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Epigenetic Risk Assesment of Assisted Reproductive Technologies

Deliverables

Report from visits to the international conferences

Report from visits to the international conferences

First reports. Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN

Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN

Report of the seminar for SME with agenda, proceedings, conclusions, lists of participants, further actions /implications for IGHZ PAN

Report of the seminar for SME with agenda, proceedings, conclusions, lists of participants, further actions /implications for IGHZ PAN

Report of the workshop on comparative experimental embryology methods with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and involved participants

Report of the workshop on comparative experimental embryology methods with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and involved participants

Cooperation agreements with partners

Cooperation agreements with partners

Second reports. Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN

Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN

Report of the Conference: What is known about offspring obtained by Assisted Reproduction Technologies with agenda, proceedings, conclusions, lists of participants, further actions and implications for IGHZ PAN and partners involved

Report of the Conference: What is known about offspring obtained by Assisted Reproduction Technologies with agenda, proceedings, conclusions, lists of participants, further actions and implications for IGHZ PAN and partners involved

Report of the workshop on oocyte maturation and fertilization and embryo culture methods in large animal models with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Report of the workshop on oocyte maturation and fertilization and embryo culture methods in large animal models with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Joint report on summer school together with UJ

Joint report on summer school together with UJ

Report of the workshop on oocytes and embryo manipulations with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Report of the workshop on oocytes and embryo manipulations with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Report of the conference on ART: Long-Term Perspectives, with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN

Report of the conference on ART: Long-Term Perspectives, with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN

Joint report (with WP 2 task 2.2) on summer school in Embryo valuation and Molecular Biology Tools in ART with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Joint report (with WP 2 task 2.2) on summer school in Embryo valuation and Molecular Biology Tools in ART with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Report with the copies of scientific papers and proceedings published in connection to the Twinning Research Group activities

Report with the copies of scientific papers and proceedings published in connection to the Twinning Research Group activities

Statement that the report has been completed

Statement that the report has been completed

Operational website of the project

Operational website of the project

Promotional brochure of the project

Promotional brochure of the project

Promotional leaflet of the project

Promotional leaflet of the project

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Publications

Developmental peculiarities in placentae of ovine uniparental conceptuses

Author(s): Roberta Arena, Federica Zacchini, Paola Toschi, Luca Palazzese, Marta Czernik, Grażyna Ewa Ptak
Published in: PLOS ONE, Issue 12/11, 2017, Page(s) e0188278, ISSN 1932-6203
DOI: 10.1371/journal.pone.0188278

Polychlorinated biphenyls (PCBs) alter DNA methylation and genomic integrity of sheep fetal cells in a simplified in vitro model of pregnancy exposure

Author(s): Debora A. Anzalone, Silvestre Sampino, Marta Czernik, Domenico Iuso, Grazyna E. Ptak
Published in: Toxicology in Vitro, Issue 46, 2018, Page(s) 39-46, ISSN 0887-2333
DOI: 10.1016/j.tiv.2017.09.017

Development to term of sheep embryos reconstructed after inner cell mass/trophoblast exchange

Author(s): Pasqualino LOI, Cesare GALLI, Giovanna LAZZARI, Kazutsugu MATSUKAWA, Josef FULKA, Jr, Frank GOERITZ, Thomas B. HILDEBRANDT
Published in: Journal of Reproduction and Development, Issue 64/2, 2018, Page(s) 187-191, ISSN 0916-8818
DOI: 10.1262/jrd.2017-109

Exploring dry storage as an alternative biobanking strategy inspired by Nature

Author(s): Joseph Saragusty, Pasqualino Loi
Published in: Theriogenology, Issue 126, 2019, Page(s) 17-27, ISSN 0093-691X
DOI: 10.1016/j.theriogenology.2018.11.027

DNA fragmentation in epididymal freeze-dried ram spermatozoa impairs embryo development

