The influence of the cell membrane asymmetry and curvature on the functioning of membrane proteins and the transport of therapeutic compounds

Resultado final

Progress Report 1

Progress report

Coherent view of the project goals, methods and schedules

Coherent view of the project goals, methods and schedules among all project participants.

Progress report 2

Progress report

Publishing and dissemination of results

Curvature-dependent potentials of mean force for drug translocation through the membrane

Dat on curvature-dependent potentials of mean force for drug translocation through the membrane.

Empirical force fields of the drugs

Working files of empirical force fields of the drugs.

Experimental markers of conformation changes in membrane-protein and membrane-drug complexes.

Data on experimental markers of conformation changes in membrane-protein and membrane-drug complexes.

Mid-term meeting

There will be only one mid-term meeting per project with timing between month 14 and 24. Definitive date is to be confirmed by the coordinator and preferably linked to a consortium event.

Comparison of experimental and simulation results

Consistent view of the curvature- and asymmetry-induced phenomena in the membranes from experimental and simulation perspectives

Curvature-dependent conformational changes of the membrane proteins

Data on curvature-dependent conformational changes of the membrane proteins

Publicaciones

The influence of curvature on the properties of the plasma membrane. Insights from atomistic molecular dynamics simulations

Autores: Semen O. Yesylevskyy, Timothée Rivel, Christophe Ramseyer
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-16450-x

Low density lipoproteins and human serum albumin as the carriers of squalenoylated drugs: insights from molecular simulations

Autores: Semen O. Yesylevskyy, Christophe Ramseyer, Mariia Savenko, Simona Mura, Patrick Couvreur
Publicado en: Molecular Pharmaceutics, 2018, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.7b00952

2D-BN nanoparticles as a spectroscopic marker and drug delivery system with protection properties

Autores: O. P. Gnatyuk, G. I. Dovbeshko, A. Yershov, S. O. Karakhim, O. Ilchenko, O. Yu. Posudievsky
Publicado en: RSC Advances, Edición 8/53, 2018, Página(s) 30404-30411, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/c8ra05085f

Double-exponential kinetics of binding and redistribution of the fluorescent dyes in cell membranes witness for the existence of lipid microdomains

Autores: Kyrylo A. Pyrshev, Semen O. Yesylevskyy, Alexander P. Demchenko
Publicado en: Biochemical and Biophysical Research Communications, Edición 508/4, 2019, Página(s) 1139-1144, ISSN 0006-291X
Editor: Academic Press
DOI: 10.1016/j.bbrc.2018.12.054

Biogenesis, transport and remodeling of lysophospholipids in Gram-negative bacteria

Autores: Lei Zheng, Yibin Lin, Shuo Lu, Jiazhe Zhang, Mikhail Bogdanov
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Edición 1862/11, 2017, Página(s) 1404-1413, ISSN 1388-1981
Editor: Elsevier BV
DOI: 10.1016/j.bbalip.2016.11.015

The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A 2 attack

Autores: Yibin Lin, Mikhail Bogdanov, Shuo Lu, Ziqiang Guan, William Margolin, Jerrold Weiss, Lei Zheng
Publicado en: Journal of Biological Chemistry, Edición 293/9, 2018, Página(s) 3386-3398, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra117.001231

Effects of elevated growth temperature and heat shock on the lipid composition of the inner and outer membranes of Yersinia pseudotuberculosis

Autores: Ludmila Davydova, Svetlana Bakholdina, Maria Barkina, Peter Velansky, Mikhail Bogdanov, Nina Sanina
Publicado en: Biochimie, Edición 123, 2016, Página(s) 103-109, ISSN 0300-9084
Editor: Elsevier BV
DOI: 10.1016/j.biochi.2016.02.004

Structures of single, double and triple layers of lipids adsorbed on graphene: Insights from all-atom molecular dynamics simulations

