Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy

Project Information

INNODERM

Grant agreement ID: 687866

DOI

10.3030/687866

Project closed

EC signature date 11 November 2015

Start date 1 March 2016

End date 31 August 2021

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Total cost

€ 4 595 125,00

EU contribution

€ 3 869 879,13

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (10)

Report on LiNBO3 vs PZT element transducers

Report on LiNBO3 vs PZT element transducers (TUM) and measured progress achieved on performance, cost and manufacturing / reliability characteristics.

Report on a validated Portfolio of Imaging Features (PIF)

Report on a validated Portfolio of Imaging Features (PIF) (HUNIMED, M60) to outline the most promising imaging/imaging features from TABLE 1, 2 confirmed in patients.

Report or publication on read-electronics speeds and efficiency

Report or publication on read-electronics speeds and efficiency (iThera) detailing the inversion speed gains of GPU implementation.

Report on safety findings of RSOM2 on skin in-vivo

Report on safety findings of RSOM2 on skin in-vivo (HUNIMED) as a function of illuminating energy delivered to tissue.

Final dissemination report

Final dissemination report (iThera, M60)

Second report on microscopy imaging features in skin diseases

Second report on microscopy imaging features in skin diseases (TUM) for the final microscopy implementation, performed in co-operation with HUNIMED and TUM.

Second report on mesoscopy imaging features in skin diseases

Second eport on mesoscopy imaging features in skin diseases (HUNIMED, M60) for the final scanner implementation, performed in co-operation with HUNIMED and the other partners.

Report on performance of RSOM2

Report on performance of RSOM2 (TUM) on phantoms and animals for detailing functional, operational and manufacturing/cost characteristics of the technology.

Report on first single element transducer implementation

Report on first single element transducer implementation (TUM) for the scanner based on single element transducer technology at 450nm-650nm and 700nm-950nm detailing technical details and performance of the system.

Report or publication on algorithmic acceleration

Report or publication on algorithmic acceleration (RAYFOS) detailing the inversion speed gains of GPU implementation.

Websites, patent fillings, videos etc. (7)

Program, presentation slides and summarized findings of dissemination workshop

Program, presentation slides and summarized findings of dissemination workshop (RAYFOS) Talks (slides) and major findings and workshop achievements and feedback will be reported

Project web site

Project web site containing INNODERM manual, logo, internal and public areas, data and document repository and description of INNODERM goals; updated regularly.

Update, communication kit

mid-term update on communication kit

First communication kit

First communication kit, beginning of project

Press release, public promotion leaflet and RSOM2 postcard

Public promotion leaflet and RSOM2 postcard (HUNIMED) Public awareness documents containing EU, Horizon 2020, INNODERM and partner logos and impressive images generated by RSOM2 and explanation of INNODERM goals, achievements and impact.

Final communication kit

final update of communication kit at the end of the project

Press release, project launch

press release when project launches in compliance with EU communication requirements

Other (2)

Final single element transducers for RSOM with low noise amplification

Final single element transducers for RSOM with low noise amplification (SONAXIS) and manufacturing and performance specification for mesoscopy implementation.

Functioning RSOM2 prototype

Functioning RSOM2 prototype (iThera) operating in mesoscopy and microscopy mode.

Publications

Peer reviewed articles (21)

Homogentisic acid-derived pigment as a biocompatible label for optoacoustic imaging of macrophages

Author(s): Ina Weidenfeld, Christian Zakian, Peter Duewell, Andriy Chmyrov, Uwe Klemm, Juan Aguirre, Vasilis Ntziachristos, Andre C. Stiel
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13041-4

Quantification of skin sensitivity to ultraviolet radiation using ultrawideband optoacoustic mesoscopy

Author(s): B. Hindelang, J. Aguirre, A. Berezhnoi, T. Biedermann, U. Darsow, B. Eberlein, V. Ntziachristos
Published in: British Journal of Dermatology, Issue 184/2, 2021, Page(s) 352-354, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjd.19463

In Vitro Characterization of Hypoxia Preconditioned Serum (HPS)—Fibrin Hydrogels: Basis for an Injectable Biomimetic Tissue Regeneration Therapy

Author(s): Ektoras Hadjipanayi, Philipp Moog, Sanjar Bekeran, Katharina Kirchhoff, Andrei Berezhnoi, Juan Aguirre, Anna-Theresa Bauer, Haydar Kükrek, Daniel Schmauss, Ursula Hopfner, Sarah Isenburg, Vasilis Ntziachristos, Milomir Ninkovic, Hans-Günther Machens, Arndt F. Schilling, Ulf Dornseifer
Published in: Journal of Functional Biomaterials, Issue 10/2, 2019, Page(s) 22, ISSN 2079-4983
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jfb10020022

High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

Author(s): Katja Haedicke, Lilach Agemy, Murad Omar, Andrei Berezhnoi, Sheryl Roberts, Camila Longo-Machado, Magdalena Skubal, Karan Nagar, Hsiao-Ting Hsu, Kwanghee Kim, Thomas Reiner, Jonathan Coleman, Vasilis Ntziachristos, Avigdor Scherz, Jan Grimm
Published in: Nature Biomedical Engineering, Issue 4/3, 2020, Page(s) 286-297, ISSN 2157-846X
Publisher: Springer Nature
DOI: 10.1038/s41551-020-0527-8

Fully automated identification of skin morphology in raster‐scan optoacoustic mesoscopy using artificial intelligence

Author(s): Serafeim Moustakidis, Murad Omar, Juan Aguirre, Pouyan Mohajerani, Vasilis Ntziachristos
Published in: Medical Physics, Issue 46/9, 2019, Page(s) 4046-4056, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.13725

Skin Surface Detection in 3D Optoacoustic Mesoscopy Based on Dynamic Programming

Author(s): Suhanyaa Nitkunanantharajah, Guillaume Zahnd, Malini Olivo, Nassir Navab, Pouyan Mohajerani, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, Issue 39/2, 2020, Page(s) 458-467, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2928393

Optoakustische Bildgebung – Licht rein, Schall raus?

