Epigenetic Risk Assesment of Assisted Reproductive Technologies

Risultati finali

Report from visits to the international conferences
First reports. Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN

Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN

Report of the seminar for SME with agenda, proceedings, conclusions, lists of participants, further actions /implications for IGHZ PAN

Report of the workshop on comparative experimental embryology methods with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and involved participants
Cooperation agreements with partners
Second reports. Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN

Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN

Report of the Conference: What is known about offspring obtained by Assisted Reproduction Technologies with agenda, proceedings, conclusions, lists of participants, further actions and implications for IGHZ PAN and partners involved
Report of the workshop on oocyte maturation and fertilization and embryo culture methods in large animal models with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Report of the workshop on oocyte maturation and fertilization and embryo culture methods in large animal models with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Joint report on summer school together with UJ
Report of the workshop on oocytes and embryo manipulations with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved
Report of the conference on ART: Long-Term Perspectives, with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN
Joint report (with WP 2 task 2.2) on summer school in Embryo valuation and Molecular Biology Tools in ART with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Joint report (with WP 2 task 2.2) on summer school in Embryo valuation and Molecular Biology Tools in ART with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved

Report with the copies of scientific papers and proceedings published in connection to the Twinning Research Group activities
Statement that the report has been completed

Operational website of the project
Promotional brochure of the project
Promotional leaflet of the project

Pubblicazioni

Developmental peculiarities in placentae of ovine uniparental conceptuses

Autori: Roberta Arena, Federica Zacchini, Paola Toschi, Luca Palazzese, Marta Czernik, Grażyna Ewa Ptak
Pubblicato in: PLOS ONE, Numero 12/11, 2017, Pagina/e e0188278, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0188278

Polychlorinated biphenyls (PCBs) alter DNA methylation and genomic integrity of sheep fetal cells in a simplified in vitro model of pregnancy exposure

Autori: Debora A. Anzalone, Silvestre Sampino, Marta Czernik, Domenico Iuso, Grazyna E. Ptak
Pubblicato in: Toxicology in Vitro, Numero 46, 2018, Pagina/e 39-46, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/j.tiv.2017.09.017

Development to term of sheep embryos reconstructed after inner cell mass/trophoblast exchange

Autori: Pasqualino LOI, Cesare GALLI, Giovanna LAZZARI, Kazutsugu MATSUKAWA, Josef FULKA, Jr, Frank GOERITZ, Thomas B. HILDEBRANDT
Pubblicato in: Journal of Reproduction and Development, Numero 64/2, 2018, Pagina/e 187-191, ISSN 0916-8818
Editore: IPEC Inc.
DOI: 10.1262/jrd.2017-109

Exploring dry storage as an alternative biobanking strategy inspired by Nature

Autori: Joseph Saragusty, Pasqualino Loi
Pubblicato in: Theriogenology, Numero 126, 2019, Pagina/e 17-27, ISSN 0093-691X
Editore: Elsevier BV
DOI: 10.1016/j.theriogenology.2018.11.027

DNA fragmentation in epididymal freeze-dried ram spermatozoa impairs embryo development

Autori: Luca PALAZZESE, Jaime GOSÁLVEZ, Debora A. ANZALONE, Pasqualino LOI, Joseph SARAGUSTY
Pubblicato in: Journal of Reproduction and Development, Numero 64/5, 2018, Pagina/e 393-400, ISSN 0916-8818
Editore: IPEC Inc.
DOI: 10.1262/jrd.2018-033

Embryos and embryonic stem cells from the white rhinoceros

Autori: Thomas B. Hildebrandt, Robert Hermes, Silvia Colleoni, Sebastian Diecke, Susanne Holtze, Marilyn B. Renfree, Jan Stejskal, Katsuhiko Hayashi, Micha Drukker, Pasqualino Loi, Frank Göritz, Giovanna Lazzari, Cesare Galli
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04959-2

Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts

Autori: Luca Palazzese, Marta Czernik, Domenico Iuso, Paola Toschi, Pasqualino Loi
Pubblicato in: PLOS ONE, Numero 13/3, 2018, Pagina/e e0193954, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0193954

Allele-specific methylation of imprinted genes in fetal cord blood is influenced by cis-acting genetic variants and parental factors

Autori: Ramya Potabattula, Marcus Dittrich, Julia Böck, Larissa Haertle, Tobias Müller, Thomas Hahn, Martin Schorsch, Nady El Hajj, Thomas Haaf
Pubblicato in: Epigenomics, Numero 10/10, 2018, Pagina/e 1315-1326, ISSN 1750-1911
Editore: Future Medicine Ltd.
DOI: 10.2217/epi-2018-0059

Gene expression and epigenetic aberrations in F1-placentas fathered by obese males

