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microRNA biomarkers in an innovative biophotonic sensor kit for high-specific diagnosis

Obiettivo

Since 2001’s discovery of microRNAs (miRNAs) in humans, progress in genomics and transcriptomics has increased our comprehension of gene expression regulation. miRNAs are small, noncoding RNA molecules showing huge promise as clinical biomarkers and diagnostic tools for illness and disease, as significant changes in their expression occur in response to pathological states. However, miRNA detection is still challenging nowadays, since costly, complex sample preparations and RNA amplifications are not yet reliable enough for clinical decision making. In this context, three innovative EU companies, Optoi Microelectronics - with microelectronic knowhow and manufacturing skills - DestiNA Genomics - with ‘error free’ chemical technology for microRNAs recognition – and GeneXplain – with bioinformatic capabilities - joined forces with four key academic research groups from the Universities of Trento (Italy), Granada (Spain), Hannover Medical School (Germany) and Santa Catarina (Brazil). All the parties combined their knowledge with respect to miRNA biomarkers with a particular focus on lung cancer, to develop a novel and reliable miRNA detection system for this disease. To this end, research collaborations will address the analysis of miRNAs specifically over-expressed in lung cancer, continuing experimental work already started in the past years, but with greater integration and focus.
Existing close partnerships with healthcare institutions will be strengthened, ensuring multi-site and multi-ethnic sampling. In parallel, optimization and validation of a miRNA detection kit based on Optoi semiconductor optical detector will continue. The DestiNA patented technology for specific nucleic acid recognition will be refined to reach the integration and result reliability required for use in clinical point of care testing. The strong network created between the companies and the academic institutions will thus provide a unique scientific and technological environment to turn the research outputs into an innovative product for healthcare advance and progress.

Coordinatore

OPTOELETTRONICA ITALIA SRL
Contribution nette de l'UE
€ 126 000,00
Indirizzo
Via Vienna 8
38121 Trento
Italia

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Regione
Nord-Est Provincia Autonoma di Trento Trento
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Altri finanziamenti
€ 126 000,00

Partecipanti (5)

DESTINA GENOMICA SLNE
Spagna
Contribution nette de l'UE
€ 112 500,00
Indirizzo
Avenida De La Innoaci0n 1 Edificio Bic
18100 Granada

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PMI

L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.

Regione
Andalucía Granada
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Altri finanziamenti
€ 112 500,00
UNIVERSITA DEGLI STUDI DI TRENTO
Italia
Contribution nette de l'UE
€ 126 000,00
Indirizzo
Via Calepina 14
38122 Trento

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Regione
Nord-Est Provincia Autonoma di Trento Trento
Tipo di attività
Higher or Secondary Education Establishments
Altri finanziamenti
€ 126 000,00
UNIVERSIDAD DE GRANADA
Spagna
Contribution nette de l'UE
€ 27 000,00
Indirizzo
Cuesta Del Hospicio Sn
18071 Granada

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Regione
Andalucía Granada
Tipo di attività
Higher or Secondary Education Establishments
Altri finanziamenti
€ 27 000,00
MEDIZINISCHE HOCHSCHULE HANNOVER
Germania
Contribution nette de l'UE
€ 36 000,00
Indirizzo
Carl-neuberg-strasse 1
30625 Hannover

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Regione
Niedersachsen Hannover Region Hannover
Tipo di attività
Higher or Secondary Education Establishments
Altri finanziamenti
€ 36 000,00
GENEXPLAIN GMBH
Germania
Contribution nette de l'UE
€ 18 000,00
Indirizzo
Am Exer 19 B
38302 Wolfenbuttel

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PMI

L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.

Regione
Niedersachsen Braunschweig Wolfenbüttel
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Altri finanziamenti
€ 18 000,00

Partner (1)

Partner

Le organizzazioni partner contribuiscono all’attuazione dell’azione, ma non sottoscrivono l’accordo di sovvenzione.

UNIVERSIDADE FEDERAL DE SANTA CATARINA.
Brasile
Contribution nette de l'UE
€ 0,00
Indirizzo
Campus Universitario Trindade
88040-900 Florianopolis

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Tipo di attività
Higher or Secondary Education Establishments
Altri finanziamenti
€ 0,00