Author(s): Luca PALAZZESE, Jaime GOSÁLVEZ, Debora A. ANZALONE, Pasqualino LOI, Joseph SARAGUSTY
Published in: Journal of Reproduction and Development, Issue 64/5, 2018, Page(s) 393-400, ISSN 0916-8818
DOI: 10.1262/jrd.2018-033

Embryos and embryonic stem cells from the white rhinoceros

Author(s): Thomas B. Hildebrandt, Robert Hermes, Silvia Colleoni, Sebastian Diecke, Susanne Holtze, Marilyn B. Renfree, Jan Stejskal, Katsuhiko Hayashi, Micha Drukker, Pasqualino Loi, Frank Göritz, Giovanna Lazzari, Cesare Galli
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-04959-2

Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts

Author(s): Luca Palazzese, Marta Czernik, Domenico Iuso, Paola Toschi, Pasqualino Loi
Published in: PLOS ONE, Issue 13/3, 2018, Page(s) e0193954, ISSN 1932-6203
DOI: 10.1371/journal.pone.0193954

Allele-specific methylation of imprinted genes in fetal cord blood is influenced by cis-acting genetic variants and parental factors

Author(s): Ramya Potabattula, Marcus Dittrich, Julia Böck, Larissa Haertle, Tobias Müller, Thomas Hahn, Martin Schorsch, Nady El Hajj, Thomas Haaf
Published in: Epigenomics, Issue 10/10, 2018, Page(s) 1315-1326, ISSN 1750-1911
DOI: 10.2217/epi-2018-0059

Gene expression and epigenetic aberrations in F1-placentas fathered by obese males

Author(s): Megan Mitchell, Reiner Strick, Pamela L. Strissel, Ralf Dittrich, Nicole O. McPherson, Michelle Lane, Galyna Pliushch, Ramya Potabattula, Thomas Haaf, Nady El Hajj
Published in: Molecular Reproduction and Development, Issue 84/4, 2017, Page(s) 316-328, ISSN 1040-452X
DOI: 10.1002/mrd.22784

Epigenetic signatures of gestational diabetes mellitus on cord blood methylation

Author(s): Larissa Haertle, Nady El Hajj, Marcus Dittrich, Tobias Müller, Indrajit Nanda, Harald Lehnen, Thomas Haaf
Published in: Clinical Epigenetics, Issue 9/1, 2017, ISSN 1868-7075
DOI: 10.1186/s13148-017-0329-3

Prenatal and postnatal experiences associated with epigenetic changes in the adult mouse brain

Author(s): Felix Mattern, Antonia Post, Franziska Solger, Aet O’Leary, David A. Slattery, Andreas Reif, Thomas Haaf
Published in: Behavioural Brain Research, Issue 359, 2019, Page(s) 143-148, ISSN 0166-4328
DOI: 10.1016/j.bbr.2018.10.037

Embryo biopsy and development: the known and the unknown

Author(s): Federica Zacchini, Roberta Arena, Adam Abramik, Grazyna E Ptak
Published in: Reproduction, Issue 154/5, 2017, Page(s) R143-R148, ISSN 1470-1626
DOI: 10.1530/rep-17-0431

A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis

Author(s): Megumi Tsuchiya, M. Rezaul Karim, Taro Matsumoto, Hidesato Ogawa, Hiroaki Taniguchi
Published in: Journal of Visualized Experiments, Issue 119, 2017, ISSN 1940-087X
DOI: 10.3791/55077

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Author(s): Takehiro Yamazaki, Hiroaki Taniguchi, Shoto Tsuji, Shiho Sato, Takahiro Kenmotsu, Kenichi Yoshikawa, Koichiro Sadakane
Published in: Journal of Visualized Experiments, Issue 140, 2018, ISSN 1940-087X
DOI: 10.3791/57815

Manipulating Living Cells to Construct a 3D Single-Cell Assembly without an Artificial Scaffold

