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The influence of the cell membrane asymmetry and curvature on the functioning of membrane proteins and the transport of therapeutic compounds

Objective

Real cell membranes are essentially asymmetric and non-planar. Outer leaflets of the plasma membranes contain neutral lipids and glycolipids, while the inner leaflets host practically all anionic lipids and phosphoinositides. In addition to asymmetric composition the membranes are usually curved due to spontaneous curvature of the membrane lipids and an influence of membrane proteins and cytoskeleton. There are many cellular phenomena, which are influenced by the asymmetry and the membrane curvature such as formation of synaptic vesicles, blebs and apoptotic bodies, membrane fusion and splitting, budding of enveloped viruses, endo and exocytosis, etc.
In this work we propose comprehensive interdisciplinary study of the influence of membrane asymmetry and curvature on the functioning of integral membrane proteins and the transmembrane transport of therapeutic compounds (such as cisplatin and its derivatives).
The goal is to reveal major physical factors, which distinguish asymmetric and curved membrane environment and govern interactions, orientation and diffusion of the small molecules (drugs) and large integral proteins.
The combination of experimental methods (“wet” biochemistry and molecular biology, enhanced infrared and Raman spectroscopy) and computer simulations (coarse-grained and atomistic molecular dynamics, quantum chemistry) would be used in the project in complimentary manner.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/lipids
  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/molecular biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry
  • /natural sciences/chemical sciences/physical chemistry/quantum chemistry

Call for proposal

H2020-MSCA-RISE-2015
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
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Coordinator

INSTITUTE OF PHYSICS OF NATIONAL ACADEMY OF SCIENCE OF UKRAINE
Address
Prospect Nauky 46
03680 Kyiv
Ukraine
Activity type
Research Organisations
EU contribution
€ 54 000

Participants (6)

UNIVERSITE DE FRANCHE-COMTE
France
EU contribution
€ 63 000
Address
1 Rue Claude Goudimel
25000 Besancon
Activity type
Higher or Secondary Education Establishments
LATVIJAS UNIVERSITATES CIETVIELU FIZIKAS INSTITUTS
Latvia
EU contribution
€ 45 000
Address
Kengaraga Iela 8
LV-1063 Riga
Activity type
Higher or Secondary Education Establishments
TARTU ULIKOOL
Estonia
EU contribution
€ 27 000
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
MATERIALS RESEARCH CENTER
Ukraine
EU contribution
€ 9 000
Address
Yaroslaviv Val/olisya Gonchara Street, 19/33-A
01034 Kiev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GRAPHENE LIGHT PROJECT
Poland
EU contribution
€ 4 500
Address
Okolna 2
50-422 Wroclaw
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FERENTIS
Lithuania
EU contribution
€ 0
Address
Savanoriu 231
02300 Vilnius
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (2)

THE UNIVERSITY OF TEXAS SYSTEM
United States
Address
Colorado Street 601
78701 2982 Austin
Activity type
Higher or Secondary Education Establishments
Universidade Federal de Juiz de Fora
Brazil
Address
Rua Jose Lourenco Kelmer, S/n Camp Uni-sao Pedro
36036-330 Juiz De Fora
Activity type
Higher or Secondary Education Establishments