Targeting oxidative repair proteins for treatment of cancer and inflammation

Información del proyecto

TAROX

Identificador del acuerdo de subvención: 695376

DOI

10.3030/695376

Proyecto cerrado

Fecha de la firma de la CE 19 Julio 2016

Fecha de inicio 1 Agosto 2016

Fecha de finalización 31 Julio 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 279 406,00

Aportación de la UE

€ 2 279 406,00

Coordinado por

KAROLINSKA INSTITUTET
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (23)

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Autores: Torkild Visnes, Carlos Benítez-Buelga, Armando Cázares-Körner, Kumar Sanjiv, Bishoy M F Hanna, Oliver Mortusewicz, Varshni Rajagopal, Julian J Albers, Daniel W Hagey, Tove Bekkhus, Saeed Eshtad, Juan Miguel Baquero, Geoffrey Masuyer, Olov Wallner, Sarah Müller, Therese Pham, Camilla Göktürk, Azita Rasti, Sharda Suman, Raúl Torres-Ruiz, Antonio Sarno, Elisée Wiita, Evert J Homan, Stella Kar
Publicado en: Nucleic Acids Research, Edición 48/21, 2020, Página(s) 12234-12251, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa1048

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

Autores: Jana Škerlová, Judith Unterlass, Mona Göttmann, Petra Marttila, Evert Homan, Thomas Helleday, Ann-Sofie Jemth, Pål Stenmark
Publicado en: Journal of Biological Chemistry, Edición 295/33, 2020, Página(s) 11656-11668, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.013695

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Autores: Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-06287-x

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG

Autores: Sean G. Rudd, Helge Gad, Kumar Sanjiv, Nuno Amaral, Anna Hagenkort, Petra Groth, Cecilia E. Ström, Oliver Mortusewicz, Ulrika Warpman Berglund, Thomas Helleday
Publicado en: Cancer Research, Edición 80/17, 2020, Página(s) 3530-3541, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-0883

Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma

Autores: Morten P. Oksvold, Ulrika Warpman Berglund, Helge Gad, Baoyan Bai, Trond Stokke, Idun Dale Rein, Therese Pham, Kumar Sanjiv, Geir Frode Øy, Jens Henrik Norum, Erlend B. Smeland, June H. Myklebust, Thomas Helleday, Thea Kristin Våtsveen
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-85613-8

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

Autores: Emma Rose Scaletti, Karl S. Vallin, Lars Bräutigam, Antonio Sarno, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark, Ann-Sofie Jemth
Publicado en: Journal of Biological Chemistry, Edición 295/15, 2020, Página(s) 4761-4772, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.012636

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir

Autores: Si Min Zhang, Daniel Rehling, Ann-Sofie Jemth, Adam Throup, Natalia Landázuri, Ingrid Almlöf, Mona Göttmann, Nicholas C.K. Valerie, Sanjay R. Borhade, Prasad Wakchaure, Brent D.G. Page, Matthieu Desroses, Evert J. Homan, Martin Scobie, Sean G. Rudd, Ulrika Warpman Berglund, Cecilia Söderberg-Nauclér, Pål Stenmark, Thomas Helleday
Publicado en: Cell Chemical Biology, 2021, ISSN 2451-9456
Editor: Elsevier BV
DOI: 10.1016/j.chembiol.2021.06.001

NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis

Autores: Zhenjun Zhao, Helge Gad, Carlos Benitez-Buelga, Kumar Sanjiv, Hua Xiangwei, He Kang, Mingxuan Feng, Zhicong Zhao, Ulrika Warpman Berglund, Qiang Xia, Thomas Helleday
Publicado en: Cancer Research, Edición 81/15, 2021, Página(s) 4079-4093, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-1028

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

Autores: Juan Miguel Baquero, Carlos Benítez-Buelga, Varshni Rajagopal, Zhao Zhenjun, Raúl Torres-Ruiz, Sarah Müller, Bishoy M. F. Hanna, Olga Loseva, Olov Wallner, Maurice Michel, Sandra Rodríguez-Perales, Helge Gad, Torkild Visnes, Thomas Helleday, Javier Benítez, Ana Osorio
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-82917-7

Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation

Autores: Sofia Henriksson, Petra Groth, Nina Gustafsson, Thomas Helleday
Publicado en: Cell Cycle, Edición 17/5, 2018, Página(s) 568-579, ISSN 1538-4101
Editor: Landes Bioscience
DOI: 10.1080/15384101.2017.1387696

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

Autores: Daniel Rehling, Si Min Zhang, Ann-Sofie Jemth, Tobias Koolmeister, Adam Throup, Olov Wallner, Emma Scaletti, Takaya Moriyama, Rina Nishii, Jonathan Davies, Matthieu Desroses, Sean G. Rudd, Martin Scobie, Evert Homan, Ulrika Warpman Berglund, Jun J. Yang, Thomas Helleday, Pål Stenmark
Publicado en: Journal of Biological Chemistry, Edición 296, 2021, Página(s) 100568, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100568