Author(s): Aoi Yoshida, Shoto Tsuji, Hiroaki Taniguchi, Takahiro Kenmotsu, Koichiro Sadakane, Kenichi Yoshikawa
Published in: Polymers, Issue 9/12, 2017, Page(s) 319, ISSN 2073-4360
DOI: 10.3390/polym9080319

Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications

Author(s): Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E. Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T. Scotti, Rajeev K. Singla, Thonos Alexiou, Atanas G. Atanasov, Vadim V. Tarasov, P. Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev, Mohammad Amjad Kamal
Published in: Current Pharmaceutical Design, Issue 23/30, 2017, ISSN 1381-6128
DOI: 10.2174/1381612823666170823103830

64 Impaired Post-Implantation Development Following Blastomere Biopsy is Associated with Placental Hypomethylation

Author(s): F. Zacchini, M. Ogluska, R. Arena, G. E. Ptak
Published in: Reproduction, Fertility and Development, Issue 30/1, 2018, Page(s) 171, ISSN 1031-3613
DOI: 10.1071/rdv30n1ab64

Evidence of Placental Autophagy during Early Pregnancy after Transfer of In Vitro Produced (IVP) Sheep Embryos

Author(s): Paola Toschi, Marta Czernik, Federica Zacchini, Antonella Fidanza, Pasqualino Loi, Grażyna Ewa Ptak
Published in: PLOS ONE, Issue 11/6, 2016, Page(s) e0157594, ISSN 1932-6203
DOI: 10.1371/journal.pone.0157594

Cobalamin supplementation during in vitro maturation improves developmental competence of sheep oocytes

Author(s): Federica Zacchini, Paola Toschi, Grazyna Ewa Ptak
Published in: Theriogenology, Issue 93, 2017, Page(s) 55-61, ISSN 0093-691X
DOI: 10.1016/j.theriogenology.2017.01.035

Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses

Author(s): Marta Czernik, Paola Toschi, Federica Zacchini, Domenico Iuso, Grażyna Ewa Ptak
Published in: PLOS ONE, Issue 12/1, 2017, Page(s) e0169579, ISSN 1932-6203
DOI: 10.1371/journal.pone.0169579

Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation

Author(s): Stefanie Atsem, Juliane Reichenbach, Ramya Potabattula, Marcus Dittrich, Caroline Nava, Christel Depienne, Lena Böhm, Simone Rost, Thomas Hahn, Martin Schorsch, Thomas Haaf, Nady El Hajj
Published in: Human Molecular Genetics, 2016, Page(s) ddw328, ISSN 0964-6906
DOI: 10.1093/hmg/ddw328

Remodeling somatic nuclei via exogenous expression of protamine 1 to create spermatid-like structures for somatic nuclear transfer

Author(s): Marta Czernik, Domenico Iuso, Paola Toschi, Saadi Khochbin, Pasqualino Loi
Published in: Nature Protocols, Issue 11/11, 2016, Page(s) 2170-2188, ISSN 1754-2189
DOI: 10.1038/nprot.2016.130

DNA methylation signatures in cord blood of ICSI children

Author(s): Nady El Hajj, Larissa Haertle, Marcus Dittrich, Sarah Denk, Harald Lehnen, Thomas Hahn, Martin Schorsch, Thomas Haaf
Published in: Human Reproduction, 2017, Page(s) 1-9, ISSN 0268-1161
DOI: 10.1093/humrep/dex209

Epigenetics of stress adaptations in the brain

Author(s): Adrian M. Stankiewicz, Artur H. Swiergiel, Pawel Lisowski
Published in: Brain Research Bulletin, Issue 98, 2013, Page(s) 76-92, ISSN 0361-9230
DOI: 10.1016/j.brainresbull.2013.07.003

