Neurovascular interplay in the hematopoietic stem cell niches in homeostasis and myeloproliferative neoplasias

Project Information

NVHSC

Grant agreement ID: 708411

DOI 10.3030/708411

Project closed

EC signature date 21 March 2016

Start date 1 April 2016

End date 31 March 2018

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 183 454,80

EU contribution € 183 454,80

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Objective

Research of the bone marrow (BM) hematopoietic stem cell (HSC) niche has long been the study of mesenchymal cell populations. Only recently, distinct vascular niches have been identified to balance HSC activation and quiescence. Whereas arterioles together with sympathetic nerves and NG2+Nesbright cells form a niche for quiescent HSC, actively proliferating HSC are closely located to sinusoidal vessels and LepR+Neslow cells. However, it is still elusive how different blood vessels interact with different niche cells in distinct vascular niches during BM homeostasis and leukemic progression. Therefore, the present proposal aims at studying the role of distinct vascular BM niches in controlling HSC maintenance and malignant progression by means of genetic mouse models, FACS analysis, high resolution whole mount BM imaging and RNA sequencing. Besides investigating the direct influence of EC on HSC in different vascular niches, the interaction of EC with perivascular MSC and particularly neurons will be compared between the sinusoidal and arteriolar niche under steady-state and malignant conditions. Changes of the vasculature and downstream effects on HSC and other niche cells will be analyzed during therapeutic targeting of leukemia and the vascular compartment will be evaluated as novel target for niche-targeting leukemia combination therapies.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• social sciences › sociology › demography
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › transplantation
• medical and health sciences › clinical medicine › oncology › leukemia
• medical and health sciences › basic medicine › physiology › homeostasis

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Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Call for proposal

H2020-MSCA-IF-2015

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• Net EU contribution: € 183 454,80
• Address: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; United Kingdom
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 183 454,80