Autores: Timothée Rivel, Semen O. Yesylevskyy, Christophe Ramseyer
Publicado en: Carbon, Edición 118, 2017, Página(s) 358-369, ISSN 0008-6223
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2017.03.072

Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin

Autores: Julie Mougin, Semen O. Yesylevskyy, Claudie Bourgaux, David Chapron, Jean-Philippe Michel, Franco Dosio, Barbara Stella, Christophe Ramseyer, Patrick Couvreur
Publicado en: ACS Nano, Edición 13/11, 2019, Página(s) 12870-12879, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.9b05303

Fate of cisplatin and its main hydrolysed forms in the presence of thiolates: a comprehensive computational and experimental study

Autores: Thibault Minervini, Bruno Cardey, Sarah Foley, Christophe Ramseyer, Mironel Enescu
Publicado en: Metallomics, Edición 11/4, 2019, Página(s) 833-844, ISSN 1756-5901
Editor: Royal Society of Chemistry
DOI: 10.1039/c8mt00371h

The asymmetry of plasma membranes and their cholesterol content influence the uptake of cisplatin

Autores: Timothée Rivel, Christophe Ramseyer, Semen Yesylevskyy
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-41903-w

Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine

Autores: Semen Yesylevskyy, Timothée Rivel, Christophe Ramseyer
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-53952-2

Squalene versus cholesterol: Which is the best nanocarrier for the delivery to cells of the anticancer drug gemcitabine?

Autores: Arnaud Peramo, Simona Mura, Semen O. Yesylevskyy, Bruno Cardey, Dunja Sobot, Stephanie Denis, Christophe Ramseyer, Didier Desmaële, Patrick Couvreur
Publicado en: Comptes Rendus Chimie, Edición 21/10, 2018, Página(s) 974-986, ISSN 1631-0748
Editor: Elsevier Masson
DOI: 10.1016/j.crci.2018.02.008

Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

Autores: Dunja Sobot, Simona Mura, Semen O. Yesylevskyy, Laura Dalbin, Fanny Cayre, Guillaume Bort, Julie Mougin, Didier Desmaële, Sinda Lepetre-Mouelhi, Grégory Pieters, Bohdan Andreiuk, Andrey S. Klymchenko, Jean-Louis Paul, Christophe Ramseyer, Patrick Couvreur
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 15678, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms15678

Spectral and kinetic effects accompanying the assembly of core complexes of Rhodobacter sphaeroides

Autores: Arvi Freiberg, Manoop Chenchiliyan, Margus Rätsep, Kõu Timpmann
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición 1857/11, 2016, Página(s) 1727-1733, ISSN 0005-2728
Editor: Elsevier BV
DOI: 10.1016/j.bbabio.2016.08.001

Hydrogen bonds in the vicinity of the special pair of the bacterial reaction center probed by hydrostatic high-pressure absorption spectroscopy

Autores: Liina Kangur, Michael R. Jones, Arvi Freiberg
Publicado en: Biophysical Chemistry, 2017, ISSN 0301-4622
Editor: Elsevier BV
DOI: 10.1016/j.bpc.2017.04.003

High-pressure modulation of the structure of the bacterial photochemical reaction center at physiological and cryogenic temperatures

Autores: Kõu Timpmann, Liina Kangur, Ants Lõhmus, Arvi Freiberg
Publicado en: Journal of Physics B: Atomic, Molecular and Optical Physics, Edición 50/14, 2017, Página(s) 144006, ISSN 0953-4075
Editor: Institute of Physics Publishing
DOI: 10.1088/1361-6455/aa77e4

Dimerization of core complexes as an efficient strategy for energy trapping in Rhodobacter sphaeroides

Autores: Manoop Chenchiliyan, Kõu Timpmann, Erko Jalviste, Peter G. Adams, C. Neil Hunter, Arvi Freiberg
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición 1857/6, 2016, Página(s) 634-642, ISSN 0005-2728
Editor: Elsevier BV
DOI: 10.1016/j.bbabio.2016.03.020

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