Targeting oxidative repair proteins for treatment of cancer and inflammation

Publications

Peer reviewed articles (6)

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Author(s): Torkild Visnes, Armando Cázares-Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisée Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina v
Published in: Science, Issue 362/6416, 2018, Page(s) 834-839, ISSN 0036-8075
DOI: 10.1126/science.aar8048

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

Author(s): Ann-Sofie Jemth, Robert Gustafsson, Lars Bräutigam, Linda Henriksson, Karl S A Vallin, Antonio Sarno, Ingrid Almlöf, Evert Homan, Azita Rasti, Ulrika Warpman Berglund, Pål Stenmark, Thomas Helleday
Published in: Nucleic Acids Research, 2018, ISSN 0305-1048
DOI: 10.1093/nar/gky896

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

Author(s): Jordi Carreras-Puigvert, Marinka Zitnik, Ann-Sofie Jemth, Megan Carter, Judith E. Unterlass, Björn Hallström, Olga Loseva, Zhir Karem, José Manuel Calderón-Montaño, Cecilia Lindskog, Per-Henrik Edqvist, Damian J. Matuszewski, Hammou Ait Blal, Ronnie P. A. Berntsson, Maria Häggblad, Ulf Martens, Matthew Studham, Bo Lundgren, Carolina Wählby, Erik L. L. Sonnhammer, Emma Lundberg, Pål Stenmar
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-01642-w

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Author(s): Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Bea
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-017-02293-7

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1

Author(s): Linda Pudelko, Pegah Rouhi, Kumar Sanjiv, Helge Gad, Christina Kalderén, Andreas Höglund, Massimo Squatrito, Alberto J. Schuhmacher, Steven Edwards, Daniel Hägerstrand, Ulrika Warpman Berglund, Thomas Helleday, Lars Bräutigam
Published in: Oncotarget, Issue 8/49, 2017, ISSN 1949-2553
DOI: 10.18632/oncotarget.19404

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. Structure. Feb 6;26(2):295-303.e6.

Author(s): "Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martínez Carranza M, Vallin KSA, Throup A, Helleday T#, Stenmark P#."
Published in: Structure, Issue 26/2, 2018, Page(s) 295-303.e6, ISSN 2352-0124
DOI: 10.1016/j.str.2018.01.004

Other (2)

MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression

Author(s): Sean G Rudd, Helge Gad, Nuno Amaral, Anna Hagenkort, Petra Groth, Cecilia E Ström, OliverMortusewicz, Ulrika Warpman Berglund, Thomas Helleday
Published in: bioRxiv, 2019
DOI: 10.1101/573931

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

Author(s): Helge Gad, Oliver Mortusewicz, Sean G Rudd, Ailine Stolz, Nuno Amaral, Lars Brautigham, Linda Pudelko, Kumar Sanjiv, Christina Kaldéren, Ann-Sofie Jemth, Ingrid Almlöf, Torkild Visnes, Niklas Schultz, JohanBoström, José Manuel Calderon Montano, Anna Hagenkort, Petra Groth, Olga Loseva, Camilla Gokturk, Tobias Koolmeister, Prasad Wakchaure, Evert Homan, Cecilia E Ström, Martin Scobie, Holger
Published in: 2019
DOI: 10.1101/575290