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Exploiting Protein Complexes that Induce Cell-death



Patents protecting the intellectual property of EPIC.


Dissemination of scientific discoveries through peer reviewed publications, and/or oral and poster presentations at international scientific meetings.


Apoptosome formation upon overexpression of native and truncated Apaf-1 in cell-free and cell-based systems

Autoren: Ali Reza Noori, Elaheh Sadat Hosseini, Maryam Nikkhah, Saman Hosseinkhani
Veröffentlicht in: Archives of Biochemistry and Biophysics, 642, 2018, Page(s) 46-51, ISSN 0003-9861
Herausgeber: Academic Press
DOI: 10.1016/

How do we fit ferroptosis in the family of regulated cell death?

Autoren: Howard O Fearnhead, Peter Vandenabeele, Tom Vanden Berghe
Veröffentlicht in: Cell Death and Differentiation, 24/12, 2017, Page(s) 1991-1998, ISSN 1350-9047
Herausgeber: Nature Publishing Group
DOI: 10.1038/cdd.2017.149

A new split‐luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation

Autoren: Amin Tashakor, Mahshid H‐Dehkordi, Enda O'Connell, Sergi Gomez Ganau, Rafael Gozalbes, Leif A. Eriksson, Saman Hosseinkhani, Howard O. Fearnhead
Veröffentlicht in: FEBS Open Bio, 9/7, 2019, Page(s) 1194-1203, ISSN 2211-5463
Herausgeber: Elsevier BV
DOI: 10.1002/2211-5463.12646