Effects of blastomere biopsy on post-natal growth and behavior in mice

Author(s): S. Sampino, F. Zacchini, A. H. Swiergiel, A. J. Modlinski, P. Loi, G. E. Ptak
Published in: Human Reproduction, Issue 29/9, 2014, Page(s) 1875-1883, ISSN 0268-1161
DOI: 10.1093/humrep/deu145

Global gene expression profiling of porcine endometria on Days 12 and 16 of the estrous cycle and pregnancy

Author(s): Jolanta Kiewisz, Kamil Krawczynski, Pawel Lisowski, Agnieszka Blitek, Lech Zwierzchowski, Adam J. Ziecik, Monika M. Kaczmarek
Published in: Theriogenology, Issue 82/6, 2014, Page(s) 897-909, ISSN 0093-691X
DOI: 10.1016/j.theriogenology.2014.07.009

Studies on Survival of Horse Oocytes After Rapid-i Method Vitrification

Author(s): Agnieszka Nowak, Joanna Kochan, Krzysztof Papis, Adam Okólski
Published in: Journal of Equine Veterinary Science, Issue 34/5, 2014, Page(s) 675-679, ISSN 0737-0806
DOI: 10.1016/j.jevs.2013.12.013

The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice

Author(s): Adrian M. Stankiewicz, Joanna Goscik, Alicja Majewska, Artur H. Swiergiel, Grzegorz R. Juszczak
Published in: PLOS ONE, Issue 10/11, 2015, Page(s) e0142195, ISSN 1932-6203
DOI: 10.1371/journal.pone.0142195

PEG3 domain gene expression in maternal and foetal placenta in intrauterine growth restricted bovine foetuses

Author(s): Shun Li, Hubert Pausch, Heli Venhoranta, Krzysztof Adamowicz, Magnus Andersson, Lech Zwierzchowski, Alexander Kind, Angelika Schnieke, Krzysztof Flisikowski
Published in: Animal Genetics, Issue 47/1, 2016, Page(s) 106-109, ISSN 0268-9146
DOI: 10.1111/age.12373

Children born from frozen embryos stored for 10 years – analysis of 5 cases

Author(s): Krzysztof Papis, Piotr Lewandowski, Jan Wolski, Katarzyna Kozioł
Published in: Polish Gynaecology, Issue 84, 2013, ISSN 0017-0011
DOI: 10.17772/gp/1669

Genomic Stability of Lyophilized Sheep Somatic Cells before and after Nuclear Transfer

Author(s): Domenico Iuso, Marta Czernik, Fiorella Di Egidio, Silvestre Sampino, Federica Zacchini, Michal Bochenek, Zdzislaw Smorag, Jacek A. Modlinski, Grazyna Ptak, Pasqualino Loi
Published in: PLoS ONE, Issue 8/1, 2013, Page(s) e51317, ISSN 1932-6203
DOI: 10.1371/journal.pone.0051317

Anatomy of a blastocyst: Cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo

Author(s): Nadine Schrode, Panagiotis Xenopoulos, Anna Piliszek, Stephen Frankenberg, Berenika Plusa, Anna-Katerina Hadjantonakis
Published in: genesis, Issue 51/4, 2013, Page(s) 219-233, ISSN 1526-954X
DOI: 10.1002/dvg.22368

Cell fate in animal and human blastocysts and the determination of viability

Author(s): Anna Piliszek, Joanna B. Grabarek, Stephen R. Frankenberg, Berenika Plusa
Published in: Molecular Human Reproduction, 2016, Page(s) gaw002, ISSN 1360-9947
DOI: 10.1093/molehr/gaw002

Grand-paternal age and the development of autism-like symptoms in mice progeny

Author(s): S Sampino, G R Juszczak, F Zacchini, A H Swiergiel, J A Modlinski, P Loi, G E Ptak
Published in: Translational Psychiatry, Issue 4/4, 2014, Page(s) e386, ISSN 2158-3188
DOI: 10.1038/tp.2014.27

