Therapeutic approaches to enhance innate immunity against Tumors

Project Information

TNT-TUMORS

Grant agreement ID: 694883

DOI

10.3030/694883

Project closed

EC signature date 27 July 2016

Start date 1 September 2016

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 646,00

EU contribution

€ 2 499 646,00

Coordinated by

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

Author(s): Jörg Klufa, Thomas Bauer, Buck Hanson, Craig Herbold, Philipp Starkl, Beate Lichtenberger, Dagmar Srutkova, Daniel Schulz, Igor Vujic, Thomas Mohr, Klemens Rappersberger, Bernd Bodenmiller, Hana Kozakova, Sylvia Knapp, Alexander Loy, Maria Sibilia
Published in: Science Translational Medicine, Issue 11/522, 2019, Page(s) eaax2693, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax2693

Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

Author(s): Theresa Benezeder, Clemens Painsi, VijayKumar Patra, Saptaswa Dey, Martin Holcmann, Bernhard Lange-Asschenfeldt, Maria Sibilia, Peter Wolf
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56991

Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease

Author(s): Farida Benhadou, Elisabeth Glitzner, Audrey Brisebarre, Benjamin Swedlund, Yura Song, Christine Dubois, Milena Rozzi, Catherine Paulissen, Veronique del Marmol, Maria Sibilia, Cédric Blanpain
Published in: Science Advances, Issue 6/2, 2020, Page(s) eaax5849, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aax5849

Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells

Author(s): Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam‐Amersdorfer, Patrick M Brunner, Georg Stary, Latifa Bakiri, Erwin F Wagner, Herbert Strobl, Maria Sibilia
Published in: EMBO Molecular Medicine, Issue 13/4, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012409

Dual inhibition of TGFβ and AXL as a novel therapy for human colorectal adenocarcinoma with mesenchymal phenotype.

Author(s): Ciardiello D, Blauensteiner B, Matrone N, Belli V, Mohr T, Vitiello PP, Martini G, Poliero L, Cardone C, Napolitano S, De Falco V, Giunta EF, Ciaramella V, Corte CD, Barra G, Selvaggi F, Franco R, Marino FZ, Cuomo A, Morgillo F, Troiani T, Sibilia M, Ciardiello F, Martinelli E.
Published in: Med Oncol., 2020, ISSN 1559-131X
Publisher: Springer Switzerland
DOI: 10.1007/s12032-021-01464-3

IDO1+ Paneth cells promote immune escape of colorectal cancer.

Author(s): Sandra Pflügler; Jasmin Svinka; Irene Scharf; Ilija Crncec; Martin Filipits; Pornpimol Charoentong; Pornpimol Charoentong; Markus Tschurtschenthaler; Markus Tschurtschenthaler; Lukas Kenner; Lukas Kenner; Monira Awad; Judith Stift; Marina Schernthanner; Romana Bischl; Dietmar Herndler-Brandstetter; Elisabeth Glitzner; Herwig P. Moll; Emilio Casanova; Gerald Timelthaler; Maria Sibilia; Michael Gna
Published in: Communications Biology, 2020, ISSN 2399-3642
Publisher: Communications Biology
DOI: 10.17863/cam.70312

Wnt signaling and Loxl2 promote aggressive osteosarcoma

Author(s): Kazuhiko Matsuoka, Latifa Bakiri, Lena I. Wolff, Markus Linder, Amanda Mikels-Vigdal, Ana Patiño-García, Fernando Lecanda, Christine Hartmann, Maria Sibilia, Erwin F. Wagner
Published in: Cell Research, Issue 30/10, 2020, Page(s) 885-901, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-020-0370-1

Lipid Metabolism Interplay in CRC—An Update

Author(s): Dana Krauß; Ourania Fari; Maria Sibilia
Published in: Metabolites, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo12030213

Fos regulates macrophage infiltration against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila.

