Magnetic Solid Lipid Nanoparticles as a Multifunctional Platform against Glioblastoma Multiforme

Project Information

SLaMM

Grant agreement ID: 709613

DOI

10.3030/709613

Project closed

EC signature date 19 December 2016

Start date 1 March 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 997,42

EU contribution

€ 1 499 997,42

Coordinated by

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Porous Optically Transparent Cellulose Acetate Scaffolds for Biomimetic Blood-Brain Barrierin vitro Models

Author(s): Attilio Marino, Micol Baronio, Umberto Buratti, Elisa Mele, Gianni Ciofani
Published in: Frontiers in Bioengineering and Biotechnology, Issue 9, 2021, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2021.630063

Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells.

Author(s): Carlotta Pucci; Attilio Marino; Özlem Şen; Daniele De Pasquale; Martina Bartolucci; Nerea Iturrioz-Rodríguez; Nicoletta di Leo; Giuseppe de Vito; Doriana Debellis; Andrea Petretto; Gianni Ciofani
Published in: Acta Biomaterialia, Issue 139, 2022, Page(s) 218-236, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2021.04.005

Combining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid carriers during blood-brain barrier crossing

Author(s): Matteo Battaglini, Natalia Feiner, Christos Tapeinos, Daniele De Pasquale, Carlotta Pucci, Attilio Marino, Martina Bartolucci, Andrea Petretto, Lorenzo Albertazzi, Gianni Ciofani
Published in: Nanoscale, Issue 20403364, 2022, Page(s) 13292-13307, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr00484d

Drug-loaded lipid magnetic nanoparticles for combined local hyperthermia and chemotherapy against glioblastoma multiforme

Author(s): Beola Lilianne, Iturrioz-Rodríguez Nera, Pucci Carlotta, Bertorelli Rosalia, Ciofani Gianni
Published in: ACS Nano, Issue 17(18), 2023, Page(s) 18441-18455, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c06085

Nanotechnology‐Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

Author(s): Özlem Şen, Melis Emanet, Gianni Ciofani
Published in: Advanced Healthcare Materials, Issue 10/10, 2021, Page(s) 2002163, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202002163

Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors

Author(s): Ozlem Sen, Attilio Marino, Carlotta Pucci, Gianni Ciofani
Published in: Materials Today Bio, Issue 13, 2022, Page(s) 100196, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2021.100196

Magnetic Nanotransducers in Biomedicine

Author(s): Agostina Grillone, Gianni Ciofani
Published in: Chemistry - A European Journal, Issue 23/64, 2017, Page(s) 16109-16114, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201703660

Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine

Author(s): Giada Graziana Genchi, Attilio Marino, Christos Tapeinos, Gianni Ciofani
Published in: Frontiers in Bioengineering and Biotechnology, Issue 5, 2017, Page(s) 8, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2017.00080

Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases

Author(s): Christos Tapeinos, Matteo Battaglini, Gianni Ciofani
Published in: Journal of Controlled Release, Issue 264, 2017, Page(s) 306-332, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2017.08.033

A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography

Author(s): Attilio Marino, Omar Tricinci, Matteo Battaglini, Carlo Filippeschi, Virgilio Mattoli, Edoardo Sinibaldi, Gianni Ciofani
Published in: Small, Issue 14/6, 2018, Page(s) 1702959, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201702959

Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy

Author(s): Christos Tapeinos, Attilio Marino, Matteo Battaglini, Simone Migliorin, Rosaria Brescia, Alice Scarpellini, César De Julián Fernández, Mirko Prato, Filippo Drago, Gianni Ciofani
Published in: Nanoscale, Issue 11/1, 2019, Page(s) 72-88, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8NR05520C

Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme

Author(s): Attilio Marino, Enrico Almici, Simone Migliorin, Christos Tapeinos, Matteo Battaglini, Valentina Cappello, Marco Marchetti, Giuseppe de Vito, Riccardo Cicchi, Francesco Saverio Pavone, Gianni Ciofani
Published in: Journal of Colloid and Interface Science, Issue 538, 2019, Page(s) 449-461, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.1016/j.jcis.2018.12.014

Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment

Author(s): Agostina Grillone, Matteo Battaglini, Stefania Moscato, Letizia Mattii, César de Julián Fernández, Alice Scarpellini, Mario Giorgi, Edoardo Sinibaldi, Gianni Ciofani
Published in: Nanomedicine, Issue 14/6, 2019, Page(s) 727-752, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2018-0436

Nanostructured carriers as innovative tools for cancer diagnosis and therapy

Author(s): Chiara Martinelli, Carlotta Pucci, Gianni Ciofani
Published in: APL Bioengineering, Issue 3/1, 2019, Page(s) 011502, ISSN 2473-2877
Publisher: AIP
DOI: 10.1063/1.5079943

Cell Membrane‐Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme

Author(s): Christos Tapeinos, Francesca Tomatis, Matteo Battaglini, Aitor Larrañaga, Attilio Marino, Iker Aguirrezabal Telleria, Makis Angelakeris, Doriana Debellis, Filippo Drago, Francesca Brero, Paolo Arosio, Alessandro Lascialfari, Andrea Petretto, Edoardo Sinibaldi, Gianni Ciofani
Published in: Advanced Healthcare Materials, Issue 8(18), 2019, Page(s) 1900612, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201900612

Innovative approaches for cancer treatment: current perspectives and new challenges

Author(s): Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
Published in: ecancermedicalscience, Issue 13, 2019, Page(s) 961, ISSN 1754-6605
Publisher: eCancer Global Foundation
DOI: 10.3332/ecancer.2019.961

Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors: dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment

Author(s): Attilio Marino, Alice Camponovo, Andrea Degl'Innocenti, Martina Bartolucci, Christos Tapeinos, Chiara Martinelli, Daniele De Pasquale, Francesca Santoro, Valentina Mollo, Satoshi Arai, Madoka Suzuki, Yoshie Harada, Andrea Petretto, Gianni Ciofani
Published in: Nanoscale, Issue 11/44, 2019, Page(s) 21227-21248, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr07976a

Genetic Hallmarks and Heterogeneity of Glioblastoma in the Single‐Cell Omics Era

Author(s): Andrea Degl'Innocenti, Nicoletta di Leo, Gianni Ciofani
Published in: Advanced Therapeutics, Issue 3/1, 2019, Page(s) 1900152, ISSN 2366-3987
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adtp.201900152

What does the future hold for chemotherapy with the use of lipid-based nanocarriers?

Author(s): Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
Published in: Future Oncology, Issue 16/5, 2020, Page(s) 81-84, ISSN 1479-6694
Publisher: Future Medicine Ltd.
DOI: 10.2217/fon-2019-0767

Editorial: Advanced Theranostic Nanomedicine in Oncology

Author(s): Christos Tapeinos, Attilio Marino, Gianni Ciofani
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.00142

Homotypic targeting and drug delivery in glioblastoma cells through cell membrane-coated boron nitride nanotubes

Author(s): Daniele De Pasquale, Attilio Marino, Christos Tapeinos, Carlotta Pucci, Silvia Rocchiccioli, Elena Michelucci, Francesco Finamore, Liam McDonnell, Alice Scarpellini, Simone Lauciello, Mirko Prato, Aitor Larrañaga, Filippo Drago, Gianni Ciofani
Published in: Materials & Design, Issue 192, 2020, Page(s) 108742, ISSN 0264-1275
Publisher: Elsevier BV
DOI: 10.1016/j.matdes.2020.108742

Hybrid Magnetic Nanovectors Promote Selective Glioblastoma Cell Death through a Combined Effect of Lysosomal Membrane Permeabilization and Chemotherapy

Author(s): Carlotta Pucci, Daniele De Pasquale, Attilio Marino, Chiara Martinelli, Simone Lauciello, Gianni Ciofani
Published in: ACS Applied Materials & Interfaces, Issue 12/26, 2020, Page(s) 29037-29055, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c05556

Lipid‐Based Nanocarriers for The Treatment of Glioblastoma

Author(s): Nerea Iturrioz-Rodríguez, Rosalia Bertorelli, Gianni Ciofani
Published in: Advanced NanoBiomed Research, Issue 1/2, 2021, Page(s) 2000054, ISSN 2699-9307
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/anbr.202000054

Intellectual Property Rights

Patent (1)

CELL CO-CULTURE SYSTEM AND METHOD

Application/Publication number: 20 796929
Date: 2020-10-06
Applicant(s): FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA