Discovery of anticancer polymeric drugs that mimic the action of TRAIL

Projektinformationen

PolyDrug Discovery

ID Finanzhilfevereinbarung: 703466

DOI

10.3030/703466

Das Projekt endete am 1 Januar 2017

EK-Unterschriftsdatum 10 Februar 2016

Startdatum 1 März 2016

Enddatum 28 Februar 2018

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 173 857,20

EU-Beitrag

€ 173 857,20

Koordiniert durch

KAROLINSKA INSTITUTET
Sweden

Periodic Reporting for period 1 - PolyDrug Discovery (Discovery of anticancer polymeric drugs that mimic the action of TRAIL)

Berichtszeitraum: 2016-03-01 bis 2018-02-28

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

The objective of this project was to develop a polymeric drug (PolyDrug) that mimics the activity of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) for the treatment of breast cancer. Having such a polymeric and therefore synthetic replacement for this therapeutic would have tremendous benefits including greater drug stability and biodistribution. Therefore, this project outlined a two year plan to develop such a drug by following the standard drug discovery process.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

While this fellowship is being terminated early, I have achieved the goals set out over this 10 month period. This progress is critical as I plan to continue this project in my lab at Rutgers University. I was successful in preparing a variety of death receptor targeting peptides and managed to select a few peptides with low nM affinity towards this receptor. This was a main objective of this first year and these peptides will move on to further evaluation in my new position. During this first year, I also optimized the technique for preparing the polymers and showed that we are able to make all drug variations needed for the drug discovery process. In parallel, I also developed the drug screening cell culture assay that is need to run the drug discovery process. This culmination of this work puts me on target with the fellowship in order to continue at Rutgers University.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

This project is ongoing in my new position and the expected impact is still to be determined. Hopefully in one years time (as originally outlined), we will have a better update on the overall impact of this research.

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