Therapeutic approaches to enhance innate immunity against Tumors

Información del proyecto

TNT-TUMORS

Identificador del acuerdo de subvención: 694883

DOI

10.3030/694883

Proyecto cerrado

Fecha de la firma de la CE 27 Julio 2016

Fecha de inicio 1 Septiembre 2016

Fecha de finalización 31 Agosto 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 646,00

Aportación de la UE

€ 2 499 646,00

Coordinado por

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

Autores: Jörg Klufa, Thomas Bauer, Buck Hanson, Craig Herbold, Philipp Starkl, Beate Lichtenberger, Dagmar Srutkova, Daniel Schulz, Igor Vujic, Thomas Mohr, Klemens Rappersberger, Bernd Bodenmiller, Hana Kozakova, Sylvia Knapp, Alexander Loy, Maria Sibilia
Publicado en: Science Translational Medicine, Edición 11/522, 2019, Página(s) eaax2693, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax2693

Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

Autores: Theresa Benezeder, Clemens Painsi, VijayKumar Patra, Saptaswa Dey, Martin Holcmann, Bernhard Lange-Asschenfeldt, Maria Sibilia, Peter Wolf
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.56991

Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease

Autores: Farida Benhadou, Elisabeth Glitzner, Audrey Brisebarre, Benjamin Swedlund, Yura Song, Christine Dubois, Milena Rozzi, Catherine Paulissen, Veronique del Marmol, Maria Sibilia, Cédric Blanpain
Publicado en: Science Advances, Edición 6/2, 2020, Página(s) eaax5849, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aax5849

Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells

Autores: Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam‐Amersdorfer, Patrick M Brunner, Georg Stary, Latifa Bakiri, Erwin F Wagner, Herbert Strobl, Maria Sibilia
Publicado en: EMBO Molecular Medicine, Edición 13/4, 2021, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012409

Dual inhibition of TGFβ and AXL as a novel therapy for human colorectal adenocarcinoma with mesenchymal phenotype.

Autores: Ciardiello D, Blauensteiner B, Matrone N, Belli V, Mohr T, Vitiello PP, Martini G, Poliero L, Cardone C, Napolitano S, De Falco V, Giunta EF, Ciaramella V, Corte CD, Barra G, Selvaggi F, Franco R, Marino FZ, Cuomo A, Morgillo F, Troiani T, Sibilia M, Ciardiello F, Martinelli E.
Publicado en: Med Oncol., 2020, ISSN 1559-131X
Editor: Springer Switzerland
DOI: 10.1007/s12032-021-01464-3

IDO1+ Paneth cells promote immune escape of colorectal cancer.

Autores: Sandra Pflügler; Jasmin Svinka; Irene Scharf; Ilija Crncec; Martin Filipits; Pornpimol Charoentong; Pornpimol Charoentong; Markus Tschurtschenthaler; Markus Tschurtschenthaler; Lukas Kenner; Lukas Kenner; Monira Awad; Judith Stift; Marina Schernthanner; Romana Bischl; Dietmar Herndler-Brandstetter; Elisabeth Glitzner; Herwig P. Moll; Emilio Casanova; Gerald Timelthaler; Maria Sibilia; Michael Gna
Publicado en: Communications Biology, 2020, ISSN 2399-3642
Editor: Communications Biology
DOI: 10.17863/cam.70312

Wnt signaling and Loxl2 promote aggressive osteosarcoma

Autores: Kazuhiko Matsuoka, Latifa Bakiri, Lena I. Wolff, Markus Linder, Amanda Mikels-Vigdal, Ana Patiño-García, Fernando Lecanda, Christine Hartmann, Maria Sibilia, Erwin F. Wagner
Publicado en: Cell Research, Edición 30/10, 2020, Página(s) 885-901, ISSN 1001-0602
Editor: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-020-0370-1

Lipid Metabolism Interplay in CRC—An Update

Autores: Dana Krauß; Ourania Fari; Maria Sibilia
Publicado en: Metabolites, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo12030213

Fos regulates macrophage infiltration against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila.