Autori: Megan Mitchell, Reiner Strick, Pamela L. Strissel, Ralf Dittrich, Nicole O. McPherson, Michelle Lane, Galyna Pliushch, Ramya Potabattula, Thomas Haaf, Nady El Hajj
Pubblicato in: Molecular Reproduction and Development, Numero 84/4, 2017, Pagina/e 316-328, ISSN 1040-452X
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrd.22784

Epigenetic signatures of gestational diabetes mellitus on cord blood methylation

Autori: Larissa Haertle, Nady El Hajj, Marcus Dittrich, Tobias Müller, Indrajit Nanda, Harald Lehnen, Thomas Haaf
Pubblicato in: Clinical Epigenetics, Numero 9/1, 2017, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-017-0329-3

Prenatal and postnatal experiences associated with epigenetic changes in the adult mouse brain

Autori: Felix Mattern, Antonia Post, Franziska Solger, Aet O’Leary, David A. Slattery, Andreas Reif, Thomas Haaf
Pubblicato in: Behavioural Brain Research, Numero 359, 2019, Pagina/e 143-148, ISSN 0166-4328
Editore: Elsevier BV
DOI: 10.1016/j.bbr.2018.10.037

Embryo biopsy and development: the known and the unknown

Autori: Federica Zacchini, Roberta Arena, Adam Abramik, Grazyna E Ptak
Pubblicato in: Reproduction, Numero 154/5, 2017, Pagina/e R143-R148, ISSN 1470-1626
Editore: Society for Reproduction and Fertility
DOI: 10.1530/rep-17-0431

A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis

Autori: Megumi Tsuchiya, M. Rezaul Karim, Taro Matsumoto, Hidesato Ogawa, Hiroaki Taniguchi
Pubblicato in: Journal of Visualized Experiments, Numero 119, 2017, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/55077

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Autori: Takehiro Yamazaki, Hiroaki Taniguchi, Shoto Tsuji, Shiho Sato, Takahiro Kenmotsu, Kenichi Yoshikawa, Koichiro Sadakane
Pubblicato in: Journal of Visualized Experiments, Numero 140, 2018, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/57815

Manipulating Living Cells to Construct a 3D Single-Cell Assembly without an Artificial Scaffold

Autori: Aoi Yoshida, Shoto Tsuji, Hiroaki Taniguchi, Takahiro Kenmotsu, Koichiro Sadakane, Kenichi Yoshikawa
Pubblicato in: Polymers, Numero 9/12, 2017, Pagina/e 319, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym9080319

Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications

Autori: Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E. Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T. Scotti, Rajeev K. Singla, Thonos Alexiou, Atanas G. Atanasov, Vadim V. Tarasov, P. Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev, Mohammad Amjad Kamal
Pubblicato in: Current Pharmaceutical Design, Numero 23/30, 2017, ISSN 1381-6128
Editore: Bentham Science Publishers
DOI: 10.2174/1381612823666170823103830

64 Impaired Post-Implantation Development Following Blastomere Biopsy is Associated with Placental Hypomethylation

Autori: F. Zacchini, M. Ogluska, R. Arena, G. E. Ptak
Pubblicato in: Reproduction, Fertility and Development, Numero 30/1, 2018, Pagina/e 171, ISSN 1031-3613
Editore: Commonwealth Scientific and Industrial Research Organization Publishing
DOI: 10.1071/rdv30n1ab64

Evidence of Placental Autophagy during Early Pregnancy after Transfer of In Vitro Produced (IVP) Sheep Embryos

Autori: Paola Toschi, Marta Czernik, Federica Zacchini, Antonella Fidanza, Pasqualino Loi, Grażyna Ewa Ptak
Pubblicato in: PLOS ONE, Numero 11/6, 2016, Pagina/e e0157594, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0157594

Cobalamin supplementation during in vitro maturation improves developmental competence of sheep oocytes

Autori: Federica Zacchini, Paola Toschi, Grazyna Ewa Ptak
Pubblicato in: Theriogenology, Numero 93, 2017, Pagina/e 55-61, ISSN 0093-691X
Editore: Elsevier BV
DOI: 10.1016/j.theriogenology.2017.01.035

Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses

Autori: Marta Czernik, Paola Toschi, Federica Zacchini, Domenico Iuso, Grażyna Ewa Ptak
Pubblicato in: PLOS ONE, Numero 12/1, 2017, Pagina/e e0169579, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0169579

Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation

Autori: Stefanie Atsem, Juliane Reichenbach, Ramya Potabattula, Marcus Dittrich, Caroline Nava, Christel Depienne, Lena Böhm, Simone Rost, Thomas Hahn, Martin Schorsch, Thomas Haaf, Nady El Hajj
Pubblicato in: Human Molecular Genetics, 2016, Pagina/e ddw328, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddw328