The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo

Author(s): S. Nowotschin, I. Costello, A. Piliszek, G. S. Kwon, C.-a. Mao, W. H. Klein, E. J. Robertson, A.-K. Hadjantonakis
Published in: Genes & Development, Issue 27/9, 2013, Page(s) 997-1002, ISSN 0890-9369
DOI: 10.1101/gad.215152.113

Impaired Placental Vasculogenesis Compromises the Growth of Sheep Embryos Developed In Vitro

Author(s): A. Fidanza, P. Toschi, F. Zacchini, M. Czernik, C. Palmieri, P. Scapolo, J. A. Modlinski, P. Loi, G. E. Ptak
Published in: Biology of Reproduction, Issue 91/1, 2014, Page(s) 21-21, ISSN 0006-3363
DOI: 10.1095/biolreprod.113.113902

Partial hydatidiform mole diagnosis in a cat: a case report

Author(s): P. Jurka, M. Sacharczuk, M. Kawka, M. Sobczak-Filipiak, M. Golicz
Published in: Journal of Feline Medicine and Surgery, Issue 16/2, 2014, Page(s) 180-182, ISSN 1098-612X
DOI: 10.1177/1098612X13496247

Developmental potential of selectively enucleated mouse zygotes reconstituted with embryonic cell, embryonic stem cell and somatic cell nuclei.

Author(s): GRĘDA P., MODLIŃSKI J.A., PILISZEK A.
Published in: Animal Science Papers and Reports, Issue 33, 2015, Page(s) 323-336, ISSN 0860-4037

Polymorphisms of the osteopontin gene and level of its expression in the reproductive tract of sows / Polimorfizm w genie osteopontyny i poziom jej ekspresji w układzie rozrodczym loch

Author(s): Agnieszka Korwin-Kossakowska, Dorota Goluch, Wojciech Kapelański, Maria Bocian, Grażyna Sender
Published in: Annals of Animal Science, Issue 13/2, 2013, ISSN 1642-3402
DOI: 10.2478/aoas-2013-0006

Autophagy and apoptosis: parent-of-origin genome-dependent mechanisms of cellular self-destruction

Author(s): G. E. Ptak, P. Toschi, A. Fidanza, M. Czernik, F. Zacchini, J. A. Modlinski, P. Loi
Published in: Open Biology, Issue 4/6, 2014, Page(s) 140027-140027, ISSN 2046-2441
DOI: 10.1098/rsob.140027

Effects of vitrification of partially denuded bovine immature oocytes.

Author(s): Papis K., Shimizu M., Saha S., Izaike Y., MODLIŃSKI J.A.
Published in: Animal Science Papers and Reports, Issue 31, 2013, Page(s) 5-14, ISSN 0860-4037

Expression pattern of STAT5A gene during early bovine embryogenesis

Author(s): Krzysztof Flisikowski, Marc Boulhaeve, Fabiola P. Lopes, Eckhard Wolf, Lech Zwierzchowski
Published in: Zygote, Issue 23/02, 2015, Page(s) 307-311, ISSN 0967-1994
DOI: 10.1017/S0967199413000427

Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures

Author(s): Domenico Iuso, Marta Czernik, Paola Toschi, Antonella Fidanza, Federica Zacchini, Robert Feil, Sandrine Curtet, Thierry Buchou, Hitoshi Shiota, Saadi Khochbin, Grazyna Ewa Ptak, Pasqualino Loi
Published in: Cell Reports, Issue 13/9, 2015, Page(s) 1765-1771, ISSN 2211-1247
DOI: 10.1016/j.celrep.2015.10.066

Embryonic diapause in humans: time to consider?

Author(s): Grazyna E Ptak, Jacek A Modlinski, Pasqualino Loi
Published in: Reproductive Biology and Endocrinology, Issue 11/1, 2013, Page(s) 92, ISSN 1477-7827
DOI: 10.1186/1477-7827-11-92