Solute carrier proteins as the gates managing chemical access to cells

Pubblicazioni

Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states

Autori: Kai-Chun Li, Enrico Girardi, Felix Kartnig, Sarah Grosche, Tea Pemovska, Johannes W. Bigenzahn, Ulrich Goldmann, Vitaly Sedlyarov, Ariel Bensimon, Sandra Schick, Jung-Ming G. Lin, Bettina Gürtl, Daniela Reil, Kristaps Klavins, Stefan Kubicek, Sara Sdelci, Giulio Superti-Furga
Pubblicato in: Nature Metabolism, Numero 3/5, 2021, Pagina/e 651-664, ISSN 2522-5812
Editore: Nature Metabolism
DOI: 10.1038/s42255-021-00386-8

Recent developments in ligands and chemical probes targeting solute carrier transporters

Autori: Andrea Casiraghi, Ariel Bensimon, Giulio Superti-Furga
Pubblicato in: Current Opinion in Chemical Biology, Numero 62, 2021, Pagina/e 53-63, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2021.01.012

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

Autori: Iris Steinparzer, Vitaly Sedlyarov, Jonathan D. Rubin, Kevin Eislmayr, Matthew D. Galbraith, Cecilia B. Levandowski, Terezia Vcelkova, Lucy Sneezum, Florian Wascher, Fabian Amman, Renata Kleinova, Heather Bender, Zdenek Andrysik, Joaquin M. Espinosa, Giulio Superti-Furga, Robin D. Dowell, Dylan J. Taatjes, Pavel Kovarik
Pubblicato in: Molecular Cell, Numero 76/3, 2019, Pagina/e 485-499.e8, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.07.034

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

Autori: Enrico Girardi, Adrián César-Razquin, Sabrina Lindinger, Konstantinos Papakostas, Justyna Konecka, Jennifer Hemmerich, Stefanie Kickinger, Felix Kartnig, Bettina Gürtl, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Anna Koren, Charles-Hugues Lardeau, Richard Kumaran Kandasamy, Stefan Kubicek, Gerhard F. Ecker, Giulio Superti-Furga
Pubblicato in: Nature Chemical Biology, Numero 16/4, 2020, Pagina/e 469-478, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-020-0483-3

A guide to plasma membrane solute carrier proteins

Autori: Mattia D. Pizzagalli, Ariel Bensimon, Giulio Superti‐Furga
Pubblicato in: The FEBS Journal, 2020, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.15531

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis

Autori: Ariel Bensimon, Mattia D. Pizzagalli, Felix Kartnig, Vojtech Dvorak, Patrick Essletzbichler, Georg E. Winter, Giulio Superti-Furga
Pubblicato in: Cell Chemical Biology, Numero 27/6, 2020, Pagina/e 728-739.e9, ISSN 2451-9456
Editore: Cell Chemical Biology
DOI: 10.1016/j.chembiol.2020.04.003

Insights into the transport side of the human SLC38A9 transceptor

Autori: Mariafrancesca Scalise, Michele Galluccio, Lorena Pochini, Jessica Cosco, Miriam Trotta, Manuele Rebsamen, Giulio Superti-Furga, Cesare Indiveri
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Numero 1861/9, 2019, Pagina/e 1558-1567, ISSN 0005-2736
Editore: Elsevier BV
DOI: 10.1016/j.bbamem.2019.07.006

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9

Autori: Leonhard X. Heinz, JangEun Lee, Utkarsh Kapoor, Felix Kartnig, Vitaly Sedlyarov, Konstantinos Papakostas, Adrian César-Razquin, Patrick Essletzbichler, Ulrich Goldmann, Adrijana Stefanovic, Johannes W. Bigenzahn, Stefania Scorzoni, Mattia D. Pizzagalli, Ariel Bensimon, André C. Müller, F. James King, Jun Li, Enrico Girardi, M. Lamine Mbow, Charles E. Whitehurst, Manuele Rebsamen, Giulio Superti
Pubblicato in: Nature, Numero 581/7808, 2020, Pagina/e 316-322, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2282-0

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

Autori: Enrico Girardi, Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri, Giulio Superti-Furga
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19871-x

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

Autori: Thomas Karonitsch, Richard K. Kandasamy, Felix Kartnig, Barbara Herdy, Karolina Dalwigk, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Reinhard Windhager, Martin Bilban, Thomas Weichhart, Marcus Säemann, Thomas Pap, Günter Steiner, Josef S. Smolen, Hans P. Kiener, Giulio Superti-Furga
Pubblicato in: Cell Reports, Numero 23/7, 2018, Pagina/e 2157-2167, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.04.044

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking

Autori: Astrid Fauster, Manuele Rebsamen, Katharina L. Willmann, Adrian César-Razquin, Enrico Girardi, Johannes W. Bigenzahn, Fiorella Schischlik, Stefania Scorzoni, Manuela Bruckner, Justyna Konecka, Katrin Hörmann, Leonhard X. Heinz, Kaan Boztug, Giulio Superti-Furga
Pubblicato in: Cell Death & Differentiation, Numero 26/6, 2019, Pagina/e 1138-1155, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-018-0192-6

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay

Autori: Mari Hashimoto, Enrico Girardi, Ruth Eichner, Giulio Superti-Furga
Pubblicato in: ACS Chemical Biology, Numero 13/6, 2018, Pagina/e 1480-1486, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.8b00270

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification

Autori: Vitaly Sedlyarov, Ruth Eichner, Enrico Girardi, Patrick Essletzbichler, Ulrich Goldmann, Paula Nunes-Hasler, Ismet Srndic, Anna Moskovskich, Leonhard X. Heinz, Felix Kartnig, Johannes W. Bigenzahn, Manuele Rebsamen, Pavel Kovarik, Nicolas Demaurex, Giulio Superti-Furga
Pubblicato in: Cell Host & Microbe, Numero 23/6, 2018, Pagina/e 766-774.e5, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2018.04.013

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

Autori: Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04329-y

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection

Autori: Anna Moskovskich, Ulrich Goldmann, Felix Kartnig, Sabrina Lindinger, Justyna Konecka, Giuseppe Fiume, Enrico Girardi, Giulio Superti-Furga
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-46952-9

LZTR1 is a regulator of RAS ubiquitination and signaling

Autori: Johannes W. Bigenzahn, Giovanna M. Collu, Felix Kartnig, Melanie Pieraks, Gregory I. Vladimer, Leonhard X. Heinz, Vitaly Sedlyarov, Fiorella Schischlik, Astrid Fauster, Manuele Rebsamen, Katja Parapatics, Vincent A. Blomen, André C. Müller, Georg E. Winter, Robert Kralovics, Thijn R. Brummelkamp, Marek Mlodzik, Giulio Superti-Furga
Pubblicato in: Science, Numero 362/6419, 2018, Pagina/e 1171-1177, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aap8210

A substrate‐based ontology for human solute carriers

Autori: Eva Meixner, Ulrich Goldmann, Vitaly Sedlyarov, Stefania Scorzoni, Manuele Rebsamen, Enrico Girardi, Giulio Superti‐Furga
Pubblicato in: Molecular Systems Biology, Numero 16/7, 2020, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.20209652

Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters

Autori: Giulio Superti-Furga; Giulio Superti-Furga; Pedro Mendes; Enrico Girardi; Douglas B. Kell; Douglas B. Kell
Pubblicato in: bioRxiv, Numero 1, 2020
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.01.16.909507

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