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Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy

Deliverables

Report on LiNBO3 vs PZT element transducers

Report on LiNBO3 vs PZT element transducers (TUM) and measured progress achieved on performance, cost and manufacturing / reliability characteristics.

Report or publication on read-electronics speeds and efficiency

Report or publication on read-electronics speeds and efficiency (iThera) detailing the inversion speed gains of GPU implementation.

Report on safety findings of RSOM2 on skin in-vivo

Report on safety findings of RSOM2 on skin in-vivo (HUNIMED) as a function of illuminating energy delivered to tissue.

Report on performance of RSOM2

Report on performance of RSOM2 (TUM) on phantoms and animals for detailing functional, operational and manufacturing/cost characteristics of the technology.

Report on first single element transducer implementation

Report on first single element transducer implementation (TUM) for the scanner based on single element transducer technology at 450nm-650nm and 700nm-950nm detailing technical details and performance of the system.

Report or publication on algorithmic acceleration

Report or publication on algorithmic acceleration (RAYFOS) detailing the inversion speed gains of GPU implementation.

Project web site

Project web site containing INNODERM manual, logo, internal and public areas, data and document repository and description of INNODERM goals; updated regularly.

Update, communication kit

mid-term update on communication kit

First communication kit

First communication kit, beginning of project

Press release, project launch

press release when project launches in compliance with EU communication requirements

Final single element transducers for RSOM with low noise amplification

Final single element transducers for RSOM with low noise amplification (SONAXIS) and manufacturing and performance specification for mesoscopy implementation.

Functioning RSOM2 prototype

Functioning RSOM2 prototype (iThera) operating in mesoscopy and microscopy mode.

Searching for OpenAIRE data...

Publications

Motion correction in optoacoustic mesoscopy

Author(s): Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-11277-y

Role of the HLA-C*06 allele in clinical response to ustekinumab: evidence from real life in a large cohort of European patients

Author(s): M. Talamonti, M. Galluzzo, J.M. van den Reek, E.M. de Jong, J.L.W. Lambert, P. Malagoli, L. Bianchi, A. Costanzo
Published in: British Journal of Dermatology, Issue 177/2, 2017, Page(s) 489-496, ISSN 0007-0963
DOI: 10.1111/bjd.15387

Diagnostic imaging: Listening in to skin disease

Author(s): Alessandra Narcisi, Rebecca Favaro, Antonio Costanzo
Published in: Nature Biomedical Engineering, Issue 1/5, 2017, Page(s) 0076, ISSN 2157-846X
DOI: 10.1038/s41551-017-0076

Non-invasive imaging in dermatology and the unique potential of Raster-Scan Optoacoustic Mesoscopy (RSOM)

Author(s): B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Published in: Journal of the European Academy of Dermatology and Venereology, 2018, ISSN 0926-9959
DOI: 10.1111/jdv.15342

Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy

Author(s): J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Published in: Photoacoustics, Issue 10, 2018, Page(s) 31-37, ISSN 2213-5979
DOI: 10.1016/j.pacs.2018.02.002

Continuous wave laser diodes enable fast optoacoustic imaging

Author(s): Antonios Stylogiannis, Ludwig Prade, Andreas Buehler, Juan Aguirre, George Sergiadis, Vasilis Ntziachristos
Published in: Photoacoustics, Issue 9, 2018, Page(s) 31-38, ISSN 2213-5979
DOI: 10.1016/j.pacs.2017.12.002

Optoacoustic mesoscopy for biomedicine

Author(s): Murad Omar, Juan Aguirre, Vasilis Ntziachristos
Published in: Nature Biomedical Engineering, 2019, ISSN 2157-846X
DOI: 10.1038/s41551-019-0377-4

Motion quantification and automated correction in clinical RSOM

Author(s): Juan Aguirre, Andrei Berezhnoi, Hailong He, Mathias Schwarz, Benedikt Hindelang, Murad Omar, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, 2019, Page(s) 1-1, ISSN 0278-0062
DOI: 10.1109/tmi.2018.2883154

Optoacoustic Dermoscopy of the Human Skin: Tuning Excitation Energy for Optimal Detection Bandwidth with Fast and Deep Imaging in vivo

Author(s): Mathias Schwarz, Dominik Soliman, Murad Omar, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Published in: IEEE Transactions on Medical Imaging, 2017, Page(s) 1-1, ISSN 0278-0062
DOI: 10.1109/TMI.2017.2664142

Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy

Author(s): Juan Aguirre, Mathias Schwarz, Natalie Garzorz, Murad Omar, Andreas Buehler, Kilian Eyerich, Vasilis Ntziachristos
Published in: Nature Biomedical Engineering, Issue 1/5, 2017, Page(s) 0068, ISSN 2157-846X
DOI: 10.1038/s41551-017-0068