermatologie, Numéro 46/04, 2020, Page(s) 171-178, ISSN 0340-2541
Éditeur: Georg Thieme Verlag
DOI: 10.1055/a-1072-7195

Optical features of human skin revealed by optoacoustic mesoscopy in the visible and short-wave infrared regions

Auteurs: Andrei Berezhnoi, Juan Aguirre, Benedikt Hindelang, Natalie Garzorz-Stark, Murad Omar, Ulf Darsow, Kilian Eyerich, Vasilis Ntziachristos
Publié dans: Optics Letters, Numéro 44/17, 2019, Page(s) 4119, ISSN 0146-9592
Éditeur: Optical Society of America
DOI: 10.1364/ol.44.004119

Motion correction in optoacoustic mesoscopy

Auteurs: Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-11277-y

Role of the HLA-C*06 allele in clinical response to ustekinumab: evidence from real life in a large cohort of European patients

Auteurs: M. Talamonti, M. Galluzzo, J.M. van den Reek, E.M. de Jong, J.L.W. Lambert, P. Malagoli, L. Bianchi, A. Costanzo
Publié dans: British Journal of Dermatology, Numéro 177/2, 2017, Page(s) 489-496, ISSN 0007-0963
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bjd.15387

Diagnostic imaging: Listening in to skin disease

Auteurs: Alessandra Narcisi, Rebecca Favaro, Antonio Costanzo
Publié dans: Nature Biomedical Engineering, Numéro 1/5, 2017, Page(s) 0076, ISSN 2157-846X
Éditeur: Nature Biomedical Engineering
DOI: 10.1038/s41551-017-0076

Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy

Auteurs: Andrei Berezhnoi, Mathias Schwarz, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Publié dans: Journal of Biophotonics, Numéro 11/11, 2018, Page(s) e201700359, ISSN 1864-063X
Éditeur: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201700359

Non-invasive imaging in dermatology and the unique potential of Raster-Scan Optoacoustic Mesoscopy (RSOM)

Auteurs: B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Publié dans: Journal of the European Academy of Dermatology and Venereology, 2018, ISSN 0926-9959
Éditeur: Elsevier BV
DOI: 10.1111/jdv.15342

Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy

Auteurs: J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Publié dans: Photoacoustics, Numéro 10, 2018, Page(s) 31-37, ISSN 2213-5979
Éditeur: Elsevier GmbH
DOI: 10.1016/j.pacs.2018.02.002

Continuous wave laser diodes enable fast optoacoustic imaging

Auteurs: Antonios Stylogiannis, Ludwig Prade, Andreas Buehler, Juan Aguirre, George Sergiadis, Vasilis Ntziachristos
Publié dans: Photoacoustics, Numéro 9, 2018, Page(s) 31-38, ISSN 2213-5979
Éditeur: Elsevier GmbH
DOI: 10.1016/j.pacs.2017.12.002

Optoacoustic mesoscopy for biomedicine

Auteurs: Murad Omar, Juan Aguirre, Vasilis Ntziachristos
Publié dans: Nature Biomedical Engineering, 2019, ISSN 2157-846X
Éditeur: Springer Nature
DOI: 10.1038/s41551-019-0377-4

Motion quantification and automated correction in clinical RSOM

Auteurs: Juan Aguirre, Andrei Berezhnoi, Hailong He, Mathias Schwarz, Benedikt Hindelang, Murad Omar, Vasilis Ntziachristos
Publié dans: IEEE Transactions on Medical Imaging, 2019, Page(s) 1-1, ISSN 0278-0062
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2018.2883154

Optoacoustic Dermoscopy of the Human Skin: Tuning Excitation Energy for Optimal Detection Bandwidth with Fast and Deep Imaging in vivo

Auteurs: Mathias Schwarz, Dominik Soliman, Murad Omar, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Publié dans: IEEE Transactions on Medical Imaging, 2017, Page(s) 1-1, ISSN 0278-0062
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TMI.2017.2664142

Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy

Auteurs: Juan Aguirre, Mathias Schwarz, Natalie Garzorz, Murad Omar, Andreas Buehler, Kilian Eyerich, Vasilis Ntziachristos
Publié dans: Nature Biomedical Engineering, Numéro 1/5, 2017, Page(s) 0068, ISSN 2157-846X
Éditeur: nature publishing group
DOI: 10.1038/s41551-017-0068

Optoacoustic mesoscopy shows potential to increase accuracy of allergy patch testing

Auteurs: Benedikt Hindelang, Juan Aguirre, Andrei Berezhnoi, Hailong He, Kilian Eyerich, Vasilis Ntziachristos, Tilo Biedermann, Ulf Darsow
Publié dans: Contact Dermatitis, Numéro 83/3, 2020, Page(s) 206-214, ISSN 0105-1873
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cod.13563

Concomitant Pyoderma Gangrenosum-like and Amicrobial Pustulosis of the Folds: a Case Report

Auteurs: Paola Facheris, Maria De Santis, Luigi Gargiulo, Giulia Pavia, Mario Valenti, Sofia Manara, Riccardo G. Borroni, Antonio Costanzo, Alessandra Narcisi
Publié dans: Journal of Clinical Immunology, Numéro 40/7, 2020, Page(s) 1038-1040, ISSN 0271-9142
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-020-00819-1

Book chapters (1)

Optical and Optoacoustic Imaging

Auteurs: Daniel Razansky, Vasilis Ntziachristos
Publié dans: Molecular Imaging in Oncology, Numéro 216, 2020, Page(s) 155-187, ISBN 978-3-030-42617-0
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-42618-7_5