In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization

Autores: Maurice Michel, Evert J. Homan, Elisée Wiita, Kia Pedersen, Ingrid Almlöf, Anna-Lena Gustavsson, Thomas Lundbäck, Thomas Helleday, Ulrika Warpman Berglund
Publicado en: Frontiers in Chemistry, Edición 8, 2020, ISSN 2296-2646
Editor: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00443

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity

Autores: Jaime A. Espinoza, Asimina Zisi, Dimitris C. Kanellis, Jordi Carreras-Puigvert, Martin Henriksson, Daniela Hühn, Kenji Watanabe, Thomas Helleday, Mikael S. Lindström, Jiri Bartek
Publicado en: Cell Death & Differentiation, Edición 27/2, 2020, Página(s) 773-789, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-019-0387-5

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Autores: Torkild Visnes, Armando Cázares-Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisée Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina v
Publicado en: Science, Edición 362/6416, 2018, Página(s) 834-839, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aar8048

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

Autores: Jordi Carreras-Puigvert, Marinka Zitnik, Ann-Sofie Jemth, Megan Carter, Judith E. Unterlass, Björn Hallström, Olga Loseva, Zhir Karem, José Manuel Calderón-Montaño, Cecilia Lindskog, Per-Henrik Edqvist, Damian J. Matuszewski, Hammou Ait Blal, Ronnie P. A. Berntsson, Maria Häggblad, Ulf Martens, Matthew Studham, Bo Lundgren, Carolina Wählby, Erik L. L. Sonnhammer, Emma Lundberg, Pål Stenmar
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-01642-w

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Autores: Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Bea
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02293-7

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1

Autores: Linda Pudelko, Pegah Rouhi, Kumar Sanjiv, Helge Gad, Christina Kalderén, Andreas Höglund, Massimo Squatrito, Alberto J. Schuhmacher, Steven Edwards, Daniel Hägerstrand, Ulrika Warpman Berglund, Thomas Helleday, Lars Bräutigam
Publicado en: Oncotarget, Edición 8/49, 2017, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.19404

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. Structure. Feb 6;26(2):295-303.e6.

Autores: "Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martínez Carranza M, Vallin KSA, Throup A, Helleday T#, Stenmark P#."
Publicado en: Structure, Edición 26/2, 2018, Página(s) 295-303.e6, ISSN 2352-0124
Editor: Elsevier Limited
DOI: 10.1016/j.str.2018.01.004

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

Autores: Bishoy M. F. Hanna, Thomas Helleday, Oliver Mortusewicz
Publicado en: Biomolecules, Edición 10/11, 2020, Página(s) 1483, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom10111483

NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487

Autores: Bishoy M. F. Hanna, Maurice Michel, Thomas Helleday, Oliver Mortusewicz
Publicado en: International Journal of Molecular Sciences, Edición 22/9, 2021, Página(s) 4542, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094542

Development of a chemical probe against NUDT15

Autores: Si Min Zhang, Matthieu Desroses, Anna Hagenkort, Nicholas C. K. Valerie, Daniel Rehling, Megan Carter, Olov Wallner, Tobias Koolmeister, Adam Throup, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Thomas Lundbäck, Hanna Axelsson, Shruti Regmi, Antonio Sarno, Andreas Krämer, Linda Pudelko, Lars Bräutigam, Azita Rasti, Mona Göttmann, Elisée Wiita, Juliane Kutzner, Torsten Schaller, Christina Kal
Publicado en: Nature Chemical Biology, Edición 16/10, 2020, Página(s) 1120-1128, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-020-0592-z

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

Autores: Stella Karsten, Roland Fiskesund, Xing-Mei Zhang, Petra Marttila, Kumar Sanjiv, Therese Pham, Azita Rasti, Lars Bräutigam, Ingrid Almlöf, Maritha Marcusson-Ståhl, Carolina Sandman, Björn Platzack, Robert A. Harris, Christina Kalderén, Karin Cederbrant, Thomas Helleday, Ulrika Warpman Berglund
Publicado en: Cell Death & Differentiation, 2020, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-021-00854-4

Computational and Experimental Druggability Assessment of Human DNA Glycosylases

Autores: Maurice Michel, Torkild Visnes, Evert J. Homan, Brinton Seashore-Ludlow, Mattias Hedenström, Elisée Wiita, Karl Vallin, Cynthia B. J. Paulin, Jiaxi Zhang, Olov Wallner, Martin Scobie, Andreas Schmidt, Annika Jenmalm-Jensen, Ulrika Warpman Berglund, Thomas Helleday
Publicado en: ACS Omega, Edición 4/7, 2019, Página(s) 11642-11656, ISSN 2470-1343
Editor: MDPI
DOI: 10.1021/acsomega.9b00162

Derechos de propiedad intelectual

Patent (1)

Preparation of novel functionalized purine-2,6-diones and their use in medicine

Número de solicitud/publicación: WO 2019020828
Fecha: 2017-07-27
Solicitante(s): KAROLINSKA INSTITUTET