Objective
When it is inhaled, asbestos triggers a chain of events that can lead to mesothelioma, an aggressive cancer of the lung lining, and to lung cancer. After prolonged stay in the lungs the asbestos fibers develop an iron coating that is thought to be responsible for the cytotoxic response, and which nature is still unclear. The fibres with their coating, developed after prolonged stay in human lungs, are known as asbestos bodies. Despite the large and increasing incidence of respiratory/pulmonary diseases among the general population due to asbestos and other toxic fibers, the carcinogenic mechanism is not yet fully understood. A deeper knowledge of the interaction between the fibers and the biological tissue can help scientists to develop more efficient medical treatments and to improve prevention strategies. The proposed research project aims to reveal the composition and formation mechanism of asbestos bodies combining cutting-edge synchrotron radiation fluorescence and imaging microtomography and microdiffraction with transmission electron microscopy. Synchrotron radiation techniques will allow revealing the elemental distribution and morphology of unaltered lung tissue samples with unprecedented level of detail, preserving their tridimensional structure. Microdiffraction and transmission electron microscopy will reveal possible degradation of the embedded asbestos fibres, which is a long standing question. The project will exploit an innovative collaboration between physicists, chemists, doctors, and biologists. In particular, physics techniques usually employed in the field of fundamental research or in material science will be combined with laboratory methodologies, creating an environment favourable for breaking-through results. The methodologies developed during the project can be extended to the study of other toxic particulate, such as vehicular or industrial particulate matter and man-made nanoparticles, which are of increasing concern for human health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology materials engineering fibers
- medical and health sciences clinical medicine oncology lung cancer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences health sciences infectious diseases RNA viruses coronaviruses
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00185 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.