Solute carrier proteins as the gates managing chemical access to cells

Publicaciones

Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states

Autores: Kai-Chun Li, Enrico Girardi, Felix Kartnig, Sarah Grosche, Tea Pemovska, Johannes W. Bigenzahn, Ulrich Goldmann, Vitaly Sedlyarov, Ariel Bensimon, Sandra Schick, Jung-Ming G. Lin, Bettina Gürtl, Daniela Reil, Kristaps Klavins, Stefan Kubicek, Sara Sdelci, Giulio Superti-Furga
Publicado en: Nature Metabolism, Edición 3/5, 2021, Página(s) 651-664, ISSN 2522-5812
Editor: Nature Metabolism
DOI: 10.1038/s42255-021-00386-8

Recent developments in ligands and chemical probes targeting solute carrier transporters

Autores: Andrea Casiraghi, Ariel Bensimon, Giulio Superti-Furga
Publicado en: Current Opinion in Chemical Biology, Edición 62, 2021, Página(s) 53-63, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/j.cbpa.2021.01.012

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

Autores: Iris Steinparzer, Vitaly Sedlyarov, Jonathan D. Rubin, Kevin Eislmayr, Matthew D. Galbraith, Cecilia B. Levandowski, Terezia Vcelkova, Lucy Sneezum, Florian Wascher, Fabian Amman, Renata Kleinova, Heather Bender, Zdenek Andrysik, Joaquin M. Espinosa, Giulio Superti-Furga, Robin D. Dowell, Dylan J. Taatjes, Pavel Kovarik
Publicado en: Molecular Cell, Edición 76/3, 2019, Página(s) 485-499.e8, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2019.07.034

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

Autores: Enrico Girardi, Adrián César-Razquin, Sabrina Lindinger, Konstantinos Papakostas, Justyna Konecka, Jennifer Hemmerich, Stefanie Kickinger, Felix Kartnig, Bettina Gürtl, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Anna Koren, Charles-Hugues Lardeau, Richard Kumaran Kandasamy, Stefan Kubicek, Gerhard F. Ecker, Giulio Superti-Furga
Publicado en: Nature Chemical Biology, Edición 16/4, 2020, Página(s) 469-478, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-020-0483-3

A guide to plasma membrane solute carrier proteins

Autores: Mattia D. Pizzagalli, Ariel Bensimon, Giulio Superti‐Furga
Publicado en: The FEBS Journal, 2020, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.15531

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis

Autores: Ariel Bensimon, Mattia D. Pizzagalli, Felix Kartnig, Vojtech Dvorak, Patrick Essletzbichler, Georg E. Winter, Giulio Superti-Furga
Publicado en: Cell Chemical Biology, Edición 27/6, 2020, Página(s) 728-739.e9, ISSN 2451-9456
Editor: Cell Chemical Biology
DOI: 10.1016/j.chembiol.2020.04.003

Insights into the transport side of the human SLC38A9 transceptor

Autores: Mariafrancesca Scalise, Michele Galluccio, Lorena Pochini, Jessica Cosco, Miriam Trotta, Manuele Rebsamen, Giulio Superti-Furga, Cesare Indiveri
Publicado en: Biochimica et Biophysica Acta (BBA) - Biomembranes, Edición 1861/9, 2019, Página(s) 1558-1567, ISSN 0005-2736
Editor: Elsevier BV
DOI: 10.1016/j.bbamem.2019.07.006

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9

Autores: Leonhard X. Heinz, JangEun Lee, Utkarsh Kapoor, Felix Kartnig, Vitaly Sedlyarov, Konstantinos Papakostas, Adrian César-Razquin, Patrick Essletzbichler, Ulrich Goldmann, Adrijana Stefanovic, Johannes W. Bigenzahn, Stefania Scorzoni, Mattia D. Pizzagalli, Ariel Bensimon, André C. Müller, F. James King, Jun Li, Enrico Girardi, M. Lamine Mbow, Charles E. Whitehurst, Manuele Rebsamen, Giulio Superti
Publicado en: Nature, Edición 581/7808, 2020, Página(s) 316-322, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2282-0

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

Autores: Enrico Girardi, Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri, Giulio Superti-Furga
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19871-x

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

Autores: Thomas Karonitsch, Richard K. Kandasamy, Felix Kartnig, Barbara Herdy, Karolina Dalwigk, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Reinhard Windhager, Martin Bilban, Thomas Weichhart, Marcus Säemann, Thomas Pap, Günter Steiner, Josef S. Smolen, Hans P. Kiener, Giulio Superti-Furga
Publicado en: Cell Reports, Edición 23/7, 2018, Página(s) 2157-2167, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.04.044

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking

Autores: Astrid Fauster, Manuele Rebsamen, Katharina L. Willmann, Adrian César-Razquin, Enrico Girardi, Johannes W. Bigenzahn, Fiorella Schischlik, Stefania Scorzoni, Manuela Bruckner, Justyna Konecka, Katrin Hörmann, Leonhard X. Heinz, Kaan Boztug, Giulio Superti-Furga
Publicado en: Cell Death & Differentiation, Edición 26/6, 2019, Página(s) 1138-1155, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-018-0192-6

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay

Autores: Mari Hashimoto, Enrico Girardi, Ruth Eichner, Giulio Superti-Furga
Publicado en: ACS Chemical Biology, Edición 13/6, 2018, Página(s) 1480-1486, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.8b00270

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification

Autores: Vitaly Sedlyarov, Ruth Eichner, Enrico Girardi, Patrick Essletzbichler, Ulrich Goldmann, Paula Nunes-Hasler, Ismet Srndic, Anna Moskovskich, Leonhard X. Heinz, Felix Kartnig, Johannes W. Bigenzahn, Manuele Rebsamen, Pavel Kovarik, Nicolas Demaurex, Giulio Superti-Furga
Publicado en: Cell Host & Microbe, Edición 23/6, 2018, Página(s) 766-774.e5, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2018.04.013

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

Autores: Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04329-y

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection

Autores: Anna Moskovskich, Ulrich Goldmann, Felix Kartnig, Sabrina Lindinger, Justyna Konecka, Giuseppe Fiume, Enrico Girardi, Giulio Superti-Furga
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-46952-9

LZTR1 is a regulator of RAS ubiquitination and signaling

Autores: Johannes W. Bigenzahn, Giovanna M. Collu, Felix Kartnig, Melanie Pieraks, Gregory I. Vladimer, Leonhard X. Heinz, Vitaly Sedlyarov, Fiorella Schischlik, Astrid Fauster, Manuele Rebsamen, Katja Parapatics, Vincent A. Blomen, André C. Müller, Georg E. Winter, Robert Kralovics, Thijn R. Brummelkamp, Marek Mlodzik, Giulio Superti-Furga
Publicado en: Science, Edición 362/6419, 2018, Página(s) 1171-1177, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aap8210

A substrate‐based ontology for human solute carriers

Autores: Eva Meixner, Ulrich Goldmann, Vitaly Sedlyarov, Stefania Scorzoni, Manuele Rebsamen, Enrico Girardi, Giulio Superti‐Furga
Publicado en: Molecular Systems Biology, Edición 16/7, 2020, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.20209652

Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters

Autores: Giulio Superti-Furga; Giulio Superti-Furga; Pedro Mendes; Enrico Girardi; Douglas B. Kell; Douglas B. Kell
Publicado en: bioRxiv, Edición 1, 2020
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.01.16.909507

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