Remodeling somatic nuclei via exogenous expression of protamine 1 to create spermatid-like structures for somatic nuclear transfer

Autori: Marta Czernik, Domenico Iuso, Paola Toschi, Saadi Khochbin, Pasqualino Loi
Pubblicato in: Nature Protocols, Numero 11/11, 2016, Pagina/e 2170-2188, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/nprot.2016.130

DNA methylation signatures in cord blood of ICSI children

Autori: Nady El Hajj, Larissa Haertle, Marcus Dittrich, Sarah Denk, Harald Lehnen, Thomas Hahn, Martin Schorsch, Thomas Haaf
Pubblicato in: Human Reproduction, 2017, Pagina/e 1-9, ISSN 0268-1161
Editore: Oxford University Press
DOI: 10.1093/humrep/dex209

Epigenetics of stress adaptations in the brain

Autori: Adrian M. Stankiewicz, Artur H. Swiergiel, Pawel Lisowski
Pubblicato in: Brain Research Bulletin, Numero 03619230, 2013, Pagina/e 76-92, ISSN 0361-9230
Editore: Elsevier BV
DOI: 10.1016/j.brainresbull.2013.07.003

Effects of blastomere biopsy on post-natal growth and behavior in mice

Autori: S. Sampino, F. Zacchini, A. H. Swiergiel, A. J. Modlinski, P. Loi, G. E. Ptak
Pubblicato in: Human Reproduction, Numero 02681161, 2014, Pagina/e 1875-1883, ISSN 0268-1161
Editore: Oxford University Press
DOI: 10.1093/humrep/deu145

Global gene expression profiling of porcine endometria on Days 12 and 16 of the estrous cycle and pregnancy

Autori: Jolanta Kiewisz, Kamil Krawczynski, Pawel Lisowski, Agnieszka Blitek, Lech Zwierzchowski, Adam J. Ziecik, Monika M. Kaczmarek
Pubblicato in: Theriogenology, Numero 0093691X, 2014, Pagina/e 897-909, ISSN 0093-691X
Editore: Elsevier BV
DOI: 10.1016/j.theriogenology.2014.07.009

Studies on Survival of Horse Oocytes After Rapid-i Method Vitrification

Autori: Agnieszka Nowak, Joanna Kochan, Krzysztof Papis, Adam Okólski
Pubblicato in: Journal of Equine Veterinary Science, Numero 07370806, 2014, Pagina/e 675-679, ISSN 0737-0806
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jevs.2013.12.013

The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice

Autori: Adrian M. Stankiewicz, Joanna Goscik, Alicja Majewska, Artur H. Swiergiel, Grzegorz R. Juszczak
Pubblicato in: PLOS ONE, Numero 19326203, 2015, Pagina/e e0142195, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0142195

PEG3 domain gene expression in maternal and foetal placenta in intrauterine growth restricted bovine foetuses

Autori: Shun Li, Hubert Pausch, Heli Venhoranta, Krzysztof Adamowicz, Magnus Andersson, Lech Zwierzchowski, Alexander Kind, Angelika Schnieke, Krzysztof Flisikowski
Pubblicato in: Animal Genetics, Numero 02689146, 2016, Pagina/e 106-109, ISSN 0268-9146
Editore: Blackwell Publishing Inc.
DOI: 10.1111/age.12373

Children born from frozen embryos stored for 10 years – analysis of 5 cases

Autori: Krzysztof Papis, Piotr Lewandowski, Jan Wolski, Katarzyna Kozioł
Pubblicato in: Polish Gynaecology, Numero 00170011, 2013, ISSN 0017-0011
Editore: Poskie Towarzystwo Ginekologiczne/Polish Society of Gynaecology
DOI: 10.17772/gp/1669

Genomic Stability of Lyophilized Sheep Somatic Cells before and after Nuclear Transfer

Autori: Domenico Iuso, Marta Czernik, Fiorella Di Egidio, Silvestre Sampino, Federica Zacchini, Michal Bochenek, Zdzislaw Smorag, Jacek A. Modlinski, Grazyna Ptak, Pasqualino Loi
Pubblicato in: PLoS ONE, Numero 19326203, 2013, Pagina/e e51317, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0051317

Anatomy of a blastocyst: Cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo

Autori: Nadine Schrode, Panagiotis Xenopoulos, Anna Piliszek, Stephen Frankenberg, Berenika Plusa, Anna-Katerina Hadjantonakis
Pubblicato in: genesis, Numero 1526954X, 2013, Pagina/e 219-233, ISSN 1526-954X
Editore: John Wiley & Sons Inc.
DOI: 10.1002/dvg.22368