Author(s): Vera Belyaeva; Stephanie Wachner; Attila Gyoergy; Shamsi Emtenani; Igor Gridchyn; Maria Akhmanova; Markus Linder; Marko Roblek; Maria Sibilia; Daria Siekhaus
Published in: PLoS Biology, 2022, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001494

Stress signaling boosts interferon-induced gene transcription in macrophages

Author(s): Boccuni L, Podgorschek E, Schmiedeberg M, Platanitis E, Traxler P, Fischer P, Schirripa A, Philipp Novoszel, Nebreda AR, Arthur JSC, Fortelny N, Farlik M, Sexl V, Bock C, Maria Sibilia, Kovarik P, Müller M, Decker T.
Published in: Sci Signal. 2022 Dec 13;15(764), 2022, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abq5389

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Author(s): Sriram Srivatsa, Mariel C. Paul, Claudia Cardone, Martin Holcmann, Nicole Amberg, Paulina Pathria, Michaela A. Diamanti, Markus Linder, Gerald Timelthaler, Hans P. Dienes, Lukas Kenner, Fritz Wrba, Gerald W. Prager, Stefan Rose-John, Robert Eferl, Giuseppina Liguori, Gerardo Botti, Erika Martinelli, Florian R. Greten, Fortunato Ciardiello, Maria Sibilia
Published in: Gastroenterology, Issue 153/1, 2017, Page(s) 178-190.e10, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.03.053

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation

Author(s): Markus Linder, Manfred Hecking, Elisabeth Glitzner, Karin Zwerina, Martin Holcmann, Latifa Bakiri, Maria Grazia Ruocco, Jan Tuckermann, Georg Schett, Erwin F. Wagner, Maria Sibilia
Published in: Cell Death & Differentiation, Issue 25/6, 2018, Page(s) 1094-1106, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-017-0054-7

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

Author(s): Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F Wagner, Maria Sibilia
Published in: EMBO Molecular Medicine, Issue 10/11, 2018, Page(s) e9408, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809408

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

Author(s): Stefanie Schmidt, Neele Schumacher, Jeanette Schwarz, Simone Tangermann, Lukas Kenner, Michaela Schlederer, Maria Sibilia, Markus Linder, Annelore Altendorf-Hofmann, Thomas Knösel, Elisabeth S. Gruber, Georg Oberhuber, Julia Bolik, Ateequr Rehman, Anupam Sinha, Juliane Lokau, Philipp Arnold, Anne-Sophie Cabron, Friederike Zunke, Christoph Becker-Pauly, Adele Preaudet, Paul Nguyen, Jennifer Huynh,
Published in: The Journal of Experimental Medicine, Issue 215/4, 2018, Page(s) 1205-1225, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20171696

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

Author(s): Debanjan Dhar, Laura Antonucci, Hayato Nakagawa, Ju Youn Kim, Elisabeth Glitzner, Stefano Caruso, Shabnam Shalapour, Ling Yang, Mark A Valasek, Sooyeon Lee, Kerstin Minnich, Ekihiro Seki, Jan Tuckermann, Maria Sibilia, Jessica Zucman-Rossi, Michael Karin
Published in: Cancer Cell, 2018, ISSN 1878-3686
Publisher: Cancer Cell
DOI: 10.1016/j.ccell.2018.05.003

EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner.

Author(s): Nicole Amberg; Panagiota A. Sotiropoulou; Gerwin Heller; Beate M. Lichtenberger; Martin Holcmann; Bahar Z. Camurdanoglu; Temenuschka Baykuscheva-Gentscheva; Cédric Blanpain; Maria Sibilia
Published in: iScience, 2019, ISSN 2589-0042
Publisher: iScience
DOI: 10.1016/j.isci.2019.04.018

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Author(s): Philipp Novoszel, Barbara Drobits, Martin Holcmann, Cristiano De Sa Fernandes, Roland Tschismarov, Sophia Derdak, Thomas Decker, Erwin F. Wagner, Maria Sibilia
Published in: Cell Death & Differentiation, 2021, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-021-00765-4