Autores: Vera Belyaeva; Stephanie Wachner; Attila Gyoergy; Shamsi Emtenani; Igor Gridchyn; Maria Akhmanova; Markus Linder; Marko Roblek; Maria Sibilia; Daria Siekhaus
Publicado en: PLoS Biology, 2022, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3001494

Stress signaling boosts interferon-induced gene transcription in macrophages

Autores: Boccuni L, Podgorschek E, Schmiedeberg M, Platanitis E, Traxler P, Fischer P, Schirripa A, Philipp Novoszel, Nebreda AR, Arthur JSC, Fortelny N, Farlik M, Sexl V, Bock C, Maria Sibilia, Kovarik P, Müller M, Decker T.
Publicado en: Sci Signal. 2022 Dec 13;15(764), 2022, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abq5389

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Autores: Sriram Srivatsa, Mariel C. Paul, Claudia Cardone, Martin Holcmann, Nicole Amberg, Paulina Pathria, Michaela A. Diamanti, Markus Linder, Gerald Timelthaler, Hans P. Dienes, Lukas Kenner, Fritz Wrba, Gerald W. Prager, Stefan Rose-John, Robert Eferl, Giuseppina Liguori, Gerardo Botti, Erika Martinelli, Florian R. Greten, Fortunato Ciardiello, Maria Sibilia
Publicado en: Gastroenterology, Edición 153/1, 2017, Página(s) 178-190.e10, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.03.053

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation

Autores: Markus Linder, Manfred Hecking, Elisabeth Glitzner, Karin Zwerina, Martin Holcmann, Latifa Bakiri, Maria Grazia Ruocco, Jan Tuckermann, Georg Schett, Erwin F. Wagner, Maria Sibilia
Publicado en: Cell Death & Differentiation, Edición 25/6, 2018, Página(s) 1094-1106, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-017-0054-7

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

Autores: Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F Wagner, Maria Sibilia
Publicado en: EMBO Molecular Medicine, Edición 10/11, 2018, Página(s) e9408, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809408

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

Autores: Stefanie Schmidt, Neele Schumacher, Jeanette Schwarz, Simone Tangermann, Lukas Kenner, Michaela Schlederer, Maria Sibilia, Markus Linder, Annelore Altendorf-Hofmann, Thomas Knösel, Elisabeth S. Gruber, Georg Oberhuber, Julia Bolik, Ateequr Rehman, Anupam Sinha, Juliane Lokau, Philipp Arnold, Anne-Sophie Cabron, Friederike Zunke, Christoph Becker-Pauly, Adele Preaudet, Paul Nguyen, Jennifer Huynh,
Publicado en: The Journal of Experimental Medicine, Edición 215/4, 2018, Página(s) 1205-1225, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20171696

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

Autores: Debanjan Dhar, Laura Antonucci, Hayato Nakagawa, Ju Youn Kim, Elisabeth Glitzner, Stefano Caruso, Shabnam Shalapour, Ling Yang, Mark A Valasek, Sooyeon Lee, Kerstin Minnich, Ekihiro Seki, Jan Tuckermann, Maria Sibilia, Jessica Zucman-Rossi, Michael Karin
Publicado en: Cancer Cell, 2018, ISSN 1878-3686
Editor: Cancer Cell
DOI: 10.1016/j.ccell.2018.05.003

EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner.

Autores: Nicole Amberg; Panagiota A. Sotiropoulou; Gerwin Heller; Beate M. Lichtenberger; Martin Holcmann; Bahar Z. Camurdanoglu; Temenuschka Baykuscheva-Gentscheva; Cédric Blanpain; Maria Sibilia
Publicado en: iScience, 2019, ISSN 2589-0042
Editor: iScience
DOI: 10.1016/j.isci.2019.04.018

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Autores: Philipp Novoszel, Barbara Drobits, Martin Holcmann, Cristiano De Sa Fernandes, Roland Tschismarov, Sophia Derdak, Thomas Decker, Erwin F. Wagner, Maria Sibilia
Publicado en: Cell Death & Differentiation, 2021, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-021-00765-4