Cell fate in animal and human blastocysts and the determination of viability

Autori: Anna Piliszek, Joanna B. Grabarek, Stephen R. Frankenberg, Berenika Plusa
Pubblicato in: Molecular Human Reproduction, Numero 13609947, 2016, Pagina/e gaw002, ISSN 1360-9947
Editore: Oxford University Press
DOI: 10.1093/molehr/gaw002

Grand-paternal age and the development of autism-like symptoms in mice progeny

Autori: S Sampino, G R Juszczak, F Zacchini, A H Swiergiel, J A Modlinski, P Loi, G E Ptak
Pubblicato in: Translational Psychiatry, Numero 21583188, 2014, Pagina/e e386, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/tp.2014.27

The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo

Autori: S. Nowotschin, I. Costello, A. Piliszek, G. S. Kwon, C.-a. Mao, W. H. Klein, E. J. Robertson, A.-K. Hadjantonakis
Pubblicato in: Genes & Development, Numero 08909369, 2013, Pagina/e 997-1002, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.215152.113

Impaired Placental Vasculogenesis Compromises the Growth of Sheep Embryos Developed In Vitro

Autori: A. Fidanza, P. Toschi, F. Zacchini, M. Czernik, C. Palmieri, P. Scapolo, J. A. Modlinski, P. Loi, G. E. Ptak
Pubblicato in: Biology of Reproduction, Numero 00063363, 2014, Pagina/e 21-21, ISSN 0006-3363
Editore: Society for the Study of Reproduction
DOI: 10.1095/biolreprod.113.113902

Partial hydatidiform mole diagnosis in a cat: a case report

Autori: P. Jurka, M. Sacharczuk, M. Kawka, M. Sobczak-Filipiak, M. Golicz
Pubblicato in: Journal of Feline Medicine and Surgery, Numero 1098612X, 2014, Pagina/e 180-182, ISSN 1098-612X
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1177/1098612X13496247

Developmental potential of selectively enucleated mouse zygotes reconstituted with embryonic cell, embryonic stem cell and somatic cell nuclei.

Autori: GRĘDA P., MODLIŃSKI J.A., PILISZEK A.
Pubblicato in: Animal Science Papers and Reports, Numero 33, 2015, Pagina/e 323-336, ISSN 0860-4037
Editore: Polish Scientific Publishers PWN

Polymorphisms of the osteopontin gene and level of its expression in the reproductive tract of sows / Polimorfizm w genie osteopontyny i poziom jej ekspresji w układzie rozrodczym loch

Autori: Agnieszka Korwin-Kossakowska, Dorota Goluch, Wojciech Kapelański, Maria Bocian, Grażyna Sender
Pubblicato in: Annals of Animal Science, Numero 16423402, 2013, ISSN 1642-3402
Editore: National Research Institute of Animal Production
DOI: 10.2478/aoas-2013-0006

Autophagy and apoptosis: parent-of-origin genome-dependent mechanisms of cellular self-destruction

Autori: G. E. Ptak, P. Toschi, A. Fidanza, M. Czernik, F. Zacchini, J. A. Modlinski, P. Loi
Pubblicato in: Open Biology, Numero 20462441, 2014, Pagina/e 140027-140027, ISSN 2046-2441
Editore: Royal Society Publishing
DOI: 10.1098/rsob.140027

Effects of vitrification of partially denuded bovine immature oocytes.

Autori: Papis K., Shimizu M., Saha S., Izaike Y., MODLIŃSKI J.A.
Pubblicato in: Animal Science Papers and Reports, Numero 31, 2013, Pagina/e 5-14, ISSN 0860-4037
Editore: Polish Scientific Publishers PWN

Expression pattern of STAT5A gene during early bovine embryogenesis

Autori: Krzysztof Flisikowski, Marc Boulhaeve, Fabiola P. Lopes, Eckhard Wolf, Lech Zwierzchowski
Pubblicato in: Zygote, Numero 09671994, 2015, Pagina/e 307-311, ISSN 0967-1994
Editore: Cambridge University Press
DOI: 10.1017/S0967199413000427

Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures

Autori: Domenico Iuso, Marta Czernik, Paola Toschi, Antonella Fidanza, Federica Zacchini, Robert Feil, Sandrine Curtet, Thierry Buchou, Hitoshi Shiota, Saadi Khochbin, Grazyna Ewa Ptak, Pasqualino Loi
Pubblicato in: Cell Reports, Numero 22111247, 2015, Pagina/e 1765-1771, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2015.10.066

Embryonic diapause in humans: time to consider?

Autori: Grazyna E Ptak, Jacek A Modlinski, Pasqualino Loi
Pubblicato in: Reproductive Biology and Endocrinology, Numero 14777827, 2013, Pagina/e 92, ISSN 1477-7827
Editore: BioMed Central
DOI: 10.1186/1477-7827-11-92

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