Therapeutic approaches to enhance innate immunity against Tumors

Publications

Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

Auteurs: Jörg Klufa, Thomas Bauer, Buck Hanson, Craig Herbold, Philipp Starkl, Beate Lichtenberger, Dagmar Srutkova, Daniel Schulz, Igor Vujic, Thomas Mohr, Klemens Rappersberger, Bernd Bodenmiller, Hana Kozakova, Sylvia Knapp, Alexander Loy, Maria Sibilia
Publié dans: Science Translational Medicine, Numéro 11/522, 2019, Page(s) eaax2693, ISSN 1946-6234
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax2693

Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

Auteurs: Theresa Benezeder, Clemens Painsi, VijayKumar Patra, Saptaswa Dey, Martin Holcmann, Bernhard Lange-Asschenfeldt, Maria Sibilia, Peter Wolf
Publié dans: eLife, Numéro 9, 2020, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.56991

Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease

Auteurs: Farida Benhadou, Elisabeth Glitzner, Audrey Brisebarre, Benjamin Swedlund, Yura Song, Christine Dubois, Milena Rozzi, Catherine Paulissen, Veronique del Marmol, Maria Sibilia, Cédric Blanpain
Publié dans: Science Advances, Numéro 6/2, 2020, Page(s) eaax5849, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aax5849

Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells

Auteurs: Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam‐Amersdorfer, Patrick M Brunner, Georg Stary, Latifa Bakiri, Erwin F Wagner, Herbert Strobl, Maria Sibilia
Publié dans: EMBO Molecular Medicine, Numéro 13/4, 2021, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012409

Dual inhibition of TGFβ and AXL as a novel therapy for human colorectal adenocarcinoma with mesenchymal phenotype.

Auteurs: Ciardiello D, Blauensteiner B, Matrone N, Belli V, Mohr T, Vitiello PP, Martini G, Poliero L, Cardone C, Napolitano S, De Falco V, Giunta EF, Ciaramella V, Corte CD, Barra G, Selvaggi F, Franco R, Marino FZ, Cuomo A, Morgillo F, Troiani T, Sibilia M, Ciardiello F, Martinelli E.
Publié dans: Med Oncol., Numéro Feb 11;38(3):24., 2020, ISSN 1559-131X
Éditeur: Springer Switzerland
DOI: 10.1007/s12032-021-01464-3

IDO1+ Paneth cells promote immune escape of colorectal cancer.

Auteurs: Sandra Pflügler; Jasmin Svinka; Irene Scharf; Ilija Crncec; Martin Filipits; Pornpimol Charoentong; Pornpimol Charoentong; Markus Tschurtschenthaler; Markus Tschurtschenthaler; Lukas Kenner; Lukas Kenner; Monira Awad; Judith Stift; Marina Schernthanner; Romana Bischl; Dietmar Herndler-Brandstetter; Elisabeth Glitzner; Herwig P. Moll; Emilio Casanova; Gerald Timelthaler; Maria Sibilia; Michael Gna
Publié dans: Communications Biology, 2020, ISSN 2399-3642
Éditeur: Communications Biology
DOI: 10.17863/cam.70312

Wnt signaling and Loxl2 promote aggressive osteosarcoma

Auteurs: Kazuhiko Matsuoka, Latifa Bakiri, Lena I. Wolff, Markus Linder, Amanda Mikels-Vigdal, Ana Patiño-García, Fernando Lecanda, Christine Hartmann, Maria Sibilia, Erwin F. Wagner
Publié dans: Cell Research, Numéro 30/10, 2020, Page(s) 885-901, ISSN 1001-0602
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-020-0370-1

Lipid Metabolism Interplay in CRC—An Update

Auteurs: Dana Krauß; Ourania Fari; Maria Sibilia
Publié dans: Metabolites, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo12030213

Fos regulates macrophage infiltration against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila.

