Objectif
This project aims at predicting early cognitive decline using a neurofeedback performance endophenotype based on realtime functional magnetic resonance imaging in a population at risk for Alzheimer’s Disease (AD). It has been proven that AD biomarkers change decades before the development of symptoms. In addition, there is a lack of robust hypersensitive methods capable of predicting impending cognitive decline in healthy subjects at risk. This constitutes a crucial obstacle for the implementation of AD prevention trials. To address this, we will identify and characterize a novel neurofeedback performance endophenotype in a subsample from a cohort of 2743 cognitively healthy volunteers at risk for AD. This will be based on state-of-the-art neuroimaging technology, in combination with a novel sensitive neuropsychological test that detects subtle alterations in episodic memory, which has been validated for our cohort. Then, we will evaluate the impact on our newly developed neurofeedback performance endophenotype of factors known to be related to AD such as various clinical and lifestyle variables, amyloid deposition, genetic background (including, but not restricted to APOE4) and most importantly cognitive reserve. A specific aim is to test the hypothesis that neurofeedback performance can become a reliable proxy to measure cognitive reserve. Finally, we will develop a novel statistical predictive model, featuring all the relevant genetic and clinical variables and will assess the capacity of neurofeedback performance for predicting impending cognitive decline during a two-year period in AD descendants.
Champ scientifique
- natural sciencesbiological sciencesneurobiologycognitive neuroscience
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
- medical and health sciencesclinical medicinepsychiatryschizophrenia
- natural sciencescomputer and information sciencessoftwaresoftware applicationsvirtual reality
Programme(s)
Régime de financement
MSCA-IF-EF-ST - Standard EFCoordinateur
08005 Barcelona
Espagne