Engineering the 3D Niche to enHANCE functionality of hepatocytes derived from human iPSCs

Informazioni relative al progetto

ENHANCE

ID dell’accordo di sovvenzione: 705607

DOI 10.3030/705607

Progetto concluso il 20 Ottobre 2017

Data della firma CE 18 Febbraio 2016

Data di avvio 1 Marzo 2016

Data di completamento 28 Febbraio 2018

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 183 454,80

Contributo UE € 183 454,80

Coordinato da

KING'S COLLEGE LONDON
United Kingdom

Obiettivo

Induced pluripotent stem cell derived hepatocytes (i-Heps) afford us the exciting possibility of redressing the growing shortage in liver transplantation tissue and heralding in a new era of patient specific drug and disease modelling. Clinical applications are restricted by their poor functionality in comparison to the gold standard – freshly isolated primary hepatocytes. Emerging evidence suggests the three dimensional environment surrounding a cell (the niche) critically influences cellular function. The objective of ENHANCE is to identify relevant factors from the extracellular niche which promote i-Hep function in 3D and the mechanisms by which they achieve this. This new knowledge will be used to generate functionally optimized i-Hep constructs suitable for clinical transplantation, with proof of concept studies being performed in rodent models of liver failure. This European Fellowship at Kings College London will provide the researcher with advanced training in iPSC technology, i-Hep generation, 2D niche component screening, 3D cell engineering and animal transplantation. A secondment to SME DefiniGEN Ltd will evaluate the feasibility of transfer to a commercial i-Hep production platform as a critical step towards clinical trials.

Campo scientifico (EuroSciVoc)

CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.

• scienze mediche e della salute › scienze della salute › salute pubblica
• scienze mediche e della salute › biotecnologia medica › tecnologie cellulari › cellule staminali
• scienze mediche e della salute › medicina clinica › epatologia
• scienze mediche e della salute › medicina clinica › trapianto
• scienze mediche e della salute › medicina di base › tossicologia

È necessario effettuare l’accesso o registrarsi per utilizzare questa funzione

Parole chiave

• Liver transplantation
• induced pluripotent stem cells
• tissue engineering

Programma(i)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Argomento(i)

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Invito a presentare proposte

H2020-MSCA-IF-2015

Meccanismo di finanziamento

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Coordinatore

KING'S COLLEGE LONDON

• Contribution nette de l'UE: € 183 454,80
• Indirizzo: STRAND ; WC2R 2LS London ; Regno Unito
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: € 183 454,80