Solute carrier proteins as the gates managing chemical access to cells

Project Information

GameofGates

Grant agreement ID: 695214

DOI 10.3030/695214

Project closed

EC signature date 26 September 2016

Start date 1 October 2016

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 389 782,00

EU contribution € 2 389 782,00

Coordinated by

CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Austria

Publications

Peer reviewed articles (17)

Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states

Author(s): Kai-Chun Li, Enrico Girardi, Felix Kartnig, Sarah Grosche, Tea Pemovska, Johannes W. Bigenzahn, Ulrich Goldmann, Vitaly Sedlyarov, Ariel Bensimon, Sandra Schick, Jung-Ming G. Lin, Bettina Gürtl, Daniela Reil, Kristaps Klavins, Stefan Kubicek, Sara Sdelci, Giulio Superti-Furga
Published in: Nature Metabolism, Issue 3/5, 2021, Page(s) 651-664, ISSN 2522-5812
Publisher: Nature Metabolism
DOI: 10.1038/s42255-021-00386-8

Recent developments in ligands and chemical probes targeting solute carrier transporters

Author(s): Andrea Casiraghi, Ariel Bensimon, Giulio Superti-Furga
Published in: Current Opinion in Chemical Biology, Issue 62, 2021, Page(s) 53-63, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2021.01.012

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

Author(s): Iris Steinparzer, Vitaly Sedlyarov, Jonathan D. Rubin, Kevin Eislmayr, Matthew D. Galbraith, Cecilia B. Levandowski, Terezia Vcelkova, Lucy Sneezum, Florian Wascher, Fabian Amman, Renata Kleinova, Heather Bender, Zdenek Andrysik, Joaquin M. Espinosa, Giulio Superti-Furga, Robin D. Dowell, Dylan J. Taatjes, Pavel Kovarik
Published in: Molecular Cell, Issue 76/3, 2019, Page(s) 485-499.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.07.034

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

Author(s): Enrico Girardi, Adrián César-Razquin, Sabrina Lindinger, Konstantinos Papakostas, Justyna Konecka, Jennifer Hemmerich, Stefanie Kickinger, Felix Kartnig, Bettina Gürtl, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Anna Koren, Charles-Hugues Lardeau, Richard Kumaran Kandasamy, Stefan Kubicek, Gerhard F. Ecker, Giulio Superti-Furga
Published in: Nature Chemical Biology, Issue 16/4, 2020, Page(s) 469-478, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-0483-3

A guide to plasma membrane solute carrier proteins

Author(s): Mattia D. Pizzagalli, Ariel Bensimon, Giulio Superti‐Furga
Published in: The FEBS Journal, 2020, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15531

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis

Author(s): Ariel Bensimon, Mattia D. Pizzagalli, Felix Kartnig, Vojtech Dvorak, Patrick Essletzbichler, Georg E. Winter, Giulio Superti-Furga
Published in: Cell Chemical Biology, Issue 27/6, 2020, Page(s) 728-739.e9, ISSN 2451-9456
Publisher: Cell Chemical Biology
DOI: 10.1016/j.chembiol.2020.04.003

Insights into the transport side of the human SLC38A9 transceptor

Author(s): Mariafrancesca Scalise, Michele Galluccio, Lorena Pochini, Jessica Cosco, Miriam Trotta, Manuele Rebsamen, Giulio Superti-Furga, Cesare Indiveri
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1861/9, 2019, Page(s) 1558-1567, ISSN 0005-2736
Publisher: Elsevier BV
DOI: 10.1016/j.bbamem.2019.07.006

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9

Author(s): Leonhard X. Heinz, JangEun Lee, Utkarsh Kapoor, Felix Kartnig, Vitaly Sedlyarov, Konstantinos Papakostas, Adrian César-Razquin, Patrick Essletzbichler, Ulrich Goldmann, Adrijana Stefanovic, Johannes W. Bigenzahn, Stefania Scorzoni, Mattia D. Pizzagalli, Ariel Bensimon, André C. Müller, F. James King, Jun Li, Enrico Girardi, M. Lamine Mbow, Charles E. Whitehurst, Manuele Rebsamen, Giulio Superti
Published in: Nature, Issue 581/7808, 2020, Page(s) 316-322, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2282-0

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

Author(s): Enrico Girardi, Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri, Giulio Superti-Furga
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19871-x

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

Author(s): Thomas Karonitsch, Richard K. Kandasamy, Felix Kartnig, Barbara Herdy, Karolina Dalwigk, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Reinhard Windhager, Martin Bilban, Thomas Weichhart, Marcus Säemann, Thomas Pap, Günter Steiner, Josef S. Smolen, Hans P. Kiener, Giulio Superti-Furga
Published in: Cell Reports, Issue 23/7, 2018, Page(s) 2157-2167, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.04.044

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking

Author(s): Astrid Fauster, Manuele Rebsamen, Katharina L. Willmann, Adrian César-Razquin, Enrico Girardi, Johannes W. Bigenzahn, Fiorella Schischlik, Stefania Scorzoni, Manuela Bruckner, Justyna Konecka, Katrin Hörmann, Leonhard X. Heinz, Kaan Boztug, Giulio Superti-Furga
Published in: Cell Death & Differentiation, Issue 26/6, 2019, Page(s) 1138-1155, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-018-0192-6

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay

Author(s): Mari Hashimoto, Enrico Girardi, Ruth Eichner, Giulio Superti-Furga
Published in: ACS Chemical Biology, Issue 13/6, 2018, Page(s) 1480-1486, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.8b00270

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification

Author(s): Vitaly Sedlyarov, Ruth Eichner, Enrico Girardi, Patrick Essletzbichler, Ulrich Goldmann, Paula Nunes-Hasler, Ismet Srndic, Anna Moskovskich, Leonhard X. Heinz, Felix Kartnig, Johannes W. Bigenzahn, Manuele Rebsamen, Pavel Kovarik, Nicolas Demaurex, Giulio Superti-Furga
Published in: Cell Host & Microbe, Issue 23/6, 2018, Page(s) 766-774.e5, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2018.04.013

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

Author(s): Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04329-y

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection

Author(s): Anna Moskovskich, Ulrich Goldmann, Felix Kartnig, Sabrina Lindinger, Justyna Konecka, Giuseppe Fiume, Enrico Girardi, Giulio Superti-Furga
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-46952-9

LZTR1 is a regulator of RAS ubiquitination and signaling

Author(s): Johannes W. Bigenzahn, Giovanna M. Collu, Felix Kartnig, Melanie Pieraks, Gregory I. Vladimer, Leonhard X. Heinz, Vitaly Sedlyarov, Fiorella Schischlik, Astrid Fauster, Manuele Rebsamen, Katja Parapatics, Vincent A. Blomen, André C. Müller, Georg E. Winter, Robert Kralovics, Thijn R. Brummelkamp, Marek Mlodzik, Giulio Superti-Furga
Published in: Science, Issue 362/6419, 2018, Page(s) 1171-1177, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aap8210

A substrate‐based ontology for human solute carriers

Author(s): Eva Meixner, Ulrich Goldmann, Vitaly Sedlyarov, Stefania Scorzoni, Manuele Rebsamen, Enrico Girardi, Giulio Superti‐Furga
Published in: Molecular Systems Biology, Issue 16/7, 2020, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20209652

Other (1)

Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters

Author(s): Giulio Superti-Furga; Giulio Superti-Furga; Pedro Mendes; Enrico Girardi; Douglas B. Kell; Douglas B. Kell
Published in: bioRxiv, Issue 1, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.01.16.909507