Transposable elements, their controllers and the genesis of human-specific transcriptional networks

Project Information

TRANSPOS-X

Grant agreement ID: 694658

DOI

10.3030/694658

Project closed

EC signature date 13 December 2016

Start date 1 January 2017

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

Author(s): Priscilla Turelli, Christopher Playfoot, Dephine Grun, Charlène Raclot, Julien Pontis, Alexandre Coudray, Christian Thorball, Julien Duc, Eugenia V. Pankevich, Bart Deplancke, Volker Busskamp, Didier Trono
Published in: Science Advances, Issue 6/35, 2020, Page(s) eaba3200, ISSN 2375-2548
Publisher: Science Advances
DOI: 10.1126/sciadv.aba3200

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

Author(s): Gernot Wolf, Alberto de Iaco, Ming-An Sun, Melania Bruno, Matthew Tinkham, Don Hoang, Apratim Mitra, Sherry Ralls, Didier Trono, Todd S Macfarlan
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56337

A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

Author(s): Yunyuan Sun, Jeremy R. Keown, Moyra M. Black, Charlène Raclot, Nicholas Demarais, Didier Trono, Priscilla Turelli, David C. Goldstone
Published in: Journal of Molecular Biology, Issue 431/14, 2019, Page(s) 2511-2527, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.05.002

Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain

Author(s): Christopher Playfoot; Julien Duc; Shaoline Sheppard; Sagane Dind; Alexandre Coudray; Evarist Planet; Didier Trono
Published in: Genome Research, Issue 9, 2021, Page(s) 1531-1545, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.275133.120

The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

Author(s): Annamaria Kauzlaric, Gabriela Ecco, Marco Cassano, Julien Duc, Michael Imbeault, Didier Trono
Published in: PLOS ONE, Issue 12/3, 2017, Page(s) e0173746, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0173746

DUX-family transcription factors regulate zygotic genome activation in placental mammals

Author(s): Alberto De Iaco, Evarist Planet, Andrea Coluccio, Sonia Verp, Julien Duc, Didier Trono
Published in: Nature Genetics, Issue 49/6, 2017, Page(s) 941-945, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/ng.3858

Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice

Author(s): Marco Cassano, Sandra Offner, Evarist Planet, Alessandra Piersigilli, Suk Min Jang, Hugues Henry, Markus B. Geuking, Catherine Mooser, Kathy D. McCoy, Andrew J. Macpherson, Didier Trono
Published in: Hepatology, Issue 66/1, 2017, Page(s) 235-251, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.29182

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

Author(s): Andrea Coluccio, Gabriela Ecco, Julien Duc, Sandra Offner, Priscilla Turelli, Didier Trono
Published in: Epigenetics & Chromatin, Issue 11/1, 2018, ISSN 1756-8935
Publisher: BioMed Central
DOI: 10.1186/s13072-018-0177-1

KRAB zinc finger proteins

Author(s): Gabriela Ecco, Michael Imbeault, Didier Trono
Published in: Development, Issue 144/15, 2017, Page(s) 2719-2729, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.132605

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Author(s): Suk Min Jang, Annamaria Kauzlaric, Jean-Pierre Quivy, Julien Pontis, Benjamin Rauwel, Andrea Coluccio, Sandra Offner, Julien Duc, Priscilla Turelli, Geneviève Almouzni, Didier Trono
Published in: Nucleic Acids Research, 2018, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky580

ZNF445 is a primary regulator of genomic imprinting

Author(s): Nozomi Takahashi, Andrea Coluccio, Christian W. Thorball, Evarist Planet, Hui Shi, Sandra Offner, Priscilla Turelli, Michael Imbeault, Anne C. Ferguson-Smith, Didier Trono
Published in: Genes & Development, Issue 33/1-2, 2019, Page(s) 49-54, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.320069.118

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

Author(s): Pierre‐Yves Helleboid, Moritz Heusel, Julien Duc, Cécile Piot, Christian W Thorball, Andrea Coluccio, Julien Pontis, Michaël Imbeault, Priscilla Turelli, Ruedi Aebersold, Didier Trono
Published in: The EMBO Journal, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018101220

DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

Author(s): Alberto De Iaco, Alexandre Coudray, Julien Duc, Didier Trono
Published in: EMBO reports, Issue 20/5, 2019, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201847382

Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

Author(s): Julien Pontis, Evarist Planet, Sandra Offner, Priscilla Turelli, Julien Duc, Alexandre Coudray, Thorold W. Theunissen, Rudolf Jaenisch, Didier Trono
Published in: Cell Stem Cell, Issue 24/5, 2019, Page(s) 724-735.e5, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2019.03.012

DUX is a non-essential synchronizer of zygotic genome activation

Author(s): Alberto De Iaco, Sonia Verp, Sandra Offner, Delphine Grun, Didier Trono
Published in: Development, Issue 147/2, 2020, Page(s) dev177725, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.177725

KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

Author(s): Annamaria Kauzlaric, Suk Min Jang, Mehdi Morchikh, Marco Cassano, Evarist Planet, Monsef Benkirane, Didier Trono
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 375/1795, 2020, Page(s) 20190334, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2019.0334

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

Author(s): Alexandra Iouranova, Delphine Grun , Tamara Rossy , Julien Duc , Alexandre Coudray , Michael Imbeault , Jonas de Tribolet-Hardy , Priscilla Turelli , Alexandre Persat , Didier Trono
Published in: Mobile DNA, Issue 13, 2022, ISSN 1759-8753
Publisher: BioMed Central
DOI: 10.1186/s13100-021-00260-0

Other (1)

A KRABsody for Embryo-Placental Development

Author(s): Didier Trono
Published in: Developmental Cell, Issue 41/6, 2017, Page(s) 578-580, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2017.06.005