The ER located master regulation of endosomal positioning and further movements

Project Information

ERCOPE

Grant agreement ID: 694307

DOI

10.3030/694307

Project closed

EC signature date 1 August 2016

Start date 1 September 2016

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 383 625,00

EU contribution

€ 2 383 625,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

The journey of Ca2+ through the cell – pulsing through the network of ER membrane contact sites

Author(s): Cremer T, Neefjes J, Berlin I
Published in: J Cell Sci, 2020, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.249136

HLA molecules in transplantation, autoimmunity and infection control: A comic book adventure

Author(s): Reits E, Neefjes J
Published in: HLA, 2022, ISSN 0001-2815
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/tan.14626

Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture

Author(s): Spits M, Heesterbeek IT, Voortman LM, Akkermans JJ, Wijdeven RH, Cabukusta B, Neefjes J
Published in: EMBO rep, 2021, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202050815

Maintaining soluble protein homeostasis between nuclear and cytoplasmic compartments across mitosis

Author(s): van der Zanden SY, Jongsma MLM, Neefjes ACM, Berlin I, Neefjes J
Published in: Trends Cell Biol, 2022, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2022.06.002

CRISPR Activation Screening Identifies VGLL3-TEAD1-RUNX1/3 as a Transcriptional Complex for PD-L1 Expression

Author(s): Wijdeven RH, Cabukusta B, Behr FM, Qiu X, Amiri D, Borras DM, Arens R, Liang Y, Neefjes J
Published in: J Immunol, 2022, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.4049/jimmunol.2100917

What the VAP: The Expanded VAP Family of Proteins Interacting With FFAT and FFAT-Related Motifs for Interorganellar Contact

Author(s): Neefjes J, Cabukusta B
Published in: Contact (Thousand Oaks), 2021, ISSN 2158-2440
Publisher: SAGE Publications Inc.
DOI: 10.1177/25152564211012246

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class-I-Mediated Immune Responses

Author(s): Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, Kong X, Gerke C, Janssen L, Stickel E, Holst S, Plomp R, Mulder A, Ferrone S, Claas FHJ, Heemskerk MHM, Griffioen M, Halenius A, Overkleeft H, Huppa JB, Wuhrer M, Brummelkamp TR, Neefjes J, Spaapen RM
Published in: Immunity, 2021, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.11.003

Human VAPome Analysis MOSPD1 and MOSPD3 as Membrane Contac Site Proteins Internacting with FFAT-Related FFNT Motifs

Author(s): Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AWM, Akkermans JJLL, Wijdeven RHM, Janssen GMC, van Veelen PA, Neefjes J
Published in: Cell Rep, 2020, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108475

Retrofusion of interalumenal MVB membranes parallels viral infections and coexists with exosome release

Author(s): Perrin P, Janssen L, Janssen H, van den Broek B, Voortman LM, van Elsland D, Berlin I, Neefjes J
Published in: Curr Biol, 2021, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.06.022

Chemical and genetic control of IFNγ-induced MHCII expression

Author(s): Wijdeven RH, van Luijn MM, Wierenga-Wolf AF, Akkermans JJ, van den Elsen PJ, Hintzen RQ, Neefjes J
Published in: EMBO Rep., 2018, ISSN 1469-221X
Publisher: Nature Publishing Group

Total Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific Proteases

Author(s): Mulder MPC, Merkx R, Witting KF, Hameed DS, El Atmioui D, Lelieveld L, Liebelt F, Neefjes J, Berlin I, Vertegaal ACO, Ovaa H
Published in: Angew Chem Int Ed Engl., 2018, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.

Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer

Author(s): Gagnaire A, Nadel B, Raoult D, Neefjes J, Gorvel JP
Published in: Nat Rev Microbiol., 2017, ISSN 1740-1526
Publisher: Nature Publishing Group

TBC1D5 controls the GTPase cycle of Rab7b

Author(s): Borg Distefano M, Haugen LH, Wang Y, Perdreau-Dahl H, Kjos I, Jia D, Morth JP, Neefjes J, Bakke O, Progida C
Published in: J Cell Sci., 2018, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.

Increased colon cancer risk after severe Salmonella infection

Author(s): Mughini-Gras L, Schaapveld M, Kramers J, Mooij S, Neefjes-Borst EA, Pelt WV, Neefjes J
Published in: PLoS One, 2018, ISSN 1932-6203
Publisher: Public Library of Science

The EGFR odyssey - from activation to destruction in space and time

Author(s): Bakker J, Spits M, Neefjes J, Berlin I
Published in: J Cell Sci., 2017, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.

Mechanisms of lysosomal positioning and movement

Author(s): Cabukusta B, Neefjes J
Published in: Traffic, 2018, ISSN 1398-9219
Publisher: Blackwell Publishing Inc.

Present Yourself! By MHC Class I and MHC Class II Molecules

Author(s): Rock KL, Reits E, Neefjes J
Published in: Trends Immunol., 2016, ISSN 1471-4906
Publisher: Elsevier BV

Moving and positioning the endolysosomal system

Author(s): Bonifacino JS, Neefjes J
Published in: Curr Opin Cell Biol., 2017, ISSN 0955-0674
Publisher: Elsevier BV

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells

Author(s): Luimstra JJ, Garstka MA, Roex MCJ, Redeker A, Janssen GMC, van Veelen PA, Arens R, Falkenburg JHF, Neefjes J, Ovaa H
Published in: J Exp Med., 2018, ISSN 0022-1007
Publisher: Rockefeller University Press

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

Author(s): Jongsma ML, Berlin I, Wijdeven RH, Janssen L, Janssen GM, Garstka MA, Janssen H, Mensink M, van Veelen PA, Spaapen RM, Neefjes J
Published in: Cell., 2016, ISSN 2451-9456
Publisher: Cell Press

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

Author(s): Wijdeven RH, Janssen H, Nahidiazar L, Janssen L, Jalink K, Berlin I, Neefjes J
Published in: Nat Commun., 2016, ISSN 2041-1723
Publisher: Nature Publishing Group

Control of host PTM by intracellular bacteria: An opportunity toward novel anti-infective agents

Author(s): Stévenin V, Neefjes J
Published in: Cell Chem Biol, 2022, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chembiol.2022.04.004

The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

Author(s): Cremer T, Jongsma MLM, Trulsson F, Vertegaal ACO, Neefjes J, Berlin I
Published in: Cell Rep, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108659