Auteurs: Vera Belyaeva; Stephanie Wachner; Attila Gyoergy; Shamsi Emtenani; Igor Gridchyn; Maria Akhmanova; Markus Linder; Marko Roblek; Maria Sibilia; Daria Siekhaus
Publié dans: PLoS Biology, 2022, ISSN 1544-9173
Éditeur: Public Library of Science
DOI: 10.1371/journal.pbio.3001494

Stress signaling boosts interferon-induced gene transcription in macrophages

Auteurs: Boccuni L, Podgorschek E, Schmiedeberg M, Platanitis E, Traxler P, Fischer P, Schirripa A, Philipp Novoszel, Nebreda AR, Arthur JSC, Fortelny N, Farlik M, Sexl V, Bock C, Maria Sibilia, Kovarik P, Müller M, Decker T.
Publié dans: Sci Signal. 2022 Dec 13;15(764), 2022, ISSN 1937-9145
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abq5389

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Auteurs: Sriram Srivatsa, Mariel C. Paul, Claudia Cardone, Martin Holcmann, Nicole Amberg, Paulina Pathria, Michaela A. Diamanti, Markus Linder, Gerald Timelthaler, Hans P. Dienes, Lukas Kenner, Fritz Wrba, Gerald W. Prager, Stefan Rose-John, Robert Eferl, Giuseppina Liguori, Gerardo Botti, Erika Martinelli, Florian R. Greten, Fortunato Ciardiello, Maria Sibilia
Publié dans: Gastroenterology, Numéro 153/1, 2017, Page(s) 178-190.e10, ISSN 0016-5085
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.03.053

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation

Auteurs: Markus Linder, Manfred Hecking, Elisabeth Glitzner, Karin Zwerina, Martin Holcmann, Latifa Bakiri, Maria Grazia Ruocco, Jan Tuckermann, Georg Schett, Erwin F. Wagner, Maria Sibilia
Publié dans: Cell Death & Differentiation, Numéro 25/6, 2018, Page(s) 1094-1106, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/s41418-017-0054-7

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

Auteurs: Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F Wagner, Maria Sibilia
Publié dans: EMBO Molecular Medicine, Numéro 10/11, 2018, Page(s) e9408, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809408

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

Auteurs: Stefanie Schmidt, Neele Schumacher, Jeanette Schwarz, Simone Tangermann, Lukas Kenner, Michaela Schlederer, Maria Sibilia, Markus Linder, Annelore Altendorf-Hofmann, Thomas Knösel, Elisabeth S. Gruber, Georg Oberhuber, Julia Bolik, Ateequr Rehman, Anupam Sinha, Juliane Lokau, Philipp Arnold, Anne-Sophie Cabron, Friederike Zunke, Christoph Becker-Pauly, Adele Preaudet, Paul Nguyen, Jennifer Huynh,
Publié dans: The Journal of Experimental Medicine, Numéro 215/4, 2018, Page(s) 1205-1225, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20171696

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

Auteurs: Debanjan Dhar, Laura Antonucci, Hayato Nakagawa, Ju Youn Kim, Elisabeth Glitzner, Stefano Caruso, Shabnam Shalapour, Ling Yang, Mark A Valasek, Sooyeon Lee, Kerstin Minnich, Ekihiro Seki, Jan Tuckermann, Maria Sibilia, Jessica Zucman-Rossi, Michael Karin
Publié dans: Cancer Cell, 2018, ISSN 1878-3686
Éditeur: Cancer Cell
DOI: 10.1016/j.ccell.2018.05.003

EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner.

Auteurs: Nicole Amberg; Panagiota A. Sotiropoulou; Gerwin Heller; Beate M. Lichtenberger; Martin Holcmann; Bahar Z. Camurdanoglu; Temenuschka Baykuscheva-Gentscheva; Cédric Blanpain; Maria Sibilia
Publié dans: iScience, 2019, ISSN 2589-0042
Éditeur: iScience
DOI: 10.1016/j.isci.2019.04.018

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Auteurs: Philipp Novoszel, Barbara Drobits, Martin Holcmann, Cristiano De Sa Fernandes, Roland Tschismarov, Sophia Derdak, Thomas Decker, Erwin F. Wagner, Maria Sibilia
Publié dans: Cell Death & Differentiation, 2021, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/s41418-021-00765-4

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