Objectif Since 2001’s discovery of microRNAs (miRNAs) in humans, progress in genomics and transcriptomics has increased our comprehension of gene expression regulation. miRNAs are small, noncoding RNA molecules showing huge promise as clinical biomarkers and diagnostic tools for illness and disease, as significant changes in their expression occur in response to pathological states. However, miRNA detection is still challenging nowadays, since costly, complex sample preparations and RNA amplifications are not yet reliable enough for clinical decision making. In this context, three innovative EU companies, Optoi Microelectronics - with microelectronic knowhow and manufacturing skills - DestiNA Genomics - with ‘error free’ chemical technology for microRNAs recognition – and GeneXplain – with bioinformatic capabilities - joined forces with four key academic research groups from the Universities of Trento (Italy), Granada (Spain), Hannover Medical School (Germany) and Santa Catarina (Brazil). All the parties combined their knowledge with respect to miRNA biomarkers with a particular focus on lung cancer, to develop a novel and reliable miRNA detection system for this disease. To this end, research collaborations will address the analysis of miRNAs specifically over-expressed in lung cancer, continuing experimental work already started in the past years, but with greater integration and focus.Existing close partnerships with healthcare institutions will be strengthened, ensuring multi-site and multi-ethnic sampling. In parallel, optimization and validation of a miRNA detection kit based on Optoi semiconductor optical detector will continue. The DestiNA patented technology for specific nucleic acid recognition will be refined to reach the integration and result reliability required for use in clinical point of care testing. The strong network created between the companies and the academic institutions will thus provide a unique scientific and technological environment to turn the research outputs into an innovative product for healthcare advance and progress. Champ scientifique medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicineoncologylung cancernatural sciencesbiological sciencesgeneticsRNA Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Thème(s) MSCA-RISE-2015 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Appel à propositions H2020-MSCA-RISE-2015 Voir d’autres projets de cet appel Régime de financement MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinateur OPTOELETTRONICA ITALIA SRL Contribution nette de l'UE € 126 000,00 Adresse VIA VIENNA 8 38121 Trento Italie Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Nord-Est Provincia Autonoma di Trento Trento Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 139 500,00 Participants (5) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire DESTINA GENOMICA SLNE Espagne Contribution nette de l'UE € 112 500,00 Adresse AVENIDA DE LA INNOACI0N 1 EDIFICIO BIC 18100 Granada Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Sur Andalucía Granada Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 117 000,00 UNIVERSITA DEGLI STUDI DI TRENTO Italie Contribution nette de l'UE € 126 000,00 Adresse VIA CALEPINA 14 38122 Trento Voir sur la carte Région Nord-Est Provincia Autonoma di Trento Trento Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 153 000,00 UNIVERSIDAD DE GRANADA Espagne Contribution nette de l'UE € 27 000,00 Adresse CUESTA DEL HOSPICIO SN 18071 Granada Voir sur la carte Région Sur Andalucía Granada Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 27 000,00 MEDIZINISCHE HOCHSCHULE HANNOVER Allemagne Contribution nette de l'UE € 36 000,00 Adresse Carl-Neuberg-Strasse 1 30625 Hannover Voir sur la carte Région Niedersachsen Hannover Region Hannover Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 36 000,00 GENEXPLAIN GMBH Allemagne Contribution nette de l'UE € 18 000,00 Adresse AM EXER 19 B 38302 Wolfenbuttel Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Niedersachsen Braunschweig Wolfenbüttel Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 18 000,00 Partenaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire Partenaire Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention. UNIVERSIDADE FEDERAL DE SANTA CATARINA. Brésil Contribution nette de l'UE € 0,00 Adresse CAMPUS UNIVERSITARIO TRINDADE 88040-900 Florianopolis Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 45 000,00