Neurovascular interplay in the hematopoietic stem cell niches in homeostasis and myeloproliferative neoplasias

Informazioni relative al progetto

NVHSC

ID dell’accordo di sovvenzione: 708411

DOI 10.3030/708411

Progetto chiuso

Data della firma CE 21 Marzo 2016

Data di avvio 1 Aprile 2016

Data di completamento 31 Marzo 2018

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 183 454,80

Contributo UE € 183 454,80

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Obiettivo

Research of the bone marrow (BM) hematopoietic stem cell (HSC) niche has long been the study of mesenchymal cell populations. Only recently, distinct vascular niches have been identified to balance HSC activation and quiescence. Whereas arterioles together with sympathetic nerves and NG2+Nesbright cells form a niche for quiescent HSC, actively proliferating HSC are closely located to sinusoidal vessels and LepR+Neslow cells. However, it is still elusive how different blood vessels interact with different niche cells in distinct vascular niches during BM homeostasis and leukemic progression. Therefore, the present proposal aims at studying the role of distinct vascular BM niches in controlling HSC maintenance and malignant progression by means of genetic mouse models, FACS analysis, high resolution whole mount BM imaging and RNA sequencing. Besides investigating the direct influence of EC on HSC in different vascular niches, the interaction of EC with perivascular MSC and particularly neurons will be compared between the sinusoidal and arteriolar niche under steady-state and malignant conditions. Changes of the vasculature and downstream effects on HSC and other niche cells will be analyzed during therapeutic targeting of leukemia and the vascular compartment will be evaluated as novel target for niche-targeting leukemia combination therapies.

Campo scientifico (EuroSciVoc)

CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.

• scienze sociali › sociologia › demografia
• scienze mediche e della salute › biotecnologia medica › tecnologie cellulari › cellule staminali
• scienze mediche e della salute › medicina clinica › trapianto
• scienze mediche e della salute › medicina clinica › oncologia › leucemia
• scienze mediche e della salute › medicina di base › fisiologia › omeostasi

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Programma(i)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Argomento(i)

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Invito a presentare proposte

H2020-MSCA-IF-2015

Meccanismo di finanziamento

MSCA-IF-EF-ST - Standard EF

Coordinatore

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• Contribution nette de l'UE: € 183 454,80
• Indirizzo: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; Regno Unito
• Regione: East of England › East Anglia › Cambridgeshire CC
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: € 183 454,80