Transposable elements, their controllers and the genesis of human-specific transcriptional networks

Informazioni relative al progetto

TRANSPOS-X

ID dell’accordo di sovvenzione: 694658

DOI 10.3030/694658

Progetto chiuso

Data della firma CE 13 Dicembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 31 Dicembre 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 500 000,00

Contributo UE € 2 500 000,00

Coordinato da

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

Pubblicazioni

Peer reviewed articles (17)

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

Autori: Priscilla Turelli, Christopher Playfoot, Dephine Grun, Charlène Raclot, Julien Pontis, Alexandre Coudray, Christian Thorball, Julien Duc, Eugenia V. Pankevich, Bart Deplancke, Volker Busskamp, Didier Trono
Pubblicato in: Science Advances, Numero 6/35, 2020, Pagina/e eaba3200, ISSN 2375-2548
Editore: Science Advances
DOI: 10.1126/sciadv.aba3200

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

Autori: Gernot Wolf, Alberto de Iaco, Ming-An Sun, Melania Bruno, Matthew Tinkham, Don Hoang, Apratim Mitra, Sherry Ralls, Didier Trono, Todd S Macfarlan
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.56337

A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

Autori: Yunyuan Sun, Jeremy R. Keown, Moyra M. Black, Charlène Raclot, Nicholas Demarais, Didier Trono, Priscilla Turelli, David C. Goldstone
Pubblicato in: Journal of Molecular Biology, Numero 431/14, 2019, Pagina/e 2511-2527, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2019.05.002

Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain

Autori: Christopher Playfoot; Julien Duc; Shaoline Sheppard; Sagane Dind; Alexandre Coudray; Evarist Planet; Didier Trono
Pubblicato in: Genome Research, Numero 9, 2021, Pagina/e 1531-1545, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.275133.120

The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

Autori: Annamaria Kauzlaric, Gabriela Ecco, Marco Cassano, Julien Duc, Michael Imbeault, Didier Trono
Pubblicato in: PLOS ONE, Numero 12/3, 2017, Pagina/e e0173746, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0173746

DUX-family transcription factors regulate zygotic genome activation in placental mammals

Autori: Alberto De Iaco, Evarist Planet, Andrea Coluccio, Sonia Verp, Julien Duc, Didier Trono
Pubblicato in: Nature Genetics, Numero 49/6, 2017, Pagina/e 941-945, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/ng.3858

Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice

Autori: Marco Cassano, Sandra Offner, Evarist Planet, Alessandra Piersigilli, Suk Min Jang, Hugues Henry, Markus B. Geuking, Catherine Mooser, Kathy D. McCoy, Andrew J. Macpherson, Didier Trono
Pubblicato in: Hepatology, Numero 66/1, 2017, Pagina/e 235-251, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.29182

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

Autori: Andrea Coluccio, Gabriela Ecco, Julien Duc, Sandra Offner, Priscilla Turelli, Didier Trono
Pubblicato in: Epigenetics & Chromatin, Numero 11/1, 2018, ISSN 1756-8935
Editore: BioMed Central
DOI: 10.1186/s13072-018-0177-1

KRAB zinc finger proteins

Autori: Gabriela Ecco, Michael Imbeault, Didier Trono
Pubblicato in: Development, Numero 144/15, 2017, Pagina/e 2719-2729, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.132605

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Autori: Suk Min Jang, Annamaria Kauzlaric, Jean-Pierre Quivy, Julien Pontis, Benjamin Rauwel, Andrea Coluccio, Sandra Offner, Julien Duc, Priscilla Turelli, Geneviève Almouzni, Didier Trono
Pubblicato in: Nucleic Acids Research, 2018, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky580

ZNF445 is a primary regulator of genomic imprinting

Autori: Nozomi Takahashi, Andrea Coluccio, Christian W. Thorball, Evarist Planet, Hui Shi, Sandra Offner, Priscilla Turelli, Michael Imbeault, Anne C. Ferguson-Smith, Didier Trono
Pubblicato in: Genes & Development, Numero 33/1-2, 2019, Pagina/e 49-54, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.320069.118

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

Autori: Pierre‐Yves Helleboid, Moritz Heusel, Julien Duc, Cécile Piot, Christian W Thorball, Andrea Coluccio, Julien Pontis, Michaël Imbeault, Priscilla Turelli, Ruedi Aebersold, Didier Trono
Pubblicato in: The EMBO Journal, 2019, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2018101220

DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

Autori: Alberto De Iaco, Alexandre Coudray, Julien Duc, Didier Trono
Pubblicato in: EMBO reports, Numero 20/5, 2019, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.201847382

Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

Autori: Julien Pontis, Evarist Planet, Sandra Offner, Priscilla Turelli, Julien Duc, Alexandre Coudray, Thorold W. Theunissen, Rudolf Jaenisch, Didier Trono
Pubblicato in: Cell Stem Cell, Numero 24/5, 2019, Pagina/e 724-735.e5, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2019.03.012

DUX is a non-essential synchronizer of zygotic genome activation

Autori: Alberto De Iaco, Sonia Verp, Sandra Offner, Delphine Grun, Didier Trono
Pubblicato in: Development, Numero 147/2, 2020, Pagina/e dev177725, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.177725

KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

Autori: Annamaria Kauzlaric, Suk Min Jang, Mehdi Morchikh, Marco Cassano, Evarist Planet, Monsef Benkirane, Didier Trono
Pubblicato in: Philosophical Transactions of the Royal Society B: Biological Sciences, Numero 375/1795, 2020, Pagina/e 20190334, ISSN 0962-8436
Editore: Royal Society of London
DOI: 10.1098/rstb.2019.0334

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

Autori: Alexandra Iouranova, Delphine Grun , Tamara Rossy , Julien Duc , Alexandre Coudray , Michael Imbeault , Jonas de Tribolet-Hardy , Priscilla Turelli , Alexandre Persat , Didier Trono
Pubblicato in: Mobile DNA, Numero 13, 2022, ISSN 1759-8753
Editore: BioMed Central
DOI: 10.1186/s13100-021-00260-0

Other (1)

A KRABsody for Embryo-Placental Development

Autori: Didier Trono
Pubblicato in: Developmental Cell, Numero 41/6, 2017, Pagina/e 578-580, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2017.06.005