Author(s): B. Hindelang, C. Schönmann, J. Aguirre, V. Ntziachristos, T. Biedermann, U. Darsow
Published in: Aktuelle Dermatologie, Issue 46/04, 2020, Page(s) 171-178, ISSN 0340-2541
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-1072-7195

Optical features of human skin revealed by optoacoustic mesoscopy in the visible and short-wave infrared regions

Author(s): Andrei Berezhnoi, Juan Aguirre, Benedikt Hindelang, Natalie Garzorz-Stark, Murad Omar, Ulf Darsow, Kilian Eyerich, Vasilis Ntziachristos
Published in: Optics Letters, Issue 44/17, 2019, Page(s) 4119, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.44.004119

Motion correction in optoacoustic mesoscopy

Author(s): Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-11277-y

Role of the HLA-C*06 allele in clinical response to ustekinumab: evidence from real life in a large cohort of European patients

Author(s): M. Talamonti, M. Galluzzo, J.M. van den Reek, E.M. de Jong, J.L.W. Lambert, P. Malagoli, L. Bianchi, A. Costanzo
Published in: British Journal of Dermatology, Issue 177/2, 2017, Page(s) 489-496, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjd.15387

Diagnostic imaging: Listening in to skin disease

Author(s): Alessandra Narcisi, Rebecca Favaro, Antonio Costanzo
Published in: Nature Biomedical Engineering, Issue 1/5, 2017, Page(s) 0076, ISSN 2157-846X
Publisher: Nature Biomedical Engineering
DOI: 10.1038/s41551-017-0076

Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy

Author(s): Andrei Berezhnoi, Mathias Schwarz, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Published in: Journal of Biophotonics, Issue 11/11, 2018, Page(s) e201700359, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201700359

Non-invasive imaging in dermatology and the unique potential of Raster-Scan Optoacoustic Mesoscopy (RSOM)

Author(s): B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Published in: Journal of the European Academy of Dermatology and Venereology, 2018, ISSN 0926-9959
Publisher: Elsevier BV
DOI: 10.1111/jdv.15342

Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy

Author(s): J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Published in: Photoacoustics, Issue 10, 2018, Page(s) 31-37, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2018.02.002

Continuous wave laser diodes enable fast optoacoustic imaging

Author(s): Antonios Stylogiannis, Ludwig Prade, Andreas Buehler, Juan Aguirre, George Sergiadis, Vasilis Ntziachristos
Published in: Photoacoustics, Issue 9, 2018, Page(s) 31-38, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2017.12.002

Optoacoustic mesoscopy for biomedicine

Author(s): Murad Omar, Juan Aguirre, Vasilis Ntziachristos
Published in: Nature Biomedical Engineering, 2019, ISSN 2157-846X
Publisher: Springer Nature
DOI: 10.1038/s41551-019-0377-4

Motion quantification and automated correction in clinical RSOM

Author(s): Juan Aguirre, Andrei Berezhnoi, Hailong He, Mathias Schwarz, Benedikt Hindelang, Murad Omar, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, 2019, Page(s) 1-1, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2018.2883154

Optoacoustic Dermoscopy of the Human Skin: Tuning Excitation Energy for Optimal Detection Bandwidth with Fast and Deep Imaging in vivo

Author(s): Mathias Schwarz, Dominik Soliman, Murad Omar, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, 2017, Page(s) 1-1, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TMI.2017.2664142

Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy

Author(s): Juan Aguirre, Mathias Schwarz, Natalie Garzorz, Murad Omar, Andreas Buehler, Kilian Eyerich, Vasilis Ntziachristos
Published in: Nature Biomedical Engineering, Issue 1/5, 2017, Page(s) 0068, ISSN 2157-846X
Publisher: nature publishing group
DOI: 10.1038/s41551-017-0068

Optoacoustic mesoscopy shows potential to increase accuracy of allergy patch testing

Author(s): Benedikt Hindelang, Juan Aguirre, Andrei Berezhnoi, Hailong He, Kilian Eyerich, Vasilis Ntziachristos, Tilo Biedermann, Ulf Darsow
Published in: Contact Dermatitis, Issue 83/3, 2020, Page(s) 206-214, ISSN 0105-1873
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cod.13563

Concomitant Pyoderma Gangrenosum-like and Amicrobial Pustulosis of the Folds: a Case Report

Author(s): Paola Facheris, Maria De Santis, Luigi Gargiulo, Giulia Pavia, Mario Valenti, Sofia Manara, Riccardo G. Borroni, Antonio Costanzo, Alessandra Narcisi
Published in: Journal of Clinical Immunology, Issue 40/7, 2020, Page(s) 1038-1040, ISSN 0271-9142
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-020-00819-1

Book chapters (1)

Optical and Optoacoustic Imaging

Author(s): Daniel Razansky, Vasilis Ntziachristos
Published in: Molecular Imaging in Oncology, Issue 216, 2020, Page(s) 155-187, ISBN 978-3-030-42617-0
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-42618-7_5